TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 390.325 | Formula: C15H23N2O8P
H donors: 4 H acceptors: 6 LogP: -1.35 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1OC)CC(=O)NCC(=O)N(CCCP(=O)(O)O)O
InChi: 1S/C15H23N2O8P/c1-24-12-5-4-11(8-13(12)25-2)9-14(18)16-10-15(19)17(20)6-3-7-26(21,22)23/h4-5,8,20H,3,6-7,9-10H2,1-2H3,(H,16,18)(H2,21,22,23)
InChiKey: ZBZVXYVGRZDLSD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium knowlesi	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Theileria parva	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium berghei	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Babesia bovis	1-deoxy-D-xylulose 5-phosphate reductoisomerase family protein	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	Get druggable targets OG5_130462	All targets in OG5_130462
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Neospora caninum	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Chlamydia trachomatis	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium yoelii	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0011	0.003
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0608	0.3029	0.3029
Echinococcus multilocularis	hemicentin 1	0.0022	0.0027	0.0027
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0022	0.0027	0.0027
Echinococcus multilocularis	Cyclin L1	0.0121	0.0534	0.0534
Leishmania major	mitotic cyclin, putative	0.0121	0.0534	0.1532
Brugia malayi	protein unc-22	0.0019	0.0012	0.0012
Echinococcus granulosus	neuroglian	0.003	0.0068	0.0068
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0011	0.0041
Echinococcus granulosus	neuroglian	0.0022	0.0027	0.0027
Onchocerca volvulus	Netrin receptor homolog	0.0018	0.0007	0.0019
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0011	0.0041
Echinococcus multilocularis	cyclins	0.0501	0.2482	0.2482
Brugia malayi	Animal haem peroxidase family protein	0.0018	0.0007	0.0007
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0242	0.0666
Plasmodium vivax	hypothetical protein, conserved	0.0121	0.0534	0.207
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.0121	0.0534	0.0534
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0027	0.0027
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0696	0.3483	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0242	0.0695
Echinococcus multilocularis		0.0018	0.0007	0.0007
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0696	0.3483	0.3483
Onchocerca volvulus	Protein CNPPD1 homolog	0.0121	0.0534	0.1532
Toxoplasma gondii	cyclin domain protein, cyclin H family protein	0.0121	0.0534	0.207
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0088	0.0088
Brugia malayi	Prion-like-	0.0018	0.0007	0.0007
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0019	0.0012	0.0012
Plasmodium falciparum	cyclin	0.0501	0.2482	0.9627
Loa Loa (eye worm)	hypothetical protein	0.0696	0.3483	0.3483
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0022	0.0028	0.0028
Echinococcus granulosus	cyclin y	0.0121	0.0534	0.0534
Entamoeba histolytica	cyclin, putative	0.0501	0.2482	0.7126
Brugia malayi	kettin	0.0018	0.0007	0.0007
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0011	0.0011
Echinococcus multilocularis	peroxidasin	0.0022	0.0027	0.0027
Trichomonas vaginalis	cyclin D, putative	0.0121	0.0534	0.1532
Brugia malayi	Leucine Rich Repeat family protein	0.0018	0.0007	0.0007
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0027	0.0027
Trypanosoma brucei	mitotic cyclin	0.0121	0.0534	0.1506
Loa Loa (eye worm)	disorganized muscle protein 1	0.0018	0.0007	0.0007
Trichomonas vaginalis	cyclin B, putative	0.0696	0.3483	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Schistosoma mansoni	titin	0.0018	0.0007	0.0007
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0022	0.0027	0.0027
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0011	0.0011
Echinococcus multilocularis	cyclin dependent kinase 1	0.0045	0.0143	0.0143
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0839	0.4212	0.4212
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Echinococcus multilocularis	G1:S specific cyclin D1	0.1968	1	1
Echinococcus multilocularis	cyclin dependent kinase 5	0.0045	0.0143	0.0143
Schistosoma mansoni	myosin-binding protein-related	0.0018	0.0007	0.0007
Trichomonas vaginalis	cyclin B3, putative	0.0121	0.0534	0.1532
Brugia malayi	Prion-like-	0.0018	0.0007	0.0007
Loa Loa (eye worm)	CAMK protein kinase	0.0019	0.0012	0.0012
Trypanosoma brucei	cyclin 9	0.0121	0.0534	0.1506
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0011	0.0011
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0839	0.4212	0.4212
Echinococcus multilocularis	titin	0.0018	0.0007	0.0007
Schistosoma mansoni	cell adhesion molecule	0.0018	0.0007	0.0007
Echinococcus multilocularis	cyclin y	0.0121	0.0534	0.0534
Trichomonas vaginalis	cyclins, putative	0.0316	0.1535	0.4406
Trypanosoma cruzi	mitotic cyclin, putative	0.0121	0.0534	0.1532
Echinococcus multilocularis	insulin growth factor binding	0.0018	0.0007	0.0007
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0242	0.0695
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Schistosoma mansoni	titin	0.0019	0.0012	0.0012
Trichomonas vaginalis	cyclin D, putative	0.0501	0.2482	0.7126
Echinococcus multilocularis	lachesin	0.0022	0.0027	0.0027
Trichomonas vaginalis	CMGC family protein kinase	0.0045	0.0143	0.0412
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0242	0.0666
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0034	0.0132
Brugia malayi	Cyclin C	0.0121	0.0534	0.0534
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0025	0.004	0.004
Giardia lamblia	Kinase, CMGC CDK	0.0045	0.0143	0.0383
Echinococcus multilocularis	down syndrome cell adhesion	0.0018	0.0007	0.0007
Onchocerca volvulus		0.0018	0.0007	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.2578	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Loa Loa (eye worm)	TK/ROR protein kinase	0.0025	0.004	0.004
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0022	0.0027	0.0077
Echinococcus granulosus	cyclin B	0.0696	0.3483	0.3483
Echinococcus multilocularis	cyclin A3 4	0.0121	0.0534	0.0534
Chlamydia trachomatis	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.2578	1
Onchocerca volvulus		0.0121	0.0534	0.1532
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0023	0.0034	0.0092
Echinococcus multilocularis	cyclin B3 1	0.0501	0.2482	0.2482
Schistosoma mansoni	titin	0.0018	0.0007	0.0007
Trichomonas vaginalis	cyclin D, putative	0.0501	0.2482	0.7126
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Brugia malayi	hypothetical protein	0.0121	0.0534	0.0534
Leishmania major	mitotic cyclin, putative	0.0121	0.0534	0.1532
Echinococcus granulosus	titin	0.0018	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Echinococcus multilocularis	cyclins	0.0501	0.2482	0.2482
Giardia lamblia	G2/mitotic-specific cyclin B	0.0696	0.3483	1
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0023	0.0034	0.0132
Plasmodium falciparum	protein kinase 5	0.0045	0.0143	0.0557
Trichomonas vaginalis	cyclins, putative	0.0696	0.3483	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0022	0.0027	0.0027
Brugia malayi	Peroxidasin	0.0022	0.0027	0.0027
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0242	0.0695
Echinococcus multilocularis	roundabout 2	0.0034	0.0088	0.0088
Echinococcus multilocularis	cyclin y	0.0121	0.0534	0.0534
Leishmania major	cyclin	0.0696	0.3483	1
Giardia lamblia	Hypothetical protein	0.0501	0.2482	0.7117
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0045	0.0143	0.0143
Loa Loa (eye worm)	one IG domain family member	0.0018	0.0007	0.0007
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0022	0.0027	0.0027
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0034	0.0132
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0242	0.0666
Trypanosoma brucei	cyclin 3	0.0121	0.0534	0.1506
Echinococcus granulosus	cyclin y	0.0121	0.0534	0.0534
Schistosoma mansoni	slit	0.0018	0.0007	0.0007
Onchocerca volvulus		0.0083	0.0341	0.098
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Loa Loa (eye worm)	cyclin domain-containing protein	0.0121	0.0534	0.0534
Echinococcus granulosus	neuropeptide s receptor	0.0464	0.2292	0.2292
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0011	0.003
Trypanosoma brucei	cdc2-related kinase 3	0.0045	0.0143	0.0383
Onchocerca volvulus		0.0018	0.0007	0.0019
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Trichomonas vaginalis	cyclin B, putative	0.0121	0.0534	0.1532
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0025	0.004	0.004
Schistosoma mansoni	cell adhesion molecule	0.0022	0.0027	0.0027
Echinococcus granulosus	roundabout 2	0.0022	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Giardia lamblia	Hypothetical protein	0.0121	0.0534	0.1506
Brugia malayi	Protein kinase domain containing protein	0.0045	0.0143	0.0143
Schistosoma mansoni	titin	0.0018	0.0007	0.0007
Plasmodium vivax	protein kinase Crk2	0.0045	0.0143	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0027	0.0027
Trypanosoma cruzi	hypothetical protein, conserved	0.0121	0.0534	0.1532
Echinococcus multilocularis	cyclin t1	0.0121	0.0534	0.0534
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0121	0.0534	0.0534
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0027	0.0027
Onchocerca volvulus	Cyclin L homolog	0.0121	0.0534	0.1532
Toxoplasma gondii	hypothetical protein	0.038	0.1862	0.7223
Echinococcus granulosus	cyclin dependent kinase 5	0.0045	0.0143	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Toxoplasma gondii	cyclin 4, putative	0.0121	0.0534	0.207
Schistosoma mansoni	titin	0.0022	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0088	0.0088
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0.0534	0.1532
Echinococcus granulosus	cyclins	0.0501	0.2482	0.2482
Schistosoma mansoni	roundabout	0.0022	0.0027	0.0027
Schistosoma mansoni	cyclin G	0.0121	0.0534	0.0534
Echinococcus multilocularis	roundabout 2	0.0022	0.0027	0.0027
Echinococcus granulosus	nephrin	0.0018	0.0007	0.0007
Echinococcus multilocularis	titin	0.0018	0.0007	0.0007
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0242	0.0666
Schistosoma mansoni	hypothetical protein	0.0018	0.0007	0.0007
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0608	0.3029	0.3029
Echinococcus granulosus	neuropeptide receptor A26	0.0464	0.2292	0.2292
Echinococcus multilocularis	neuropeptide receptor A26	0.0464	0.2292	0.2292
Echinococcus multilocularis	hemicentin 1	0.0022	0.0027	0.0027
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0027	0.0027
Schistosoma mansoni	serine/threonine protein kinase	0.0045	0.0143	0.0143
Trypanosoma cruzi	cyclin, putative	0.0696	0.3483	1
Schistosoma mansoni	cyclin l	0.0121	0.0534	0.0534
Echinococcus multilocularis	neuropeptide s receptor	0.0464	0.2292	0.2292
Echinococcus granulosus	cyclins	0.0501	0.2482	0.2482
Echinococcus granulosus	cyclin A3 4	0.0121	0.0534	0.0534
Loa Loa (eye worm)	TK protein kinase	0.0626	0.3122	0.3122
Trichomonas vaginalis	cyclin B, putative	0.0121	0.0534	0.1532
Echinococcus multilocularis	cyclin dependent kinase 1	0.0045	0.0143	0.0143
Schistosoma mansoni	septate junction protein	0.0022	0.0027	0.0027
Trichomonas vaginalis	cyclin B3, putative	0.0501	0.2482	0.7126
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0012	0.0012
Echinococcus multilocularis	cyclins	0.0501	0.2482	0.2482
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0023	0.0032	0.0032
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Leishmania major	phosphopantetheinyl transferase-like protein	0.0023	0.0034	0.0098
Onchocerca volvulus	Peroxidasin homolog	0.0018	0.0007	0.0019
Giardia lamblia	Cyclin fold protein 1, putative	0.0121	0.0534	0.1506
Onchocerca volvulus		0.0696	0.3483	1
Echinococcus multilocularis	cyclin b3	0.0501	0.2482	0.2482
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0019	0.0012	0.0012
Schistosoma mansoni	cyclin B	0.0696	0.3483	0.3483
Schistosoma mansoni	g1/s-specific cyclin C	0.0121	0.0534	0.0534
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0121	0.0534	0.207
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0027	0.0027
Echinococcus multilocularis	pro neuregulin 2, membrane bound	0.0018	0.0007	0.0007
Leishmania major	cyclin 9, putative	0.0121	0.0534	0.1532
Schistosoma mansoni	hypothetical protein	0.0018	0.0007	0.0007
Onchocerca volvulus		0.0018	0.0007	0.0019
Trichomonas vaginalis	cyclin B, putative	0.0696	0.3483	1
Schistosoma mansoni	cyclin G2	0.0121	0.0534	0.0534
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0242	0.0666
Echinococcus granulosus	tyrosine protein kinase otk	0.0022	0.0027	0.0027
Echinococcus granulosus	pro neuregulin 2 membrane bound	0.0018	0.0007	0.0007
Entamoeba histolytica	cyclin C, putative	0.0121	0.0534	0.1532
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Trypanosoma cruzi	mitotic cyclin, putative	0.0121	0.0534	0.1532
Onchocerca volvulus		0.0019	0.0012	0.0033
Echinococcus multilocularis	cyclins	0.0501	0.2482	0.2482
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Echinococcus multilocularis	cyclin k	0.0121	0.0534	0.0534
Schistosoma mansoni	cyclin k	0.0121	0.0534	0.0534
Trichomonas vaginalis	cyclins, putative	0.0501	0.2482	0.7126
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.0121	0.0534	0.0534
Echinococcus granulosus	insulin growth factor binding	0.0018	0.0007	0.0007
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0018	0.0007	0.0007
Echinococcus granulosus	leucine rich repeats and immunoglobulin	0.0018	0.0007	0.0007
Onchocerca volvulus		0.0018	0.0007	0.0019
Echinococcus granulosus	lachesin	0.0022	0.0027	0.0027
Schistosoma mansoni	ap endonuclease	0.0019	0.0011	0.0011
Echinococcus multilocularis	cyclin	0.0121	0.0534	0.0534
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0696	0.3483	0.3483
Schistosoma mansoni	nephrin	0.0022	0.0027	0.0027
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Trypanosoma cruzi	cruzipain precursor, putative	0.0064	0.0242	0.0695
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0045	0.0143	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Echinococcus granulosus	L aminoadipate semialdehyde	0.0083	0.0341	0.0341
Loa Loa (eye worm)	hypothetical protein	0.1847	0.938	0.938
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0018	0.0007	0.0007
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0011	0.003
Schistosoma mansoni	cyclins	0.0501	0.2482	0.2482
Loa Loa (eye worm)	cyclin domain-containing protein	0.0121	0.0534	0.0534
Echinococcus multilocularis	twitchin	0.0019	0.0012	0.0012
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0023	0.0034	0.0092
Schistosoma mansoni	tyrosine kinase	0.0028	0.006	0.006
Echinococcus multilocularis	transfer RNA-Phe	0.0018	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0121	0.0534	0.0534
Brugia malayi	Prion-like-	0.0018	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Brugia malayi	Disorganized muscle protein 1	0.0018	0.0007	0.0007
Echinococcus multilocularis	cyclin B	0.0696	0.3483	0.3483
Echinococcus granulosus	cyclin dependent kinase	0.0045	0.0143	0.0143
Onchocerca volvulus		0.0018	0.0007	0.0019
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0121	0.0534	0.0534
Toxoplasma gondii	cyclin, N-terminal domain-containing protein	0.0121	0.0534	0.207
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0121	0.0534	0.0534
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0022	0.0027	0.0027
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0696	0.3483	1
Echinococcus granulosus	hemicentin 1	0.0022	0.0027	0.0027
Schistosoma mansoni	tyrosine kinase	0.0608	0.3029	0.3029
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0839	0.4212	0.4212
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0363	0.1776	0.1776
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0045	0.0143	0.0143
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0011	0.0011
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0023	0.0034	0.0092
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0023	0.0034	0.0092
Entamoeba histolytica	hypothetical protein	0.0023	0.0034	0.0098
Echinococcus granulosus	contactin	0.0022	0.0027	0.0027
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0242	0.0666
Brugia malayi	cell division control protein 2 homolog	0.0045	0.0143	0.0143
Plasmodium vivax	cyclin dependent kinase binding protein, putative	0.0121	0.0534	0.207
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0027	0.0027
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0083	0.0341	0.0341
Echinococcus multilocularis	leucine rich repeats and immunoglobulin	0.0018	0.0007	0.0007
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0121	0.0534	0.0534
Echinococcus granulosus	titin	0.0019	0.0012	0.0012
Echinococcus multilocularis	cyclin dependent kinase	0.0045	0.0143	0.0143
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.0121	0.0534	0.0534
Schistosoma mansoni	hypothetical protein	0.0018	0.0007	0.0007
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0045	0.0143	0.0557
Giardia lamblia	Kinase, CMGC CDK	0.0045	0.0143	0.0383
Echinococcus granulosus	twitchin	0.0031	0.0073	0.0073
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0121	0.0534	0.0534
Schistosoma mansoni	hypothetical protein	0.0018	0.0007	0.0007
Echinococcus granulosus	roundabout 2	0.0022	0.0027	0.0027
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0242	0.0666
Echinococcus granulosus	roundabout 2	0.0034	0.0088	0.0088
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0027	0.0027
Entamoeba histolytica	cyclin, domain containing protein	0.0121	0.0534	0.1532
Echinococcus granulosus	cyclin G2	0.0121	0.0534	0.0534
Giardia lamblia	Cyclin B-like protein	0.0121	0.0534	0.1506
Trichomonas vaginalis	cyclin B, putative	0.0696	0.3483	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0025	0.004	0.0114
Echinococcus granulosus	titin	0.0019	0.0012	0.0012
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.2578	1
Schistosoma mansoni	subfamily M23B non-peptidase homologue (M23 family)	0.0018	0.0007	0.0007
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.0172	0.0493
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.052	0.2578	1
Onchocerca volvulus	Putative titin	0.0018	0.0007	0.0019
Loa Loa (eye worm)	hypothetical protein	0.1968	1	1
Trypanosoma cruzi	cyclin 9, putative	0.0121	0.0534	0.1532
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0045	0.0143	0.0143
Echinococcus multilocularis	cyclins	0.0501	0.2482	0.2482
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0.0534	0.1532
Echinococcus granulosus	titin	0.0018	0.0007	0.0007
Echinococcus granulosus	down syndrome cell adhesion	0.0018	0.0007	0.0007
Schistosoma mansoni	Cyclin fold protein	0.0121	0.0534	0.0534
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0341	0.0341
Onchocerca volvulus	Cyclin L homolog	0.0121	0.0534	0.1532
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0626	0.3122	0.3122
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Echinococcus granulosus	cyclin	0.0121	0.0534	0.0534
Trichomonas vaginalis	cyclin A, putative	0.0696	0.3483	1
Schistosoma mansoni	hypothetical protein	0.0018	0.0007	0.0007
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0018	0.0007	0.0007
Brugia malayi	cyclin fold protein 1 variant b	0.0121	0.0534	0.0534
Onchocerca volvulus		0.0018	0.0007	0.0019
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0022	0.0027	0.0027
Giardia lamblia	Hypothetical protein	0.0121	0.0534	0.1506
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0121	0.0534	0.0534
Loa Loa (eye worm)	cyclin domain-containing protein	0.0121	0.0534	0.0534
Echinococcus granulosus	cyclin dependent kinase 1	0.0045	0.0143	0.0143
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0608	0.3029	0.3029
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0027	0.0027
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0058	0.0213	0.0613
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0022	0.0027	0.0027
Plasmodium falciparum	cyclin dependent kinase binding protein, putative	0.0121	0.0534	0.207
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0027	0.0027
Echinococcus granulosus	cyclins	0.0501	0.2482	0.2482
Onchocerca volvulus		0.0018	0.0007	0.0019
Echinococcus granulosus	Opioid binding protein:cell adhesion molecule	0.0018	0.0007	0.0007
Loa Loa (eye worm)	CYL-1 protein	0.0121	0.0534	0.0534
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Toxoplasma gondii	cyclin dependent kinase binding protein	0.0121	0.0534	0.207
Echinococcus granulosus	cyclins	0.0121	0.0534	0.0534
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0242	0.0666
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Echinococcus granulosus	cyclin t1	0.0121	0.0534	0.0534
Loa Loa (eye worm)	cyclin domain-containing protein	0.0363	0.1776	0.1776
Schistosoma mansoni	cyclin B3	0.0839	0.4212	0.4212
Entamoeba histolytica	cyclin, putative	0.0696	0.3483	1
Trypanosoma cruzi	cdc2-related kinase 1	0.0045	0.0143	0.0412
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0022	0.0027	0.0027
Trypanosoma cruzi	cdc2-related kinase 3	0.0045	0.0143	0.0412
Leishmania major	cathepsin L-like protease	0.0064	0.0242	0.0695
Trypanosoma brucei	cyclin dependent kinase-binding protein, putative	0.0121	0.0534	0.1506
Echinococcus granulosus	cyclin k	0.0121	0.0534	0.0534
Schistosoma mansoni	neuroglian	0.0022	0.0027	0.0027
Trichomonas vaginalis	cyclin B, putative	0.0501	0.2482	0.7126
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0534	0.0534
Trichomonas vaginalis	cyclins, putative	0.0696	0.3483	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Schistosoma mansoni	cell adhesion molecule	0.0018	0.0007	0.0007
Leishmania major	cathepsin L-like protease	0.0064	0.0242	0.0695
Plasmodium falciparum	cyclin 1	0.0121	0.0534	0.207
Loa Loa (eye worm)	animal heme peroxidase	0.0018	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0139	0.0139
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0018	0.0007	0.0007
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0121	0.0534	0.0534
Entamoeba histolytica	cyclin family protein	0.0501	0.2482	0.7126
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0608	0.3029	0.3029
Giardia lamblia	Cyclin A	0.0501	0.2482	0.7117
Trypanosoma cruzi	cdc2-related kinase 3	0.0045	0.0143	0.0412
Entamoeba histolytica	cyclin, domain containing protein	0.0121	0.0534	0.1532
Loa Loa (eye worm)	cyclin domain-containing protein	0.0121	0.0534	0.0534
Echinococcus granulosus	leucine rich repeat containing protein 4	0.0018	0.0007	0.0007
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0018	0.0007	0.0007
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0045	0.0143	0.0412
Loa Loa (eye worm)	cyclin domain-containing protein	0.0121	0.0534	0.0534
Trypanosoma cruzi	cdc2-related kinase 1	0.0045	0.0143	0.0412
Schistosoma mansoni	ap endonuclease	0.0019	0.0011	0.0011
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Toxoplasma gondii	hypothetical protein	0.0121	0.0534	0.207
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0011	0.003
Schistosoma mansoni	hypothetical protein	0.0018	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0027	0.0027
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0027	0.0027
Loa Loa (eye worm)	cyclin C	0.0121	0.0534	0.0534
Trichomonas vaginalis	conserved hypothetical protein	0.0501	0.2482	0.7126
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Plasmodium vivax	cyclin 4, putative	0.0121	0.0534	0.207
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0.0534	0.1532
Trichomonas vaginalis	cyclins, putative	0.0121	0.0534	0.1532
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.2578	1
Schistosoma mansoni	nephrin	0.003	0.0068	0.0068
Plasmodium vivax	cyclin homologue, putative	0.0121	0.0534	0.207
Echinococcus granulosus	peroxidasin	0.0022	0.0027	0.0027
Trichomonas vaginalis	cyclin B, putative	0.0696	0.3483	1
Brugia malayi	Wrapper/rega-1/klingon homolog protein 1	0.0018	0.0007	0.0007
Echinococcus multilocularis	cyclin G2	0.0121	0.0534	0.0534
Schistosoma mansoni	titin	0.0018	0.0007	0.0007
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0023	0.0034	0.0433
Echinococcus multilocularis	cyclins	0.0501	0.2482	0.2482
Entamoeba histolytica	cyclin family protein	0.0501	0.2482	0.7126
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0083	0.0341	0.0341
Trichomonas vaginalis	cyclins, putative	0.0121	0.0534	0.1532
Trichomonas vaginalis	cyclins, putative	0.0696	0.3483	1
Echinococcus granulosus	Cyclin L1	0.0121	0.0534	0.0534
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0011	0.003
Schistosoma mansoni	serine/threonine protein kinase	0.0045	0.0143	0.0143
Echinococcus multilocularis	cyclin G2	0.0121	0.0534	0.0534
Trichomonas vaginalis	cyclin A, putative	0.0121	0.0534	0.1532
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0027	0.0027
Trypanosoma brucei	cdc2-related kinase 1	0.0045	0.0143	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0696	0.3483	0.3483
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0018	0.0007	0.0007
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0022	0.0027	0.0027
Entamoeba histolytica	cell division protein kinase 2, putative	0.0045	0.0143	0.0412
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0121	0.0534	0.0534
Onchocerca volvulus		0.0018	0.0007	0.0019
Onchocerca volvulus		0.0018	0.0007	0.0019
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0011	0.003
Loa Loa (eye worm)	cyclin domain-containing protein	0.0839	0.4212	0.4212
Echinococcus multilocularis	neuroglian	0.0022	0.0027	0.0027
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	0.052	0.2578	1
Echinococcus multilocularis	Opioid binding protein:cell adhesion molecule	0.0018	0.0007	0.0007
Schistosoma mansoni	cyclin d	0.1968	1	1
Echinococcus granulosus	cyclin b3	0.0501	0.2482	0.2482
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0083	0.0341	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0242	0.0666
Echinococcus multilocularis	roundabout 2	0.0022	0.0027	0.0027
Echinococcus granulosus	cyclins	0.0501	0.2482	0.2482
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0027	0.0027
Echinococcus multilocularis	neuroglian	0.003	0.0068	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0007	0.0007
Echinococcus multilocularis	cyclins	0.0501	0.2482	0.2482
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0018	0.0007	0.0007
Schistosoma mansoni	hemicentin	0.0018	0.0007	0.0007
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0007	0.0007
Schistosoma mansoni	cell adhesion molecule	0.0022	0.0027	0.0027
Onchocerca volvulus		0.0018	0.0007	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.0121	0.0534	0.1532
Echinococcus multilocularis	titin	0.0018	0.0007	0.0007
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0242	0.0666
Schistosoma mansoni	titin	0.0018	0.0007	0.0007
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0018	0.0007	0.0007
Schistosoma mansoni	nephrin related	0.0018	0.0007	0.0007
Trypanosoma cruzi	cyclin 6, putative	0.0696	0.3483	1
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0018	0.0007	0.0007
Trypanosoma cruzi	cyclin, putative	0.0696	0.3483	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0018	0.0007	0.0007
Echinococcus multilocularis	tyrosine protein kinase otk	0.0022	0.0027	0.0027
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.2578	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0022	0.0027	0.0027
Echinococcus granulosus	cyclins	0.0501	0.2482	0.2482
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0045	0.0143	0.0143
Trichomonas vaginalis	cyclin B3, putative	0.0121	0.0534	0.1532
Loa Loa (eye worm)	hypothetical protein	0.0195	0.0915	0.0915
Brugia malayi	hypothetical protein	0.0121	0.0534	0.0534
Entamoeba histolytica	hypothetical protein	0.0121	0.0534	0.1532
Schistosoma mansoni	hypothetical protein	0.0121	0.0534	0.0534
Echinococcus granulosus	cyclin B3 1	0.0501	0.2482	0.2482
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0027	0.0027
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0023	0.0034	0.0132
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0012	0.0012
Schistosoma mansoni	cell adhesion molecule	0.0022	0.0027	0.0027
Echinococcus granulosus	G1:S specific cyclin D1	0.1968	1	1
Leishmania major	cathepsin L-like protease	0.0064	0.0242	0.0695
Echinococcus multilocularis	titin	0.0019	0.0012	0.0012
Trichomonas vaginalis	cyclins, putative	0.0696	0.3483	1
Entamoeba histolytica	cell division protein kinase 2, putative	0.0045	0.0143	0.0412
Schistosoma mansoni	septate junction protein	0.0022	0.0027	0.0027
Onchocerca volvulus	Peroxidasin homolog	0.0018	0.0007	0.0019
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0034	0.0068
Schistosoma mansoni	titin	0.0018	0.0007	0.0007
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0027	0.0027
Trypanosoma brucei	mitotic cyclin 6	0.0696	0.3483	1
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.052	0.2578	1
Trichomonas vaginalis	CMGC family protein kinase	0.0045	0.0143	0.0412
Echinococcus granulosus	titin	0.0018	0.0007	0.0007
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	0.0125	0.0555	1
Brugia malayi	Prion-like-	0.0022	0.0027	0.0027
Trichomonas vaginalis	CMGC family protein kinase	0.0045	0.0143	0.0412
Toxoplasma gondii	exonuclease III APE	0.0019	0.0011	0.0041
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0022	0.0027	0.0027
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0242	0.0666
Schistosoma mansoni	cell adhesion molecule	0.0018	0.0007	0.0007
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0018	0.0007	0.0007
Loa Loa (eye worm)	projectin	0.0018	0.0007	0.0007
Echinococcus granulosus	cyclin G2	0.0121	0.0534	0.0534

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= -4.85	Inhibitory concentration against DOXP reductoisomerase	ChEMBL.	15887963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL606609

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1100024