TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 489.226 | Formula: C20H15Br2N3S
H donors: 2 H acceptors: 0 LogP: 6.42 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: S=C(Nc1ccccc1)NN=C(c1cccc(c1)Br)c1cccc(c1)Br
InChi: 1S/C20H15Br2N3S/c21-16-8-4-6-14(12-16)19(15-7-5-9-17(22)13-15)24-25-20(26)23-18-10-2-1-3-11-18/h1-13H,(H2,23,25,26)
InChiKey: IAEROBOFMMECMP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0032	0.044	0.044
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0015	0.0094	0.0094
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0041	0.0615	1
Onchocerca volvulus		0.0032	0.044	1
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0224	0.2251
Echinococcus granulosus	lamin	0.003	0.0408	0.0408
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0615	0.1912
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.044	0.4419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.044	0.3201
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0178	0.2898
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0032	0.044	0.1367
Schistosoma mansoni	ap endonuclease	0.0021	0.0224	0.0611
Echinococcus multilocularis	cysteine protease	0.0032	0.044	0.044
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.044	0.4419
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.322	0.8782
Echinococcus granulosus	cathepsin L	0.0019	0.0178	0.0178
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0178	0.1791
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0041	0.0615	0.6181
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.044	0.3201
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0224	0.3642
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0615	0.1912
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0019	0.0178	0.4054
Schistosoma mansoni	hypothetical protein	0.0193	0.3666	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.044	0.4419
Onchocerca volvulus		0.0032	0.044	1
Plasmodium vivax	vivapain-2	0.0032	0.044	1
Giardia lamblia	Cathepsin B precursor	0.006	0.0996	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0224	0.5094
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0178	0.2898
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.044	0.4419
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0036	0.053	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.044	0.3201
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.044	0.12
Echinococcus granulosus	geminin	0.0193	0.3666	0.3666
Brugia malayi	cathepsin L-like precursor	0.0023	0.0262	0.0813
Trypanosoma cruzi	cysteine protease, putative	0.0019	0.0178	0.0554
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.0178	0.0554
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.044	0.1367
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.044	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0083	0.0257
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.044	0.044
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.081	0.2209
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.006	0.0996	1
Echinococcus granulosus	intermediate filament protein	0.003	0.0408	0.0408
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0036	0.053	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.0178	0.0554
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.322	0.8782
Onchocerca volvulus		0.0023	0.0262	0.5946
Plasmodium vivax	vivapain-3	0.0019	0.0178	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.044	0.4419
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0126	0.0391
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0224	0.0696
Echinococcus multilocularis	lamin dm0	0.003	0.0408	0.0408
Echinococcus multilocularis	geminin	0.0193	0.3666	0.3666
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.044	0.3201
Brugia malayi	cathepsin B-like cysteine proteinase	0.0171	0.322	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.044	0.4419
Brugia malayi	intermediate filament protein	0.003	0.0408	0.1267
Echinococcus multilocularis	cathepsin b	0.0171	0.322	0.322
Echinococcus multilocularis	musashi	0.003	0.0408	0.0408
Giardia lamblia	Cathepsin B precursor	0.006	0.0996	1
Onchocerca volvulus		0.0032	0.044	1
Plasmodium vivax	vivapain-2	0.0032	0.044	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0032	0.044	1
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0178	0.2898
Echinococcus granulosus	cathepsin L cysteine protease	0.0019	0.0178	0.0178
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.044	0.4419
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0171	0.322	0.8782
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0032	0.044	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.006	0.0996	0.2716
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0083	0.0257
Brugia malayi	Cathepsin L-like precursor	0.0032	0.044	0.1367
Trichomonas vaginalis	inositol monophosphatase, putative	0.0041	0.0615	0.6181
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0032	0.044	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0615	0.5071
Onchocerca volvulus		0.003	0.0408	0.9269
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0032	0.044	0.1367
Onchocerca volvulus		0.0032	0.044	1
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0262	0.0813
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.044	0.4419
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.044	0.715
Plasmodium vivax	vivapain-1	0.0019	0.0178	0.4054
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.0615	0.5347
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0178	0.2898
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.044	0.4419
Entamoeba histolytica	cysteine proteinase 2	0.0019	0.0178	0.2898
Echinococcus multilocularis	cysteine protease	0.0032	0.044	0.044
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.081	0.081
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.081	0.081
Echinococcus granulosus	cathepsin b	0.0171	0.322	0.322
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.044	0.3201
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.044	0.12
Schistosoma mansoni	lamin	0.003	0.0408	0.1112
Echinococcus multilocularis	cathepsin b	0.0171	0.322	0.322
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.044	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0262	0.0813
Loa Loa (eye worm)	transcription factor SMAD2	0.0136	0.2524	0.784
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0178	0.2898
Entamoeba histolytica	cysteine protease, putative	0.0032	0.044	0.715
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0224	0.0224
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0224	0.0696
Echinococcus granulosus	cathepsin l1	0.0032	0.044	0.044
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0262	0.2627
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0262	0.4251
Echinococcus multilocularis	inositol monophosphatase 1	0.0041	0.0615	0.0615
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0408	0.1267
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.044	0.1367
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.044	0.4419
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.044	0.3201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.044	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0171	0.322	1
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.044	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.044	0.1367
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0178	0.2898
Onchocerca volvulus	Cathepsin F homolog	0.0032	0.044	1
Leishmania major	cathepsin L-like protease	0.0032	0.044	0.2798
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0178	0.0487
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0178	0.2898
Loa Loa (eye worm)	ctsf protein	0.0032	0.044	0.1367
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0178	0.2898
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0262	0.2627
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.044	0.4419
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0023	0.0262	0.0813
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0178	0.2898
Leishmania major	cysteine peptidase A (CPA)	0.0032	0.044	0.2798
Leishmania major	cathepsin L-like protease	0.0032	0.044	0.2798
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.044	0.4419
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0408	0.1267
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0224	0.2251
Brugia malayi	Cathepsin L-like precursor	0.0032	0.044	0.1367
Loa Loa (eye worm)	MH2 domain-containing protein	0.0136	0.2524	0.784
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.044	0.4419
Echinococcus granulosus	inositol monophosphatase 1	0.0041	0.0615	0.0615
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0224	0.5
Onchocerca volvulus		0.0032	0.044	1
Schistosoma mansoni	ap endonuclease	0.0021	0.0224	0.0611
Toxoplasma gondii	cathepsin CPL	0.0032	0.044	0.4419
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.006	0.0996	1
Echinococcus granulosus	lamin dm0	0.003	0.0408	0.0408
Schistosoma mansoni	lamin	0.003	0.0408	0.1112
Echinococcus multilocularis	cathepsin L	0.0019	0.0178	0.0178
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.081	0.2515
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0408	0.1267
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.044	0.715
Schistosoma mansoni	inositol monophosphatase	0.0041	0.0615	0.1679
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.044	0.4419
Loa Loa (eye worm)	cysteine protease	0.0032	0.044	0.1367
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0178	0.2898
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0178	0.2898
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0178	0.0487
Leishmania major	cathepsin L-like protease	0.0032	0.044	0.2798
Loa Loa (eye worm)	hypothetical protein	0.0032	0.044	0.1367
Echinococcus multilocularis	neuropeptide receptor A26	0.051	1	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0224	0.2251
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.044	1
Toxoplasma gondii	cathepsin B	0.006	0.0996	1
Echinococcus multilocularis	neuropeptide s receptor	0.051	1	1
Echinococcus granulosus	cysteine protease	0.0019	0.0178	0.0178
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0019	0.0178	0.0554
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0171	0.322	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0032	0.044	0.1367
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0262	0.0813
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0178	0.2898
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0262	0.0813
Leishmania major	cathepsin L-like protease	0.0032	0.044	0.2798
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.081	0.081
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.044	0.4419
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0041	0.0615	1
Leishmania major	cathepsin L-like protease	0.0032	0.044	0.2798
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.006	0.0996	0.3093
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.044	0.1367
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0262	0.0714
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.044	0.4419
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0015	0.0094	0.0094
Brugia malayi	MH2 domain containing protein	0.0136	0.2524	0.784
Echinococcus multilocularis	lamin	0.003	0.0408	0.0408
Leishmania major	cathepsin L-like protease	0.0032	0.044	0.2798
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.044	0.3201
Echinococcus granulosus	neuropeptide receptor A26	0.051	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.044	0.3201
Schistosoma mansoni	hypothetical protein	0.0193	0.3666	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0408	0.1267
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.044	0.4419
Toxoplasma gondii	exonuclease III APE	0.0021	0.0224	0.2251
Schistosoma mansoni	intermediate filament proteins	0.003	0.0408	0.1112
Loa Loa (eye worm)	hypothetical protein	0.003	0.0397	0.1232
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0224	0.056
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0178	0.0554
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0178	0.2898
Entamoeba histolytica	cysteine proteinase 1, putative	0.0019	0.0178	0.2898
Brugia malayi	Cathepsin L-like precursor	0.0032	0.044	0.1367
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0224	0.0696
Echinococcus granulosus	cathepsin b	0.0171	0.322	0.322
Schistosoma mansoni	inositol monophosphatase	0.0041	0.0615	0.1679
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0262	0.0813
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0224	0.0224
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.0178	0.0554
Leishmania major	cathepsin L-like protease	0.0032	0.044	0.2798
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0041	0.0615	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0041	0.0615	0.6181
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0178	0.2898
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0023	0.0262	0.0813
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.044	0.1367
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.044	0.3201
Loa Loa (eye worm)	inositol-1	0.0041	0.0615	0.1912
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.322	0.8782
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.044	0.4419
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.081	0.2209
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.044	0.4419
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.044	0.044
Trypanosoma brucei	cysteine peptidase C (CPC)	0.006	0.0996	1
Loa Loa (eye worm)	fibroinase	0.0032	0.044	0.1367
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0126	0.0391
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.044	0.4419
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.081	0.2515
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0032	0.044	0.044
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0178	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0094	0.0291
Brugia malayi	Cathepsin L-like precursor	0.0032	0.044	0.1367
Brugia malayi	Cathepsin L-like precursor	0.0032	0.044	0.1367
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0178	0.2898
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.0178	0.0487
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0178	0.1791
Echinococcus granulosus	cathepsin l1	0.0023	0.0262	0.0262
Giardia lamblia	Cathepsin B precursor	0.006	0.0996	1
Plasmodium vivax	unspecified product	0.0019	0.0178	0.4054
Loa Loa (eye worm)	cathepsin B	0.006	0.0996	0.3093
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.044	0.044
Brugia malayi	Cathepsin L-like precursor	0.0032	0.044	0.1367
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.081	0.2209
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0224	0.0696
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.081	0.081
Brugia malayi	Inositol-1	0.0041	0.0615	0.1912
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0224	0.5094
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.044	0.4419
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0178	0.2898
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0178	0.2898
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.044	0.044
Onchocerca volvulus		0.0032	0.044	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.044	0.4419
Leishmania major	cathepsin L-like protease	0.0032	0.044	0.2798
Onchocerca volvulus		0.003	0.0408	0.9269
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.044	0.4419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.044	0.4419
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0041	0.0615	0.6181
Onchocerca volvulus		0.0032	0.044	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 10000 nM	Inhibition of human liver cathepsin L	ChEMBL.	20089402
IC50 (binding)	> 10000 nM	Inhibition of human liver cathepsin B	ChEMBL.	20089402

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL600177

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1098509