Detailed information for compound 1113199

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 482.577 | Formula: C28H30N6O2
  • H donors: 3 H acceptors: 4 LogP: 4.04 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)n1nnc(c1)c1ccccc1)CCCCCCC(=O)Nc1ccccc1N
  • InChi: 1S/C28H30N6O2/c29-24-15-8-9-16-25(24)31-28(36)18-7-2-1-6-17-27(35)30-22-13-10-14-23(19-22)34-20-26(32-33-34)21-11-4-3-5-12-21/h3-5,8-16,19-20H,1-2,6-7,17-18,29H2,(H,30,35)(H,31,36)
  • InChiKey: OWCOYDWONSDUKN-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium berghei histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum RPD3/HD1 histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Babesia bovis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Neospora caninum hypothetical protein Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi histone deacetylase 3 (HD3) Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi Histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Brugia malayi histone deacetylase 1 (HD1) Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC2 Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma cruzi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K01463 Hdac3 [EC:3.5.1.-], putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma japonicum ko:K06067 histone deacetylase 1/2, putative Get druggable targets OG5_126742 All targets in OG5_126742
Toxoplasma gondii histone deacetylase HDAC3 Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium yoelii histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania major histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium parvum histone deacetylase HDA2/Rpd3p Get druggable targets OG5_126742 All targets in OG5_126742
Theileria parva histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Giardia lamblia Histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Entamoeba histolytica histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus multilocularis histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Neospora caninum histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium knowlesi histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Echinococcus granulosus histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei gambiense histone deacetylase 1,histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 3 Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium falciparum histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Loa Loa (eye worm) histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Cryptosporidium hominis histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trichomonas vaginalis histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma congolense histone deacetylase-like 1 protein, putative Get druggable targets OG5_126742 All targets in OG5_126742
Schistosoma mansoni histone deacetylase Get druggable targets OG5_126742 All targets in OG5_126742
Trypanosoma brucei histone deacetylase 1 Get druggable targets OG5_126742 All targets in OG5_126742
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126742 All targets in OG5_126742
Plasmodium vivax histone deacetylase 1, putative Get druggable targets OG5_126742 All targets in OG5_126742
Candida albicans one of two distinct genes with strong similarity to S. cerevisiae RPD3 (YNL330C) SIN3 histone deacetylase complex component Get druggable targets OG5_126742 All targets in OG5_126742
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi histone deacetylase, putative histone deacetylase 3 428 aa 374 aa 30.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0097 0.0355 0.1149
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0012 0.0252
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0097 0.0355 0.1101
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0238 0.1036 0.2047
Leishmania major oligopeptidase b 0.0262 0.1152 0.3743
Echinococcus multilocularis g protein coupled receptor 0.0047 0.011 0.011
Trypanosoma brucei unspecified product 0.0041 0.0084 0.0177
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.011 0.011
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0047 0.011 0.0163
Schistosoma mansoni hypothetical protein 0.1043 0.4944 1
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0038 0.0086
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0038 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0194 0.0334
Giardia lamblia Alanyl dipeptidyl peptidase 0.0069 0.0218 0.2212
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0256 0.6902
Loa Loa (eye worm) hypothetical protein 0.006 0.0174 0.053
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.011 0.011
Schistosoma mansoni ATP-binding cassette transporter 0.0032 0.0039 0.0018
Echinococcus multilocularis allatostatin A receptor 0.0047 0.011 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0012 0.0252
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0047 0.011 0.011
Echinococcus multilocularis lysine specific demethylase 5A 0.0074 0.0242 0.0242
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.006 0.1574
Brugia malayi beta-lactamase family protein 0.0037 0.006 0.0157
Schistosoma mansoni kinase 0.0051 0.013 0.0204
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0047 0.011 0.0163
Brugia malayi hypothetical protein 0.0047 0.011 0.0321
Schistosoma mansoni amine GPCR 0.0047 0.011 0.0163
Echinococcus granulosus glutamate NMDA receptor subunit 0.0086 0.03 0.03
Schistosoma mansoni voltage-gated potassium channel 0.0079 0.0264 0.0476
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0012 0.0252
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0246 0.0246
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0069 0.0218 0.5859
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.011 0.0163
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Schistosoma mansoni ap endonuclease 0.0097 0.0355 0.0662
Trypanosoma cruzi DNA polymerase eta, putative 0.006 0.0174 0.056
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.011 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0238 0.1036 0.2047
Brugia malayi hypothetical protein 0.0047 0.011 0.0321
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.011 0.011
Echinococcus multilocularis G protein coupled receptor 139 0.0047 0.011 0.011
Echinococcus granulosus 7TM GPCR rhodopsin 0.0047 0.011 0.011
Schistosoma mansoni histamine h1 receptor 0.0047 0.011 0.0163
Brugia malayi neuropeptide F receptor 0.0047 0.011 0.0321
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.011 0.0321
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.011 0.0163
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0041 0.008 0.008
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0047 0.011 0.0321
Trichomonas vaginalis ap endonuclease, putative 0.0097 0.0355 0.9602
Echinococcus multilocularis importin subunit beta 1 0.003 0.003 0.003
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0047 0.011 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0174 0.0474
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0157
Echinococcus multilocularis g-protein coupled receptor 0.0047 0.011 0.011
Plasmodium vivax hypothetical protein, conserved 0.0037 0.006 0.1341
Loa Loa (eye worm) beta-lactamase 0.0037 0.006 0.0157
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0047 0.011 0.011
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0061 0.0179 0.0304
Schistosoma mansoni opsin-like receptor 0.0047 0.011 0.0163
Brugia malayi larval opioid receptor 0.0047 0.011 0.0321
Echinococcus multilocularis neuropeptide s receptor 0.0047 0.011 0.011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.006 0.0061
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.006 0.0157
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.011 0.011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0061 0.0179 0.0546
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0069 0.0218 0.0616
Schistosoma mansoni hypothetical protein 0.0047 0.011 0.0163
Schistosoma mansoni growth hormone secretagogue receptor 0.0047 0.011 0.0163
Onchocerca volvulus 0.0047 0.011 0.0167
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0174 0.0474
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0157
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0069 0.0218 0.0616
Echinococcus granulosus importin subunit beta 1 0.003 0.003 0.003
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.006 0.1574
Loa Loa (eye worm) hypothetical protein 0.0069 0.0218 0.0671
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0042 0.0088 0.5
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.006 0.006
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0246 0.0246
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.011 0.011
Brugia malayi putative neuropeptide receptor NPR1 0.0047 0.011 0.0321
Toxoplasma gondii prolyl endopeptidase 0.0658 0.3075 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0012 0.0252
Echinococcus multilocularis fmrfamide receptor 0.0047 0.011 0.011
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0041 0.008 0.008
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0246 0.044
Brugia malayi Importin beta-1 subunit 0.003 0.003 0.0059
Echinococcus granulosus neuropeptide s receptor 0.0047 0.011 0.011
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0047 0.011 0.011
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0036 0.0059 0.0059
Echinococcus granulosus allatostatin A receptor 0.0047 0.011 0.011
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0038 0.0038
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0262 0.1152 0.3685
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.011 0.011
Brugia malayi beta-lactamase 0.0037 0.006 0.0157
Brugia malayi hypothetical protein 0.0047 0.011 0.0321
Brugia malayi follicle stimulating hormone receptor 0.0047 0.011 0.0321
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0174 0.0474
Schistosoma mansoni opsin-like receptor 0.0047 0.011 0.0163
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0069 0.0218 0.0701
Echinococcus granulosus dna polymerase eta 0.006 0.0174 0.0174
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0047 0.011 0.011
Schistosoma mansoni DNA polymerase eta 0.006 0.0174 0.0294
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.011 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0174 0.0474
Onchocerca volvulus 0.0047 0.011 0.0167
Echinococcus multilocularis nmda type glutamate receptor 0.0059 0.0168 0.0168
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0012 0.0252
Leishmania major DNA polymerase kappa, putative 0.006 0.0174 0.056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0238 0.1036 0.1036
Echinococcus granulosus glutamate receptor 2 0.0041 0.008 0.008
Brugia malayi RNA, U transporter 1 0.0086 0.0302 0.0945
Plasmodium falciparum importin beta, putative 0.003 0.003 0.0461
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.011 0.0163
Entamoeba histolytica histone deacetylase, putative 0.0077 0.0256 0.6902
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0194 0.0334
Trypanosoma brucei histone deacetylase 1 0.0077 0.0256 0.0742
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0047 0.011 0.0163
Echinococcus multilocularis serotonin receptor 0.0047 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0047 0.011 0.0163
Schistosoma mansoni neuropeptide f receptor 76f 0.0047 0.011 0.0163
Echinococcus granulosus dna polymerase kappa 0.006 0.0174 0.0174
Plasmodium vivax hypothetical protein, conserved 0.0069 0.0218 0.5963
Onchocerca volvulus 0.0047 0.011 0.0167
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.011 0.011
Echinococcus granulosus orexin receptor type 2 0.0047 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0069 0.0219 0.0384
Schistosoma mansoni opsin-like receptor 0.0047 0.011 0.0163
Entamoeba histolytica hypothetical protein 0.0075 0.0246 0.6641
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0077 0.0256 0.0796
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0069 0.0218 0.0382
Onchocerca volvulus 0.0047 0.011 0.0167
Schistosoma mansoni glutamate receptor NMDA 0.0041 0.008 0.0101
Loa Loa (eye worm) hypothetical protein 0.0101 0.0374 0.1183
Echinococcus multilocularis neuropeptide receptor A26 0.0047 0.011 0.011
Echinococcus granulosus hypothetical protein 0.0047 0.011 0.011
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.006 0.0099
Loa Loa (eye worm) TYRA-2 protein 0.0047 0.011 0.0321
Echinococcus multilocularis neuropeptide receptor 0.0047 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0256 0.6902
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.011 0.011
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0047 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0067 0.0209 0.5624
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Schistosoma mansoni hypothetical protein 0.0324 0.1455 0.2899
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0157
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0238 0.1036 0.1036
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0017
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0086 0.03 0.03
Brugia malayi prolyl oligopeptidase family protein 0.0658 0.3075 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0097 0.0355 0.9602
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.011 0.0163
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0174 0.056
Schistosoma mansoni histone deacetylase 0.0077 0.0256 0.046
Plasmodium falciparum phd finger protein, putative 0.0061 0.0179 0.4841
Echinococcus multilocularis PHD finger protein rhinoceros 0.0061 0.0179 0.0179
Echinococcus granulosus histone deacetylase 3 0.0077 0.0256 0.0256
Trichomonas vaginalis helicase, putative 0.0027 0.0012 0.0252
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0047 0.011 0.0163
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0077 0.0256 0.6902
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0174 0.0474
Echinococcus multilocularis dro:myosuppressin receptor 0.0047 0.011 0.011
Brugia malayi G-protein coupled receptor 0.0047 0.011 0.0321
Echinococcus granulosus nmda type glutamate receptor 0.0059 0.0168 0.0168
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.006 0.0188
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1637 0.7827 0.7827
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.011 0.011
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0194 0.0334
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.006 0.0157
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2085 1 1
Echinococcus granulosus neuropeptide receptor 0.0047 0.011 0.011
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0069 0.0218 0.0701
Schistosoma mansoni amine GPCR 0.0047 0.011 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0012 0.0252
Onchocerca volvulus Alhambra homolog 0.0061 0.0179 0.0396
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.011 0.0163
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.011 0.011
Trypanosoma cruzi oligopeptidase b 0.0262 0.1152 0.3743
Brugia malayi TAR-binding protein 0.0064 0.0194 0.0594
Loa Loa (eye worm) hypothetical protein 0.0658 0.3075 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0012 0.0252
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0077 0.0256 0.6902
Toxoplasma gondii ABC1 family protein 0.0037 0.006 0.0099
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0026 0.0011 0.0011
Brugia malayi G-protein coupled receptor 0.0047 0.011 0.0321
Plasmodium vivax histone deacetylase 1, putative 0.0077 0.0256 0.7088
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0157
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0174 0.0474
Entamoeba histolytica prolyl oligopeptidase family protein 0.0069 0.0218 0.5859
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0248 0.1087 0.2152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0238 0.1036 0.1036
Trichomonas vaginalis CAMK family protein kinase 0.01 0.037 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0097 0.0355 0.1149
Brugia malayi Glutamate receptor 1 precursor 0.0032 0.0039 0.0087
Loa Loa (eye worm) hypothetical protein 0.0105 0.0391 0.1238
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0097 0.0355 0.1149
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Echinococcus multilocularis histone deacetylase 1 0.0077 0.0256 0.0256
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0041 0.008 0.008
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.011 0.011
Echinococcus multilocularis fmrfamide receptor 0.0047 0.011 0.011
Brugia malayi ORL1-like opioid receptor 0.0047 0.011 0.0321
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0374 0.1183
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0049 0.0121 0.0185
Entamoeba histolytica deoxycytidyl transferase, putative 0.006 0.0174 0.4682
Echinococcus multilocularis serotonin receptor 0.0047 0.011 0.011
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0194 0.0194
Brugia malayi Serotonin receptor 0.0047 0.011 0.0321
Echinococcus granulosus g protein coupled receptor 0.0047 0.011 0.011
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0174 0.1046
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0194 0.0594
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Trypanosoma cruzi histone deacetylase 1, putative 0.0077 0.0256 0.0826
Toxoplasma gondii histone deacetylase HDAC3 0.0077 0.0256 0.0742
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.006 0.0174 0.053
Onchocerca volvulus 0.0047 0.011 0.0167
Echinococcus multilocularis g protein coupled receptor 0.0047 0.011 0.011
Echinococcus granulosus serotonin receptor 0.0047 0.011 0.011
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0097 0.0355 0.2702
Trichomonas vaginalis esterase, putative 0.0037 0.006 0.1574
Schistosoma mansoni amine GPCR 0.0047 0.011 0.0163
Trypanosoma brucei prolyl oligopeptidase, putative 0.0262 0.1152 0.3685
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0658 0.3075 0.6195
Trichomonas vaginalis ap endonuclease, putative 0.0097 0.0355 0.9602
Brugia malayi hypothetical protein 0.0075 0.0246 0.0765
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0084 0.0177
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0174 0.0474
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0194 0.0334
Loa Loa (eye worm) RNA binding protein 0.0064 0.0194 0.0594
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0194 0.0594
Echinococcus granulosus Dipeptidyl peptidase 9 0.0069 0.0218 0.0218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.011 0.011
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0069 0.0218 0.0382
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0069 0.0218 0.5859
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0039 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.011 0.011
Loa Loa (eye worm) PHD-finger family protein 0.0061 0.0179 0.0546
Entamoeba histolytica hypothetical protein 0.0075 0.0246 0.6641
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0036 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Echinococcus multilocularis g protein coupled receptor 0.0047 0.011 0.011
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.006 0.1574
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0012 0.0252
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Echinococcus granulosus dro:myosuppressin receptor 0.0047 0.011 0.011
Echinococcus granulosus dnaJ subfamily B 0.0845 0.3985 0.3985
Echinococcus multilocularis dnaJ subfamily B 0.0845 0.3985 0.3985
Loa Loa (eye worm) hypothetical protein 0.0062 0.0186 0.0567
Giardia lamblia Histone deacetylase 0.0077 0.0256 0.4174
Brugia malayi CXXC zinc finger family protein 0.0117 0.0451 0.1432
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0256 0.6902
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0012 0.0252
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0017
Plasmodium vivax importin-beta 2, putative 0.003 0.003 0.0461
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0047 0.011 0.011
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0124 0.331
Brugia malayi jmjC domain containing protein 0.0081 0.0274 0.0856
Echinococcus multilocularis orexin receptor type 2 0.0047 0.011 0.011
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.0174 0.4682
Echinococcus multilocularis geminin 0.1043 0.4944 0.4944
Echinococcus multilocularis glutamate receptor 2 0.0032 0.0039 0.0039
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Trichomonas vaginalis CAMK family protein kinase 0.01 0.037 1
Loa Loa (eye worm) histone methyltransferase 0.0036 0.0059 0.0152
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0039 0.0018
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0047 0.011 0.011
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0041 0.008 0.008
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.011 0.011
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0262 0.1152 0.3743
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0017
Echinococcus multilocularis histone deacetylase 3 0.0077 0.0256 0.0256
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.011 0.011
Toxoplasma gondii histone lysine methyltransferase SET1 0.0222 0.0959 0.3051
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.011 0.0163
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Loa Loa (eye worm) melatonin receptor type 1A 0.0047 0.011 0.0321
Echinococcus multilocularis peregrin 0.0061 0.0179 0.0179
Schistosoma mansoni glutamate receptor AMPA 0.0032 0.0039 0.0018
Brugia malayi GnHR receptor homolog 0.0047 0.011 0.0321
Brugia malayi ImpB/MucB/SamB family protein 0.006 0.0174 0.053
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0179 0.049
Onchocerca volvulus 0.0047 0.011 0.0167
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0374 0.1183
Onchocerca volvulus 0.0047 0.011 0.0167
Brugia malayi F/Y-rich N-terminus family protein 0.0056 0.0153 0.0461
Brugia malayi hypothetical protein 0.0047 0.011 0.0321
Echinococcus granulosus g protein coupled receptor 0.0047 0.011 0.011
Plasmodium falciparum peptidase, putative 0.0069 0.0218 0.5963
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0097 0.0355 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0174 0.056
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0179 0.049
Schistosoma mansoni glutamate receptor NMDA 0.0086 0.03 0.0549
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.011 0.011
Echinococcus granulosus acylamino acid releasing enzyme 0.0069 0.0218 0.0218
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0589 0.274 1
Brugia malayi hypothetical protein 0.0047 0.011 0.0321
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0174 0.0474
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0047 0.011 0.0163
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0072 0.0232 0.0232
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0218 0.5859
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.0174 0.0426
Schistosoma mansoni biogenic amine receptor 0.0047 0.011 0.0163
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0041 0.008 0.008
Echinococcus granulosus peregrin 0.0061 0.0179 0.0179
Onchocerca volvulus 0.0047 0.011 0.0167
Brugia malayi RE15519p 0.0047 0.011 0.0321
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0174 0.056
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0262 0.1152 0.3743
Brugia malayi hypothetical protein 0.0047 0.011 0.0321
Trypanosoma cruzi histone deacetylase 1, putative 0.0077 0.0256 0.0826
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0047 0.011 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.0174 0.056
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0174 0.0474
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.011 0.0163
Echinococcus granulosus jumonji domain containing protein 0.0085 0.0296 0.0296
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0658 0.3075 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0047 0.011 0.011
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.011 0.011
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.0174 0.056
Trypanosoma brucei oligopeptidase b 0.0262 0.1152 0.3685
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0012 0.0252
Entamoeba histolytica prolyl oligopeptidase family protein 0.0069 0.0218 0.5859
Echinococcus granulosus lysine specific demethylase 5A 0.0081 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0084 0.0177
Echinococcus granulosus G protein coupled receptor 139 0.0047 0.011 0.011
Schistosoma mansoni hypothetical protein 0.1043 0.4944 1
Leishmania major histone deacetylase, putative 0.0077 0.0256 0.0826
Mycobacterium tuberculosis Conserved hypothetical protein 0.006 0.0174 0.0426
Onchocerca volvulus 0.0047 0.011 0.0167
Echinococcus multilocularis snurportin 1 0.0324 0.1455 0.1455
Schistosoma mansoni neuropeptide receptor 0.0047 0.011 0.0163
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0069 0.0218 0.0218
Loa Loa (eye worm) histone deacetylase 1 0.0077 0.0256 0.0796
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0067 0.0209 0.5624
Onchocerca volvulus Prolyl endopeptidase homolog 0.0658 0.3075 1
Mycobacterium tuberculosis Probable peptidase 0.0262 0.1152 0.4075
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0041 0.008 0.008
Mycobacterium ulcerans DNA polymerase IV 0.006 0.0174 0.1046
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.011 0.0163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.011 0.011
Echinococcus granulosus 7tm_1 domain containing protein 0.0047 0.011 0.011
Entamoeba histolytica hypothetical protein 0.0075 0.0246 0.6641
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0072 0.0232 0.0232
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.011 0.0163
Schistosoma mansoni amine GPCR 0.0047 0.011 0.0163
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.006 0.0174 0.0174
Trypanosoma brucei polo-like protein kinase 0.01 0.037 0.1116
Echinococcus granulosus GPCR family 2 0.0032 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.011 0.011
Brugia malayi Tachykinin-like peptides receptor 99D 0.0047 0.011 0.0321
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0029 0.0024 0.0024
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.037 0.037
Onchocerca volvulus 0.0117 0.0451 0.1296
Schistosoma mansoni neuropeptide receptor 0.0047 0.011 0.0163
Entamoeba histolytica prolyl oligopeptidase family protein 0.0069 0.0218 0.5859
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Entamoeba histolytica hypothetical protein 0.0075 0.0246 0.6641
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0069 0.0218 0.0701
Plasmodium falciparum histone deacetylase 1 0.0077 0.0256 0.7088
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0012 0.0252
Plasmodium vivax hypothetical protein, conserved 0.0061 0.0179 0.4841
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0262 0.1152 0.4075
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Toxoplasma gondii histone deacetylase HDAC2 0.0077 0.0256 0.0742
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0262 0.1152 1
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0218 0.0701
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.011 0.0163
Echinococcus multilocularis GPCR, family 2 0.0032 0.0038 0.0038
Onchocerca volvulus 0.0047 0.011 0.0167
Echinococcus granulosus fmrfamide receptor 0.0047 0.011 0.011
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0124 0.331
Schistosoma mansoni cpg binding protein 0.0124 0.0483 0.0922
Trypanosoma cruzi oligopeptidase b 0.0262 0.1152 0.3743
Trichomonas vaginalis CAMK family protein kinase 0.01 0.037 1
Echinococcus granulosus g protein coupled receptor 0.0047 0.011 0.011
Brugia malayi exodeoxyribonuclease III family protein 0.0097 0.0355 0.112
Onchocerca volvulus 0.0047 0.011 0.0167
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.011 0.0163
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0047 0.011 0.0163
Schistosoma mansoni hypothetical protein 0.0032 0.0038 0.0017
Onchocerca volvulus 0.0047 0.011 0.0167
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Echinococcus multilocularis dna polymerase kappa 0.006 0.0174 0.0174
Brugia malayi G protein-coupled receptor 0.0047 0.011 0.0321
Loa Loa (eye worm) glutamate receptor 1 0.0032 0.0039 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0194 0.0334
Schistosoma mansoni jumonji/arid domain-containing protein 0.0081 0.0274 0.0497
Brugia malayi jmjC domain containing protein 0.02 0.0854 0.2749
Giardia lamblia Alanyl dipeptidyl peptidase 0.0069 0.0218 0.2212
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0038 0.0086
Toxoplasma gondii exonuclease III APE 0.0097 0.0355 0.1068
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Brugia malayi hypothetical protein 0.0047 0.011 0.0321
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0038 0.0038
Echinococcus multilocularis somatostatin receptor 0.0047 0.011 0.011
Echinococcus granulosus geminin 0.1043 0.4944 0.4944
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0012 0.0252
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0047 0.011 0.011
Trypanosoma brucei unspecified product 0.006 0.0174 0.0474
Brugia malayi Melatonin receptor type 1A 0.0047 0.011 0.0321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.011 0.0163
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0047 0.011 0.0321
Brugia malayi Dopamine receptor protein 1 0.0047 0.011 0.0321
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0038 0.0038
Echinococcus granulosus neuropeptide receptor 0.0047 0.011 0.011
Brugia malayi prolyl oligopeptidase family protein 0.0069 0.0218 0.0671
Schistosoma mansoni biogenic amine receptor 0.0047 0.011 0.0163
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.006 0.0174 0.0294
Brugia malayi prolyl oligopeptidase family protein 0.0069 0.0218 0.0671
Echinococcus granulosus neuropeptide receptor A26 0.0047 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0047 0.011 0.0321
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0238 0.1036 0.3344
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0012 0.0252
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0256 0.6902
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0219 0.0675
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.037 0.1196
Onchocerca volvulus 0.0047 0.011 0.0167
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Schistosoma mansoni ap endonuclease 0.0097 0.0355 0.0662
Echinococcus multilocularis neuropeptide FF receptor 2 0.0047 0.011 0.011
Onchocerca volvulus 0.0047 0.011 0.0167
Schistosoma mansoni jumonji/arid domain-containing protein 0.0081 0.0274 0.0497
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.037 0.1027
Echinococcus multilocularis prolyl endopeptidase 0.0658 0.3075 0.3075
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0047 0.011 0.0321
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0069 0.0218 0.5859
Brugia malayi sulfakinin receptor protein 0.0047 0.011 0.0321
Schistosoma mansoni myosin xvIII 0.0047 0.011 0.0163
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.011 0.011
Echinococcus multilocularis sex peptide receptor 0.0047 0.011 0.011
Chlamydia trachomatis glutamine binding protein 0.0042 0.0088 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.011 0.0163
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0069 0.0218 0.5859
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0012 0.0252
Loa Loa (eye worm) jmjC domain-containing protein 0.0081 0.0274 0.0856
Trypanosoma brucei DNA polymerase eta, putative 0.006 0.0174 0.0474
Brugia malayi Serotonin receptor 0.0047 0.011 0.0321
Brugia malayi prolyl oligopeptidase family protein 0.0069 0.0218 0.0671
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Trichomonas vaginalis CAMK family protein kinase 0.01 0.037 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0026 0.0011 0.0011
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.011 0.0321
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.006 0.1574
Echinococcus granulosus histone deacetylase 1 0.0077 0.0256 0.0256
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0174 0.0474
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.011 0.0321
Brugia malayi histone deacetylase 1 (HD1) 0.0077 0.0256 0.0796
Echinococcus granulosus peptide allatostatin:somatostatin 0.0047 0.011 0.011
Echinococcus multilocularis neuropeptide receptor 0.0047 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.011 0.011
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0047 0.011 0.0167
Leishmania major hypothetical protein, conserved 0.0037 0.006 0.0188
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.02 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Echinococcus granulosus snurportin 1 0.0324 0.1455 0.1455
Schistosoma mansoni terminal deoxycytidyl transferase 0.006 0.0174 0.0294
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0072 0.0232 0.0718
Schistosoma mansoni adenoreceptor 0.0047 0.011 0.0163
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0256 0.6902
Brugia malayi histone deacetylase 3 (HD3) 0.0077 0.0256 0.0796
Echinococcus multilocularis glutamate receptor 2 0.0041 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.0174 0.4682
Echinococcus granulosus tachykinin peptides receptor 99D 0.0047 0.011 0.011
Brugia malayi hypothetical protein 0.0047 0.011 0.0321
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0038 0.0086
Onchocerca volvulus 0.0047 0.011 0.0167
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0039 0.0018
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.006 0.006
Trichomonas vaginalis CAMK family protein kinase 0.01 0.037 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.037 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.006 0.1574
Schistosoma mansoni hypothetical protein 0.0047 0.011 0.0163
Loa Loa (eye worm) hypothetical protein 0.0069 0.0218 0.0671
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0218 0.0701
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Schistosoma mansoni serine/threonine protein kinase 0.01 0.037 0.0691
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0047 0.011 0.0321
Echinococcus granulosus somatostatin receptor 0.0047 0.011 0.011
Echinococcus multilocularis cpg binding protein 0.0124 0.0483 0.0483
Schistosoma mansoni alpha-1 adrenergic receptor 0.0047 0.011 0.0163
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0038 0.0038
Loa Loa (eye worm) histone deacetylase 3 0.0077 0.0256 0.0796
Loa Loa (eye worm) prolyl oligopeptidase 0.0069 0.0218 0.0671
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.011 0.0163
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0097 0.0355 0.0355
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0069 0.0218 0.0616
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.011 0.011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0238 0.1036 0.1036
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.02 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0037 0.006 0.0157
Leishmania major DNA polymerase eta, putative 0.006 0.0174 0.056
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0069 0.0218 0.0522
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.037 0.1196
Schistosoma mansoni voltage-gated potassium channel 0.0079 0.0264 0.0476
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0084 0.0177
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0059 0.0168 0.0168
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Echinococcus granulosus tar DNA binding protein 0.0064 0.0194 0.0194
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0097 0.0355 0.1068
Brugia malayi PHD-finger family protein 0.0061 0.0179 0.0546
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0047 0.011 0.011
Trichomonas vaginalis CAMK family protein kinase 0.01 0.037 1
Giardia lamblia PHD finger protein 15 0.0061 0.0179 0.0257
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0012 0.0252
Echinococcus granulosus neuropeptide FF receptor 2 0.0047 0.011 0.011
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.0174 0.0474
Schistosoma mansoni neuropeptide receptor 0.0047 0.011 0.0163
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0047 0.011 0.0321
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0262 0.1152 0.3743
Loa Loa (eye worm) prolyl oligopeptidase 0.0069 0.0218 0.0671
Entamoeba histolytica hypothetical protein, conserved 0.0069 0.0218 0.5859
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0047 0.011 0.0321
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0174 0.0474
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.011 0.0163
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0069 0.0218 0.0616
Echinococcus multilocularis jumonji domain containing protein 0.0085 0.0296 0.0296
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0238 0.1036 0.3344
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0374 0.1183
Schistosoma mansoni amine GPCR 0.0047 0.011 0.0163
Schistosoma mansoni jumonji domain containing protein 0.0159 0.0654 0.127
Brugia malayi beta-lactamase family protein 0.0037 0.006 0.0157
Brugia malayi G protein-coupled receptor F59B2.13 0.0047 0.011 0.0321
Brugia malayi hypothetical protein 0.0047 0.011 0.0321
Onchocerca volvulus Neuropeptide F receptor homolog 0.0047 0.011 0.0167
Toxoplasma gondii hypothetical protein 0.0069 0.0218 0.0616
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Schistosoma mansoni neuropeptide receptor 0.0047 0.011 0.0163
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.006 0.0188
Brugia malayi Dopamine receptor 0.0047 0.011 0.0321
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0658 0.3075 0.6195
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0047 0.011 0.011
Schistosoma mansoni hypothetical protein 0.0061 0.0179 0.0304
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0042 0.0088 0.0252
Schistosoma mansoni cpg binding protein 0.0124 0.0483 0.0922
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0174 0.0474
Echinococcus multilocularis G-protein coupled receptor, putative 0.0047 0.011 0.011
Treponema pallidum exodeoxyribonuclease (exoA) 0.0097 0.0355 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0077 0.0256 0.6902
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0069 0.0218 0.0218
Brugia malayi neuropeptide F receptor 0.0047 0.011 0.0321
Schistosoma mansoni glutamate receptor kainate 0.0032 0.0039 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.011 0.0163
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.006 0.0061
Echinococcus granulosus cpg binding protein 0.0124 0.0483 0.0483
Brugia malayi Histone deacetylase 1 0.0077 0.0256 0.0796
Echinococcus multilocularis dna polymerase eta 0.006 0.0174 0.0174
Brugia malayi Glutamate receptor 2 precursor 0.0032 0.0039 0.0087
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.1455 0.4711
Brugia malayi putative neuropeptide receptor 0.0047 0.011 0.0321
Brugia malayi Bromodomain containing protein 0.0061 0.0179 0.0546
Schistosoma mansoni biogenic amine receptor 0.0047 0.011 0.0163
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0047 0.011 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.011 0.0163
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0097 0.0355 0.112
Loa Loa (eye worm) jmjC domain-containing protein 0.0126 0.0495 0.1577
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.011 0.0321
Trypanosoma brucei unspecified product 0.0041 0.0084 0.0177
Echinococcus multilocularis acylamino acid releasing enzyme 0.0069 0.0218 0.0218
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0041 0.008 0.008
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0041 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0097 0.0355 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0012 0.0252
Echinococcus granulosus alpha 1A adrenergic receptor 0.0047 0.011 0.011
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0042 0.0088 0.0103
Echinococcus granulosus mixed lineage leukemia protein mll 0.0029 0.0024 0.0024
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0072 0.0232 0.0718
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.037 0.1168
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.037 0.1196
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0069 0.0218 0.0616
Trypanosoma brucei prolyl endopeptidase 0.0658 0.3075 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0069 0.0218 0.0382
Schistosoma mansoni hypothetical protein 0.0047 0.011 0.0163
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0194 0.0594
Trichomonas vaginalis histone deacetylase, putative 0.0077 0.0256 0.6902
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0047 0.011 0.011
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0012 0.0252
Loa Loa (eye worm) glutamate receptor 2 0.0032 0.0039 0.0087
Trichomonas vaginalis CAMK family protein kinase 0.01 0.037 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Echinococcus granulosus g-protein coupled receptor 0.0047 0.011 0.011
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0047 0.011 0.0321
Leishmania major histone deacetylase, putative 0.0077 0.0256 0.0826
Onchocerca volvulus 0.0047 0.011 0.0167
Echinococcus granulosus PHD finger protein rhinoceros 0.0061 0.0179 0.0179
Brugia malayi RNA binding protein 0.0064 0.0194 0.0594
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.037 0.1168
Loa Loa (eye worm) hypothetical protein 0.003 0.003 0.0059
Onchocerca volvulus 0.0047 0.011 0.0167
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.037 0.037
Brugia malayi prolyl oligopeptidase family protein 0.0069 0.0218 0.0671
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0097 0.0355 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0024 0.0024
Trypanosoma cruzi prolyl endopeptidase 0.0658 0.3075 1
Brugia malayi AKH receptor 0.0047 0.011 0.0321
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.1015 0.3565
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0069 0.0218 0.0218
Brugia malayi Dopamine receptor protein 2 0.0047 0.011 0.0321
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0097 0.0355 0.9252
Giardia lamblia Kinase, PLK 0.01 0.037 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0238 0.1036 0.2047
Echinococcus granulosus sex peptide receptor 0.0047 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0069 0.0219 0.0675
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0097 0.0355 0.0355
Brugia malayi ImpB/MucB/SamB family protein 0.006 0.0174 0.053
Loa Loa (eye worm) CXXC zinc finger family protein 0.0117 0.0451 0.1432
Brugia malayi hypothetical protein 0.0047 0.011 0.0321
Schistosoma mansoni hypothetical protein 0.0845 0.3985 0.8047
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.011 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.011 0.011
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0262 0.1152 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.006 0.0174 0.0174
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0069 0.0218 0.0382
Echinococcus granulosus prolyl endopeptidase 0.0658 0.3075 0.3075
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0047 0.011 0.0321
Schistosoma mansoni cpg binding protein 0.0117 0.0451 0.0856
Schistosoma mansoni histone deacetylase 0.0077 0.0256 0.046
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.0321
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0047 0.011 0.0321
Schistosoma mansoni hypothetical protein 0.0075 0.0246 0.044

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 122 nM Inhibition of HDAC3 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs ChEMBL. 20055418
IC50 (binding) > 30000 nM Inhibition of HDAC1 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs ChEMBL. 20055418
IC50 (binding) > 30000 nM Inhibition of HDAC2 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs ChEMBL. 20055418
IC50 (binding) > 30000 nM Inhibition of HDAC8 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs ChEMBL. 20055418
IC50 (binding) > 30000 nM Inhibition of HDAC10 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs ChEMBL. 20055418
IC50 (binding) > 30000 nM Inhibition of HDAC6 assessed as blockade of decorboxylation of carboxyfluorescein labeled acetylated peptide substrate after 17 hrs ChEMBL. 20055418
IC50 (functional) > 50 uM Growth inhibition of human BxPC3 cells after 72 hrs by MTS assay ChEMBL. 20055418
IC50 (functional) > 50 uM Growth inhibition of human HUPT3 cells after 72 hrs by MTS assay ChEMBL. 20055418
IC50 (functional) > 50 uM Growth inhibition of human MIAPaCa2 cells after 72 hrs by MTS assay ChEMBL. 20055418

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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