Detailed information for compound 1063255

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 441.403 | Formula: C19H17F2NO7S
  • H donors: 1 H acceptors: 5 LogP: 2.69 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CCS(=O)(=O)c1ccccc1)OCC(=O)NC(=O)c1ccc(cc1)OC(F)F
  • InChi: 1S/C19H17F2NO7S/c20-19(21)29-14-8-6-13(7-9-14)18(25)22-16(23)12-28-17(24)10-11-30(26,27)15-4-2-1-3-5-15/h1-9,19H,10-12H2,(H,22,23,25)
  • InChiKey: OVSJYLVSPGZRJA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0099 0.0098 0.0098
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.4064 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0251 0.0479 0.0479
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0251 0.0479 0.0674
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0099 0.0098 0.026
Schistosoma mansoni hypothetical protein 0.0164 0.0262 0.0369
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0251 0.0479 0.1317
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0325 0.0663 0.0663
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.0432 1
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.1336 0.3187 0.8447
Loa Loa (eye worm) hypothetical protein 0.0099 0.0098 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Loa Loa (eye worm) hypothetical protein 0.0534 0.1186 0.1872
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0104 0.0111 0.0036
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0325 0.0663 0.4891
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.2906 0.7107 0.7107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Entamoeba histolytica hypothetical protein 0.0203 0.0358 0.0707
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0921 0.215 0.215
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0325 0.0663 0.1537
Loa Loa (eye worm) phosphatidylinositol 3 0.0325 0.0663 0.1046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Echinococcus multilocularis serine protein kinase ATM 0.0203 0.0358 0.0358
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Echinococcus multilocularis Zinc finger, PHD finger 0.0251 0.0479 0.0479
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0122 0.0156 0.0156
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0325 0.0663 0.1537
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0251 0.0479 0.1037
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0251 0.0479 0.127
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.1036 0.2438 0.2438
Loa Loa (eye worm) hypothetical protein 0.0122 0.0156 0.0247
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0099 0.0098 0.1418
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0325 0.0663 0.4891
Schistosoma mansoni hypothetical protein 0.0122 0.0156 0.022
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0122 0.0156 0.0156
Toxoplasma gondii FATC domain-containing protein 0.0203 0.0358 0.5367
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0099 0.0098 0.1418
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0561 0.1253 0.1762
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0031 0.0044
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0251 0.0479 0.1037
Trypanosoma cruzi hypothetical protein, conserved 0.1406 0.3362 0.8882
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0325 0.0663 0.1826
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Loa Loa (eye worm) hypothetical protein 0.0268 0.0522 0.0824
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0099 0.0098 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Leishmania major hypothetical protein, unknown function 0.0099 0.0098 0.0259
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0251 0.0479 0.1037
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.0583 0.4202
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0005 0.0005
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.0413 0.0652
Loa Loa (eye worm) phosphatidylinositol 3 0.0099 0.0098 0.0155
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0198 0.0536
Brugia malayi RNA binding protein 0.0072 0.0031 0.0082
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0099 0.0098 0.0098
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0408 0.0871 0.4509
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0251 0.0479 0.3301
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.1095 0.2587 0.6773
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0203 0.0358 0.0949
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0462 0.1006 0.2471
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0203 0.0358 0.0707
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Entamoeba histolytica hypothetical protein 0.1261 0.2999 0.7895
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0031 0.0044
Leishmania major phosphatidylinositol kinase related protein, putative 0.0099 0.0098 0.0259
Echinococcus granulosus serine protein kinase ATM 0.0203 0.0358 0.0358
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0203 0.0358 0.0949
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.157 0.3772 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0358 0.0707
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0203 0.0358 0.0358
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0251 0.0479 0.7211
Echinococcus granulosus muscleblind protein 0.0151 0.0229 0.0229
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0251 0.0479 0.7211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0358 0.0707
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0358 0.0707
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.1036 0.2438 0.2438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0726 0.1665 0.4265
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.0583 0.132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0358 0.0707
Loa Loa (eye worm) phosphatidylinositol 3 0.2596 0.6334 1
Schistosoma mansoni hypothetical protein 0.0164 0.0262 0.0369
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0251 0.0479 0.0479
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0198 0.0271
Entamoeba histolytica protein kinase rad3, putative 0.0203 0.0358 0.0707
Trypanosoma cruzi target of rapamycin kinase 3 0.0325 0.0663 0.1537
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0325 0.0663 0.1537
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0325 0.0663 0.1537
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Loa Loa (eye worm) hypothetical protein 0.1036 0.2438 0.385
Brugia malayi follicle stimulating hormone receptor 0.0225 0.0413 0.1094
Loa Loa (eye worm) hypothetical protein 0.0203 0.0358 0.0565
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0099 0.0098 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0325 0.0663 0.4891
Onchocerca volvulus 0.0099 0.0098 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0031 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0358 0.0707
Loa Loa (eye worm) phosphatidylinositol 3 0.0462 0.1006 0.1588
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0099 0.0098 0.1418
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0099 0.0098 0.026
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0325 0.0663 0.0663
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0251 0.0479 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0099 0.0098 0.0155
Loa Loa (eye worm) hypothetical protein 0.0151 0.0229 0.0361
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0358 0.0707
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0561 0.1253 0.3142
Echinococcus multilocularis survival motor neuron protein 1 0.0268 0.0522 0.0522
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0325 0.0663 0.0663
Toxoplasma gondii target of rapamycin (TOR), putative 0.0325 0.0663 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.157 0.3772 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0325 0.0663 0.4891
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0251 0.0479 0.0757
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.2906 0.7107 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0221 0.0403 0.2641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0325 0.0663 0.1826
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0203 0.0358 0.0707
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0005 0.0005
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0251 0.0479 0.0479
Echinococcus multilocularis muscleblind protein 0.0151 0.0229 0.0229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.2906 0.7107 0.7107
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0203 0.0358 0.2251
Loa Loa (eye worm) hypothetical protein 0.0221 0.0403 0.0636
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0203 0.0358 0.0358
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0325 0.0663 0.0933
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.157 0.3772 1
Mycobacterium ulcerans hypothetical protein 0.0154 0.0237 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0403 0.083
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.0583 0.1605
Echinococcus multilocularis muscleblind protein 1 0.0151 0.0229 0.0229
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0005 0.0007
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0251 0.0479 0.1037
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0031 0.0044
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0031 0.0031
Leishmania major phosphatidylinositol 4-kinase, putative 0.0099 0.0098 0.0259
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0251 0.0479 0.1037
Echinococcus granulosus survival motor neuron protein 1 0.0268 0.0522 0.0522
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0099 0.0098 0.026
Loa Loa (eye worm) phosphatidylinositol 3 0.0325 0.0663 0.1046
Brugia malayi hypothetical protein 0.0268 0.0522 0.1383
Schistosoma mansoni fkbp-rapamycin associated protein 0.0203 0.0358 0.0504
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0203 0.0358 0.0504
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0031 0.0044
Leishmania major phosphatidylinositol 3-kinase, putative 0.0325 0.0663 0.1826
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0561 0.1253 0.332
Echinococcus multilocularis 0.0099 0.0098 0.0098
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0325 0.0663 0.1826
Loa Loa (eye worm) phosphatidylinositol kinase 0.0099 0.0098 0.0155
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0325 0.0663 0.4891
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Loa Loa (eye worm) hypothetical protein 0.0104 0.0111 0.0176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.0583 0.132
Onchocerca volvulus 0.0099 0.0098 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0031 0.0049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1036 0.2438 0.6464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Loa Loa (eye worm) phosphatidylinositol 3 0.0099 0.0098 0.0155
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.157 0.3772 1
Giardia lamblia GTOR 0.0325 0.0663 0.3292
Brugia malayi FAT domain containing protein 0.0122 0.0156 0.0414
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0237 0.543
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0251 0.0479 0.1037
Brugia malayi Muscleblind-like protein 0.0151 0.0229 0.0606
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0111 0.0036
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0325 0.0663 0.1537
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0325 0.0663 0.0663
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0031 0.0044
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.157 0.3772 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0099 0.0098 0.2183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.157 0.3772 1
Leishmania major hypothetical protein, conserved 0.1505 0.3608 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0198 0.0864
Loa Loa (eye worm) RNA binding protein 0.0072 0.0031 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0358 0.0707
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0251 0.0479 0.0674
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0251 0.0479 0.1037
Leishmania major phosphatidylinositol kinase, putative 0.0099 0.0098 0.0259
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0099 0.0098 0.0138
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0561 0.1253 0.3142
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0561 0.1253 0.3142
Schistosoma mansoni hypothetical protein 0.0099 0.0098 0.0138
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0561 0.1253 0.3142
Echinococcus granulosus tar DNA binding protein 0.0072 0.0031 0.0031
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0325 0.0663 0.1826
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0031 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1261 0.2999 0.7895
Loa Loa (eye worm) phosphatidylinositol 3 0.0099 0.0098 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0111 0.0036
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0561 0.1253 0.3142
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0561 0.1253 0.3142
Echinococcus multilocularis geminin 0.0164 0.0262 0.0262
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0561 0.1253 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0325 0.0663 0.0933
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0099 0.0098 0.0138
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.1472 0.3526 0.9329
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0221 0.0403 0.6051
Loa Loa (eye worm) hypothetical protein 0.0151 0.0229 0.0361
Echinococcus granulosus geminin 0.0164 0.0262 0.0262
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0325 0.0663 0.1757
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0786 0.1813 1
Trichomonas vaginalis conserved hypothetical protein 0.0221 0.0403 0.083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Trichomonas vaginalis PIKK family atypical protein kinase 0.0203 0.0358 0.0707
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0203 0.0358 0.0707
Mycobacterium leprae conserved hypothetical protein 0.0099 0.0098 0.5
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0251 0.0479 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0099 0.0098 0.0098
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0325 0.0663 0.1757
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.0156 0.0159
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0099 0.0098 0.0098
Leishmania major phosphatidylinositol 3-kinase, putative 0.0251 0.0479 0.1317
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0325 0.0663 0.1537
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.157 0.3772 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.1095 0.2587 0.6773
Trichomonas vaginalis PIKK family atypical protein kinase 0.0325 0.0663 0.1537
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0005 0.0007
Brugia malayi TAR-binding protein 0.0072 0.0031 0.0082

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.