TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 308.499 | Formula: C20H36O2
H donors: 2 H acceptors: 2 LogP: 5.1 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC/C=C(/CCC1[C@](C)(O)CC[C@@H]2[C@]1(C)CCCC2(C)C)\C
InChi: 1S/C20H36O2/c1-15(10-14-21)7-8-17-19(4)12-6-11-18(2,3)16(19)9-13-20(17,5)22/h10,16-17,21-22H,6-9,11-14H2,1-5H3/b15-10+/t16-,17?,19-,20+/m0/s1
InChiKey: LEOHDQKUMQKLMP-KMLQCBPISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	nuclear receptor NHR-67	0.003	0.044	0.1344
Onchocerca volvulus	Bile acid receptor homolog	0.0063	0.1182	1
Entamoeba histolytica	hypothetical protein	0.0036	0.0574	1
Schistosoma mansoni	nuclear receptor nhr-48	0.003	0.044	0.0435
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.1138	0.193
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0019
Brugia malayi	Nuclear hormone receptor-like 1	0.0063	0.1182	0.3641
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0049	0.0872	0.2695
Brugia malayi	hypothetical protein	0.0036	0.0574	0.176
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0049	0.0864	0.0858
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0049	0.0872	0.2681
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.001	0.0006	0.0006
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0063	0.1182	0.1182
Schistosoma mansoni	hypothetical protein	0.0457	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0147	0.3062	0.3062
Echinococcus granulosus	FTZ F1 alpha	0.0063	0.1182	0.1182
Entamoeba histolytica	hypothetical protein	0.0036	0.0574	1
Schistosoma mansoni	nuclear receptor	0.003	0.044	0.0435
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0336	0.5
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0063	0.1182	0.1177
Echinococcus granulosus	lamin	0.003	0.0452	0.0452
Brugia malayi	nuclear hormone receptor	0.0063	0.1182	0.3641
Schistosoma mansoni	hypothetical protein	0.0322	0.6978	0.6976
Brugia malayi	RNA binding protein	0.007	0.134	0.4129
Echinococcus granulosus	lamin dm0	0.003	0.0452	0.0452
Echinococcus multilocularis	cyclic AMP responsive element binding protein	0.001	0.0006	0.0006
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0452	0.1396
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0033	0.052	0.0514
Schistosoma mansoni	tar DNA-binding protein	0.007	0.134	0.1335
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0336	0.5
Schistosoma mansoni	coup transcription factor	0.0063	0.1182	0.1177
Echinococcus multilocularis	lamin	0.003	0.0452	0.0452
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.003	0.044	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1182	0.3653
Loa Loa (eye worm)	hypothetical protein	0.003	0.044	0.136
Loa Loa (eye worm)	hypothetical protein	0.003	0.044	0.136
Brugia malayi	RNA recognition motif domain containing protein	0.007	0.134	0.4129
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0063	0.1182	0.3641
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0063	0.1182	0.3641
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0063	0.1182	0.1177
Loa Loa (eye worm)	hypothetical protein	0.003	0.044	0.136
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0055	0.1014	0.1009
Brugia malayi	mbt repeat family protein	0.0049	0.0864	0.2655
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0357	0.1103
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.003	0.044	0.044
Echinococcus multilocularis	ecdysone induced protein 78C	0.0063	0.1182	0.1182
Echinococcus multilocularis	musashi	0.003	0.0452	0.0452
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.003	0.044	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1182	0.3653
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0147	0.3062	0.3062
Brugia malayi	hypothetical protein	0.0025	0.0336	0.1021
Schistosoma mansoni	hypothetical protein	0.0011	0.0028	0.0022
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0496	0.1532
Schistosoma mansoni	hypothetical protein	0.0106	0.2142	0.2137
Echinococcus granulosus	intermediate filament protein	0.003	0.0452	0.0452
Schistosoma mansoni	lamin	0.003	0.0452	0.0446
Echinococcus granulosus	geminin	0.0168	0.3529	0.3529
Schistosoma mansoni	sex comb on midleg homolog	0.0049	0.0864	0.0858
Loa Loa (eye worm)	RNA binding protein	0.007	0.134	0.414
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.001	0.0006	0.0006
Echinococcus granulosus	nuclear receptor nhr 48	0.003	0.044	0.044
Brugia malayi	Nuclear hormone receptor-like 1	0.0033	0.052	0.159
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0033	0.052	0.052
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1014	0.3133
Brugia malayi	hypothetical protein	0.003	0.044	0.1344
Brugia malayi	Steroid receptor seven-up type 2	0.0063	0.1182	0.3641
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0063	0.1182	0.1182
Entamoeba histolytica	hypothetical protein	0.0036	0.0574	1
Brugia malayi	hypothetical protein	0.0033	0.052	0.159
Loa Loa (eye worm)	hypothetical protein	0.003	0.044	0.136
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0019
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.003	0.044	0.136
Schistosoma mansoni	hypothetical protein	0.0036	0.0574	0.0569
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0033	0.052	0.1606
Loa Loa (eye worm)	hypothetical protein	0.003	0.044	0.136
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.003	0.044	0.1344
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.003	0.044	0.044
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0155	0.3236	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0049	0.0872	0.0872
Giardia lamblia	Hypothetical protein	0.001	0.0006	0.5
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0139	0.0412
Brugia malayi	Nuclear hormone receptor E75	0.003	0.044	0.1344
Loa Loa (eye worm)	hypothetical protein	0.003	0.044	0.136
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0063	0.1182	0.1182
Brugia malayi	Nuclear hormone receptor E75	0.003	0.044	0.1344
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.003	0.044	0.3693
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.003	0.044	0.044
Echinococcus multilocularis	geminin	0.0168	0.3529	0.3529
Loa Loa (eye worm)	bZIP transcription factor family protein	0.001	0.0006	0.0019
Loa Loa (eye worm)	TAR-binding protein	0.007	0.134	0.414
Onchocerca volvulus		0.0049	0.0864	0.7293
Loa Loa (eye worm)	mbt repeat family protein	0.0049	0.0864	0.2669
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0063	0.1182	0.3641
Schistosoma mansoni	nuclear hormone receptor	0.003	0.044	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0033	0.052	0.1606
Entamoeba histolytica	hypothetical protein	0.0036	0.0574	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0063	0.1182	0.1182
Loa Loa (eye worm)	hypothetical protein	0.0106	0.2142	0.6619
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0063	0.1182	0.1182
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0063	0.1182	0.3641
Echinococcus granulosus	cpg binding protein	0.0034	0.0537	0.0537
Brugia malayi	nuclear receptor RXR	0.003	0.044	0.1344
Schistosoma mansoni	cpg binding protein	0.0034	0.0537	0.0531
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0049	0.0864	0.0864
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0063	0.1182	0.3641
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0336	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.0063	0.1182	0.3653
Echinococcus multilocularis	cpg binding protein	0.0034	0.0537	0.0537
Schistosoma mansoni	hypothetical protein	0.0049	0.0872	0.0867
Onchocerca volvulus		0.0032	0.0496	0.4163
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0452	0.138
Echinococcus multilocularis	tar DNA binding protein	0.007	0.134	0.134
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0019
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0049	0.0872	0.0872
Brugia malayi	hypothetical protein	0.0033	0.052	0.159
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0015	0.0103	0.0103
Echinococcus multilocularis	protocadherin 11	0.001	0.0006	0.0006
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.003	0.044	0.3693
Echinococcus granulosus	GPCR family 2	0.0049	0.0872	0.0872
Echinococcus multilocularis	FTZ F1 alpha	0.0063	0.1182	0.1182
Echinococcus multilocularis	X box binding protein 1	0.0322	0.6978	0.6978
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1182	0.3653
Schistosoma mansoni	nuclear receptor	0.003	0.044	0.0435
Brugia malayi	conserved hypotetical protein	0.003	0.044	0.1344
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0063	0.1182	0.1177
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0063	0.1182	0.3653
Loa Loa (eye worm)	hypothetical protein	0.0033	0.052	0.1606
Schistosoma mansoni	hypothetical protein	0.0168	0.3529	0.3525
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0063	0.1182	0.3653
Loa Loa (eye worm)	hypothetical protein	0.003	0.044	0.136
Brugia malayi	photoreceptor-specific nuclear receptor	0.0063	0.1182	0.3641
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0139	0.0429
Onchocerca volvulus		0.003	0.0452	0.3791
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0452	0.1396
Echinococcus granulosus	Nuclear hormone receptor HR96	0.003	0.044	0.044
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0063	0.1182	0.3641
Loa Loa (eye worm)	hypothetical protein	0.003	0.044	0.136
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0063	0.1182	0.3653
Brugia malayi	MH2 domain containing protein	0.012	0.2451	0.7569
Schistosoma mansoni	tar DNA-binding protein	0.007	0.134	0.1335
Schistosoma mansoni	tar DNA-binding protein	0.007	0.134	0.1335
Onchocerca volvulus		0.003	0.0452	0.3791
Schistosoma mansoni	hypothetical protein	0.0049	0.0872	0.0867
Schistosoma mansoni	tar DNA-binding protein	0.007	0.134	0.1335
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0033	0.052	0.052
Echinococcus multilocularis	dnaJ subfamily B	0.0457	1	1
Echinococcus multilocularis	GPCR, family 2	0.0049	0.0872	0.0872
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.003	0.044	0.044
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0336	0.1038
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0091	0.0281
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0049	0.0864	0.7293
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0191	0.4057	0.4057
Schistosoma mansoni	sex comb on midleg homolog	0.0049	0.0864	0.0858
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0063	0.1182	0.1182
Echinococcus granulosus	X box binding protein 1	0.0322	0.6978	0.6978
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0033	0.052	0.0514
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0574	0.0569
Echinococcus granulosus	tar DNA binding protein	0.007	0.134	0.134
Loa Loa (eye worm)	hypothetical protein	0.003	0.044	0.136
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0063	0.1182	0.3641
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0063	0.1182	0.1182
Onchocerca volvulus		0.0063	0.1182	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1182	0.3653
Schistosoma mansoni	RAR-like nuclear receptor	0.0063	0.1182	0.1177
Brugia malayi	tailless protein	0.003	0.044	0.1344
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0147	0.3062	0.3062
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0155	0.3236	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0049	0.0872	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1182	0.3653
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0055	0.1014	0.1014
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.044	0.044
Schistosoma mansoni	hypothetical protein	0.0049	0.0872	0.0867
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.2451	0.7573
Schistosoma mansoni	zinc finger protein	0.003	0.044	0.0435
Loa Loa (eye worm)	hypothetical protein	0.003	0.044	0.136
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0049	0.0872	0.0872
Schistosoma mansoni	lamin	0.003	0.0452	0.0446
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0063	0.1182	0.3641
Brugia malayi	nuclear hormone receptor	0.003	0.044	0.1344
Schistosoma mansoni	thyroid hormone receptor	0.0063	0.1182	0.1177
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0055	0.1014	0.1014
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0496	0.1516
Brugia malayi	nuclear hormone receptor family member nhr-6	0.003	0.044	0.1344
Loa Loa (eye worm)	hypothetical protein	0.003	0.044	0.136
Schistosoma mansoni	cpg binding protein	0.0034	0.0537	0.0531
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0015	0.0103	0.0103
Schistosoma mansoni	hypothetical protein	0.0295	0.6379	0.6376
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0063	0.1182	0.3641
Loa Loa (eye worm)	hypothetical protein	0.003	0.044	0.136
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0063	0.1182	0.1177
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0063	0.1182	0.1182
Echinococcus multilocularis	ccaat enhancer binding protein delta ccaat enhancer binding protein beta	0.001	0.0006	0.0006
Echinococcus granulosus	protocadherin 11	0.001	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1182	0.3653
Loa Loa (eye worm)	nuclear hormone receptor	0.003	0.044	0.136
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0147	0.3062	0.9459
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0063	0.1182	0.1182
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0063	0.1182	0.3653
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.007	0.134	0.414
Echinococcus multilocularis	nuclear receptor nhr 48	0.003	0.044	0.044
Echinococcus granulosus	SAM and MBT domain containing protein	0.0049	0.0864	0.0864
Loa Loa (eye worm)	hypothetical protein	0.0155	0.3236	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0147	0.3062	0.3057
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0147	0.3062	0.3057
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.001	0.0006	0.0006
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0063	0.1182	0.3641
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0872	0.2695
Onchocerca volvulus		0.003	0.044	0.3693
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0864	0.2669
Echinococcus granulosus	thyroid hormone receptor alpha	0.003	0.044	0.044
Echinococcus granulosus	transcriptional factor nfil3:e4bp4	0.001	0.0006	0.0006
Brugia malayi	ecdysone receptor	0.003	0.044	0.1344
Plasmodium vivax	mitochondrial ribosomal protein L41, putative	0.0211	0.4489	1
Brugia malayi	nuclear receptor NHR-88	0.0063	0.1182	0.3641
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0574	0.0574
Onchocerca volvulus	Protein ultraspiracle homolog	0.0063	0.1182	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0033	0.052	0.159
Loa Loa (eye worm)	nuclear receptor NHR-67	0.003	0.044	0.136
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0063	0.1182	0.1177
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0063	0.1182	0.1182
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0063	0.1182	0.1182
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0063	0.1182	0.3641
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0191	0.4057	0.4057
Loa Loa (eye worm)	hypothetical protein	0.0033	0.052	0.1606
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0055	0.1014	0.312
Plasmodium falciparum	mitochondrial ribosomal protein L41, putative	0.0211	0.4489	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0063	0.1182	0.1177
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0063	0.1182	0.3653
Brugia malayi	steroid hormone receptor	0.0063	0.1182	0.3641
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0574	0.0574
Brugia malayi	Latrophilin receptor protein 2	0.0049	0.0872	0.2681
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0063	0.1182	0.3641
Brugia malayi	intermediate filament protein	0.003	0.0452	0.138
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0063	0.1182	0.1182
Loa Loa (eye worm)	MBCTL1	0.0055	0.1014	0.3133
Echinococcus multilocularis	protocadherin 11	0.001	0.0006	0.0006
Brugia malayi	nuclear hormone receptor family member odr-7	0.003	0.044	0.1344
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0147	0.3062	0.3062
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0357	0.1087
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.13	0.1295
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0019
Echinococcus granulosus	ccaat enhancer binding protein delta	0.001	0.0006	0.0006
Schistosoma mansoni	cpg binding protein	0.0032	0.0496	0.049
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0063	0.1182	0.1182
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.044	0.044
Echinococcus granulosus	protocadherin 11	0.001	0.0006	0.0006
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0028	0.0028
Schistosoma mansoni	thyroid hormone receptor	0.0063	0.1182	0.1177
Brugia malayi	nuclear receptor NHR-88	0.003	0.044	0.1344
Toxoplasma gondii	60S ribosomal protein L27, putative	0.0211	0.4489	1
Brugia malayi	nuclear receptor RXR	0.0033	0.052	0.159
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0063	0.1182	0.3653
Echinococcus multilocularis	transcriptional factor nfil3:e4bp4	0.001	0.0006	0.0006
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0063	0.1182	0.1182
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.003	0.044	0.044
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.2451	0.7573
Loa Loa (eye worm)	cell death specification protein 2	0.001	0.0006	0.0019
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0147	0.3062	0.946
Schistosoma mansoni	hypothetical protein	0.0168	0.3529	0.3525
Echinococcus granulosus	histone acetyltransferase MYST2	0.0055	0.1014	0.1014
Echinococcus granulosus	Nuclear hormone receptor HR96	0.003	0.044	0.044
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0063	0.1182	1
Brugia malayi	hypothetical protein	0.0016	0.0138	0.0409
Schistosoma mansoni	retinoic acid receptor RXR	0.0063	0.1182	0.1177
Brugia malayi	ecdysteroid receptor	0.0063	0.1182	0.3641
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0055	0.1014	0.1014
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1182	0.3653
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0063	0.1182	0.3653
Brugia malayi	TAR-binding protein	0.007	0.134	0.4129
Loa Loa (eye worm)	hypothetical protein	0.003	0.044	0.136
Loa Loa (eye worm)	hypothetical protein	0.003	0.0452	0.1396
Loa Loa (eye worm)	hypothetical protein	0.003	0.044	0.1358
Schistosoma mansoni	hypothetical protein	0.0049	0.0872	0.0867
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.001	0.0006	0.0006
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0063	0.1182	0.1177
Schistosoma mansoni	intermediate filament proteins	0.003	0.0452	0.0446
Brugia malayi	orphan nuclear receptor NR2E1	0.003	0.044	0.1344
Onchocerca volvulus		0.003	0.044	0.3693
Echinococcus granulosus	ecdysone induced protein 78C	0.0063	0.1182	0.1182
Brugia malayi	latrophilin 2 splice variant baaae	0.0106	0.2142	0.6613
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0147	0.3062	0.3057
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0103	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1182	0.3653
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0155	0.3236	1
Schistosoma mansoni	tar DNA-binding protein	0.007	0.134	0.1335
Echinococcus granulosus	polycomb protein SCMH1	0.0049	0.0864	0.0864
Schistosoma mansoni	nuclear hormone receptor	0.0063	0.1182	0.1177
Echinococcus multilocularis	lamin dm0	0.003	0.0452	0.0452
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0063	0.1182	0.3641
Loa Loa (eye worm)	hypothetical protein	0.0033	0.052	0.1606
Loa Loa (eye worm)	hypothetical protein	0.0033	0.052	0.1606
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0019
Loa Loa (eye worm)	DR-78	0.003	0.044	0.136
Brugia malayi	hypothetical protein	0.003	0.044	0.1344
Brugia malayi	mbt repeat family protein	0.0049	0.0864	0.2655
Leishmania major	hypothetical protein, conserved	0.0025	0.0336	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.0006	0.0019
Schistosoma mansoni	nuclear hormone receptor	0.003	0.044	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0091	0.0281
Echinococcus multilocularis	polycomb protein SCMH1	0.0049	0.0864	0.0864

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 25 ug ml-1	Antiproliferative activity against human LoVo cells	ChEMBL.	20022253
IC50 (functional)	> 100 ug ml-1	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO release	ChEMBL.	20022253

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL589839

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1090107