Detailed information for compound 1048876

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 378.363 | Formula: C20H18F4N2O
  • H donors: 0 H acceptors: 1 LogP: 3.51 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)Cc1ccc(c(c1)F)F)/C=C/c1c(F)cccc1F
  • InChi: 1S/C20H18F4N2O/c21-16-2-1-3-17(22)15(16)5-7-20(27)26-10-8-25(9-11-26)13-14-4-6-18(23)19(24)12-14/h1-7,12H,8-11,13H2/b7-5+
  • InChiKey: WCNQDAWLEHCLNB-FNORWQNLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni diflavin oxidoreductase 0.0042 0.0079 0.0042
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0534 0.2996 1
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0034 0.0035 0.0072
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0085 0.0332 0.1107
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.004 0.0065 0.0173
Brugia malayi Pepsin A precursor 0.0091 0.0368 0.123
Schistosoma mansoni tyrosine kinase 0.0153 0.0739 0.0704
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0149 0.0715 0.2387
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0137 0.0645 0.2046
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0137 0.0645 0.2153
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0256 0.0855
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0164 0.0804 0.2682
Echinococcus multilocularis nmda type glutamate receptor 0.0038 0.0054 0.0135
Loa Loa (eye worm) palmitoyl-protein thioesterase 1 0.0084 0.0327 0.1092
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0486 0.2714 1
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0044 0.0091 0.0303
Entamoeba histolytica hypothetical protein 0.0035 0.0037 0.1102
Echinococcus granulosus aminopeptidase N 0.0149 0.0714 0.2348
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0085 0.0332 0.1107
Plasmodium falciparum plasmepsin VI 0.0164 0.0804 0.2682
Mycobacterium ulcerans transcriptional regulator NrdR 0.0048 0.0113 0.0024
Plasmodium vivax subtilisin-like protease 1 0.0357 0.1947 0.6499
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0164 0.0804 0.2682
Entamoeba histolytica type A flavoprotein, putative 0.0032 0.0022 0.0409
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0137 0.0645 0.2153
Schistosoma mansoni glutamate receptor NMDA 0.0043 0.0087 0.005
Loa Loa (eye worm) TK/EGFR protein kinase 0.0289 0.1545 0.5156
Trypanosoma brucei trypanothione synthetase, putative 0.0068 0.0236 0.0787
Brugia malayi hypothetical protein 0.0068 0.0232 0.0773
Brugia malayi aspartic protease BmAsp-1, identical 0.0091 0.0368 0.123
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0043 0.0087 0.0246
Schistosoma mansoni glutamate receptor AMPA 0.004 0.0065 0.0028
Brugia malayi hypothetical protein 0.0035 0.0037 0.0125
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0091 0.0368 0.0332
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0038 0.0056 0.0143
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0224 0.1156 0.1123
Loa Loa (eye worm) SRC-1 0.0038 0.0056 0.0187
Onchocerca volvulus 0.0149 0.0714 1
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0534 0.2996 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0038 0.0054 0.0135
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0534 0.2996 1
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0534 0.2996 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0038 0.0056 0.0143
Chlamydia trachomatis sulfite reductase 0.0052 0.014 0.0094
Loa Loa (eye worm) glutamate receptor 1 0.004 0.0065 0.0217
Schistosoma mansoni glutamate receptor NMDA 0.004 0.0065 0.0028
Plasmodium falciparum plasmepsin III 0.0091 0.0368 0.123
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0534 0.2996 1
Brugia malayi flavodoxin family protein 0.0032 0.0022 0.0075
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0022 0.0075
Trichomonas vaginalis sulfite reductase, putative 0.0085 0.0332 0.1149
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0486 0.2714 1
Echinococcus granulosus tar DNA binding protein 0.0072 0.0256 0.0814
Echinococcus multilocularis insulin receptor 0.0093 0.0383 0.1238
Loa Loa (eye worm) hypothetical protein 0.0164 0.0804 0.2682
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0164 0.0804 0.2649
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0534 0.2996 1
Schistosoma mansoni NADPH flavin oxidoreductase 0.0043 0.0083 0.0046
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.024 0.1251 0.1218
Leishmania major cytochrome P450 reductase, putative 0.0075 0.0275 0.0917
Plasmodium vivax aspartyl proteinase, putative 0.0164 0.0804 0.2682
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0534 0.2996 1
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0175 0.0867 0.29
Schistosoma mansoni cathepsin D (A01 family) 0.0351 0.1914 0.1884
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0093 0.0383 0.1238
Giardia lamblia Nitric oxide synthase, inducible 0.0075 0.0275 0.5
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0137 0.0645 0.2118
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0038 0.0056 0.0143
Echinococcus granulosus epidermal growth factor receptor 0.0289 0.1545 0.5134
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0038 0.0056 0.0143
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0256 0.0814
Schistosoma mansoni glutamate receptor kainate 0.004 0.0065 0.0028
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Trypanosoma cruzi trypanothione synthetase 0.0068 0.0236 0.0787
Schistosoma mansoni tyrosine kinase 0.0038 0.0056 0.0019
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0043 0.0087 0.0246
Brugia malayi Glutamate receptor 2 precursor 0.004 0.0065 0.0217
Echinococcus multilocularis tyrosine protein kinase Blk 0.0034 0.0035 0.0072
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0056 0.0143
Echinococcus granulosus tyrosine protein kinase Lyn 0.0038 0.0056 0.0143
Echinococcus granulosus tyrosine protein kinase Src42A 0.0032 0.0019 0.002
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0032 0.0022 0.0075
Loa Loa (eye worm) hypothetical protein 0.0044 0.0091 0.0303
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0256 0.0219
Toxoplasma gondii aspartyl protease ASP3 0.0091 0.0368 0.123
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0091 0.0368 0.123
Loa Loa (eye worm) peptidase family M1 containing protein 0.0105 0.0454 0.1515
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0043 0.0087 0.0246
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0091 0.0368 0.0332
Trypanosoma brucei Aminopeptidase M1, putative 0.0068 0.0232 0.0773
Brugia malayi hypothetical protein 0.0091 0.0368 0.123
Loa Loa (eye worm) flavodoxin family protein 0.0032 0.0022 0.0075
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0091 0.0368 0.0332
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0085 0.0332 0.1107
Echinococcus multilocularis palmitoyl protein thioesterase 1 0.0084 0.0327 0.1052
Brugia malayi Furin-like cysteine rich region family protein 0.0289 0.1545 0.5156
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0137 0.0645 0.2153
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0093 0.0383 0.1238
Echinococcus granulosus methionine synthase reductase 0.0052 0.014 0.0425
Echinococcus multilocularis epidermal growth factor receptor 0.0156 0.0755 0.2485
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0085 0.0332 0.1107
Schistosoma mansoni glutamate receptor AMPA 0.004 0.0065 0.0028
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0056 0.0143
Trypanosoma cruzi Aminopeptidase M1, putative 0.0068 0.0232 0.0773
Treponema pallidum ribonucleotide-diphosphate reductase subunit beta 0.0137 0.0645 0.2094
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0032 0.0022 0.0075
Leishmania major p450 reductase, putative 0.0085 0.0332 0.1107
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0052 0.014 0.0103
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0091 0.0368 0.0332
Schistosoma mansoni glutamate receptor kainate 0.004 0.0065 0.0028
Schistosoma mansoni tyrosine kinase 0.0093 0.0383 0.0346
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0091 0.0368 0.0332
Loa Loa (eye worm) TK protein kinase 0.0031 0.0013 0.0045
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0137 0.0645 0.2118
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0085 0.0332 0.1107
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0486 0.2714 1
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0085 0.0332 0.1067
Entamoeba histolytica hypothetical protein 0.0035 0.0037 0.1102
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0068 0.0232 0.0773
Loa Loa (eye worm) TK/INSR protein kinase 0.0093 0.0383 0.1277
Plasmodium falciparum plasmepsin II 0.0164 0.0804 0.2682
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0085 0.0332 0.1067
Brugia malayi ribonucleotide reductase 2 0.0137 0.0645 0.2153
Brugia malayi flavodoxin family protein 0.0085 0.0332 0.1107
Trypanosoma brucei trypanothione synthetase 0.0068 0.0236 0.0787
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0038 0.0056 0.0143
Plasmodium falciparum plasmepsin IV 0.0164 0.0804 0.2682
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0056 0.0143
Echinococcus granulosus tyrosine kinase 0.0034 0.0035 0.0072
Brugia malayi Protein kinase domain containing protein 0.0093 0.0383 0.1277
Plasmodium falciparum nitric oxide synthase, putative 0.0085 0.0332 0.1107
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0091 0.0368 0.0332
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0137 0.0645 0.2153
Entamoeba histolytica type A flavoprotein, putative 0.0032 0.0022 0.0409
Loa Loa (eye worm) FAD binding domain-containing protein 0.0052 0.014 0.0468
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0534 0.2996 1
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0486 0.2714 1
Mycobacterium ulcerans aminopeptidase N PepN 0.0068 0.0232 0.0479
Entamoeba histolytica aminopeptidase, putative 0.0068 0.0232 1
Schistosoma mansoni tyrosine kinase 0.0156 0.0755 0.072
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0043 0.0087 0.0246
Echinococcus multilocularis glutamate receptor 2 0.0043 0.0087 0.0246
Trypanosoma cruzi p450 reductase, putative 0.0085 0.0332 0.1107
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0038 0.0056 0.0143
Loa Loa (eye worm) hypothetical protein 0.0091 0.0368 0.123
Schistosoma mansoni ATP-binding cassette transporter 0.004 0.0065 0.0028
Echinococcus granulosus thyrotropin releasing hormone receptor 0.024 0.1251 0.4148
Echinococcus multilocularis glutamate receptor 2 0.004 0.0065 0.0173
Schistosoma mansoni tyrosine kinase 0.0156 0.0755 0.072
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0137 0.0645 0.2153
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0085 0.0332 0.0863
Echinococcus multilocularis 0.0089 0.0359 0.116
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0035 0.0072
Leishmania major trypanothione synthetase, putative 0.0068 0.0236 0.0787
Brugia malayi protein-tyrosine kinase 0.0034 0.0035 0.0117
Schistosoma mansoni palmitoyl-protein thioesterase 0.0084 0.0327 0.0291
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0137 0.0645 0.2153
Brugia malayi FAD binding domain containing protein 0.0052 0.014 0.0468
Entamoeba histolytica hypothetical protein 0.0035 0.0037 0.1102
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0043 0.0087 0.0246
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0164 0.0804 0.2903
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0137 0.0645 0.2153
Trypanosoma cruzi glutathionylspermidine synthase, putative 0.0356 0.1939 0.6472
Loa Loa (eye worm) hypothetical protein 0.0081 0.0313 0.1044
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.123 0.712 0.7109
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0038 0.0056 0.0143
Toxoplasma gondii subtilisin SUB1 0.0357 0.1947 0.6499
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0044 0.0091 0.0053
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0038 0.0056 0.0143
Echinococcus granulosus glutamate receptor 2 0.0043 0.0087 0.0246
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0091 0.0368 0.123
Loa Loa (eye worm) hypothetical protein 0.0125 0.0573 0.1912
Plasmodium falciparum plasmepsin V 0.0091 0.0368 0.123
Entamoeba histolytica type A flavoprotein, putative 0.0032 0.0022 0.0409
Plasmodium vivax plasmepsin IV, putative 0.0164 0.0804 0.2682
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0137 0.0645 0.1845
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0032 0.0022 0.0075
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Plasmodium vivax aspartyl proteinase, putative 0.0091 0.0368 0.123
Giardia lamblia Hypothetical protein 0.0075 0.0275 0.5
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0137 0.0645 0.2046
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0137 0.0645 0.2153
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0043 0.0087 0.0246
Toxoplasma gondii flavodoxin domain-containing protein 0.0042 0.0079 0.0265
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0043 0.0087 0.0246
Trypanosoma cruzi aminopeptidase, putative 0.0068 0.0232 0.0773
Loa Loa (eye worm) FAD binding domain-containing protein 0.0085 0.0332 0.1107
Plasmodium vivax aspartyl protease, putative 0.0091 0.0368 0.123
Entamoeba histolytica hypothetical protein 0.0035 0.0037 0.1102
Echinococcus granulosus tyrosine protein kinase Blk 0.0034 0.0035 0.0072
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0256 0.0219
Echinococcus multilocularis methionine synthase reductase 0.0052 0.014 0.0425
Entamoeba histolytica type A flavoprotein, putative 0.0032 0.0022 0.0409
Brugia malayi hypothetical protein 0.0091 0.0368 0.123
Brugia malayi Palmitoyl-protein thioesterase 1 precursor 0.0084 0.0327 0.1092
Loa Loa (eye worm) hypothetical protein 0.0091 0.0368 0.123
Echinococcus multilocularis tyrosine protein kinase Srms 0.0034 0.0035 0.0072
Loa Loa (eye worm) hypothetical protein 0.0044 0.0091 0.0303
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0056 0.0143
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0037 0.0081
Plasmodium falciparum plasmepsin IX 0.0091 0.0368 0.123
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0137 0.0645 0.2153
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0256 0.0855
Echinococcus granulosus insulin receptor 0.0093 0.0383 0.1238
Echinococcus multilocularis aminopeptidase N 0.0149 0.0714 0.2348
Echinococcus granulosus nmda type glutamate receptor 0.0038 0.0054 0.0135
Schistosoma mansoni tyrosine kinase 0.0093 0.0383 0.0346
Brugia malayi SRC-1 0.0038 0.0056 0.0187
Plasmodium falciparum subtilisin-like protease 1 0.0357 0.1947 0.6499
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0164 0.0804 0.0769
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0085 0.0332 0.1107
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0534 0.2996 1
Toxoplasma gondii flavodoxin domain-containing protein 0.0042 0.0079 0.0265
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0085 0.0332 0.1067
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0486 0.2714 1
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0068 0.0232 0.0195
Schistosoma mansoni cathepsin D (A01 family) 0.0351 0.1914 0.1884
Echinococcus granulosus epidermal growth factor receptor 0.0156 0.0755 0.2485
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.0047 0.0107 0.0356
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0075 0.0275 0.0938
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0256 0.0855
Echinococcus granulosus tyrosine protein kinase Src42A 0.0038 0.0056 0.0143
Plasmodium falciparum plasmepsin VIII, putative 0.0091 0.0368 0.123
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0068 0.0232 0.0195
Mycobacterium leprae conserved hypothetical protein 0.0048 0.0113 0.0024
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0037 0.0081
Plasmodium falciparum plasmepsin X 0.0091 0.0368 0.123
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0534 0.2996 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0332 0.1107
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0032 0.0022 0.0075
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0068 0.0232 0.0778
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Toxoplasma gondii aspartyl protease ASP1 0.0164 0.0804 0.2682
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0256 0.0219
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0068 0.0232 0.0773
Toxoplasma gondii aspartyl protease 0.0091 0.0368 0.123
Loa Loa (eye worm) glutamate receptor 2 0.004 0.0065 0.0217
Echinococcus granulosus palmitoyl protein thioesterase 1 0.0084 0.0327 0.1052
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0534 0.2996 1
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0085 0.0332 0.1067
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0056 0.0143
Plasmodium vivax plasmepsin V, putative 0.0091 0.0368 0.123
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0164 0.0804 0.2649
Onchocerca volvulus 0.0091 0.0368 0.2837
Entamoeba histolytica type A flavoprotein, putative 0.0032 0.0022 0.0409
Schistosoma mansoni cytochrome P450 reductase 0.0085 0.0332 0.0295
Brugia malayi TAR-binding protein 0.0072 0.0256 0.0855
Trypanosoma brucei Aminopeptidase M1, putative 0.0068 0.0232 0.0773
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0091 0.0368 0.0332
Leishmania major hypothetical protein, conserved 0.0032 0.0022 0.0075
Echinococcus granulosus glutamate NMDA receptor subunit 0.004 0.0065 0.0173
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0032 0.0022 0.0075
Schistosoma mansoni tyrosine kinase 0.0153 0.0739 0.0704
Loa Loa (eye worm) TK protein kinase 0.0034 0.0035 0.0117
Loa Loa (eye worm) aminopeptidase N 0.0068 0.0232 0.0773
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0068 0.0232 0.0773
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0068 0.0232 0.0778
Plasmodium vivax aspartyl protease, putative 0.0091 0.0368 0.123
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.024 0.1251 0.4148
Loa Loa (eye worm) aspartyl protease 6 0.0091 0.0368 0.123
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0032 0.0022 0.0075
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0091 0.0368 0.0332
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0534 0.2996 1
Echinococcus multilocularis epidermal growth factor receptor 0.0289 0.1545 0.5134
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0534 0.2996 0.297
Trypanosoma cruzi trypanothione synthetase 0.0068 0.0236 0.0787
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0068 0.0232 0.0732
Schistosoma mansoni tyrosine kinase 0.0038 0.0056 0.0019
Brugia malayi Peptidase family M1 containing protein 0.0149 0.0714 0.2382
Schistosoma mansoni tyrosine kinase 0.0153 0.0739 0.0704
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0137 0.0645 0.2153
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0256 0.0219
Brugia malayi Glutamate receptor 1 precursor 0.004 0.0065 0.0217
Brugia malayi Eukaryotic aspartyl protease family protein 0.0091 0.0368 0.123
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0156 0.0755 0.2485
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0032 0.0019 0.002
Schistosoma mansoni tyrosine kinase 0.0289 0.1545 0.1513
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0256 0.0219
Onchocerca volvulus 0.0091 0.0368 0.2837
Plasmodium vivax flavodoxin domain containing protein 0.0075 0.0275 0.0917
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0056 0.0143
Brugia malayi RNA binding protein 0.0072 0.0256 0.0855
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0085 0.0332 0.1107
Schistosoma mansoni glutamate receptor kainate 0.004 0.0065 0.0028
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0137 0.0645 0.2153
Plasmodium falciparum plasmepsin VII 0.0091 0.0368 0.123
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0047 0.0107 0.0356
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0137 0.0645 0.061
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0085 0.0332 0.1107
Loa Loa (eye worm) RNA binding protein 0.0072 0.0256 0.0855
Brugia malayi aspartic protease BmAsp-2, identical 0.0091 0.0368 0.123
Echinococcus granulosus tyrosine protein kinase Src64B 0.0038 0.0056 0.0143
Plasmodium vivax aspartyl protease, putative 0.0091 0.0368 0.123
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0043 0.0087 0.0246
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0085 0.0332 0.1107
Brugia malayi FAD binding domain containing protein 0.0085 0.0332 0.1107
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0044 0.0091 0.0259
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0137 0.0645 0.2153
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0047 0.0107 0.0356
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0068 0.0232 0.0773
Brugia malayi Peptidase family M1 containing protein 0.0068 0.0232 0.0773
Plasmodium falciparum plasmepsin I 0.0164 0.0804 0.2682

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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