Detailed information for compound 106689

Basic information

Technical information
  • TDR Targets ID: 106689
  • Name: 3-bromobenzoic acid
  • MW: 201.017 | Formula: C7H5BrO2
  • H donors: 1 H acceptors: 2 LogP: 2.14 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cccc(c1)C(=O)O
  • InChi: 1S/C7H5BrO2/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,(H,9,10)
  • InChiKey: VOIZNVUXCQLQHS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 585-76-2
  • m-Bromobenzoic acid
  • NSC 32739
  • BENZOIC ACID,2-BROMO
  • NSC 3980
  • InChI=1/C7H5BrO2/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,(H,9,10
  • ST5319447
  • NSC32739
  • 186295_ALDRICH
  • 16330_FLUKA
  • AI3-08854
  • NCIOpen2_009262
  • Benzoic acid, m-bromo- (8CI)
  • NSC176129
  • EINECS 209-562-3
  • Benzoic acid, 3-bromo-
  • Benzoic acid, m-bromo-
  • NSC3980

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.002 0.0011 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0376 0.1353
Trichomonas vaginalis ankyrin, putative 0.002 0.0011 0.0014
Leishmania major hypothetical protein, conserved 0.002 0.0011 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0011 0.004
Giardia lamblia Hypothetical protein 0.002 0.0011 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0014
Trypanosoma cruzi WLM domain containing protein, putative 0.0394 0.2708 1
Schistosoma mansoni peter pan-related 0.002 0.0011 0.0014
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.002 0.0011 0.0014
Trypanosoma cruzi WLM domain containing protein, putative 0.0394 0.2708 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.002 0.0011 0.0014
Echinococcus granulosus Zinc finger RanBP2 type 0.0394 0.2708 0.2708
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.002 0.0011 0.0011
Trichomonas vaginalis ion channel nompc, putative 0.002 0.0011 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0376 0.1353
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0394 0.2708 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0376 0.1353
Trypanosoma cruzi hypothetical protein, conserved 0.0394 0.2708 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Trypanosoma cruzi hypothetical protein 0.002 0.0011 0.004
Schistosoma mansoni fusion 0.0394 0.2708 0.3448
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0394 0.2708 0.3448
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0011 0.004
Echinococcus multilocularis ring finger protein 113a 0.002 0.0011 0.0011
Giardia lamblia Hypothetical protein 0.002 0.0011 0.5
Leishmania major hypothetical protein, conserved 0.002 0.0011 0.004
Brugia malayi brahma associated protein 60 kDa 0.1108 0.7854 1
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.002 0.0011 0.0011
Plasmodium vivax E3 ubiquitin-protein ligase, putative 0.002 0.0011 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Loa Loa (eye worm) RiNg Finger protein family member 0.002 0.0011 0.0014
Giardia lamblia Kinase, NEK 0.002 0.0011 0.5
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Schistosoma mansoni hypothetical protein 0.1108 0.7854 1
Loa Loa (eye worm) hypothetical protein 0.0206 0.135 0.1718
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.002 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0014
Schistosoma mansoni RNA binding protein 0.0394 0.2708 0.3448
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Echinococcus granulosus RING finger protein 185 0.002 0.0011 0.0011
Echinococcus multilocularis 0.002 0.0011 0.0011
Echinococcus multilocularis RING finger protein 185 0.002 0.0011 0.0011
Onchocerca volvulus 0.002 0.0011 0.0014
Giardia lamblia Hypothetical protein 0.002 0.0011 0.5
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Schistosoma mansoni brg-1 associated factor 0.1108 0.7854 1
Onchocerca volvulus 0.1108 0.7854 1
Toxoplasma gondii hypothetical protein 0.002 0.0011 0.0014
Schistosoma mansoni cellular tumor antigen P53 0.0206 0.135 0.1718
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1108 0.7854 1
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.002 0.0011 0.0014
Echinococcus granulosus SWI:SNF matrix associated 0.1108 0.7854 0.7854
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Leishmania major hypothetical protein, conserved 0.002 0.0011 0.004
Entamoeba histolytica zinc finger domain containing protein 0.002 0.0011 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0014
Onchocerca volvulus 0.002 0.0011 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Chlamydia trachomatis DNA topoisomerase I 0.1108 0.7854 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0376 0.1353
Echinococcus granulosus ring finger protein 170 0.002 0.0011 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0011 0.004
Onchocerca volvulus 0.002 0.0011 0.0014
Toxoplasma gondii RING zinc finger protein 0.002 0.0011 0.0014
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0394 0.2708 0.3448
Schistosoma mansoni hypothetical protein 0.0188 0.122 0.1553
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.1108 0.7854 1
Entamoeba histolytica SPRY domain protein 0.002 0.0011 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Brugia malayi SWIB/MDM2 domain containing protein 0.1108 0.7854 1
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Schistosoma mansoni hypothetical protein 0.0394 0.2708 0.3448
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0394 0.2708 1
Leishmania major hypothetical protein, conserved 0.0394 0.2708 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0014
Schistosoma mansoni hypothetical protein 0.002 0.0011 0.0014
Brugia malayi Zinc finger, C2H2 type family protein 0.002 0.0011 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0394 0.2708 1
Leishmania major hypothetical protein, conserved 0.002 0.0011 0.004
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0394 0.2708 0.2708
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Trichomonas vaginalis ankyrin, putative 0.002 0.0011 0.0014
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Onchocerca volvulus 0.0206 0.135 0.1718
Echinococcus multilocularis tumor protein p63 0.1405 1 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.002 0.0011 0.0014
Onchocerca volvulus RING finger protein 141 homolog 0.002 0.0011 0.0014
Leishmania major cathepsin L-like protease 0.0071 0.0376 0.1388
Plasmodium falciparum zinc finger protein, putative 0.002 0.0011 0.0014
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Giardia lamblia Kinase 0.002 0.0011 0.5
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Giardia lamblia E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B 0.002 0.0011 0.5
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Schistosoma mansoni hypothetical protein 0.002 0.0011 0.0014
Giardia lamblia Kinase, NEK 0.002 0.0011 0.5
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1108 0.7854 0.7854
Leishmania major hypothetical protein, conserved 0.002 0.0011 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0376 0.1353
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0014
Schistosoma mansoni zinc finger protein 0.0394 0.2708 0.3448
Leishmania major hypothetical protein, conserved 0.0394 0.2708 1
Giardia lamblia Zinc finger domain 0.002 0.0011 0.5
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.002 0.0011 0.0011
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Plasmodium falciparum E3 ubiquitin-protein ligase, putative 0.002 0.0011 0.0014
Onchocerca volvulus Protein neuralized homolog 0.002 0.0011 0.0014
Toxoplasma gondii hypothetical protein 0.002 0.0011 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0376 0.1388
Toxoplasma gondii helicase, putative 0.002 0.0011 0.0014
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0394 0.2708 1
Toxoplasma gondii ran binding protein 0.0394 0.2708 0.3448
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.002 0.0011 0.0014
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.002 0.0011 0.0011
Toxoplasma gondii SWI2/SNF2-containing protein RAD5 0.002 0.0011 0.0014
Brugia malayi hypothetical protein 0.002 0.0011 0.0014
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Onchocerca volvulus 0.0394 0.2708 0.3448
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1108 0.7854 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Entamoeba histolytica hypothetical protein 0.002 0.0011 1
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1108 0.7854 1
Giardia lamblia Ribonuclease 0.002 0.0011 0.5
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0394 0.2708 1
Entamoeba histolytica zinc finger domain containing protein 0.002 0.0011 1
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0011 0.004
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.002 0.0011 0.0011
Onchocerca volvulus 0.0394 0.2708 0.3448
Loa Loa (eye worm) hypothetical protein 0.0394 0.2708 0.3448
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0376 0.1388
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.002 0.0011 0.0011
Plasmodium vivax E3 ubiquitin-protein ligase RNF5, putative 0.002 0.0011 0.0014
Brugia malayi Neuralized family protein 0.002 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0014
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.002 0.0011 0.004
Plasmodium vivax RING zinc finger protein, putative 0.002 0.0011 0.0014
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0394 0.2708 0.3448
Loa Loa (eye worm) brahma associated protein 0.1108 0.7854 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Leishmania major hypothetical protein, conserved 0.002 0.0011 0.004
Brugia malayi B-box zinc finger family protein 0.002 0.0011 0.0014
Schistosoma mansoni hypothetical protein 0.002 0.0011 0.0014
Onchocerca volvulus 0.002 0.0011 0.0014
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.002 0.0011 0.0014
Echinococcus granulosus geminin 0.0188 0.122 0.122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0376 0.1353
Leishmania major hypothetical protein, conserved 0.002 0.0011 0.004
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Onchocerca volvulus 0.0394 0.2708 0.3448
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.002 0.0011 0.0011
Brugia malayi YY1-associated factor 2 0.0394 0.2708 0.3448
Onchocerca volvulus 0.0167 0.1073 0.1366
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Echinococcus granulosus zinc finger protein Ran binding 0.0394 0.2708 0.2708
Plasmodium vivax zinc finger protein, putative 0.002 0.0011 0.0014
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.002 0.0011 0.0011
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Loa Loa (eye worm) hypothetical protein 0.0394 0.2708 0.3448
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0394 0.2708 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Toxoplasma gondii hypothetical protein 0.002 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0394 0.2708 0.3448
Loa Loa (eye worm) hypothetical protein 0.0167 0.1073 0.1366
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Leishmania major hypothetical protein, unknown function 0.002 0.0011 0.004
Brugia malayi RING zinc finger protein 0.002 0.0011 0.0014
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1108 0.7854 1
Plasmodium vivax DNA repair protein RAD5, putative 0.002 0.0011 0.0014
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.002 0.0011 0.0014
Giardia lamblia Hypothetical protein 0.002 0.0011 0.5
Schistosoma mansoni peter pan-related 0.002 0.0011 0.0014
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Schistosoma mansoni hypothetical protein 0.1108 0.7854 1
Giardia lamblia Hypothetical protein 0.002 0.0011 0.5
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.002 0.0011 0.0011
Brugia malayi hypothetical protein 0.002 0.0011 0.0014
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1108 0.7854 0.7854
Entamoeba histolytica zinc finger domain containing protein 0.002 0.0011 1
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0394 0.2708 0.2708
Leishmania major hypothetical protein 0.002 0.0011 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0376 0.1353
Leishmania major hypothetical protein, conserved 0.002 0.0011 0.004
Giardia lamblia Hypothetical protein 0.002 0.0011 0.5
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Echinococcus granulosus cell growth regulator with ring finger domain 0.002 0.0011 0.0011
Echinococcus granulosus ring finger protein 113a 0.002 0.0011 0.0011
Schistosoma mansoni mind bomb 0.002 0.0011 0.0014
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.002 0.0011 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Onchocerca volvulus Putative RING finger protein 207 0.002 0.0011 0.0014
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.002 0.0011 0.0011
Echinococcus multilocularis SWI:SNF matrix associated 0.1108 0.7854 0.7854
Onchocerca volvulus 0.002 0.0011 0.0014
Trypanosoma brucei hypothetical protein, conserved 0.0394 0.2708 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.002 0.0011 0.004
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0394 0.2708 0.3448
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Brugia malayi brahma associated protein 60 kDa 0.1108 0.7854 1
Brugia malayi RING finger protein 20 0.002 0.0011 0.0014
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Entamoeba histolytica zinc finger domain containing protein 0.002 0.0011 1
Leishmania major DNA repair protein-like protein 0.002 0.0011 0.004
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0394 0.2708 1
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0011 0.004
Entamoeba histolytica zinc finger domain containing protein 0.002 0.0011 1
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.0376 0.1388
Leishmania major cathepsin L-like protease 0.0071 0.0376 0.1388
Leishmania major hypothetical protein, conserved 0.002 0.0011 0.004
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0267 0.0985
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0394 0.2708 0.3448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0376 0.1353
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Entamoeba histolytica zinc finger domain containing protein 0.002 0.0011 1
Toxoplasma gondii Bardet-Biedl syndrome 5, putative 0.002 0.0011 0.0014
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0011 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0394 0.2708 1
Giardia lamblia Hypothetical protein 0.002 0.0011 0.5
Schistosoma mansoni TRABID protein (C64 family) 0.0394 0.2708 0.3448
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.002 0.0011 0.0014
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0394 0.2708 0.3448
Trichomonas vaginalis ankyrin, putative 0.002 0.0011 0.0014
Schistosoma mansoni zinc finger protein 0.002 0.0011 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0376 0.1388
Brugia malayi hypothetical protein 0.002 0.0011 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0376 0.1353
Loa Loa (eye worm) hypothetical protein 0.0394 0.2708 0.3448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0376 0.1353
Trypanosoma cruzi hypothetical protein 0.002 0.0011 0.004
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Echinococcus multilocularis zinc finger protein Ran binding 0.0394 0.2708 0.2708
Schistosoma mansoni hypothetical protein 0.0188 0.122 0.1553
Leishmania major hypothetical protein, conserved 0.0394 0.2708 1
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Leishmania major hypothetical protein, conserved 0.002 0.0011 0.004
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0014
Echinococcus multilocularis ring finger protein 170 0.002 0.0011 0.0011
Giardia lamblia Zinc finger domain 0.002 0.0011 0.5
Brugia malayi Zinc finger protein 183 homolog 0.002 0.0011 0.0014
Plasmodium falciparum RING zinc finger protein, putative 0.002 0.0011 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Loa Loa (eye worm) hypothetical protein 0.0394 0.2708 0.3448
Loa Loa (eye worm) RING finger protein 20 0.002 0.0011 0.0014
Leishmania major hypothetical protein, conserved 0.002 0.0011 0.004
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Trichomonas vaginalis hypothetical protein 0.002 0.0011 0.0014
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Plasmodium vivax trophozoite exported protein 1, putative 0.002 0.0011 0.0014
Entamoeba histolytica zinc finger domain containing protein 0.002 0.0011 1
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Schistosoma mansoni hypothetical protein 0.1108 0.7854 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Entamoeba histolytica hypothetical protein 0.002 0.0011 1
Leishmania major cathepsin L-like protease 0.0071 0.0376 0.1388
Brugia malayi hypothetical protein 0.0167 0.1073 0.1366
Entamoeba histolytica zinc finger domain containing protein 0.002 0.0011 1
Giardia lamblia Ser/Thr protein kinase 0.002 0.0011 0.5
Plasmodium falciparum E3 ubiquitin-protein ligase RNF5, putative 0.002 0.0011 0.0014
Trichomonas vaginalis sex-determining protein fem-1, putative 0.002 0.0011 0.0014
Onchocerca volvulus 0.002 0.0011 0.0014
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.0332 0.1224
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Echinococcus multilocularis geminin 0.0188 0.122 0.122
Schistosoma mansoni rnf5 0.002 0.0011 0.0014
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1108 0.7854 1
Leishmania major hypothetical protein, conserved 0.0394 0.2708 1
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0394 0.2708 0.3448
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0394 0.2708 0.2708
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Plasmodium vivax hypothetical protein, conserved 0.1108 0.7854 1
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1108 0.7854 1
Brugia malayi hypothetical protein 0.002 0.0011 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0011 0.004
Leishmania major hypothetical protein, conserved 0.002 0.0011 0.004
Trypanosoma brucei hypothetical protein, conserved 0.0394 0.2708 1
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Brugia malayi hypothetical protein 0.002 0.0011 0.0014
Leishmania major hypothetical protein, conserved 0.002 0.0011 0.004
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Schistosoma mansoni ring finger protein 151 0.002 0.0011 0.0014
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0011 0.004
Leishmania major hypothetical protein, conserved 0.0394 0.2708 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.002 0.0011 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0014
Echinococcus multilocularis ring and YY1 binding protein 0.0394 0.2708 0.2708
Giardia lamblia Protein 21.1 0.002 0.0011 0.5
Toxoplasma gondii hypothetical protein 0.002 0.0011 0.0014
Echinococcus multilocularis SWI:SNF matrix associated 0.1108 0.7854 0.7854
Chlamydia trachomatis SWIB complex protein 0.1108 0.7854 0.5
Plasmodium falciparum trophozoite exported protein 1 0.002 0.0011 0.0014
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.002 0.0011 0.0014
Echinococcus multilocularis SWI:SNF matrix associated 0.1108 0.7854 0.7854
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0376 0.1353
Onchocerca volvulus 0.0394 0.2708 0.3448
Brugia malayi hypothetical protein 0.002 0.0011 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0011 0.004
Echinococcus granulosus ring and YY1 binding protein 0.0394 0.2708 0.2708
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0394 0.2708 1
Toxoplasma gondii zinc finger, C3HC4 type (RING finger) domain-containing protein 0.002 0.0011 0.0014

Activities

Activity type Activity value Assay description Source Reference
Hammett constant (ADMET) = 0.39 Hammett constant was evaluated ChEMBL. 8667357
Hammett constant (binding) = 0.39 Hammett constant was determined ChEMBL. 8411009
Log 1/C (ADMET) = 1.71 log (1/C') of the compound was determined ChEMBL. 1527790
logD (ADMET) = 2.86 Partition coefficient (logD2.0) ChEMBL. 1527790

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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