Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 5 | References | |
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 502 aa | 458 aa | 24.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.000854701 | 0.0170696 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.000854701 | 0.0170696 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.000854701 | 0.0170696 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.000854701 | 0.0170696 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.000854701 | 0.0170696 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.000854701 | 0.0170696 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.00248392 | 0.058094 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.000854701 | 0.0170696 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.00248392 | 0.058094 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.000854701 | 0.0170696 | 0.5 |
Brugia malayi | cytochrome P450 | 0.000854701 | 0.0170696 | 0.293828 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.00248392 | 0.058094 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.000854701 | 0.0170696 | 0.293828 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.000854701 | 0.0170696 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.00248392 | 0.058094 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.000854701 | 0.0170696 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.000854701 | 0.0170696 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.000854701 | 0.0170696 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.000854701 | 0.0170696 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.00248392 | 0.058094 | 1 |
Echinococcus multilocularis | active breakpoint cluster region | 0.0398904 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.00248392 | 0.058094 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.000854701 | 0.0170696 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.000854701 | 0.0170696 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.00248392 | 0.058094 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.000854701 | 0.0170696 | 0.293828 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.000854701 | 0.0170696 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.00248392 | 0.058094 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.000854701 | 0.0170696 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.000854701 | 0.0170696 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00162922 | 0.0365723 | 0.475394 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.000854701 | 0.0170696 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.000854701 | 0.0170696 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.000854701 | 0.0170696 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.000854701 | 0.0170696 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.000854701 | 0.0170696 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.000854701 | 0.0170696 | 0.5 |
Echinococcus granulosus | active breakpoint cluster region | 0.0398904 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.00248392 | 0.058094 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.000854701 | 0.0170696 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.00248392 | 0.058094 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.000854701 | 0.0170696 | 0.0161912 |
Echinococcus multilocularis | 0.000854701 | 0.0170696 | 0.0161912 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.0245 uM | DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro. | ChEMBL. | No reference |
IC50 (functional) | = 0.025 uM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen TcVI extracellular trypomastigotes forms transfected with beta-galactosidase gene infected in rat L6 cells assessed as inhibition of parasite growth after 4 days | ChEMBL. | 23462713 |
IC50 (ADMET) | = 5.6 uM | Inhibition of CYP3A4/5 in human liver microsomes assessed as reduction in testosterone-beta-hydroxylation | ChEMBL. | 23462713 |
IC90 (functional) | = 0.0725 uM | DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro. | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 23462713 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.