Detailed information for compound 1047198

Basic information

Technical information
  • TDR Targets ID: 1047198
  • Name: 3-azaniumylpropyl-[4-(3-azaniumylpropylazaniu myl)butyl]-[4-(7-chloroquinolin-4-yl)azaniumy lbutyl]azanium pentachloride
  • MW: 617.354 | Formula: C23H44Cl6N6
  • H donors: 4 H acceptors: 1 LogP: 6.68 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: NCCCNCCCCN(CCCN)CCCCNc1ccnc2c1ccc(c2)Cl.Cl.Cl.Cl.Cl.Cl
  • InChi: 1S/C23H39ClN6.5ClH/c24-20-7-8-21-22(9-15-29-23(21)19-20)28-14-2-4-17-30(18-6-11-26)16-3-1-12-27-13-5-10-25;;;;;/h7-9,15,19,27H,1-6,10-14,16-18,25-26H2,(H,28,29);5*1H
  • InChiKey: MUIWELILGSNQMR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-azaniumylpropyl-[4-(3-azaniumylpropylammonio)butyl]-[4-[(7-chloro-4-quinolyl)ammonio]butyl]ammonium pentachloride
  • 3-ammoniopropyl-[4-(3-ammoniopropylammonio)butyl]-[4-[(7-chloro-4-quinolyl)ammonio]butyl]ammonium pentachloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0364 0.0357
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0571 0.7167 1
Brugia malayi Guanylyl cyclase protein 23 0.0009 0.0018 0.002
Echinococcus granulosus DNA repair and recombination protein RAD54B 0.0008 0.0003 0.0000089063
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.005 0.0066
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0571 0.7167 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.005 0.0047
Brugia malayi Thioredoxin reductase 0.0081 0.0934 0.1299
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0183 0.0101
Brugia malayi Sugar transporter family protein 0.0016 0.0112 0.0151
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.005 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Entamoeba histolytica hypothetical protein 0.0026 0.0234 0.0327
Plasmodium falciparum calcium-dependent protein kinase 1 0.0036 0.0358 0.0571
Echinococcus granulosus dna repair and recombination protein rad54 0.0008 0.0003 0.0000089063
Onchocerca volvulus 0.0016 0.0112 0.0132
Onchocerca volvulus 0.0016 0.0112 0.0132
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0089 0.0086
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0183 0.018
Schistosoma mansoni tyrosine kinase 0.0009 0.0018 0.0014
Trypanosoma cruzi hexose transporter 0.0036 0.0364 0.1686
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0358 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0117 0.139 0.1812
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.139 0.1387
Plasmodium falciparum calcium-dependent protein kinase 4 0.0036 0.0358 0.0571
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.005 0.0047
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0364 0.1686
Brugia malayi glutathione reductase 0.0081 0.0934 0.1299
Schistosoma mansoni thyroid hormone receptor 0.0012 0.005 0.0047
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0035 0.0349 0.0346
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0193 0.0116
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0364 0.0357
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0183 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0364 0.0357
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0183 0.018
Onchocerca volvulus 0.0016 0.0112 0.0132
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0028 0.026 0.12
Loa Loa (eye worm) glutathione reductase 0.0081 0.0934 0.1299
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0176 0.2142 0.2877
Plasmodium falciparum protein kinase 7 0.033 0.4105 0.6603
Loa Loa (eye worm) thioredoxin reductase 0.0081 0.0934 0.1299
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0098 0.1153 0.1608
Brugia malayi hypothetical protein 0.0022 0.0183 0.0251
Onchocerca volvulus 0.0016 0.0112 0.0132
Echinococcus multilocularis thioredoxin glutathione reductase 0.0082 0.0948 0.0945
Loa Loa (eye worm) hypothetical protein 0.0022 0.0183 0.0251
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0571 0.7167 1
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0112 0.0151
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0183 0.018
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0038 0.0381 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0081 0.0934 0.1708
Loa Loa (eye worm) hypothetical protein 0.0035 0.0349 0.0482
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0183 0.018
Plasmodium vivax calcium-dependent protein kinase, putative 0.0036 0.0358 0.0571
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0185 0.0182
Trypanosoma brucei glucose transporter, putative 0.0036 0.0364 0.1686
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0026 0.0234 0.1081
Toxoplasma gondii lysine-tRNA ligase 0.0026 0.0234 0.0308
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0358 0.0355
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0028 0.026 0.0257
Echinococcus multilocularis calcium dependent protein kinase 0.0034 0.033 0.0327
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0183 0.018
Leishmania major glucose transporter/membrane transporter D2, putative 0.0036 0.0364 0.1686
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Schistosoma mansoni protein kinase 0.0009 0.0018 0.0014
Echinococcus multilocularis General substrate transporter 0.01 0.1181 0.1178
Echinococcus granulosus tyrosine protein kinase shark 0.0237 0.2919 0.2916
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.0184 0.0151
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0183 0.0251
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.026 0.12
Loa Loa (eye worm) RGC/RGC protein kinase 0.0009 0.0018 0.002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.005 0.0047
Plasmodium falciparum protein kinase 6 0.0496 0.6216 1
Brugia malayi Glutamate receptor 2 precursor 0.0015 0.0089 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.005 0.0066
Plasmodium falciparum glutathione reductase 0.0081 0.0934 0.1498
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0358 0.0355
Echinococcus multilocularis solute carrier family 22 0.0016 0.0112 0.0108
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0028 0.026 0.12
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Treponema pallidum NADH oxidase 0.0028 0.026 0.6227
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.005 0.0047
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0364 0.1686
Chlamydia trachomatis lysine--tRNA ligase 0.0026 0.0234 0.5434
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.005 0.0066
Entamoeba histolytica hypothetical protein 0.0022 0.0183 0.0255
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0205 0.2518 0.4998
Echinococcus granulosus geminin 0.0168 0.2044 0.2042
Onchocerca volvulus 0.0016 0.0112 0.0132
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.139 0.1387
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0016 0.0112 0.0174
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0036 0.0358 0.0571
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0112 0.0108
Echinococcus multilocularis NMDA receptor 0.0015 0.0089 0.0086
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.005 0.0066
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0189 0.2306 0.5495
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.005 0.0066
Schistosoma mansoni ATP-binding cassette transporter 0.0015 0.0089 0.0086
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0571 0.7167 1
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.005 0.0047
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0028 0.026 0.0257
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0571 0.7167 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0066
Schistosoma mansoni protein kinase 0.0036 0.0358 0.0355
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.005 0.0066
Brugia malayi PXA domain containing protein 0.0022 0.0183 0.0251
Onchocerca volvulus 0.0016 0.0112 0.0132
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Plasmodium falciparum hexose transporter 0.0117 0.139 0.2232
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.005 0.0047
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0345 0.4297 0.5995
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0183 0.018
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0036 0.0358 0.0571
Schistosoma mansoni tyrosine kinase 0.0237 0.2919 0.2916
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0035 0.0349 0.0482
Trypanosoma cruzi hexose transporter, putative 0.0016 0.0112 0.0506
Loa Loa (eye worm) sugar transporter 0.0117 0.139 0.1936
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.005 0.0047
Onchocerca volvulus 0.0016 0.0112 0.0132
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0183 0.0251
Plasmodium vivax proline--tRNA ligase, putative 0.0041 0.0423 0.0675
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0183 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0183 0.0101
Leishmania major myo-inositol/proton symporter (MIT) 0.0016 0.0112 0.0506
Onchocerca volvulus 0.0016 0.0112 0.0132
Loa Loa (eye worm) sugar transporter 0.0016 0.0112 0.0151
Echinococcus granulosus solute carrier family 22 0.0016 0.0112 0.0108
Trypanosoma cruzi glucose transporter, putative 0.0016 0.0112 0.0506
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0028 0.026 0.0371
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0183 0.018
Trichomonas vaginalis glutathione reductase, putative 0.0028 0.026 0.021
Echinococcus multilocularis 0.0008 0.0003 0.0000089063
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0117 0.139 0.1387
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Brugia malayi hypothetical protein 0.0016 0.0112 0.0151
Echinococcus granulosus solute carrier family 22 0.0016 0.0112 0.0108
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0015 0.0089 0.0086
Mycobacterium tuberculosis Probable oxidoreductase 0.0205 0.2518 0.4998
Trypanosoma cruzi hypothetical protein, conserved 0.0176 0.2142 1
Mycobacterium ulcerans sugar transporter 0.0016 0.0112 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.005 0.0066
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0028 0.026 0.0281
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.005 0.0047
Trypanosoma brucei glucose transporter, putative 0.0036 0.0364 0.1686
Trypanosoma cruzi trypanothione reductase, putative 0.0081 0.0934 0.4353
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0364 0.0357
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0052 0.0568 0.0565
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0028 0.026 0.0281
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0035 0.0349 0.0336
Onchocerca volvulus 0.0016 0.0112 0.0132
Loa Loa (eye worm) hypothetical protein 0.0026 0.0234 0.0323
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0571 0.7167 1
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0089 0.0086
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0183 0.018
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0015 0.0089 0.0086
Echinococcus multilocularis geminin 0.0168 0.2044 0.2042
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0016 0.0112 0.0506
Schistosoma mansoni microtubule-associated protein tau 0.0793 1 1
Entamoeba histolytica hypothetical protein 0.0098 0.1153 0.1608
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0066
Schistosoma mansoni glutamate receptor NMDA 0.0015 0.0089 0.0086
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.0184 0.0151
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0022 0.0185 0.0182
Schistosoma mansoni sugar transporter 0.0016 0.0112 0.0108
Onchocerca volvulus 0.0016 0.0112 0.0132
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0183 0.0251
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0183 0.018
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0038 0.0381 0.0452
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0364 0.0357
Leishmania major hypothetical protein, conserved 0.0176 0.2142 1
Entamoeba histolytica hypothetical protein 0.0022 0.0183 0.0255
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0571 0.7167 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.005 0.0046
Entamoeba histolytica DNA repair protein, putative 0.0008 0.0003 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0183 0.0101
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.005 0.0066
Echinococcus multilocularis expressed protein 0.0429 0.5364 0.5363
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0036 0.0358 0.0571
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0364 0.1686
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0183 0.018
Schistosoma mansoni glucose transport protein 0.0117 0.139 0.1387
Giardia lamblia NADH oxidase lateral transfer candidate 0.0028 0.026 0.021
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0024 0.0211 0.029
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0185 0.2256 0.4452
Echinococcus granulosus General substrate transporter 0.01 0.1181 0.1178
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0036 0.0358 0.0617
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0035 0.0349 0.0487
Plasmodium falciparum calcium-dependent protein kinase 5 0.0036 0.0358 0.0571
Plasmodium falciparum lysine--tRNA ligase 0.0026 0.0234 0.0372
Onchocerca volvulus 0.0016 0.0112 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.005 0.0066
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0185 0.2256 0.4452
Entamoeba histolytica protein kinase, putative 0.0036 0.0358 0.0499
Leishmania major hypothetical protein, conserved 0.0016 0.0112 0.0506
Schistosoma mansoni protein kinase 0.0036 0.0358 0.0355
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0112 0.0151
Trypanosoma brucei glucose transporter 2A 0.0036 0.0364 0.1686
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0183 0.018
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0026 0.0234 0.0214
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0028 0.026 0.0358
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0185 0.2256 0.4452
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0028 0.026 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0183 0.0101
Brugia malayi steroid hormone receptor 0.0012 0.005 0.0066
Leishmania major trypanothione reductase 0.0081 0.0934 0.4353
Loa Loa (eye worm) hypothetical protein 0.0035 0.0349 0.0482
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.005 0.0047
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0423 0.1961
Plasmodium vivax thioredoxin reductase, putative 0.0081 0.0934 0.1498
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0571 0.7167 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0496 0.6216 1
Trypanosoma brucei glucose transporter, putative 0.0036 0.0364 0.1686
Trypanosoma cruzi sugar transporter, putative 0.0016 0.0112 0.0506
Giardia lamblia Lysyl-tRNA synthetase 0.0026 0.0234 0.0174
Brugia malayi major facilitator superfamily protein 0.0016 0.0112 0.0151
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0183 0.018
Echinococcus multilocularis beta adrenergic receptor kinase 0.0024 0.0211 0.0208
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0183 0.018
Trypanosoma brucei glucose transporter, putative 0.0036 0.0364 0.1686
Toxoplasma gondii protein kinase, putative 0.033 0.4105 1
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.005 0.0047
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0176 0.2142 1
Onchocerca volvulus 0.0016 0.0112 0.0132
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0016 0.0112 0.0108
Echinococcus multilocularis microtubule associated protein 2 0.0793 1 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0082 0.0948 0.0945
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0066
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0015 0.0089 0.0086
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.026 0.12
Schistosoma mansoni tyrosine kinase 0.0232 0.285 0.2847
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0183 0.018
Echinococcus granulosus receptor type guanylyl cyclase 0.0009 0.0018 0.0014
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0571 0.7167 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0028 0.026 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0183 0.0101
Loa Loa (eye worm) hypothetical protein 0.0022 0.0183 0.0251
Echinococcus granulosus lysyl tRNA synthetase 0.0026 0.0234 0.0231
Brugia malayi nuclear receptor NHR-88 0.0012 0.005 0.0066
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.026 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.005 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0358 0.0349
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0028 0.026 0.0281
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0183 0.0251
Schistosoma mansoni sugar transporter 0.0016 0.0112 0.0108
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0028 0.026 0.0308
Loa Loa (eye worm) glutamate receptor 1 0.0015 0.0089 0.012
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0026 0.0234 0.1081
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0028 0.026 0.0413
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0035 0.0349 0.0482
Loa Loa (eye worm) glutamate receptor 2 0.0015 0.0089 0.012
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0183 0.018
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0358 0.0355
Echinococcus granulosus glutamate receptor subunit protein glur 0.0015 0.0089 0.0086
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0205 0.2518 0.4998
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0066
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0036 0.0358 0.0495
Brugia malayi Cam kinase protein 1 0.0036 0.0358 0.0495
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0036 0.0358 0.0617
Leishmania major glucose transporter, lmgt1 0.0036 0.0364 0.1686
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0183 0.018
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.005 0.0046
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0205 0.2518 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0423 0.1961
Trypanosoma cruzi trypanothione reductase, putative 0.0028 0.026 0.12
Brugia malayi Glutamate receptor 1 precursor 0.0015 0.0089 0.012
Trypanosoma brucei glucose transporter, putative 0.0036 0.0364 0.1686
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0015 0.0089 0.0086
Echinococcus multilocularis solute carrier family 22 0.0016 0.0112 0.0108
Echinococcus granulosus glutamate NMDA receptor subunit 0.0015 0.0089 0.0086
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.0423 0.1961
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0112 0.0108
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0183 0.018
Onchocerca volvulus 0.0016 0.0112 0.0132
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0024 0.0211 0.0291
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0183 0.0251
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.005 0.0047
Schistosoma mansoni hypothetical protein 0.0168 0.2044 0.2042
Echinococcus granulosus solute carrier family 22 0.0016 0.0112 0.0108
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.005 0.0066
Brugia malayi PXA domain containing protein 0.0022 0.0183 0.0251
Trypanosoma brucei trypanothione reductase 0.0081 0.0934 0.4353
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0183 0.018
Brugia malayi lysyl-tRNA synthetase 0.0026 0.0234 0.0323
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0183 0.018
Trypanosoma brucei glucose transporter, putative 0.0036 0.0364 0.1686
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0038 0.0381 1
Mycobacterium tuberculosis Probable reductase 0.0185 0.2256 0.4452
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0358 0.0355
Leishmania major lysyl-tRNA synthetase, putative 0.0026 0.0234 0.1081
Plasmodium vivax glutathione reductase, putative 0.0081 0.0934 0.1498
Loa Loa (eye worm) hypothetical protein 0.0022 0.0183 0.0251
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.005 0.0066
Trypanosoma brucei sugar transporter, putative 0.0016 0.0112 0.0506
Trypanosoma brucei glucose transporter 1E 0.0036 0.0364 0.1686
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0189 0.2306 0.3707
Plasmodium vivax hexose transporter 0.0117 0.139 0.2232
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.026 0.12
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0234 0.0245
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.005 0.0046
Trypanosoma cruzi hexose transporter, putative 0.002 0.0155 0.0707
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0036 0.0358 0.1658
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.005 0.0047
Trichomonas vaginalis mercuric reductase, putative 0.0028 0.026 0.021
Schistosoma mansoni coup transcription factor 0.0012 0.005 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.005 0.0066
Echinococcus granulosus beta-adrenergic receptor kinase 0.0024 0.0211 0.0208
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0016 0.0112 0.0073
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Schistosoma mansoni nuclear hormone receptor 0.0012 0.005 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0183 0.0101
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.0089 0.0086
Brugia malayi Sugar transporter family protein 0.0016 0.0112 0.0151
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0183 0.018
Schistosoma mansoni tyrosine kinase 0.0009 0.0018 0.0014
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.139 0.1387
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.005 0.0047
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0358 0.0355
Schistosoma mansoni thyroid hormone receptor 0.0012 0.005 0.0047
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0024 0.0211 0.0291
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0185 0.0182
Echinococcus multilocularis tyrosine protein kinase shark 0.0237 0.2919 0.2916
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0211 0.0208
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.005 0.0047
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0364 0.1686
Toxoplasma gondii thioredoxin reductase 0.0081 0.0934 0.2059
Trypanosoma brucei glucose transporter, putative 0.0036 0.0364 0.1686
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.005 0.0047
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.139 0.1387
Onchocerca volvulus 0.0016 0.0112 0.0132
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.026 0.12
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0185 0.0182
Loa Loa (eye worm) hypothetical protein 0.0022 0.0183 0.0251
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.005 0.0066
Schistosoma mansoni sugar transporter 0.0016 0.0112 0.0108
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.005 0.0047
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0176 0.2142 0.2877
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0185 0.0182
Trypanosoma brucei glucose transporter, putative 0.0036 0.0364 0.1686
Leishmania major glucose transporter, lmgt2 0.0036 0.0364 0.1686
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0183 0.018
Schistosoma mansoni glucose transport protein 0.0117 0.139 0.1387
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.005 0.0047
Leishmania major glucose transporter, lmgt3 0.0036 0.0364 0.1686
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0183 0.0251
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0183 0.0251
Onchocerca volvulus 0.0016 0.0112 0.0132
Echinococcus multilocularis solute carrier family 22 0.0016 0.0112 0.0108
Toxoplasma gondii NADPH-glutathione reductase 0.0028 0.026 0.0371
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.005 0.0066
Loa Loa (eye worm) RGC/RGC protein kinase 0.0009 0.0018 0.002
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.0089 0.0086
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.005 0.0047
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0036 0.0358 0.0495
Brugia malayi hypothetical protein 0.0016 0.0112 0.0151
Mycobacterium ulcerans integral membrane transport protein 0.0016 0.0112 0.0073
Onchocerca volvulus 0.0571 0.7167 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Mycobacterium tuberculosis Probable dehydrogenase 0.0185 0.2256 0.4452
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0183 0.018
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0349 0.0346
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0364 0.1686
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0112 0.0108
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0183 0.018
Schistosoma mansoni glucose transporter 0.0016 0.0112 0.0108
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0183 0.018
Entamoeba histolytica DNA repair protein, putative 0.0008 0.0003 0.0005
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0028 0.026 0.12
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0036 0.0358 0.0495
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.026 0.12
Echinococcus granulosus FTZ F1 alpha 0.0012 0.005 0.0047
Plasmodium falciparum calcium-dependent protein kinase 2 0.0036 0.0358 0.0571
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0211 0.0208
Echinococcus granulosus expressed protein 0.0429 0.5364 0.5363
Schistosoma mansoni hypothetical protein 0.0117 0.139 0.1387
Loa Loa (eye worm) hypothetical protein 0.0022 0.0183 0.0251
Plasmodium falciparum thioredoxin reductase 0.0028 0.026 0.0413
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0571 0.7167 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0189 0.2306 0.3707
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0234 0.0245
Brugia malayi hypothetical protein 0.0022 0.0183 0.0251
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.0185 0.0182
Loa Loa (eye worm) hypothetical protein 0.0022 0.0183 0.0251
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0185 0.2256 0.8875
Schistosoma mansoni hypothetical protein 0.0168 0.2044 0.2042
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0015 0.0089 0.0086
Echinococcus multilocularis nmda type glutamate receptor 0.0052 0.0568 0.0565
Loa Loa (eye worm) hypothetical protein 0.0028 0.0265 0.0365
Onchocerca volvulus Putative transporter 0.0016 0.0112 0.0132
Schistosoma mansoni glutamate receptor NMDA 0.0022 0.0185 0.0182
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0066
Loa Loa (eye worm) RGC/RGC protein kinase 0.0009 0.0018 0.002
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0066
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0086 0.0115
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0423 0.1961
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.005 0.0066
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.005 0.0047
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0015 0.0089 0.0086
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.005 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.0423 0.1961
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.026 0.12
Loa Loa (eye worm) hypothetical protein 0.0012 0.005 0.0066
Plasmodium vivax sugar transporter, putative 0.0016 0.0112 0.0174
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0571 0.7167 1
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0112 0.0151
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0015 0.0089 0.0086
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0117 0.139 0.1387
Loa Loa (eye worm) hypothetical protein 0.0009 0.0018 0.002
Leishmania major protein kinase, putative 0.0036 0.0358 0.1658
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.005 0.0066
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0183 0.018
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0035 0.0349 0.0704
Echinococcus granulosus nmda type glutamate receptor 0.0052 0.0568 0.0565
Echinococcus multilocularis lysyl tRNA synthetase 0.0026 0.0234 0.0231
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0089 0.0086
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0571 0.7167 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0165 0.0226
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.026 0.12
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.026 0.12
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.139 0.1387
Brugia malayi Receptor family ligand binding region containing protein 0.0009 0.0018 0.002
Echinococcus granulosus glutamate receptor 2 0.0022 0.0185 0.0182
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.005 0.0047
Plasmodium falciparum calcium-dependent protein kinase 3 0.0036 0.0358 0.0571
Schistosoma mansoni glucose transport protein 0.0117 0.139 0.1387
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.005 0.0047
Entamoeba histolytica protein kinase, putative 0.0036 0.0358 0.0499
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0038 0.0381 0.0559
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0183 0.018
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.005 0.0066
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0036 0.0358 0.0355
Echinococcus multilocularis solute carrier family 22 0.0016 0.0112 0.0108
Toxoplasma gondii facilitative glucose transporter GT1 0.0117 0.139 0.3201
Brugia malayi Sugar transporter family protein 0.0117 0.139 0.1936
Plasmodium falciparum glutathione reductase 0.0028 0.026 0.0413
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0036 0.0358 0.0617
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0211 0.0208
Plasmodium vivax lysine--tRNA ligase, putative 0.0026 0.0234 0.0372
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0028 0.026 0.0257
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0016 0.0112 0.0073
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0041 0.0423 0.0779
Onchocerca volvulus 0.0016 0.0112 0.0132
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0349 0.0346
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.005 0.0066
Giardia lamblia DNA repair protein RAD52 0.0345 0.4297 0.5932
Brugia malayi nuclear hormone receptor 0.0012 0.005 0.0066
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.026 0.12
Trichomonas vaginalis glucose transporter, putative 0.0036 0.0364 0.0357
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0117 0.139 0.1387
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.005 0.0066
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0234 0.0231
Schistosoma mansoni glutamate receptor kainate 0.0015 0.0089 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.005 0.0066
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0026 0.0234 0.0174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.005 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.005 0.0066
Echinococcus multilocularis dna repair and recombination protein rad54 0.0008 0.0003 0.0000089063
Giardia lamblia Prolyl-tRNA synthetase 0.0035 0.0349 0.0336
Onchocerca volvulus 0.0012 0.005 0.0046
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0395 0.4927 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0009 0.0019 0.0016
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0112 0.0151
Brugia malayi major facilitator superfamily protein 0.0016 0.0112 0.0151
Schistosoma mansoni hypothetical protein 0.0015 0.0089 0.0086
Echinococcus granulosus calcium dependent protein kinase 0.0034 0.033 0.0327
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.026 0.12
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0165 0.0226
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0112 0.0151
Echinococcus granulosus solute carrier family 22 0.0016 0.0112 0.0108
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0035 0.0349 0.0346
Plasmodium falciparum proline--tRNA ligase 0.0041 0.0423 0.0675
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.026 0.12
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.005 0.0047
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.005 0.0066
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0234 0.0231
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0183 0.018
Trichomonas vaginalis sugar transporter, putative 0.0036 0.0364 0.0357
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.005 0.0047
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0028 0.026 0.12
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0038 0.0381 1
Entamoeba histolytica hypothetical protein 0.0022 0.0183 0.0255
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0358 0.0355
Echinococcus multilocularis tyrosine kinase 0.0009 0.0018 0.0014
Schistosoma mansoni sugar transporter 0.0016 0.0112 0.0108
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0028 0.026 0.6227
Trypanosoma cruzi hypothetical protein, conserved 0.0176 0.2142 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0028 0.026 0.0413
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0358 0.0355
Schistosoma mansoni protein kinase 0.0036 0.0358 0.0355
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0028 0.026 0.12
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0112 0.0108
Trypanosoma brucei THT1 - hexose transporter, putative 0.0036 0.0364 0.1686
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.0185 0.0182
Loa Loa (eye worm) hypothetical protein 0.0036 0.0358 0.0495
Echinococcus multilocularis receptor type guanylyl cyclase 0.0009 0.0018 0.0014
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0185 0.2256 0.4452
Plasmodium falciparum thioredoxin reductase 0.0081 0.0934 0.1498
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0151
Brugia malayi ecdysteroid receptor 0.0012 0.005 0.0066
Echinococcus multilocularis glutamate receptor 2 0.0022 0.0185 0.0182
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0022 0.0185 0.0182
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0028 0.026 1
Chlamydia trachomatis glutamine binding protein 0.0038 0.0381 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0183 0.0101
Echinococcus granulosus tyrosine kinase 0.0009 0.0018 0.0014
Brugia malayi hypothetical protein 0.0016 0.0112 0.0151
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.005 0.0066

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 100 uM Cytotoxicity against murine leukemia (L1210) cells was determined at 47h ChEMBL. 11606133
IC50 (functional) > 100 uM Cytotoxicity against murine leukemia (L1210) cells was determined at 94h ChEMBL. 11606133

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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