TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 367.413 | Formula: C22H22FNO3
H donors: 1 H acceptors: 2 LogP: 5.15 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)c1noc(c1)c1c(O)c(C)c(c2c1CCC(O2)(C)C)C
InChi: 1S/C22H22FNO3/c1-12-13(2)21-16(9-10-22(3,4)26-21)19(20(12)25)18-11-17(24-27-18)14-5-7-15(23)8-6-14/h5-8,11,25H,9-10H2,1-4H3
InChiKey: AZVGBCGUTFLSQJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.1085	0.6421
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0418	0.0418
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0395	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.001	0.0395	0.0395
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.1611	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.1611	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0418	0.1556
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.001	0.0395	0.1722
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0418	0.0418
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0142	0.0142
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.1611	1
Schistosoma mansoni	topbp1	0.001	0.0395	0.1471
Echinococcus multilocularis	smad	0.0009	0.0245	0.0912
Loa Loa (eye worm)	MH2 domain-containing protein	0.0127	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0418	0.0418
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0395	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.1085	0.6617
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0418	0.0418
Brugia malayi	Smad1	0.0009	0.0245	0.0245
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.1	0.6071
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0418	0.0418
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.0142	0.0546
Entamoeba histolytica	hypothetical protein	0.001	0.0395	0.0994
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.1611	1
Entamoeba histolytica	hypothetical protein	0.0038	0.2686	1
Echinococcus granulosus	smad	0.0009	0.0245	0.0912
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.2686	1
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0418	0.1556
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0395	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0142	0.0142
Loa Loa (eye worm)	oxidoreductase	0.0007	0.0142	0.0142
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.1611	1
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0395	1
Brugia malayi	MH1 domain containing protein	0.0009	0.0245	0.0245
Echinococcus granulosus	nibrin	0.001	0.0395	0.1471
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1611	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0142	0.0142
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.1611	0.5772
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0142	0.0546
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0418	0.1556
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0418	0.0418
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0418	0.0418
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0418	0.0418
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0245	0.0912
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0395	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0418	0.0418
Giardia lamblia	Replication factor C, subunit 1	0.001	0.0395	0.5
Brugia malayi	topoisomerase	0.001	0.0395	0.0395
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0418	0.1556
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0395	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1085	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1611	0.1611
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0142	0.0546
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0007	0.0142	0.0529
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0142	0.0546
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0418	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0418	0.0418
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0245	0.0245
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0007	0.0142	0.0529
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0395	1
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0418	0.1556
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0395	1
Mycobacterium ulcerans	hypothetical protein	0.0025	0.1611	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0418	0.1556
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.1611	1
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0395	0.1471
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0418	0.1878
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0245	0.0912
Onchocerca volvulus		0.0025	0.1611	1
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0395	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.2686	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0418	0.1556
Schistosoma mansoni	smad	0.0009	0.0245	0.0912
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0418	0.0418
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0395	0.1471
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0395	0.1471
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0418	0.0418
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0418	0.1556
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0418	0.1556
Schistosoma mansoni	hypothetical protein	0.0038	0.2686	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0418	0.1556
Schistosoma mansoni	DNA ligase IV	0.001	0.0395	0.1471
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0395	1
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0142	0.0142
Schistosoma mansoni	acetyl-CoA synthetase	0.0007	0.0142	0.0529
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0418	0.1556
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0245	0.0912
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.1085	1
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.0142	0.0546
Loa Loa (eye worm)	Smad1	0.0009	0.0245	0.0245
Plasmodium vivax	replication factor C subunit 1, putative	0.001	0.0395	0.2682
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0395	1
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.1611	0.1611
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0245	0.0912
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0418	0.0418
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.1611	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0418	0.1878
Brugia malayi	DKFZp564C0469 protein	0.001	0.0395	0.0395
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0418	0.0418
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0418	0.0418
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.1	0.6071
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.1611	1
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.0142	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1085	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0418	0.0418
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0418	0.0418
Onchocerca volvulus		0.0011	0.0418	0.1878
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0245	0.0912
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0418	0.1556
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0142	0.0142
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0418	0.1556
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0418	0.0418
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.1611	1
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0007	0.0142	0.0142
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.1611	1
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0418	0.0418
Brugia malayi	MH2 domain containing protein	0.0009	0.0245	0.0245
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.1611	0.5772
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0395	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0418	0.1556
Entamoeba histolytica	hypothetical protein	0.0038	0.2686	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.1611	0.1611
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0418	0.1556
Schistosoma mansoni	Smad4	0.0009	0.0245	0.0912
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0418	0.1556
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0418	0.0418
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0245	0.0912
Echinococcus granulosus	Smad4	0.0009	0.0245	0.0912
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0142	0.0142
Entamoeba histolytica	hypothetical protein	0.0038	0.2686	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0418	0.1556
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.001	0.0395	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0418	0.0418
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.1085	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0418	0.0418
Echinococcus multilocularis	nibrin	0.001	0.0395	0.1471
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0245	0.0912
Entamoeba histolytica	hypothetical protein	0.0038	0.2686	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0395	0.0395
Loa Loa (eye worm)	hypothetical protein	0.001	0.0395	0.0395
Echinococcus multilocularis	Smad4	0.0009	0.0245	0.0912
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.001	0.0395	0.1722
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0395	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0418	0.0418
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0418	0.0418
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0418	0.1878
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0418	0.1556
Brugia malayi	nuclear hormone receptor	0.0011	0.0418	0.0418
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0395	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.1	0.6071
Loa Loa (eye worm)	hypothetical protein	0.001	0.0395	0.0395
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0245	0.0912
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0418	0.1556
Loa Loa (eye worm)	hypothetical protein	0.001	0.0395	0.0395
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.1611	1
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.0142	0.0546
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.1611	0.1611
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0395	0.0395
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0418	0.1556
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0418	0.1556
Brugia malayi	hypothetical protein	0.001	0.0395	0.0395
Treponema pallidum	DNA ligase (lig)	0.001	0.0395	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.0395	0.0395
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0418	0.0418
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0418	0.1556
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.001	0.0395	0.5
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0418	0.1556
Schistosoma mansoni	topbp1	0.001	0.0395	0.1471
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.1085	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0418	0.1556
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.2686	1
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0142	0.0546
Brugia malayi	hypothetical protein	0.0038	0.2686	0.2686
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.1	0.6071
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0418	0.1556
Brugia malayi	MH2 domain containing protein	0.0009	0.0245	0.0245
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0418	0.0418
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0418	0.0418
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0395	0.0994
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0418	0.0418
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.1611	0.1611
Brugia malayi	MH1 domain containing protein	0.0009	0.0245	0.0245
Loa Loa (eye worm)	transcription factor SMAD2	0.0127	1	1
Schistosoma mansoni	coup transcription factor	0.0011	0.0418	0.1556
Onchocerca volvulus		0.001	0.0395	0.1722
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0395	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.1611	1
Brugia malayi	hypothetical protein	0.001	0.0395	0.0395
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.0142	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1085	0.1085
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0418	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0418	0.0418
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0418	0.0418
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.1611	0.5772
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.1611	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1085	0.1085
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0418	0.0418
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0007	0.0142	0.0142
Brugia malayi	ecdysteroid receptor	0.0011	0.0418	0.0418
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0418	0.1556
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0245	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0019	0.1085	0.1085
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.0142	0.0546
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.1611	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0418	0.0418
Brugia malayi	steroid hormone receptor	0.0011	0.0418	0.0418
Plasmodium falciparum	replication factor C subunit 1, putative	0.001	0.0395	0.2682
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0418	0.1556
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0418	0.1556
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0395	0.0395
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0418	0.1556
Trypanosoma cruzi	FHA domain containing protein, putative	0.001	0.0395	1
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.0142	0.0546

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 0.52 uM	Neuroprotective activity against glutamate-indcued depletion of intracellular glutathione in mouse HT22 cells assessed as increase in cell viability after 24 hrs by MTT assay	ChEMBL.	21778061
Efficacy (functional)	= 77 %	Neuroprotective activity against glutamate-indcued depletion of intracellular glutathione in mouse HT22 cells assessed as increase in cell viability at 10 uM after 24 hrs by MTT assay relative to control	ChEMBL.	21778061

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mus musculus	ChEMBL23	21778061

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1813358

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1095892