Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Angiotensin II type 1a (AT-1a) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0167 | 0.1864 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0167 | 0.1864 | 0.1864 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0167 | 0.1864 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0167 | 0.1864 | 0.5 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0147 | 0 | 0.5 |
Onchocerca volvulus | 0.0147 | 0 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0167 | 0.1864 | 0.1864 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0255 | 1 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0255 | 1 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0167 | 0.1864 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0167 | 0.1864 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0255 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0255 | 1 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0147 | 0 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0167 | 0.1864 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0167 | 0.1864 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0167 | 0.1864 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0167 | 0.1864 | 0.5 |
Onchocerca volvulus | 0.0147 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.000001 M | Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex | ChEMBL. | 8340921 |
IC50 (binding) | = 0.000001 M | Inhibition of specific binding of [125 I ] Angiotensin-II (0.2 nM) to bovine adrenal cortex | ChEMBL. | 8340921 |
Inhibition (functional) | = 66 % | Percent inhibition of the Angiotensin-II (0.1microg/kg, iv) induced pressor response after 3 hours of administration (3 mg/kg po) in rats | ChEMBL. | 8340921 |
Inhibition (functional) | = 66 % | Percent inhibition of the Angiotensin-II (0.1microg/kg, iv) induced pressor response after 3 hours of administration (3 mg/kg po) in rats | ChEMBL. | 8340921 |
Inhibition (functional) | = 93 % | Percent inhibition of the Angiotensin-II (0.1microg/kg, iv) induced pressor response after 7 hours of administration (3 mg/kg po) in rats | ChEMBL. | 8340921 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.