TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 361.434 | Formula: C18H20FN3O2S
H donors: 1 H acceptors: 2 LogP: 3.29 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O/N=C(/c1ccc(nc1OCc1ccccc1F)C)\N1CCSCC1
InChi: 1S/C18H20FN3O2S/c1-13-6-7-15(17(21-23)22-8-10-25-11-9-22)18(20-13)24-12-14-4-2-3-5-16(14)19/h2-7,23H,8-12H2,1H3/b21-17-
InChiKey: ULKQNKFHSCQVCA-FXBPSFAMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0093	0.0176
Schistosoma mansoni	hypothetical protein	0.0117	0.1078	0.3632
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0561	0.1866
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0046	0.0296	0.0366
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0025	0.0069	0.0071
Trichomonas vaginalis	penicillin-binding protein, putative	0.0146	0.1388	0.2625
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0061	0.0461	0.058
Onchocerca volvulus		0.0057	0.0418	0.0791
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0069	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0406	0.088
Echinococcus granulosus	smad	0.0025	0.0069	0.0071
Brugia malayi	Pre-SET motif family protein	0.0426	0.4466	1
Mycobacterium tuberculosis	Conserved protein	0.0146	0.1388	0.1151
Schistosoma mansoni	transcription factor LCR-F1	0.0159	0.1534	0.5188
Leishmania major	hypothetical protein, conserved	0.0146	0.1388	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0254	0.2573	0.5749
Trypanosoma brucei	trypanothione reductase	0.0044	0.0268	0.1932
Echinococcus multilocularis	smad	0.0025	0.0069	0.0071
Entamoeba histolytica	hypothetical protein	0.0159	0.1534	1
Onchocerca volvulus		0.0485	0.5112	1
Brugia malayi	glutaminase DH11.1	0.0287	0.2943	0.6579
Loa Loa (eye worm)	beta-lactamase	0.0146	0.1388	0.3085
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1388	0.3085
Onchocerca volvulus		0.0106	0.0949	0.1833
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0192	0.0257
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0044	0.0274	0.0338
Loa Loa (eye worm)	glutathione reductase	0.0044	0.0268	0.057
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0192	0.0257
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0166	0.0205
Loa Loa (eye worm)	glutaminase	0.0287	0.2943	0.6579
Mycobacterium tuberculosis	Probable reductase	0.0099	0.0881	0.063
Trichomonas vaginalis	D-aminoacylase, putative	0.0146	0.1388	0.2625
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0046	0.0296	0.0863
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0371	0.3862	0.8643
Brugia malayi	Latrophilin receptor protein 2	0.0117	0.1078	0.239
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0063	0.0001
Mycobacterium tuberculosis	Probable dehydrogenase	0.0099	0.0881	0.063
Entamoeba histolytica	hypothetical protein	0.0159	0.1534	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0296	0.0462
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0061	0.0461	0.1523
Trypanosoma cruzi	trypanothione reductase, putative	0.0044	0.0268	0.063
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0046	0.0296	0.0863
Schistosoma mansoni	intermediate filament proteins	0.0057	0.0418	0.1377
Brugia malayi	MH1 domain containing protein	0.0025	0.0069	0.0123
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0063	0.0001
Onchocerca volvulus		0.0146	0.1388	0.2694
Mycobacterium tuberculosis	Probable oxidoreductase	0.011	0.1003	0.0755
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0089	0.0053
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0092	0.0059
Trypanosoma cruzi	hypothetical protein, conserved	0.0146	0.1388	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0146	0.1388	0.1785
Mycobacterium tuberculosis	Probable hydrolase	0.0146	0.1388	0.1151
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0166	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1388	0.3085
Mycobacterium ulcerans	glutaminase	0.0287	0.2943	1
Trichomonas vaginalis	esterase, putative	0.0146	0.1388	0.2625
Toxoplasma gondii	ABC1 family protein	0.0146	0.1388	1
Echinococcus multilocularis	GPCR, family 2	0.0117	0.1078	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0949	0.2099
Brugia malayi	RNA binding protein	0.007	0.0561	0.1227
Echinococcus granulosus	tar DNA binding protein	0.007	0.0561	0.071
Loa Loa (eye worm)	thioredoxin reductase	0.0044	0.0268	0.057
Trichomonas vaginalis	set domain proteins, putative	0.0485	0.5112	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0092	0.0059
Schistosoma mansoni	hypothetical protein	0.0255	0.2588	0.8788
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0046	0.0296	0.0863
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0255	0.2588	0.3345
Loa Loa (eye worm)	glutaminase 2	0.0287	0.2943	0.6579
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0371	0.3862	0.8643
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0061	0.0461	0.058
Trichomonas vaginalis	D-aminoacylase, putative	0.0146	0.1388	0.2625
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0146	0.1388	0.1785
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0461	0.1523
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0022	0.0029	0.021
Plasmodium vivax	SET domain protein, putative	0.0061	0.0461	0.1718
Brugia malayi	MH2 domain containing protein	0.0373	0.3888	0.8702
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0046	0.0296	0.2132
Mycobacterium tuberculosis	Probable lipase LipE	0.0146	0.1388	0.1151
Brugia malayi	beta-lactamase family protein	0.0146	0.1388	0.3085
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0081	0.015
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0046	0.0296	0.0961
Schistosoma mansoni	Smad4	0.0025	0.0069	0.0186
Schistosoma mansoni	glutaminase	0.0287	0.2943	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0046	0.0296	0.0863
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0089	0.0053
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0255	0.2588	0.3345
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0117	0.1078	0.239
Echinococcus multilocularis	lamin dm0	0.0057	0.0418	0.0524
Brugia malayi	intermediate filament protein	0.0057	0.0418	0.0906
Schistosoma mansoni	thyroid hormone receptor	0.0275	0.2813	0.9555
Echinococcus granulosus	GPCR family 2	0.0117	0.1078	0.1383
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0129	0.0132
Loa Loa (eye worm)	TAR-binding protein	0.007	0.0561	0.1227
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0146	0.1388	0.1151
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0117	0.1078	0.1383
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0059	0.0436	0.0548
Trichomonas vaginalis	penicillin-binding protein, putative	0.0146	0.1388	0.2625
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0192	0.0257
Onchocerca volvulus		0.0057	0.0418	0.0791
Brugia malayi	beta-lactamase	0.0146	0.1388	0.3085
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0117	0.1078	0.1383
Leishmania major	trypanothione reductase	0.0044	0.0268	0.063
Echinococcus multilocularis	lamin	0.0057	0.0418	0.0524
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0166	0.0205
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0561	0.1866
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0063	0.0001
Echinococcus granulosus	tumor protein p63	0.0721	0.7708	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0222	0.0315
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0426	0.4466	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1388	0.3085
Schistosoma mansoni	cellular tumor antigen P53	0.0106	0.0949	0.319
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0046	0.0296	0.0366
Mycobacterium leprae	Probable lipase LipE	0.0146	0.1388	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0275	0.2813	0.3637
Loa Loa (eye worm)	intermediate filament protein	0.0057	0.0418	0.0906
Echinococcus granulosus	intermediate filament protein	0.0057	0.0418	0.0524
Echinococcus granulosus	Smad4	0.0025	0.0069	0.0071
Trypanosoma cruzi	hypothetical protein, conserved	0.0146	0.1388	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.011	0.1003	0.2401
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1388	0.3085
Schistosoma mansoni	hypothetical protein	0.0159	0.1534	0.5188
Plasmodium falciparum	glutathione reductase	0.0044	0.0268	0.5
Loa Loa (eye worm)	MH1 domain-containing protein	0.0025	0.0069	0.0123
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0031	0.0126	0.0251
Brugia malayi	Thioredoxin reductase	0.0044	0.0268	0.057
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0371	0.3862	0.8643
Loa Loa (eye worm)	RNA binding protein	0.007	0.0561	0.1227
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0028	0.0093	0.0102
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0117	0.1078	0.239
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.011	0.1003	0.0755
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.007	0.0561	0.1227
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0296	0.0462
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0561	0.1866
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0117	0.1078	0.1383
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0561	0.1866
Brugia malayi	Intermediate filament tail domain containing protein	0.0057	0.0418	0.0906
Entamoeba histolytica	hypothetical protein	0.0159	0.1534	1
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0025	0.0069	0.0071
Brugia malayi	beta-lactamase family protein	0.0146	0.1388	0.3085
Schistosoma mansoni	hypothetical protein	0.0254	0.2573	0.8738
Echinococcus multilocularis	tumor protein p63	0.0721	0.7708	1
Loa Loa (eye worm)	hypothetical protein	0.0371	0.3862	0.8643
Brugia malayi	MH1 domain containing protein	0.0025	0.0069	0.0123
Plasmodium vivax	hypothetical protein, conserved	0.0146	0.1388	1
Toxoplasma gondii	thioredoxin reductase	0.0044	0.0268	0.0834
Giardia lamblia	GTOR	0.0046	0.0296	0.5
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0099	0.0881	0.063
Schistosoma mansoni	tar DNA-binding protein	0.007	0.0561	0.1866
Schistosoma mansoni	smad	0.0025	0.0069	0.0186
Onchocerca volvulus		0.0061	0.0461	0.0875
Trichomonas vaginalis	D-aminoacylase, putative	0.0146	0.1388	0.2625
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0025	0.0069	0.0071
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0166	0.0205
Trypanosoma brucei	hypothetical protein, conserved	0.0146	0.1388	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0057	0.0418	0.0906
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1078	0.239
Brugia malayi	hypothetical protein	0.0159	0.1534	0.3414
Echinococcus granulosus	lamin	0.0057	0.0418	0.0524
Brugia malayi	Pre-SET motif family protein	0.0061	0.0461	0.1002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0166	0.0205
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0192	0.0257
Brugia malayi	MH2 domain containing protein	0.0025	0.0069	0.0123
Echinococcus granulosus	thioredoxin glutathione reductase	0.0044	0.0274	0.0338
Loa Loa (eye worm)	MH2 domain-containing protein	0.0025	0.0069	0.0123
Brugia malayi	Smad1	0.0025	0.0069	0.0123
Loa Loa (eye worm)	phosphatidylinositol 3	0.0046	0.0296	0.0632
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0192	0.0257
Echinococcus multilocularis	Smad4	0.0025	0.0069	0.0071
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0037	0.0193	0.1389
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0146	0.1388	0.3085
Brugia malayi	cytoplasmic intermediate filament protein	0.0031	0.0126	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0254	0.2573	0.5749
Loa Loa (eye worm)	transcription factor SMAD2	0.0373	0.3888	0.8702
Schistosoma mansoni	hypothetical protein	0.0117	0.1078	0.3632
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0069	0.0186
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0025	0.0069	0.0186
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0046	0.0296	0.2132
Loa Loa (eye worm)	MH2 domain-containing protein	0.0373	0.3888	0.8702
Echinococcus granulosus	mothers against decapentaplegic 5	0.0025	0.0069	0.0071
Echinococcus granulosus	lamin dm0	0.0057	0.0418	0.0524
Onchocerca volvulus		0.0146	0.1388	0.2694
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1388	0.3085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0166	0.0205
Schistosoma mansoni	lamin	0.0057	0.0418	0.1377
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0166	0.0205
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0461	0.1523
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0146	0.1388	0.469
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0063	0.0001
Schistosoma mansoni	hypothetical protein	0.0117	0.1078	0.3632
Schistosoma mansoni	hypothetical protein	0.0117	0.1078	0.3632
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0061	0.0461	0.1523
Brugia malayi	MH2 domain containing protein	0.0025	0.0069	0.0123
Mycobacterium leprae	conserved hypothetical protein	0.0146	0.1388	1
Schistosoma mansoni	lamin	0.0057	0.0418	0.1377
Mycobacterium tuberculosis	Probable esterase LipL	0.0146	0.1388	0.1151
Brugia malayi	glutathione reductase	0.0044	0.0268	0.057
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0092	0.0059
Echinococcus multilocularis	musashi	0.0057	0.0418	0.0524
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0099	0.0881	0.063
Schistosoma mansoni	thyroid hormone receptor	0.0275	0.2813	0.9555
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0099	0.0881	0.063
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0159	0.1534	0.1975
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0418	0.0906
Mycobacterium tuberculosis	Conserved protein	0.0146	0.1388	0.1151
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0028	0.0093	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0081	0.015
Onchocerca volvulus		0.0146	0.1388	0.2694
Trichomonas vaginalis	glutaminase, putative	0.0287	0.2943	0.5705
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0146	0.1388	0.1151
Echinococcus multilocularis	tar DNA binding protein	0.007	0.0561	0.071
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1388	0.3085
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0099	0.0881	0.063
Mycobacterium tuberculosis	Probable lipase LipD	0.0146	0.1388	0.1151
Brugia malayi	RNA recognition motif domain containing protein	0.007	0.0561	0.1227
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0461	0.1002
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0146	0.1388	0.3085
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.011	0.1003	0.0755
Mycobacterium tuberculosis	Conserved protein	0.0146	0.1388	0.1151
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0117	0.1078	0.1383
Schistosoma mansoni	smad1 5 8 and	0.0025	0.0069	0.0186
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0296	0.0462
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0061	0.0461	0.2409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0118	0.011
Brugia malayi	TAR-binding protein	0.007	0.0561	0.1227
Entamoeba histolytica	hypothetical protein	0.0159	0.1534	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0159	0.1534	0.1975
Plasmodium falciparum	thioredoxin reductase	0.0044	0.0268	0.5
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0146	0.1388	0.1151
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0046	0.0296	0.0632
Loa Loa (eye worm)	Smad1	0.0025	0.0069	0.0123
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0146	0.1388	0.469
Echinococcus granulosus	histone lysine methyltransferase setb	0.0061	0.0461	0.058

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 3 %	DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1860723

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1048528