Detailed information for compound 1101807

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 289.394 | Formula: C12H23N3O3S
  • H donors: 3 H acceptors: 3 LogP: 0.88 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: SCC(=O)N[C@H](C(=O)N[C@H](C(=O)N)C(C)C)C(C)C
  • InChi: 1S/C12H23N3O3S/c1-6(2)9(11(13)17)15-12(18)10(7(3)4)14-8(16)5-19/h6-7,9-10,19H,5H2,1-4H3,(H2,13,17)(H,14,16)(H,15,18)/t9-,10-/m0/s1
  • InChiKey: HZTPOAPCICWCII-UWVGGRQHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) Pseudolysin Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0215 0.0274
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0215 0.3653
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0367 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0141 0.3703
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0243 0.0243
Schistosoma mansoni cpg binding protein 0.0036 0.0365 0.0365
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0367 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0141 0.3703
Brugia malayi hypothetical protein 0.0017 0.0131 0.2233
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.007 0.1184
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0253
Loa Loa (eye worm) hypothetical protein 0.0036 0.0367 0.6235
Brugia malayi ecdysteroid receptor 0.0012 0.007 0.1184
Brugia malayi beta-lactamase family protein 0.0036 0.0367 0.6235
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0367 0.0367
Trichomonas vaginalis esterase, putative 0.0036 0.0367 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.007 0.1184
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0246 0.3361
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.007 0.007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.0253
Onchocerca volvulus 0.0023 0.0215 0.3565
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.1184
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.007 0.007
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.005 0.0853
Brugia malayi beta-lactamase family protein 0.0036 0.0367 0.6235
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.007 0.007
Brugia malayi intermediate filament protein 0.0053 0.0588 1
Echinococcus multilocularis microtubule associated protein 2 0.0809 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.007 0.1184
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0246 0.6642
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.007 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.007 0.1184
Echinococcus granulosus lamin 0.0053 0.0588 0.0588
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.007 0.1184
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0215 0.5766
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0367 1
Echinococcus multilocularis cpg binding protein 0.0036 0.0365 0.0365
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.007 0.007
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0008 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.007 0.1184
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0215 0.5766
Loa Loa (eye worm) hypothetical protein 0.0036 0.0367 0.6235
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0253
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0367 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.007 0.1184
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0215 0.3653
Leishmania major hypothetical protein, conserved 0.0026 0.0246 0.6642
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.007 0.007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.0253
Brugia malayi CXXC zinc finger family protein 0.0034 0.0341 0.5807
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0052 0.0052
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0367 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.007 0.1184
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.007 0.007
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0008 0.0008
Onchocerca volvulus 0.0012 0.007 0.1063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.007 0.1184
Echinococcus multilocularis geminin 0.0334 0.4089 0.4089
Loa Loa (eye worm) hypothetical protein 0.0036 0.0367 0.6235
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0215 0.5766
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0215 0.5766
Echinococcus granulosus dnaJ subfamily B 0.0479 0.5895 0.5895
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0152 0.6978
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.007 0.1184
Loa Loa (eye worm) beta-lactamase 0.0036 0.0367 0.6235
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0367 0.0476
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0026 0.0026
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.007 0.007
Brugia malayi steroid hormone receptor 0.0012 0.007 0.1184
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.2394
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0253
Loa Loa (eye worm) hypothetical protein 0.0036 0.0367 0.6235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.007 0.1184
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0129 0.016
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0588 1
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0008 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0253
Schistosoma mansoni hypothetical protein 0.0334 0.4089 0.4089
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0008 0.0136
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.007 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.007 0.1184
Brugia malayi nuclear hormone receptor 0.0012 0.007 0.1184
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0588 1
Trichomonas vaginalis helicase, putative 0.0008 0.0017 0.0253
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0215 0.5766
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0008 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.2394
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0215 0.5766
Brugia malayi nuclear receptor NHR-88 0.0012 0.007 0.1184
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.007 0.1063
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0253
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0215 0.5766
Toxoplasma gondii ABC1 family protein 0.0036 0.0367 0.5061
Schistosoma mansoni lamin 0.0053 0.0588 0.0588
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0243 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.007 0.1184
Loa Loa (eye worm) hypothetical protein 0.0025 0.0231 0.3933
Schistosoma mansoni microtubule-associated protein tau 0.0809 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0215 0.3653
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.007 0.007
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0246 1
Onchocerca volvulus 0.0036 0.0367 0.6183
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.1184
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0215 0.5766
Schistosoma mansoni ap endonuclease 0.0018 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0025 0.0231 0.3933
Mycobacterium ulcerans lipase LipD 0.0036 0.0367 1
Echinococcus granulosus cpg binding protein 0.0036 0.0365 0.0365
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0367 0.0476
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0008 0.0008
Mycobacterium ulcerans hypothetical protein 0.0023 0.0215 0.5766
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0246 0.6642
Schistosoma mansoni ap endonuclease 0.0018 0.0152 0.0152
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0052 0.0052
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0341 0.5807
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0136
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0026 0.0026
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0215 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0152 0.4024
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0367 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.007 0.1184
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0367 0.6235
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.007 0.007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.007 0.1184
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.1184
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.007 0.007
Onchocerca volvulus 0.0053 0.0588 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0215 1
Echinococcus multilocularis dnaJ subfamily B 0.0479 0.5895 0.5895
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.007 0.1063
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0026 0.0246 0.4187
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0215 0.5766
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0279 0.4741
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0367 0.0476
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0008 0.0136
Loa Loa (eye worm) hypothetical protein 0.0052 0.0576 0.9793
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0129 0.016
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0152 0.0152
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0152 0.0192
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0367 0.0476
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0246 0.6642
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0367 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0141 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.007 0.1184
Mycobacterium tuberculosis Conserved protein 0.0036 0.0367 0.0476
Loa Loa (eye worm) hypothetical protein 0.0053 0.0588 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0152 0.259
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.2762 0.3656
Schistosoma mansoni nuclear hormone receptor 0.0012 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.2394
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.1184
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.1184
Loa Loa (eye worm) hypothetical protein 0.0036 0.0367 0.6235
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.1184
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0152 0.4024
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0279 0.4741
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.007 0.1184
Loa Loa (eye worm) hypothetical protein 0.0023 0.0215 0.3653
Echinococcus granulosus intermediate filament protein 0.0053 0.0588 0.0588
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0253
Brugia malayi hypothetical protein 0.0026 0.0246 0.4187
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.0253
Echinococcus granulosus lamin dm0 0.0053 0.0588 0.0588
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.007 0.1184
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0215 0.5766
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.007 0.007
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0215 0.3653
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0152 0.4024
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0136
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0036 0.0367 0.6235
Onchocerca volvulus 0.0034 0.0341 0.5749
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0152 0.5
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0152 0.4024
Mycobacterium leprae Probable lipase LipE 0.0036 0.0367 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0152 0.259
Mycobacterium tuberculosis Conserved protein 0.0036 0.0367 0.0476
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.007 0.007
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.007 0.007
Loa Loa (eye worm) oxidoreductase 0.0007 0.0008 0.0136
Schistosoma mansoni coup transcription factor 0.0012 0.007 0.007
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0017 0.0253
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0141 0.0176
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0215 0.5766
Loa Loa (eye worm) histone methyltransferase 0.001 0.0052 0.0881
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0026 0.0026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0129 0.016
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.007 0.007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.0253
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.007 0.007
Echinococcus granulosus geminin 0.0334 0.4089 0.4089
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.007 0.1184
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.2394
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0152 0.4024
Schistosoma mansoni thyroid hormone receptor 0.0012 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0012 0.0067 0.0067
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.007 0.007
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0367 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0367 0.0367
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0367 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0367 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0367 0.6235
Mycobacterium tuberculosis Conserved protein 0.0036 0.0367 0.0476
Mycobacterium tuberculosis Possible exported protein 0.0612 0.7543 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0017 0.0253
Schistosoma mansoni lamin 0.0053 0.0588 0.0588
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0008 0.0136
Mycobacterium ulcerans hypothetical protein 0.0036 0.0367 1
Echinococcus granulosus FTZ F1 alpha 0.0012 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.1184
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0253
Echinococcus multilocularis lamin dm0 0.0053 0.0588 0.0588
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0246 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.007 0.007
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0367 0.0476
Onchocerca volvulus 0.0036 0.0367 0.6183
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0367 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0152 0.6058
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.007 0.007
Brugia malayi beta-lactamase 0.0036 0.0367 0.6235
Schistosoma mansoni hypothetical protein 0.0334 0.4089 0.4089
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0008 0.0008
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.007 0.1063
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0008 0.0136
Onchocerca volvulus 0.0036 0.0367 0.6183
Mycobacterium ulcerans beta-lactamase 0.0036 0.0367 1
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0367 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.007 0.1184
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0141 0.5575
Schistosoma mansoni hypothetical protein 0.0479 0.5895 0.5895
Toxoplasma gondii exonuclease III APE 0.0018 0.0152 0.2036
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0367 0.0367
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0026 0.0026
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.007 0.1184
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.007 0.007
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0215 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0367 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0215 0.0274
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.007 0.007
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0067 0.0067
Onchocerca volvulus 0.0053 0.0588 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0017 0.0253
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0246 0.6642
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0152 0.4024
Schistosoma mansoni intermediate filament proteins 0.0053 0.0588 0.0588
Loa Loa (eye worm) hypothetical protein 0.0023 0.0215 0.3653
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.007 0.1184
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0367 0.0476
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0812 0.0812
Leishmania major hypothetical protein, conserved 0.0036 0.0367 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0717 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0152 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.007 0.007
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0152 0.4024
Echinococcus multilocularis lamin 0.0053 0.0588 0.0588
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0215 0.5766
Loa Loa (eye worm) hypothetical protein 0.0012 0.007 0.1184
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0152 0.4024
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.007 0.007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0152 0.0152
Schistosoma mansoni thyroid hormone receptor 0.0012 0.007 0.007
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0588 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0017 0.0253
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0152 0.5
Echinococcus multilocularis musashi 0.0053 0.0588 0.0588
Schistosoma mansoni cpg binding protein 0.0036 0.0365 0.0365
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0129 0.016
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0008 0.0136
Loa Loa (eye worm) hypothetical protein 0.0018 0.0141 0.2394
Loa Loa (eye worm) hypothetical protein 0.0026 0.0243 0.414
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.007 0.1184
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0367 0.0476
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.007 0.1184
Schistosoma mansoni cpg binding protein 0.0034 0.0341 0.0341

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 10 uM Inhibition of Pseudomonas aeruginosa LasB by fluorimetric assay in buffer of pH 7.2 ChEMBL. 19773163

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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