TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 324.42 | Formula: C19H24N4O
H donors: 1 H acceptors: 2 LogP: 4.23 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cccc(c1)c1occ(n1)CNc1cc(nn1C)C(C)(C)C
InChi: 1S/C19H24N4O/c1-13-7-6-8-14(9-13)18-21-15(12-24-18)11-20-17-10-16(19(2,3)4)22-23(17)5/h6-10,12,20H,11H2,1-5H3
InChiKey: ILAJNGSTBCLUBK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0462	1
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0462	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.1383	0.1383
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0111	0.2487	1
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0111	0.0111
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0111	0.2487	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0462	0.0626
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0462	0.1699
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0007	0.0048	0.0065
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0111	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0314	0.0425
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0111	0.0111
Onchocerca volvulus	Glucosylceramidase homolog	0.0178	0.407	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0511	0.0692
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0111	0.0151
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0111	0.0151
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0048	0.0018
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0111	0.0111
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0111	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0462	0.0626
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0111	0.0111
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0048	0.0546
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0244	0.0244
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0111	0.0111
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0111	0.0111
Trichomonas vaginalis	glucosylceramidase, putative	0.0178	0.407	0.6472
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0462	1
Onchocerca volvulus		0.001	0.0111	0.0158
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0048	0.0065
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.0048	0.0546
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0111	0.0111
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0111	0.0111
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0048	0.0018
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0111	0.2487	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0052	0.0052
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0111	0.0111
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0111	0.0111
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0111	0.2487	1
Echinococcus granulosus	GPCR family 2	0.0016	0.0244	0.0244
Trichomonas vaginalis	glucosylceramidase, putative	0.0178	0.407	0.6472
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0111	0.0111
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0462	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0111	0.0151
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0111	0.0151
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0052	0.0052
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0111	0.0111
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0314	0.6421
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.0048	0.0546
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.1039	0.1407
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0111	0.2487	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0111	0.0111
Schistosoma mansoni	cpg binding protein	0.0032	0.0627	0.0627
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0111	0.0151
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0314	0.6617
Brugia malayi	CXXC zinc finger family protein	0.003	0.0586	0.0794
Onchocerca volvulus		0.0025	0.0462	0.1031
Trichomonas vaginalis	glucosylceramidase, putative	0.0178	0.407	0.6472
Trichomonas vaginalis	glucosylceramidase, putative	0.0271	0.6268	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0462	0.1699
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0111	0.0151
Trypanosoma brucei	hypothetical protein	0.0111	0.2487	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0244	0.0244
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.029	0.6071
Trypanosoma brucei	calpain, putative	0.0111	0.2487	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0111	0.0151
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0111	0.0151
Echinococcus granulosus	hypothetical protein	0.0027	0.051	0.051
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0244	0.0244
Loa Loa (eye worm)	hypothetical protein	0.001	0.0111	0.0151
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0111	0.0151
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.0048	0.0546
Schistosoma mansoni	hypothetical protein	0.0034	0.0671	0.0671
Echinococcus multilocularis	dnaJ subfamily B	0.0429	1	1
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0007	0.0048	0.0048
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0111	0.0151
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0462	0.0626
Loa Loa (eye worm)	hypothetical protein	0.001	0.0111	0.0151
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.001	0.0111	0.0151
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0095	0.0095
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0271	0.6268	0.8492
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0111	0.0111
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0111	0.0111
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0671	0.0909
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0271	0.6268	0.8492
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0048	0.0065
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0052	0.0052
Brugia malayi	tumor suppressor.	0.0318	0.7381	1
Schistosoma mansoni	acetyl-CoA synthetase	0.0007	0.0048	0.0048
Schistosoma mansoni	coup transcription factor	0.001	0.0111	0.0111
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0111	0.0111
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.1222	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0271	0.6268	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0462	0.1699
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0007	0.0048	0.0048
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0111	0.2487	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0111	0.0111
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0111	0.2487	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0111	0.0151
Echinococcus granulosus	protein quaking	0.0027	0.051	0.051
Trichomonas vaginalis	glucosylceramidase, putative	0.0178	0.407	0.6472
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0314	0.0425
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0007	0.0048	0.0065
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0462	1
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.0048	0.0546
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0048	0.0065
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0244	0.033
Trichomonas vaginalis	glucosylceramidase, putative	0.0178	0.407	0.6472
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0244	0.033
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0048	0.0546
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0111	0.2487	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0244	0.0244
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0095	0.0129
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0111	0.0111
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0111	0.0151
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0048	0.0546
Trypanosoma brucei	calpain-like protein, putative	0.0111	0.2487	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0671	0.0909
Schistosoma mansoni	hypothetical protein	0.0027	0.051	0.051
Loa Loa (eye worm)	hypothetical protein	0.001	0.0111	0.0151
Trichomonas vaginalis	glucosylceramidase, putative	0.0187	0.4296	0.6835
Loa Loa (eye worm)	tumor suppressor	0.0318	0.7381	1
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.0048	0.0546
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0111	0.2487	1
Trypanosoma brucei	variant surface glycoprotein (VSG), putative	0.0111	0.2487	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0314	0.0425
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0111	0.0151
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0111	0.0151
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0052	0.0052
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0095	0.0095
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0462	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0048	0.0065
Trichomonas vaginalis	glucosylceramidase, putative	0.0271	0.6268	1
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0462	0.0626
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0111	0.0111
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.0048	0.0546
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0244	0.0244
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0314	1
Loa Loa (eye worm)	oxidoreductase	0.0007	0.0048	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0314	0.0425
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0048	0.0546
Loa Loa (eye worm)	hypothetical protein	0.001	0.0111	0.0151
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0111	0.0111
Brugia malayi	hypothetical protein	0.0027	0.0511	0.0692
Brugia malayi	nuclear receptor NHR-88	0.001	0.0111	0.0151
Brugia malayi	nuclear hormone receptor	0.001	0.0111	0.0151
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0111	0.0151
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0111	0.2487	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0111	0.0151
Loa Loa (eye worm)	hypothetical protein	0.001	0.0111	0.0151
Brugia malayi	steroid hormone receptor	0.001	0.0111	0.0151
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0462	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0314	0.5
Schistosoma mansoni	hypothetical protein	0.0016	0.0244	0.0244
Trichomonas vaginalis	glucosylceramidase, putative	0.0271	0.6268	1
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0111	0.2487	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.1039	0.1407
Schistosoma mansoni	cpg binding protein	0.003	0.0586	0.0586
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0111	0.0151
Echinococcus multilocularis	protein quaking	0.0027	0.051	0.051
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0048	0.0065
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0314	1
Brugia malayi	Temporarily assigned gene name protein 44	0.0027	0.0511	0.0692
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0111	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0314	0.0425
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0052	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1039	0.1407
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0462	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0462	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0271	0.6268	1
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0048	0.0065
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0111	0.0111
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0111	0.0151
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0462	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0111	0.0111
Trichomonas vaginalis	glucosylceramidase, putative	0.0187	0.4296	0.6835
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.001	0.0111	0.0151
Schistosoma mansoni	cpg binding protein	0.0032	0.0627	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0462	0.0626
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0462	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0462	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0111	0.0158
Echinococcus granulosus	cpg binding protein	0.0032	0.0627	0.0627
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0111	0.2487	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0271	0.6268	1
Echinococcus multilocularis	cpg binding protein	0.0032	0.0627	0.0627
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0111	0.2487	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0111	0.0158
Schistosoma mansoni	hypothetical protein	0.0429	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0462	0.0626
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.029	0.6071
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0462	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0462	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0111	0.2487	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0048	0.0065
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0111	0.0111
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0244	0.0244
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.0048	0.0546
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0244	0.033
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.029	0.6071
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0111	0.0158
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0111	0.0151
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0111	0.0111
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0048	0.0065
Brugia malayi	ecdysteroid receptor	0.001	0.0111	0.0151
Schistosoma mansoni	hypothetical protein	0.0016	0.0244	0.0244
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0111	0.0111
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0111	0.0151
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0462	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0111	0.0151
Schistosoma mansoni	hypothetical protein	0.0027	0.051	0.051
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0586	0.0794
Onchocerca volvulus		0.003	0.0586	0.1339
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0093	0.0125
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0244	0.033
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0111	0.0111
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0111	0.0111
Trichomonas vaginalis	glucosylceramidase, putative	0.0178	0.407	0.6472
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0111	0.0111
Schistosoma mansoni	hypothetical protein	0.0016	0.0244	0.0244
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.1039	0.1407
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.029	0.6071
Trichomonas vaginalis	glucosylceramidase, putative	0.0178	0.407	0.6472
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0111	0.0151

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= -10 %	DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1860989

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1054361