Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.008 | 0.028 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0072 | 0.0259 | 0.0259 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0044 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0539 | 0.1894 |
Leishmania major | sterol C-24 reductase, putative | 0.0046 | 0.0072 | 0.0301 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0148 | 0.0797 | 0.2802 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0438 | 0.2844 | 1 |
Brugia malayi | hypothetical protein | 0.0122 | 0.0607 | 0.2134 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0072 | 0.0259 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.008 | 0.028 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.145 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0072 | 0.0259 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0072 | 0.0259 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0072 | 0.0259 | 0.5 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0072 | 0.0259 | 0.1082 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0465 | 0.1635 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0438 | 0.2844 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.006 | 0.021 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0072 | 0.0259 | 0.1082 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0065 | 0.0205 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0374 | 0.2393 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0372 | 0.1307 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.0563 | 0.1979 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0438 | 0.2844 | 0.2844 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.008 | 0.008 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.008 | 0.008 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0072 | 0.0259 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0805 | 0.5437 | 0.5437 |
Schistosoma mansoni | microtubule-associated protein tau | 0.145 | 1 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0112 | 0.0539 | 0.0539 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0072 | 0.0259 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0374 | 0.2393 | 0.8414 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.006 | 0.006 |
Echinococcus granulosus | serotonin transporter | 0.0088 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0088 | 0.0372 | 0.1307 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1101 | 0.1101 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0607 | 0.2134 |
Trypanosoma cruzi | C-14 sterol reductase, putative | 0.0088 | 0.0372 | 0.1556 |
Echinococcus multilocularis | serotonin transporter | 0.0088 | 0.0372 | 0.0372 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0148 | 0.0797 | 0.2802 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0112 | 0.0539 | 0.0539 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0372 | 0.1307 |
Loa Loa (eye worm) | glutamate receptor | 0.0091 | 0.039 | 0.1372 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0228 | 0.1361 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0072 | 0.0253 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0374 | 0.2393 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0088 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0607 | 0.2134 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0076 | 0.0286 | 0.0286 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0072 | 0.0259 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.008 | 0.008 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.006 | 0.006 |
Schistosoma mansoni | inositol monophosphatase | 0.0072 | 0.0259 | 0.0259 |
Echinococcus granulosus | lamin b receptor | 0.0088 | 0.0372 | 0.0372 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0044 | 0.0061 | 0.0213 |
Trypanosoma cruzi | C-14 sterol reductase, putative | 0.0088 | 0.0372 | 0.1556 |
Loa Loa (eye worm) | inositol-1 | 0.0072 | 0.0259 | 0.091 |
Trypanosoma cruzi | sterol C-24 reductase, putative | 0.0046 | 0.0072 | 0.0301 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0072 | 0.0259 | 0.0259 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.006 | 0.006 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0438 | 0.2844 | 0.2844 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.008 | 0.028 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0101 | 0.0465 | 0.1635 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0797 | 0.2802 |
Echinococcus multilocularis | geminin | 0.0191 | 0.1101 | 0.1101 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0091 | 0.039 | 0.1372 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.008 | 0.008 |
Onchocerca volvulus | 0.0088 | 0.0372 | 0.1307 | |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0072 | 0.0259 | 0.1082 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.006 | 0.006 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0148 | 0.0797 | 0.2802 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.006 | 0.006 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.008 | 0.008 |
Loa Loa (eye worm) | serotonin transporter b | 0.0088 | 0.0372 | 0.1307 |
Echinococcus granulosus | geminin | 0.0191 | 0.1101 | 0.1101 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1101 | 0.1101 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.0607 | 0.2134 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0076 | 0.0286 | 0.0286 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.008 | 0.028 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.008 | 0.008 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0082 | 0.033 | 0.1159 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.006 | 0.006 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0088 | 0.0372 | 0.1307 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.0607 | 0.2134 |
Trypanosoma cruzi | sterol C-24 reductase, putative | 0.0046 | 0.0072 | 0.0301 |
Leishmania major | C-14 sterol reductase, putative | 0.0088 | 0.0372 | 0.1556 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0438 | 0.2844 | 0.2844 |
Schistosoma mansoni | Lamin B receptor (ERG24) | 0.0088 | 0.0372 | 0.0372 |
Schistosoma mansoni | inositol monophosphatase | 0.0072 | 0.0259 | 0.0259 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.0563 | 0.1979 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.0563 | 0.1979 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.008 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.2393 | 0.8414 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0076 | 0.0286 | 0.0286 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0438 | 0.2844 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0072 | 0.0259 | 0.1082 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0372 | 0.1307 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.006 | 0.021 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0103 | 0.0478 | 0.0478 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.008 | 0.008 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0088 | 0.0372 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0036 | 0 | 0.0001 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0088 | 0.0372 | 0.1307 |
Brugia malayi | Inositol-1 | 0.0072 | 0.0259 | 0.091 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0465 | 0.0465 |
Trypanosoma brucei | C-14 sterol reductase, putative | 0.0088 | 0.0372 | 0.1556 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.006 | 0.006 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.008 | 0.008 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0374 | 0.2393 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0088 | 0.0372 | 0.0372 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.008 | 0.008 |
Echinococcus multilocularis | lamin b receptor | 0.0088 | 0.0372 | 0.0372 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0065 | 0.0205 | 0.1507 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC90 (functional) | = 64 ug ml-1 | Antifungal activity against Cryptococcus neoformans by NCCLS broth microdilution method | ChEMBL. | 20138517 |
MIC90 (functional) | = 128 ug ml-1 | Antifungal activity against Candida albicans by NCCLS broth microdilution method | ChEMBL. | 20138517 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.