TDR Targets

Basic information

Technical information

TDR Targets ID: 113189
Name: 2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-3,4-dih ydrochromene-6-carbonitrile
MW: 270.326 | Formula: C16H18N2O2
H donors: 0 H acceptors: 2 LogP: 1.76 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1ccc2c(c1)C(CC(O2)(C)C)N1CCCC1=O
InChi: 1S/C16H18N2O2/c1-16(2)9-13(18-7-3-4-15(18)19)12-8-11(10-17)5-6-14(12)20-16/h5-6,8,13H,3-4,7,9H2,1-2H3
InChiKey: ASVOPFFRMQDCTM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chromane-6-carbonitrile
2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-3,4-dihydro-2H-1-benzopyran-6-carbonitrile
4-(2-ketopyrrolidino)-2,2-dimethyl-chroman-6-carbonitrile
2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile
2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-6-chromancarbonitrile
4-(2-ketopyrrolidin-1-yl)-2,2-dimethyl-chroman-6-carbonitrile

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0184	0.1093	0.1093
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1032	0.1032
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0175	0.1032	0.1287
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Loa Loa (eye worm)	norepinephrine transporter	0.0744	0.5045	0.5045
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0126	0.0686	0.0855
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0175	0.1032	0.1287
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0744	0.5045	0.5045
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0058	1
Echinococcus multilocularis	nAChR subunit	0.0359	0.233	0.2904
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0126	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0359	0.233	0.233
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0359	0.233	0.2904
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1032	0.1032
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0126	0.0686	0.0686
Onchocerca volvulus		0.0184	0.1093	0.104
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0359	0.233	0.233
Schistosoma mansoni	nAChR subunit	0.0359	0.233	0.233
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1032	0.1032
Loa Loa (eye worm)	ACC-1 protein	0.0359	0.233	0.233
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0359	0.233	0.2904
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0058	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.1093	0.1093
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0184	0.1093	0.1093
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0058	0.0073
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0359	0.233	0.2904
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0359	0.233	0.2904
Loa Loa (eye worm)	acetylcholine receptor protein	0.0175	0.1032	0.1032
Brugia malayi	Cation transporter family protein	0.0359	0.233	0.233
Schistosoma mansoni	nAChR subunit	0.0359	0.233	0.233
Brugia malayi	hypothetical protein	0.0175	0.1032	0.1032
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0359	0.233	0.2904
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1032	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Schistosoma mansoni	acetylcholine receptor-related	0.0175	0.1032	0.1032
Loa Loa (eye worm)	serotonin transporter b	0.0744	0.5045	0.5045
Plasmodium vivax	amine transporter, putative	0.0126	0.0686	1
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1032	0.1032
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0175	0.1032	0.1287
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0126	0.0686	0.5
Brugia malayi	beta-lactamase family protein	0.0037	0.0058	0.0058
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0126	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1032	0.1032
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.1166	0.8024	0.8024
Treponema pallidum	sodium- and chloride- dependent transporter	0.0744	0.5045	0.5
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0359	0.233	0.233
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0359	0.233	0.233
Echinococcus multilocularis	glycine receptor subunit beta	0.0359	0.233	0.2904
Onchocerca volvulus	Putative nachr subunit	0.1166	0.8024	0.8013
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0359	0.233	0.2904
Echinococcus granulosus	glycine receptor subunit beta	0.0359	0.233	0.2904
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0452	0.2987	0.2987
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1032	0.1032
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0175	0.1032	0.1032
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0359	0.233	0.2904
Loa Loa (eye worm)	GABA receptor subunit	0.0184	0.1093	0.1093
Schistosoma mansoni	nAChR subunit	0.0175	0.1032	0.1032
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0175	0.1032	0.1032
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0058	1
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0686	0.0686
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0126	0.0686	1
Loa Loa (eye worm)	hypothetical protein	0.0744	0.5045	0.5045
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0058	1
Brugia malayi	hypothetical protein	0.0175	0.1032	0.1032
Echinococcus granulosus	serotonin transporter	0.0744	0.5045	0.6287
Brugia malayi	excitatory GABA receptor EXP-1A	0.0359	0.233	0.233
Brugia malayi	Cytochrome P450 family protein	0.0061	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0359	0.233	0.233
Onchocerca volvulus		0.0126	0.0686	0.0632
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0126	0.0686	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0126	0.0686	0.0686
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0058	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0359	0.233	0.233
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0075	0.0325	0.0405
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0359	0.233	0.233
Loa Loa (eye worm)	hypothetical protein	0.0359	0.233	0.233
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0238	0.1478	1
Onchocerca volvulus		0.0359	0.233	0.2285
Loa Loa (eye worm)	hypothetical protein	0.1166	0.8024	0.8024
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0686	0.0686
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0126	0.0686	0.0686
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0126	0.0686	0.0855
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0058	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.1166	0.8024	0.8024
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0359	0.233	0.233
Echinococcus granulosus	glycine receptor subunit beta	0.0359	0.233	0.2904
Echinococcus granulosus	jumonji domain containing protein	0.0032	0.002	0.0025
Plasmodium falciparum	amino acid transporter, putative	0.0126	0.0686	0.5
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0058	1
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0686	0.0686
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0359	0.233	0.233
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.1166	0.8024	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0075	0.0325	0.0405
Loa Loa (eye worm)	cytochrome P450 family protein	0.0061	0.0224	0.0224
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0126	0.0686	0.0855
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0126	0.0686	0.0855
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.1446	1	1
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1032	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0359	0.233	0.233
Loa Loa (eye worm)	hypothetical protein	0.0184	0.1093	0.1093
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0184	0.1093	0.1093
Echinococcus multilocularis	nAChR subunit	0.0184	0.1093	0.1362
Schistosoma mansoni	neurotransmitter gated ion channel	0.0175	0.1032	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0359	0.233	0.233
Brugia malayi	jmjC domain containing protein	0.0075	0.0325	0.0325
Brugia malayi	beta-lactamase family protein	0.0037	0.0058	0.0058
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0359	0.233	0.2904
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0452	0.2987	0.2987
Loa Loa (eye worm)	hypothetical protein	0.0359	0.233	0.233
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0359	0.233	0.233
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1032	0.1032
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0126	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1032	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0359	0.233	0.233
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0184	0.1093	0.1093
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0359	0.233	0.233
Schistosoma mansoni	nAChR subunit	0.0359	0.233	0.233
Schistosoma mansoni	neurotransmitter gated ion channel	0.0184	0.1093	0.1093
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0359	0.233	0.233
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0126	0.0686	0.0686
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0058	0.0058
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.1166	0.8024	1
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0359	0.233	0.233
Onchocerca volvulus		0.0175	0.1032	0.098
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0359	0.233	0.233
Brugia malayi	Cation transporter family protein	0.0359	0.233	0.233
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0359	0.233	0.233
Loa Loa (eye worm)	hypothetical protein	0.0744	0.5045	0.5045
Schistosoma mansoni	microtubule-associated protein tau	0.0542	0.3622	0.3622
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Echinococcus granulosus	microtubule associated protein 2	0.0542	0.3622	0.4514
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0029	0	0.5
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0744	0.5045	0.5045
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0126	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0686	0.0686
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0058	0.0058
Onchocerca volvulus		0.1446	1	1
Loa Loa (eye worm)	hypothetical protein	0.0359	0.233	0.233
Loa Loa (eye worm)	hypothetical protein	0.0184	0.1093	0.1093
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0359	0.233	0.2904
Onchocerca volvulus		0.0175	0.1032	0.098
Onchocerca volvulus		0.0744	0.5045	0.5016
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0359	0.233	0.233
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0126	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.1271	0.8763	0.8763
Brugia malayi	hypothetical protein	0.0175	0.1032	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0184	0.1093	0.1093
Schistosoma mansoni	nAChR subunit	0.0359	0.233	0.233
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.1446	1	1
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1032	0.1032
Echinococcus granulosus	sodium and chloride dependent glycine	0.0126	0.0686	0.0855
Loa Loa (eye worm)	hypothetical protein	0.1446	1	1
Plasmodium vivax	hypothetical protein, conserved	0.0126	0.0686	1
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0175	0.1032	0.1032
Brugia malayi	hypothetical protein	0.0126	0.0686	0.0686
Onchocerca volvulus		0.1446	1	1
Loa Loa (eye worm)	hypothetical protein	0.0359	0.233	0.233
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0184	0.1093	0.1093
Loa Loa (eye worm)	hypothetical protein	0.0359	0.233	0.233
Toxoplasma gondii	hypothetical protein	0.0126	0.0686	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0359	0.233	0.2904
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0175	0.1032	0.1032
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0184	0.1093	0.1093
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0686	0.0686
Echinococcus multilocularis	jumonji domain containing protein	0.0032	0.002	0.0025
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0359	0.233	0.233
Loa Loa (eye worm)	hypothetical protein	0.1446	1	1
Schistosoma mansoni	nAChR subunit	0.0175	0.1032	0.1032
Echinococcus multilocularis	serotonin transporter	0.0744	0.5045	0.6287
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0359	0.233	0.2904
Onchocerca volvulus		0.0184	0.1093	0.104
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0058	1
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0058	0.5
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1032	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1032	0.1032
Onchocerca volvulus		0.0359	0.233	0.2285
Leishmania major	hypothetical protein, conserved	0.0037	0.0058	1
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0126	0.0686	0.0855
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0126	0.0686	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0184	0.1093	0.1093
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0126	0.0686	0.0686
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0175	0.1032	0.1032
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0744	0.5045	0.5045
Onchocerca volvulus		0.0175	0.1032	0.098
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0126	0.0686	0.0855
Schistosoma mansoni	nAChR subunit	0.0359	0.233	0.233
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0058	1
Loa Loa (eye worm)	hypothetical protein	0.0359	0.233	0.233
Toxoplasma gondii	ABC1 family protein	0.0037	0.0058	0.0852
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0744	0.5045	0.5045
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.1166	0.8024	1
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0452	0.2987	0.3723
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0175	0.1032	0.1287
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0359	0.233	0.233
Toxoplasma gondii	hypothetical protein	0.0126	0.0686	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0175	0.1032	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0686	0.0686
Echinococcus multilocularis	microtubule associated protein 2	0.0542	0.3622	0.4514
Echinococcus granulosus	sodium and chloride dependent glycine	0.0126	0.0686	0.0855
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0359	0.233	0.233
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.1166	0.8024	1
Schistosoma mansoni	nAChR subunit	0.0359	0.233	0.233
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0452	0.2987	0.3723
Onchocerca volvulus		0.0359	0.233	0.2285
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0126	0.0686	0.0686
Brugia malayi	hypothetical protein	0.0175	0.1032	0.1032
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0126	0.0686	0.0686
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0359	0.233	0.233
Loa Loa (eye worm)	hypothetical protein	0.0359	0.233	0.233
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0058	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0126	0.0686	0.0855
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0058	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0184	0.1093	0.1093
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0359	0.233	0.233
Echinococcus granulosus	nAChR subunit	0.0184	0.1093	0.1362
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.1166	0.8024	1
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1032	0.1032
Entamoeba histolytica	hypothetical protein	0.0184	0.1093	1
Brugia malayi	beta-lactamase	0.0037	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0359	0.233	0.233
Schistosoma mansoni	jumonji domain containing protein	0.006	0.0216	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0359	0.233	0.233
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0175	0.1032	0.1032
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0058	1
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0175	0.1032	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0359	0.233	0.233
Loa Loa (eye worm)	hypothetical protein	0.0359	0.233	0.233
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0126	0.0686	0.0686
Trichomonas vaginalis	esterase, putative	0.0037	0.0058	1
Schistosoma mansoni	neurotransmitter gated ion channel	0.0175	0.1032	0.1032
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0126	0.0686	0.0686
Schistosoma mansoni	sodium/chloride dependent transporter	0.0744	0.5045	0.5045
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0184	0.1093	0.1093
Loa Loa (eye worm)	hypothetical protein	0.0184	0.1093	0.1093
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0452	0.2987	0.3723
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0359	0.233	0.233
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0058	0.0058
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0058	0.5
Mycobacterium ulcerans	lipase LipD	0.0037	0.0058	1
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1032	0.1032
Schistosoma mansoni	sodium/chloride dependent transporter	0.0126	0.0686	0.0686
Onchocerca volvulus		0.1446	1	1
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0175	0.1032	0.1287
Onchocerca volvulus		0.0126	0.0686	0.0632
Loa Loa (eye worm)	jmjC domain-containing protein	0.0047	0.0129	0.0129
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0058	0.0073
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0126	0.0686	0.0855
Loa Loa (eye worm)	hypothetical protein	0.0359	0.233	0.233
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0126	0.0686	0.0686
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0175	0.1032	0.1032
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0126	0.0686	0.0855
Loa Loa (eye worm)	LGC-31 protein	0.0359	0.233	0.233
Loa Loa (eye worm)	ACC-1 protein	0.0359	0.233	0.233
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0359	0.233	0.233
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0058	0.0058
Schistosoma mansoni	nAChR subunit	0.0359	0.233	0.233
Plasmodium falciparum	transporter, putative	0.0126	0.0686	0.5
Onchocerca volvulus		0.0126	0.0686	0.0632
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.1166	0.8024	1
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0452	0.2987	0.3723
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0126	0.0686	1
Brugia malayi	hypothetical protein	0.0175	0.1032	0.1032
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0359	0.233	0.2904
Echinococcus granulosus	nAChR subunit	0.0359	0.233	0.2904

Activities

Activity type	Activity value	Assay description	Source	Reference
Max fall in blood pressure (functional)	= 15 %	Maximum fall in blood pressure was evaluated at an oral dose of 1.0 mg/kg in (SHR) spontaneous hypertensive rats	ChEMBL.	3783581
Max fall in blood pressure (functional)	= 45 %	Maximum fall in blood pressure was evaluated at an oral dose of 3.0 mg/kg in (SHR)spontaneous hypertensive rats	ChEMBL.	3783581

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL306196
PubChem: 13704372

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 113189