TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 318.369 | Formula: C20H18N2O2
H donors: 0 H acceptors: 1 LogP: 3.72 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CN(Cc1ccco1)Cc1coc(n1)c1cccc2c1cccc2
InChi: 1S/C20H18N2O2/c1-22(13-17-8-5-11-23-17)12-16-14-24-20(21-16)19-10-4-7-15-6-2-3-9-18(15)19/h2-11,14H,12-13H2,1H3
InChiKey: AYQPTYQIAYOHSF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Leishmania major	protein kinase, putative	0.0037	0.0639	0.855
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Schistosoma mansoni	lysyl-tRNA synthetase	0.0027	0.0442	0.1769
Brugia malayi	major facilitator superfamily protein	0.0017	0.0245	0.1072
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0245	0.1072
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0245	0.1072
Echinococcus multilocularis	solute carrier family 22	0.0017	0.0245	0.0894
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0037	0.0639	0.0925
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0036	0.0624	0.2728
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0007	0.0045	0.0196
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0037	0.0639	0.2648
Onchocerca volvulus		0.0017	0.0245	0.5
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.012	0.2288	1
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0042	0.0742	0.1081
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0072	0.012
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0017	0.0245	0.303
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0007	0.0045	0.0196
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Trypanosoma brucei	glucose transporter, putative	0.0037	0.0648	0.868
Schistosoma mansoni	sugar transporter	0.0017	0.0245	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0245	0.1072
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Trichomonas vaginalis	glucose transporter, putative	0.0017	0.0245	0.0956
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0037	0.0639	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Loa Loa (eye worm)	sugar transporter	0.0017	0.0245	0.1072
Chlamydia trachomatis	lysine--tRNA ligase	0.0027	0.0442	1
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Brugia malayi	MH1 domain containing protein	0.0008	0.0072	0.0314
Leishmania major	lysyl-tRNA synthetase, putative	0.0027	0.0442	0.5783
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Echinococcus granulosus	lysyl tRNA synthetase	0.0027	0.0442	0.1769
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0007	0.0045	0.0468
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0245	0.0956
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0815	0.3432
Brugia malayi	Sugar transporter family protein	0.0017	0.0245	0.1072
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0013	0.0163	0.3243
Echinococcus granulosus	solute carrier family 22	0.0017	0.0245	0.0894
Onchocerca volvulus		0.0017	0.0245	0.5
Mycobacterium ulcerans	integral membrane transport protein	0.0017	0.0245	0.5239
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0042	0.0742	1
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0036	0.0624	0.2583
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0245	0.0956
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0037	0.0639	0.2793
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0245	0.303
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0037	0.0639	0.0597
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0036	0.0624	0.2583
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0245	0.1072
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0245	0.1072
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0245	0.1072
Onchocerca volvulus		0.0017	0.0245	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0072	0.0314
Trichomonas vaginalis	sugar transporter, putative	0.0037	0.0648	0.274
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0072	0.012
Brugia malayi	Sugar transporter family protein	0.012	0.2288	1
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0037	0.0639	0.0597
Trypanosoma cruzi	hexose transporter	0.0037	0.0648	0.868
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0245	0.1072
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0017	0.0245	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0042	0.0742	1
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Toxoplasma gondii	glycyl-tRNA synthetase	0.0007	0.0045	0.0024
Trypanosoma brucei	glucose transporter, putative	0.0037	0.0648	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Brugia malayi	hypothetical protein	0.0017	0.0245	0.1072
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0648	0.274
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0245	0.1072
Giardia lamblia	Hexose transporter	0.0017	0.0245	0.346
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0491	0.2144
Plasmodium falciparum	lysine--tRNA ligase	0.0027	0.0442	0.0399
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0648	0.274
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0007	0.0045	0.0218
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0007	0.0045	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0442	0.193
Giardia lamblia	Prolyl-tRNA synthetase	0.0036	0.0624	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0027	0.0442	1
Brugia malayi	Cam kinase protein 1	0.0037	0.0639	0.2793
Brugia malayi	MH2 domain containing protein	0.0008	0.0072	0.0314
Echinococcus multilocularis	solute carrier family 22	0.0017	0.0245	0.0894
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0037	0.0639	0.0597
Brugia malayi	Major Facilitator Superfamily protein	0.0017	0.0245	0.1072
Onchocerca volvulus		0.0017	0.0245	0.5
Trypanosoma brucei	glucose transporter, putative	0.0037	0.0648	0.868
Brugia malayi	lysyl-tRNA synthetase	0.0027	0.0442	0.193
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0027	0.0442	0.1826
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.012	0.2288	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0245	0.1072
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0037	0.0639	0.2648
Trypanosoma brucei	glucose transporter, putative	0.0037	0.0648	0.868
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.012	0.2288	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0037	0.0648	0.868
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0037	0.0639	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0624	0.2728
Toxoplasma gondii	sugar transporter ST1	0.0017	0.0245	0.0327
Brugia malayi	Major Facilitator Superfamily protein	0.0017	0.0245	0.1072
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0245	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Leishmania major	glucose transporter, lmgt1	0.0037	0.0648	0.868
Echinococcus granulosus	smad	0.0008	0.0072	0.012
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0815	0.3432
Onchocerca volvulus		0.0017	0.0245	0.5
Trichomonas vaginalis	myo-inositol transporter, putative	0.0017	0.0245	0.0956
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0007	0.0045	0.0024
Toxoplasma gondii	facilitative glucose transporter GT1	0.012	0.2288	0.3424
Schistosoma mansoni	glucose transport protein	0.012	0.2288	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0042	0.0742	1
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0007	0.0045	0.0196
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0037	0.0639	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0042	0.0742	1
Trypanosoma brucei	glucose transporter 1E	0.0037	0.0648	0.868
Schistosoma mansoni	protein kinase	0.0037	0.0639	0.2648
Trichomonas vaginalis	conserved hypothetical protein	0.012	0.2288	1
Toxoplasma gondii	protein kinase, putative	0.0339	0.6627	1
Mycobacterium ulcerans	sugar transporter	0.0017	0.0245	0.5239
Onchocerca volvulus		0.0017	0.0245	0.5
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0036	0.0624	0.2728
Plasmodium vivax	hexose transporter	0.012	0.2288	0.2253
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0037	0.0639	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Treponema pallidum	prolyl-tRNA synthetase	0.0013	0.0163	1
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0245	0.0956
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0815	0.3432
Schistosoma mansoni	lysyl-tRNA synthetase	0.0027	0.0442	0.1769
Onchocerca volvulus	Putative transporter	0.0017	0.0245	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Onchocerca volvulus		0.0017	0.0245	0.5
Schistosoma mansoni	sugar transporter	0.0017	0.0245	0.0894
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0376	0.1536
Onchocerca volvulus		0.0017	0.0245	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0815	0.3432
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0072	0.012
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0037	0.0639	0.2648
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0037	0.0639	0.2648
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.012	0.2288	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0037	0.0639	0.0925
Trichomonas vaginalis	CAMK family protein kinase	0.0037	0.0639	0.2699
Trichomonas vaginalis	sugar transporter, putative	0.0037	0.0648	0.274
Entamoeba histolytica	protein kinase, putative	0.0037	0.0639	1
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0007	0.0045	0.0218
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0815	0.356
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0037	0.0639	0.0597
Trichomonas vaginalis	glucose transporter, putative	0.0037	0.0648	0.274
Trypanosoma cruzi	hexose transporter, putative	0.0037	0.0648	0.868
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0624	0.2728
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0072	0.012
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0017	0.0245	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0245	0.1072
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Trichomonas vaginalis	glucose transporter, putative	0.0037	0.0648	0.274
Plasmodium vivax	proline--tRNA ligase, putative	0.0042	0.0742	0.0701
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.012	0.2288	1
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0036	0.0624	0.2634
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0245	0.1072
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0037	0.0639	0.0925
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0007	0.0045	0.0218
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0072	0.012
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.012	0.2288	1
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0072	0.012
Brugia malayi	glycyl-tRNA synthetase	0.0007	0.0045	0.0196
Plasmodium falciparum	hexose transporter	0.012	0.2288	0.2253
Echinococcus granulosus	synaptic vesicle 2 protein	0.0017	0.0245	0.0894
Onchocerca volvulus		0.0017	0.0245	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Echinococcus granulosus	calcium dependent protein kinase	0.0034	0.0594	0.2448
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0036	0.0624	1
Leishmania major	threonyl-tRNA synthetase, putative	0.0007	0.0045	0.0218
Schistosoma mansoni	glucose transport protein	0.012	0.2288	1
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0007	0.0045	0.0218
Onchocerca volvulus		0.0017	0.0245	0.5
Plasmodium vivax	sugar transporter, putative	0.0017	0.0245	0.0201
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0007	0.0045	0.0377
Trypanosoma cruzi	hexose transporter, putative	0.0037	0.0648	0.868
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0007	0.0045	0.0196
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0017	0.0245	0.1072
Trypanosoma brucei	glucose transporter 2A	0.0037	0.0648	0.868
Schistosoma mansoni	sugar transporter	0.0017	0.0245	0.0894
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0037	0.0639	0.2793
Brugia malayi	Smad1	0.0008	0.0072	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0639	0.2793
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0194	0.3752	0.3724
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0023	0.0362	1
Giardia lamblia	Sugar-proton symporter	0.0017	0.0245	0.346
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0017	0.0245	0.5239
Trypanosoma cruzi	glucose transporter, putative	0.0017	0.0245	0.303
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0007	0.0045	0.0377
Trichomonas vaginalis	sugar transporter, putative	0.0037	0.0648	0.274
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0027	0.0442	0.5783
Schistosoma mansoni	glucose transport protein	0.012	0.2288	1
Echinococcus multilocularis	solute carrier family 22	0.0017	0.0245	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Toxoplasma gondii	sugar transporter ST3	0.0017	0.0245	0.0327
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0245	0.0956
Toxoplasma gondii	transporter, major facilitator family protein	0.0017	0.0245	0.0327
Schistosoma mansoni	protein kinase	0.0037	0.0639	0.2648
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.2269	0.9918
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0017	0.0245	0.5239
Toxoplasma gondii	sugar transporter ST2	0.0017	0.0245	0.0327
Loa Loa (eye worm)	sugar transporter	0.012	0.2288	1
Schistosoma mansoni	glucose transporter	0.0017	0.0245	0.0894
Echinococcus granulosus	Smad4	0.0008	0.0072	0.012
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0509	1	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0245	0.1072
Brugia malayi	Sugar transporter family protein	0.0017	0.0245	0.1072
Leishmania major	myo-inositol/proton symporter (MIT)	0.0017	0.0245	0.303
Echinococcus granulosus	General substrate transporter	0.0103	0.1954	0.851
Trypanosoma brucei	glucose transporter, putative	0.0037	0.0648	0.868
Plasmodium vivax	lysine--tRNA ligase, putative	0.0027	0.0442	0.0399
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0017	0.0245	0.0201
Brugia malayi	hypothetical protein	0.0017	0.0245	0.1072
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Echinococcus multilocularis	Smad4	0.0008	0.0072	0.012
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0036	0.0624	0.2583
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0037	0.0648	0.868
Brugia malayi	Major Facilitator Superfamily protein	0.0017	0.0245	0.1072
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0036	0.0624	0.9752
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0017	0.0245	0.6499
Entamoeba histolytica	hypothetical protein	0.0027	0.0442	0.6679
Schistosoma mansoni	protein kinase	0.0037	0.0639	0.2648
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0072	0.0314
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0037	0.0648	0.868
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0245	0.1072
Echinococcus multilocularis	solute carrier family 22	0.0017	0.0245	0.0894
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0072	0.012
Onchocerca volvulus		0.0017	0.0245	0.5
Trypanosoma brucei	glucose transporter, putative	0.0037	0.0648	0.868
Trypanosoma cruzi	hexose transporter, putative	0.002	0.0314	0.3994
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0027	0.0442	1
Echinococcus multilocularis	General substrate transporter	0.0103	0.1954	0.851
Echinococcus granulosus	solute carrier family 22	0.0017	0.0245	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0017	0.0245	1
Onchocerca volvulus		0.0017	0.0245	0.5
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0037	0.0648	0.868
Trypanosoma brucei	glucose transporter, putative	0.0037	0.0648	0.868
Onchocerca volvulus		0.0017	0.0245	0.5
Schistosoma mansoni	smad	0.0008	0.0072	0.012
Brugia malayi	hypothetical protein	0.0017	0.0245	0.1072
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.2269	0.9918
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0037	0.0639	0.2648
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0037	0.0639	0.855
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0036	0.0624	0.2583
Brugia malayi	MH2 domain containing protein	0.0008	0.0072	0.0314
Trypanosoma cruzi	sugar transporter, putative	0.0017	0.0245	0.303
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0037	0.0639	0.2793
Schistosoma mansoni	sugar transporter	0.0017	0.0245	0.0894
Leishmania major	glucose transporter, lmgt3	0.0037	0.0648	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0007	0.0045	0.0069
Trypanosoma brucei	glucose transporter, putative	0.0037	0.0648	0.868
Plasmodium falciparum	protein kinase 7	0.0339	0.6627	0.6612
Onchocerca volvulus		0.0017	0.0245	0.5
Echinococcus granulosus	solute carrier family 22	0.0017	0.0245	0.0894
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0023	0.0362	0.5587
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0042	0.0742	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.012	0.2288	1
Onchocerca volvulus		0.0017	0.0245	0.5
Brugia malayi	MH2 domain containing protein	0.0119	0.2269	0.9918
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0245	0.1072
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0017	0.0245	0.1072
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Onchocerca volvulus		0.0017	0.0245	0.5
Entamoeba histolytica	protein kinase, putative	0.0037	0.0639	1
Echinococcus multilocularis	smad	0.0008	0.0072	0.012
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0815	0.356
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0194	0.3752	0.3724
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0037	0.0639	0.2648
Echinococcus granulosus	solute carrier family 22	0.0017	0.0245	0.0894
Loa Loa (eye worm)	Smad1	0.0008	0.0072	0.0314
Schistosoma mansoni	hypothetical protein	0.012	0.2288	1
Leishmania major	hypothetical protein, conserved	0.0017	0.0245	0.303
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0023	0.0362	1
Toxoplasma gondii	lysine-tRNA ligase	0.0027	0.0442	0.0625
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0017	0.0245	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0045	0.0196
Brugia malayi	major facilitator superfamily protein	0.0017	0.0245	0.1072
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0027	0.0442	0.6932
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0072	0.012
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0815	0.3432
Trichomonas vaginalis	sugar transport protein, putative	0.0017	0.0245	0.0956
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0037	0.0639	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Trypanosoma brucei	sugar transporter, putative	0.0017	0.0245	0.303
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0017	0.0245	0.6499
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0815	0.3432
Echinococcus multilocularis	lysyl tRNA synthetase	0.0027	0.0442	0.1769
Brugia malayi	MH1 domain containing protein	0.0008	0.0072	0.0314
Schistosoma mansoni	serine/threonine protein kinase	0.0037	0.0639	0.2648
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0815	0.3432
Echinococcus multilocularis	calcium dependent protein kinase	0.0034	0.0594	0.2448
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0027	0.0442	0.5783
Trypanosoma cruzi	hexose transporter, putative	0.0037	0.0648	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0015	0.0204	0.0891
Schistosoma mansoni	Smad4	0.0008	0.0072	0.012
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.012	0.2288	1
Chlamydia trachomatis	proline--tRNA ligase	0.0013	0.0163	0.2978
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0017	0.0245	0.0894
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0037	0.0639	0.2648
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0037	0.0639	0.0597
Plasmodium falciparum	proline--tRNA ligase	0.0042	0.0742	0.0701
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0194	0.3752	0.5643
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0245	0.1072
Leishmania major	glucose transporter, lmgt2	0.0037	0.0648	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0017	0.0245	0.0956
Giardia lamblia	Lysyl-tRNA synthetase	0.0027	0.0442	0.6849

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= -1 %	DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1860853

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1049016