Detailed information for compound 1081935

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 235.229 | Formula: C13H11F2NO
  • H donors: 1 H acceptors: 1 LogP: 2.97 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc2c(c1F)[nH]c1c(c2=O)CCCC1
  • InChi: 1S/C13H11F2NO/c14-9-6-5-8-12(11(9)15)16-10-4-2-1-3-7(10)13(8)17/h5-6H,1-4H2,(H,16,17)
  • InChiKey: SCIUNOSNEGJWTF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis aminopeptidase N 0.0118 0.3099 0.3099
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0373 0.4028
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0673 0.0673
Onchocerca volvulus 0.0031 0.0566 0.1828
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.1197 0.1197
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0869 0.0869
Brugia malayi TAR-binding protein 0.0073 0.1788 0.2352
Schistosoma mansoni hypothetical protein 0.0174 0.474 0.474
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0191 0.1973
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0566 0.0566
Schistosoma mansoni aminopeptidase A (M01 family) 0.0012 0.0016 0.0016
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0023 0.0317 0.0317
Echinococcus granulosus aminopeptidase N 0.0118 0.3099 0.3099
Loa Loa (eye worm) RNA binding protein 0.0073 0.1788 0.1788
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0191 0.1897
Entamoeba histolytica Ran family GTPase 0.0024 0.0373 0.2197
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0373 0.3873
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0938 1
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0029 0.0146
Brugia malayi TATA binding protein associated factor 0.0012 0.0016 0.0021
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0191 0.1897
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0191 0.1973
Loa Loa (eye worm) aminopeptidase N 0.0035 0.0673 0.0673
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0014 0.0081 0.0081
Leishmania major cytochrome p450-like protein 0.0013 0.0029 0.0146
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0224 1
Plasmodium falciparum importin beta, putative 0.0033 0.0629 0.7514
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0224 0.2256
Brugia malayi Importin beta-1 subunit 0.0033 0.0629 0.0827
Echinococcus multilocularis survival motor neuron protein 1 0.0273 0.7603 0.7603
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0903 0.9614
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0023 0.0317 0.0317
Schistosoma mansoni hypothetical protein 0.0355 1 1
Schistosoma mansoni hypothetical protein 0.0174 0.474 0.474
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0373 0.2197
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0629 0.6646
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0191 0.0191
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0035 0.0673 0.0673
Echinococcus multilocularis geminin 0.0174 0.474 0.474
Loa Loa (eye worm) hypothetical protein 0.0033 0.0629 0.0629
Echinococcus granulosus intermediate filament protein 0.0031 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0023 0.0317 0.0317
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0029 0.0029
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.3883 0.3883
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0832 1
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1788 0.1788
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.1197 0.1197
Loa Loa (eye worm) hypothetical protein 0.0273 0.7603 0.7603
Loa Loa (eye worm) hypothetical protein 0.0043 0.0903 0.0903
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0673 0.0673
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0224 0.2346
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0832 0.8955
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1788 0.1788
Schistosoma mansoni ap endonuclease 0.0019 0.0224 0.0224
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0903 0.0903
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0373 0.0373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1197 0.1197
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0673 0.0673
Loa Loa (eye worm) hypothetical protein 0.0083 0.2086 0.2086
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1788 0.1788
Echinococcus multilocularis snurportin 1 0.0355 1 1
Onchocerca volvulus 0.0012 0.0016 0.0053
Loa Loa (eye worm) TATA binding protein associated factor 0.0012 0.0016 0.0016
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0629 0.0629
Entamoeba histolytica hypothetical protein 0.0041 0.0869 0.9504
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0035 0.0673 0.7404
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0224 0.0295
Brugia malayi RNA binding protein 0.0073 0.1788 0.2352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.1197 0.1197
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0191 0.2144
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0224 0.0224
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0903 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0035 0.0673 0.7118
Schistosoma mansoni ran 0.0024 0.0373 0.0373
Schistosoma mansoni importin beta-1 0.0033 0.0629 0.0629
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0012 0.0016 0.0016
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0029 0.0146
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0903 0.0903
Entamoeba histolytica hypothetical protein 0.0041 0.0869 0.9504
Echinococcus multilocularis musashi 0.0031 0.0566 0.0566
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0191 0.0191
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0016 0.0016
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0629 0.6913
Onchocerca volvulus 0.0035 0.0673 0.2171
Echinococcus multilocularis tar DNA binding protein 0.0073 0.1788 0.1788
Echinococcus granulosus survival motor neuron protein 1 0.0273 0.7603 0.7603
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0012 0.0016 0.0016
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0566 0.0566
Echinococcus granulosus lamin dm0 0.0031 0.0566 0.0566
Echinococcus multilocularis lamin dm0 0.0031 0.0566 0.0566
Schistosoma mansoni ap endonuclease 0.0019 0.0224 0.0224
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0373 0.0373
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0903 0.0903
Plasmodium vivax importin-beta 2, putative 0.0033 0.0629 0.6646
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0903 0.0903
Loa Loa (eye worm) hypothetical protein 0.0015 0.0098 0.0098
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0903 0.0903
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0903 0.9614
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0903 1
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0012 0.0016 0.0016
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0029 0.0197
Onchocerca volvulus 0.0118 0.3099 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0373 0.0373
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0023 0.0317 0.3389
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1197 0.1197
Brugia malayi RNA, U transporter 1 0.0095 0.2415 0.3176
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.1197 0.1197
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0903 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0355 1 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0373 0.4028
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0903 0.0903
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.1197 0.1197
Loa Loa (eye worm) hypothetical protein 0.0014 0.0081 0.0081
Schistosoma mansoni lamin 0.0031 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0106 0.2743 0.2743
Loa Loa (eye worm) peptidase family M1 containing protein 0.0095 0.2442 0.2442
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0903 0.1187
Brugia malayi Cytochrome P450 family protein 0.0013 0.0029 0.0038
Onchocerca volvulus 0.0056 0.1281 0.4133
Schistosoma mansoni survival motor neuron protein 0.0056 0.1281 0.1281
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0191 0.0191
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0903 1
Echinococcus multilocularis lamin 0.0031 0.0566 0.0566
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0373 0.4028
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0373 0.3873
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0673 0.0673
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0035 0.0673 0.0673
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0869 0.0869
Brugia malayi hypothetical protein 0.0273 0.7603 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0098 0.0098
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0673 0.0673
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0191 0.0191
Mycobacterium ulcerans aminopeptidase N PepN 0.0035 0.0673 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0012 0.0016 0.0016
Brugia malayi Peptidase family M1 containing protein 0.0118 0.3099 0.4075
Brugia malayi Cytochrome P450 family protein 0.0013 0.0029 0.0038
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0446 0.4659
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0938 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0224 0.5
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0016 0.0021
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0035 0.0673 0.7404
Echinococcus granulosus lamin 0.0031 0.0566 0.0566
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0029 0.0029
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0029 0.0146
Entamoeba histolytica hypothetical protein 0.0041 0.0869 0.9504
Leishmania major GTP-binding protein, putative 0.0024 0.0373 0.4028
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1788 0.1788
Echinococcus granulosus leukotriene A 4 hydrolase 0.0012 0.0016 0.0016
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0191 0.1973
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.1197 0.1574
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0191 0.1973
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0938 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0903 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0446 0.4659
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0938 0.0938
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0903 0.0903
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0224 0.3169
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.4005 0.4005
Schistosoma mansoni intermediate filament proteins 0.0031 0.0566 0.0566
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1197 0.1197
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0035 0.0673 0.7404
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.1788 0.2352
Brugia malayi isocitrate dehydrogenase 0.0018 0.0191 0.0251
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0224 0.2256
Trypanosoma brucei Aminopeptidase M1, putative 0.0035 0.0673 0.7404
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0191 0.0191
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0673 0.0673
Loa Loa (eye worm) TAR-binding protein 0.0073 0.1788 0.1788
Schistosoma mansoni ran 0.0024 0.0373 0.0373
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0224 0.2346
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0566 0.0745
Onchocerca volvulus 0.0031 0.0566 0.1828
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0903 0.9614
Trypanosoma cruzi aminopeptidase, putative 0.0035 0.0673 0.7404
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0224 0.2346
Schistosoma mansoni lamin 0.0031 0.0566 0.0566
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0869 0.0869
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0029 0.0029
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0191 0.1973
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0191 0.0251
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0446 0.4659
Trypanosoma brucei Aminopeptidase M1, putative 0.0035 0.0673 0.7404
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0224 0.255
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0016 0.0016
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0903 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0938 1
Entamoeba histolytica hypothetical protein 0.0027 0.0446 0.3267
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0224 0.2256
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0224 0.2346
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0191 0.0191
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0146 0.0192
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1788 0.1788
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0035 0.0673 0.0673
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0035 0.0673 0.7118
Loa Loa (eye worm) hypothetical protein 0.0031 0.0566 0.0566
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.1788 0.1788
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0673 0.0673
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.4005 0.4005
Entamoeba histolytica aminopeptidase, putative 0.0035 0.0673 0.6608
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.4005 0.5268
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.0673 0.0673
Entamoeba histolytica hypothetical protein 0.0041 0.0869 0.9504
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0191 0.0191
Toxoplasma gondii exonuclease III APE 0.0019 0.0224 0.2256
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0903 0.0903
Brugia malayi hypothetical protein 0.0041 0.0869 0.1143
Brugia malayi Peptidase family M1 containing protein 0.0035 0.0673 0.0885
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0224 0.5
Loa Loa (eye worm) acetyltransferase 0.0149 0.4005 0.4005
Brugia malayi intermediate filament protein 0.0031 0.0566 0.0745
Brugia malayi hypothetical protein 0.0012 0.0016 0.0021
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0224 0.0224
Schistosoma mansoni hypothetical protein 0.0056 0.1281 0.1281
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.0673 0.0673
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0023 0.0317 0.0317
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0191 0.1897
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0224 0.0224
Brugia malayi hypothetical protein 0.0035 0.0673 0.0885
Echinococcus granulosus importin subunit beta 1 0.0033 0.0629 0.0629
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0373 0.0491
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0035 0.0673 0.7404
Echinococcus granulosus geminin 0.0174 0.474 0.474
Loa Loa (eye worm) hypothetical protein 0.0031 0.055 0.055
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.1281 0.1684
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0446 0.4846
Trypanosoma cruzi Aminopeptidase M1, putative 0.0035 0.0673 0.7404
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0629 0.6913
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0373 0.4378
Trichomonas vaginalis ran, putative 0.0024 0.0373 0.3873
Echinococcus granulosus tar DNA binding protein 0.0073 0.1788 0.1788
Leishmania major importin beta-1 subunit, putative 0.0027 0.0446 0.4846
Schistosoma mansoni hypothetical protein 0.0041 0.0869 0.0869
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0832 0.8955
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0098 0.0098
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0938 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 378 nM Antimalarial activity against chloroquine, mefloquine, pyrimethamine and atovaquone-resistant Plasmodium falciparum TM90-C2B infected in human A positive erythrocytes after 72 hrs by SYBR Green I assay ChEMBL. 21630666
EC50 (functional) = 1050 nM Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2 infected in human A positive erythrocytes after 72 hrs by SYBR Green I assay ChEMBL. 21630666
EC50 (ADMET) > 40 uM Cytotoxicity against mouse J774 cells after 72 hrs by Cell titer 96 aqueous one solution cell proliferation assay ChEMBL. 21630666
Ratio EC50 (functional) = 0.36 Resistance index, ratio of EC50 for chloroquine, mefloquine, pyrimethamine and atovaquone-resistant Plasmodium falciparum TM90-C2B to EC50 for chloroquine and pyrimethamine-resistant Plasmodium falciparum W2 ChEMBL. 21630666

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 21630666

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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