Detailed information for compound 1095804

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 413.13 | Formula: C14H11Br2N3S
  • H donors: 2 H acceptors: 0 LogP: 4.46 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=S)NN=C(c1ccc(cc1)Br)c1ccc(cc1)Br
  • InChi: 1S/C14H11Br2N3S/c15-11-5-1-9(2-6-11)13(18-19-14(17)20)10-3-7-12(16)8-4-10/h1-8H,(H3,17,19,20)
  • InChiKey: FPBINNFTNQSQFI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0032 0.0395 0.1126
Brugia malayi serine/threonine-protein kinase plk-2 0.0102 0.3506 0.5355
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0395 0.1126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0395 0.1126
Echinococcus multilocularis GPCR, family 2 0.0033 0.0442 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0395 0.1126
Loa Loa (eye worm) hypothetical protein 0.0032 0.0395 0.0603
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0705 0.2011
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.122 0.3481
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0442 0.0675
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0395 0.1126
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.2137 0.3265
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.3506 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0395 0.1126
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0442 0.0076
Brugia malayi Cathepsin L-like precursor 0.0032 0.0395 0.0603
Onchocerca volvulus 0.0039 0.0705 0.2011
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0705 0.1077
Echinococcus multilocularis cathepsin b 0.0171 0.6546 1
Trypanosoma brucei polo-like protein kinase 0.0102 0.3506 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0171 0.6546 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0705 0.1077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0395 0.1126
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0705 1
Onchocerca volvulus 0.0032 0.0395 0.1126
Loa Loa (eye worm) hypothetical protein 0.0104 0.3599 0.5498
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0395 0.1126
Loa Loa (eye worm) ctsf protein 0.0032 0.0395 0.0603
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0102 0.3506 0.5355
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0032 0.0395 0.5
Toxoplasma gondii cathepsin B 0.006 0.1625 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0395 0.1126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0395 0.1126
Schistosoma mansoni kinase 0.0052 0.128 0.1956
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0442 0.0675
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0102 0.3506 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.6546 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0395 0.1126
Echinococcus granulosus cathepsin b 0.0171 0.6546 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0395 0.1126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0395 0.1126
Echinococcus granulosus GPCR family 2 0.0033 0.0442 0.0675
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0395 0.1126
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.3506 0.5355
Brugia malayi beta-lactamase family protein 0.0039 0.0705 0.1077
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0395 0.0603
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0395 0.1126
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0395 0.0603
Plasmodium falciparum cysteine proteinase falcipain 3 0.0032 0.0395 0.5
Trypanosoma brucei cysteine peptidase C (CPC) 0.006 0.1625 0.3954
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0705 0.1077
Loa Loa (eye worm) hypothetical protein 0.0039 0.0705 0.1077
Brugia malayi Cathepsin L-like precursor 0.0032 0.0395 0.0603
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.3506 1
Mycobacterium ulcerans beta-lactamase 0.0039 0.0705 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0442 0.0675
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.3599 0.5498
Onchocerca volvulus Serine\/threonine kinase homolog 0.0102 0.3506 1
Loa Loa (eye worm) beta-lactamase 0.0039 0.0705 0.1077
Onchocerca volvulus 0.0032 0.0395 0.1126
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0395 0.0603
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0705 0.5
Brugia malayi Cathepsin L-like precursor 0.0032 0.0395 0.0603
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.3506 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0102 0.3506 0.5355
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0705 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0032 0.0395 0.0603
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.3506 1
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0442 0.0675
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.006 0.1625 0.2482
Mycobacterium ulcerans hypothetical protein 0.0039 0.0705 0.5
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.006 0.1625 0.2482
Schistosoma mansoni hypothetical protein 0.0033 0.0442 0.0675
Schistosoma mansoni hypothetical protein 0.0033 0.0442 0.0675
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0705 0.1077
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.006 0.1625 0.4635
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0395 0.1126
Loa Loa (eye worm) hypothetical protein 0.0039 0.0705 0.1077
Onchocerca volvulus 0.0032 0.0395 0.1126
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0395 0.0603
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0705 0.2011
Trichomonas vaginalis esterase, putative 0.0039 0.0705 0.2011
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.122 0.3481
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0705 0.1077
Mycobacterium ulcerans lipase LipD 0.0039 0.0705 0.5
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.006 0.1625 0.3954
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0395 0.1126
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0102 0.3506 0.5355
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0705 0.2011
Loa Loa (eye worm) fibroinase 0.0032 0.0395 0.0603
Mycobacterium leprae Probable lipase LipE 0.0039 0.0705 0.5
Onchocerca volvulus Cathepsin F homolog 0.0032 0.0395 0.1126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0395 0.1126
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0395 0.0603
Loa Loa (eye worm) hypothetical protein 0.0039 0.0705 0.1077
Loa Loa (eye worm) hypothetical protein 0.0171 0.6546 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0705 0.1077
Schistosoma mansoni hypothetical protein 0.0033 0.0442 0.0675
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0395 0.0603
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.3506 1
Echinococcus granulosus cathepsin b 0.0171 0.6546 1
Loa Loa (eye worm) cysteine protease 0.0032 0.0395 0.0603
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0705 0.0998
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0395 0.1126
Trypanosoma cruzi polo-like protein kinase, putative 0.0102 0.3506 0.5355
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0102 0.3506 0.5057
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.0395 0.1126
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0705 0.2011
Onchocerca volvulus Cathepsin L homolog 0.0032 0.0395 0.1126
Brugia malayi Cathepsin L-like precursor 0.0032 0.0395 0.0603
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0171 0.6546 1
Leishmania major hypothetical protein, conserved 0.0039 0.0705 0.0998
Entamoeba histolytica cysteine protease, putative 0.0032 0.0395 0.1126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0395 0.1126
Echinococcus multilocularis cathepsin b 0.0171 0.6546 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.0395 0.1126
Schistosoma mansoni hypothetical protein 0.0033 0.0442 0.0675
Brugia malayi cathepsin B-like cysteine proteinase 0.0171 0.6546 1
Echinococcus granulosus cathepsin l1 0.0032 0.0395 0.0603
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0032 0.0395 0.0603
Onchocerca volvulus 0.0039 0.0705 0.2011
Giardia lamblia Kinase, PLK 0.0102 0.3506 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0032 0.0395 0.0603
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.3506 1
Onchocerca volvulus 0.0032 0.0395 0.1126
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0705 0.0505
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0395 0.1126
Loa Loa (eye worm) cathepsin B 0.006 0.1625 0.2482
Trichomonas vaginalis CAMK family protein kinase 0.0102 0.3506 1
Onchocerca volvulus Cathepsin L homolog 0.0032 0.0395 0.1126
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0395 0.0603
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0442 0.0675
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.6546 1
Brugia malayi Cathepsin L-like precursor 0.0032 0.0395 0.0603
Loa Loa (eye worm) hypothetical protein 0.0039 0.0705 0.1077
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0442 0.0076
Onchocerca volvulus 0.0039 0.0705 0.2011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0705 0.1077
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0705 0.2011
Brugia malayi beta-lactamase family protein 0.0039 0.0705 0.1077
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0032 0.0395 0.0603
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0395 0.1126
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.6546 1
Schistosoma mansoni hypothetical protein 0.0071 0.2137 0.3265
Loa Loa (eye worm) hypothetical protein 0.0071 0.2137 0.3265
Entamoeba histolytica serine/threonine protein kinase, putative 0.0102 0.3506 1
Brugia malayi beta-lactamase 0.0039 0.0705 0.1077
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0442 0.0675
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.3599 0.5498
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0395 0.1126
Onchocerca volvulus 0.0032 0.0395 0.1126
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0705 0.1077
Echinococcus granulosus cathepsin l cysteine peptidase 0.0032 0.0395 0.0603
Toxoplasma gondii ABC1 family protein 0.0039 0.0705 0.2523
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0395 0.1126
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0705 0.1077
Onchocerca volvulus 0.0032 0.0395 0.1126
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.3599 0.5498
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0395 0.1126
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0032 0.0395 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0395 0.1126
Brugia malayi Cathepsin L-like precursor 0.0032 0.0395 0.0603
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0705 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10000 nM Inhibition of human liver cathepsin L ChEMBL. 20089402
IC50 (binding) > 10000 nM Inhibition of human liver cathepsin B ChEMBL. 20089402

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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