Detailed information for compound 1098957

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 278.327 | Formula: C13H14N2O3S
  • H donors: 1 H acceptors: 1 LogP: 2.5 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)COc1cccc2c1cc(s2)C(=N)N
  • InChi: 1S/C13H14N2O3S/c1-2-17-12(16)7-18-9-4-3-5-10-8(9)6-11(19-10)13(14)15/h3-6H,2,7H2,1H3,(H3,14,15)
  • InChiKey: SWZWOPSAPAUDNP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor IX Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.3378 0.4553
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0046 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0046 0.0238
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0616 1
Schistosoma mansoni hypothetical protein 0.0048 0.0928 0.0899
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.085 0.1113
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0046 0.0021
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.1078 0.1423
Trichomonas vaginalis glutaminase, putative 0.0288 0.6654 1
Onchocerca volvulus Arrow homolog 0.0016 0.0166 0.1851
Echinococcus granulosus smad 0.0017 0.0177 0.0174
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0186 0.421 0.631
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0133 0.0153
Echinococcus multilocularis smad 0.0017 0.0177 0.0174
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.2009 0.2007
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0086 0.0083
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0756 0.1093
Mycobacterium ulcerans hypothetical protein 0.0035 0.0616 0.0882
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0046 0.0021
Mycobacterium tuberculosis Conserved hypothetical protein 0.0168 0.3785 0.7043
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0046 0.0042
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0046 0.0068
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0032 0.0029
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.1078 1
Echinococcus multilocularis chromobox protein 1 0.0068 0.1397 0.1394
Brugia malayi hypothetical protein 0.0035 0.0615 0.0925
Trichomonas vaginalis esterase, putative 0.0035 0.0616 0.0882
Brugia malayi MH2 domain containing protein 0.0244 0.5589 0.84
Entamoeba histolytica hypothetical protein 0.0011 0.0046 0.0239
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0177 0.0146
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0928 0.1395
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.3406 0.5119
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0616 0.0882
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.1078 0.1619
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0616 0.0882
Brugia malayi MH2 domain containing protein 0.0017 0.0177 0.0266
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0032 0.0048
Loa Loa (eye worm) hypothetical protein 0.0016 0.0166 0.0249
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0616 0.0795
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0068
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0177 0.0266
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0068
Trichomonas vaginalis hypothetical protein 0.0011 0.0046 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0046 0.0021
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.1078 0.1075
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0616 0.0795
Brugia malayi Fibulin-1 precursor 0.0016 0.0166 0.0249
Onchocerca volvulus 0.0035 0.0616 0.8073
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0928 0.1395
Brugia malayi hypothetical protein 0.0011 0.0046 0.0068
Echinococcus multilocularis GPCR, family 2 0.0048 0.0928 0.0925
Schistosoma mansoni chromobox protein 0.0011 0.0046 0.0014
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.1078 0.1075
Brugia malayi MAP kinase sur-1 0.0054 0.1078 0.1619
Brugia malayi SET domain containing protein 0.0012 0.0061 0.0092
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0928 0.1395
Schistosoma mansoni smad1 5 8 and 0.0017 0.0177 0.0146
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0616 0.0882
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.085 0.1113
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0046 0.0068
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0615 0.0586
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0616 0.0586
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.1078 0.9433
Leishmania major fatty acid transporter protein-like protein 0.0178 0.4015 0.5024
Trypanosoma brucei protein kinase, putative 0.0054 0.1078 0.1423
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0166 0.1208
Echinococcus granulosus chromobox protein 1 0.0068 0.1397 0.1394
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0616 0.1467
Schistosoma mansoni hypothetical protein 0.0048 0.0928 0.0899
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.1078 0.1423
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0046 1
Schistosoma mansoni hypothetical protein 0.0172 0.387 0.3851
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0046 0.0021
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0046 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0499 0.0749
Onchocerca volvulus 0.0012 0.0061 0.0409
Echinococcus granulosus Smad4 0.0017 0.0177 0.0174
Onchocerca volvulus 0.0011 0.0046 0.0192
Schistosoma mansoni smad1 5 8 and 0.0017 0.0177 0.0146
Echinococcus multilocularis Chromo domain 0.0011 0.0046 0.0042
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0046 0.0014
Trichomonas vaginalis Heterochromatin protein, putative 0.0011 0.0046 0.0021
Echinococcus granulosus nibrin 0.0011 0.0032 0.0029
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0166 0.0249
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0048
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0068
Onchocerca volvulus 0.0035 0.0616 0.8073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0208 0.0267
Loa Loa (eye worm) hypothetical protein 0.0035 0.0616 0.0926
Schistosoma mansoni chromobox protein 0.0068 0.1397 0.1369
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.7382 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0046 0.0021
Schistosoma mansoni hypothetical protein 0.0429 1 1
Brugia malayi Protein cec-1. 0.0011 0.0046 0.0068
Brugia malayi glutaminase DH11.1 0.0288 0.6654 1
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0046 0.0021
Schistosoma mansoni egf-like domain protein 0.0016 0.0166 0.0134
Schistosoma mansoni glutaminase 0.0288 0.6654 0.6643
Brugia malayi topoisomerase 0.0011 0.0032 0.0048
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.085 0.1113
Echinococcus multilocularis chromobox protein 2 0.0011 0.0046 0.0042
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0616 0.0613
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0048
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0046 0.0126
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.5115 1
Brugia malayi CXXC zinc finger family protein 0.003 0.0499 0.0749
Toxoplasma gondii hypothetical protein 0.0051 0.1007 0.8797
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.3406 0.5119
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.2009 0.302
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0319 0.7382 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0061 0.003
Schistosoma mansoni hypothetical protein 0.0172 0.387 0.3851
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0616 0.0795
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.2009 0.1984
Echinococcus multilocularis long chain fatty acid transport protein 4 0.018 0.4072 0.407
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.3406 0.5119
Leishmania major mitochondrial DNA polymerase beta 0.0319 0.7382 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0121 0.0135
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0003 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0208 0.0267
Echinococcus granulosus geminin 0.0172 0.387 0.3868
Brugia malayi MH1 domain containing protein 0.0017 0.0177 0.0266
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0928 0.0925
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0133 0.0153
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0032 0.0029
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0046 0.0239
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.085 0.1113
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0046 0.0042
Loa Loa (eye worm) hypothetical protein 0.0152 0.3406 0.5119
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.7382 1
Brugia malayi hypothetical protein 0.0011 0.0032 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0046 0.0021
Mycobacterium ulcerans beta-lactamase 0.0035 0.0616 0.0882
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0046 0.0068
Loa Loa (eye worm) hypothetical protein 0.0035 0.0616 0.0926
Schistosoma mansoni chromobox protein 0.0068 0.1397 0.1369
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1397 0.2061
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.114 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.1084 0.1431
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0186 0.421 0.6328
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0166 0.0163
Toxoplasma gondii ABC1 family protein 0.0035 0.0616 0.527
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.2009 0.302
Schistosoma mansoni hypothetical protein 0.0011 0.0046 0.0014
Onchocerca volvulus 0.003 0.0499 0.6452
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0046 0.0239
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.1397 0.2099
Echinococcus granulosus long chain fatty acid transport protein 4 0.018 0.4072 0.407
Entamoeba histolytica hypothetical protein 0.0035 0.0615 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0166 0.1208
Loa Loa (eye worm) hypothetical protein 0.0104 0.2259 0.3395
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1078 0.1579
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0046 0.0021
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.3378 0.4083
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0177 0.0174
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1078 0.1579
Loa Loa (eye worm) hypothetical protein 0.0035 0.0616 0.0926
Schistosoma mansoni cpg binding protein 0.0032 0.054 0.051
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0046 0.0014
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0928 0.0925
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0086 0.0055
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0928 0.0925
Schistosoma mansoni hypothetical protein 0.0035 0.0615 0.0586
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.1078 0.1075
Echinococcus multilocularis laminin 0.0016 0.0166 0.0163
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0166 0.0249
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0615 0.0612
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0166 0.0249
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.2009 0.2007
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0177 0.0174
Brugia malayi Heterochromatin protein 1 0.0068 0.1397 0.2099
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.1078 0.1049
Echinococcus multilocularis nibrin 0.0011 0.0032 0.0029
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0208 0.0267
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0687 0.0989
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.2009 0.2007
Chlamydia trachomatis DNA ligase 0.0011 0.0032 0.5
Echinococcus multilocularis geminin 0.0172 0.387 0.3868
Loa Loa (eye worm) hypothetical protein 0.0016 0.0166 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0422 0.059
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0756 1
Schistosoma mansoni cpg binding protein 0.0032 0.054 0.051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0208 0.0267
Trichomonas vaginalis chromobox protein, putative 0.0011 0.0046 0.0021
Loa Loa (eye worm) beta-lactamase 0.0035 0.0616 0.0926
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0756 0.1093
Brugia malayi hypothetical protein 0.0011 0.0032 0.0048
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.1078 0.0682
Echinococcus granulosus Tolloid protein 1 0.0016 0.0166 0.0163
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0177 0.0174
Brugia malayi chromobox protein homolog 3 0.0038 0.0687 0.1032
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0046 0.0126
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0046 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0046 0.0021
Echinococcus granulosus chromobox protein 1 0.0068 0.1397 0.1394
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0068
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0166 0.0249
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0208 0.0267
Brugia malayi MH1 domain containing protein 0.0017 0.0177 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0687 0.0989
Mycobacterium ulcerans hypothetical protein 0.0168 0.3785 0.5667
Loa Loa (eye worm) helicase 0.0011 0.0046 0.0068
Schistosoma mansoni hypothetical protein 0.0048 0.0928 0.0899
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0178 0.4015 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0068
Echinococcus granulosus GPCR family 2 0.0048 0.0928 0.0925
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.5589 0.84
Loa Loa (eye worm) glutaminase 0.0288 0.6654 1
Schistosoma mansoni smad 0.0017 0.0177 0.0146
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0208 0.0267
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0011 0.0032 0.5
Echinococcus multilocularis chromobox protein 1 0.0068 0.1397 0.1394
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0046 0.0239
Loa Loa (eye worm) hypothetical protein 0.0038 0.0687 0.1032
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0046 0.0021
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0208 0.0267
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.5589 0.84
Entamoeba histolytica hypothetical protein 0.0035 0.0615 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0177 0.0266
Schistosoma mansoni hypothetical protein 0.0104 0.2259 0.2235
Loa Loa (eye worm) hypothetical protein 0.003 0.0491 0.0738
Brugia malayi MH2 domain containing protein 0.0017 0.0177 0.0266
Brugia malayi beta-lactamase 0.0035 0.0616 0.0926
Brugia malayi beta-lactamase family protein 0.0035 0.0616 0.0926
Brugia malayi DKFZp564C0469 protein 0.0011 0.0032 0.0048
Schistosoma mansoni chromobox protein 0.0011 0.0046 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0616 0.0882
Mycobacterium ulcerans glutaminase 0.0288 0.6654 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0687 0.905
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0151 0.3378 0.4553
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0616 0.0926
Schistosoma mansoni cpg binding protein 0.003 0.0499 0.0468
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0616 0.0613
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0046 1
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.018 0.4072 0.5496
Entamoeba histolytica hypothetical protein 0.0011 0.0046 0.0239
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0616 0.0882
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.2009 0.1984
Loa Loa (eye worm) glutaminase 2 0.0288 0.6654 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0048
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0166 0.0249
Onchocerca volvulus 0.0035 0.0616 0.8073
Brugia malayi AMP-binding enzyme family protein 0.0186 0.421 0.6328
Schistosoma mansoni Smad4 0.0017 0.0177 0.0146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0178 0.4015 0.7556
Echinococcus granulosus cpg binding protein 0.0032 0.054 0.0537
Echinococcus multilocularis cpg binding protein 0.0032 0.054 0.0537
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.2009 0.1984
Loa Loa (eye worm) hypothetical protein 0.0016 0.0166 0.0249
Echinococcus granulosus Chromobox protein 3 0.0011 0.0046 0.0042
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0928 0.0925
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0177 0.0174
Loa Loa (eye worm) hypothetical protein 0.0016 0.0166 0.0249
Echinococcus multilocularis Smad4 0.0017 0.0177 0.0174
Onchocerca volvulus 0.003 0.0491 0.6347
Loa Loa (eye worm) hypothetical protein 0.0016 0.0166 0.0249
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0046 0.0021
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0046 0.0238
Loa Loa (eye worm) hypothetical protein 0.0035 0.0616 0.0926
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0616 0.0586
Loa Loa (eye worm) hypothetical protein 0.0035 0.0616 0.0926
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0068
Treponema pallidum DNA ligase (lig) 0.0011 0.0032 0.5
Echinococcus multilocularis fibrillin 1 0.0016 0.0166 0.0163
Echinococcus granulosus chromobox protein 2 0.0011 0.0046 0.0042
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.1303 0.1275
Loa Loa (eye worm) hypothetical protein 0.0048 0.0928 0.1395
Loa Loa (eye worm) Smad1 0.0017 0.0177 0.0266
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.1078 0.1423
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0422 0.059
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1397 0.2061
Onchocerca volvulus 0.0011 0.0046 0.0192
Schistosoma mansoni hypothetical protein 0.0048 0.0928 0.0899
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0086 0.0083
Entamoeba histolytica hypothetical protein 0.0035 0.0615 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.1078 0.1423
Entamoeba histolytica hypothetical protein 0.0035 0.0615 1
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.2259 0.3395
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0046 0.0126
Brugia malayi Smad1 0.0017 0.0177 0.0266
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0048
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.1078 0.0682
Mycobacterium leprae Probable lipase LipE 0.0035 0.0616 0.1467
Loa Loa (eye worm) hypothetical protein 0.0035 0.0616 0.0926
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0032 0.0048
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.1078 0.1423
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1078 0.1579
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0048
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0615 0.0612
Schistosoma mansoni smad1 5 8 and 0.0017 0.0177 0.0146
Brugia malayi CHD4 protein 0.0013 0.0086 0.013
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0616 0.0882
Entamoeba histolytica hypothetical protein 0.0011 0.0046 0.0239
Mycobacterium ulcerans lipase LipD 0.0035 0.0616 0.0882
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0616 0.0882
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0046 0.0238
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0046 0.0021
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0208 0.0267
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0616 0.0926
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1078 0.1579
Loa Loa (eye worm) hypothetical protein 0.0011 0.0032 0.0048
Echinococcus granulosus laminin 0.0016 0.0166 0.0163
Echinococcus granulosus Chromo domain 0.0011 0.0046 0.0042
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0086 0.013
Schistosoma mansoni FFA transport protein 0.018 0.4072 0.4053
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.1078 0.1075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.2009 0.2007
Echinococcus multilocularis dnaJ subfamily B 0.0429 1 1
Brugia malayi beta-lactamase family protein 0.0035 0.0616 0.0926
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0046 0.0068
Loa Loa (eye worm) hypothetical protein 0.0011 0.0046 0.0068
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.018 0.4072 0.5496
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0046 0.0021
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0166 0.0134

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) Inhibition of factor 10 by amidolytic assay ChEMBL. 20121198
Ki (binding) = 11.9 uM Inhibition of human recombinant factor 9a by amidolytic assay ChEMBL. 20121198

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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