TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 363.337 | Formula: C17H16F3N5O
H donors: 1 H acceptors: 3 LogP: 3.66 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: FC(c1ccccc1OC1CCN(CC1)c1ncc2c(n1)[nH]cn2)(F)F
InChi: 1S/C17H16F3N5O/c18-17(19,20)12-3-1-2-4-14(12)26-11-5-7-25(8-6-11)16-21-9-13-15(24-16)23-10-22-13/h1-4,9-11H,5-8H2,(H,21,22,23,24)
InChiKey: YHSOKGLZUGZMOD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Acyl-CoA desaturase 1	Starlite/ChEMBL	References
Homo sapiens	stearoyl-CoA desaturase (delta-9-desaturase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Loa Loa (eye worm)	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium falciparum	stearoyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	stearic acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma congolense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei gambiense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium yoelii	delta-9 fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania mexicana	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Brugia malayi	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium knowlesi	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium berghei	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania mexicana	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Neospora caninum	fatty acyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase	Acyl-CoA desaturase 1	358 aa	317 aa	27.1 %
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase	Acyl-CoA desaturase 1	358 aa	317 aa	27.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0094	0.0154
Trichomonas vaginalis	alpha-glucosidase, putative	0.003	0.0153	0.033
Onchocerca volvulus		0.0207	0.2494	0.9257
Trypanosoma cruzi	major cysteine proteinase, putative	0.0054	0.0472	0.1753
Plasmodium vivax	importin-beta 2, putative	0.0031	0.0171	0.0535
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.007	0.0691	0.2564
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.2161	0.6277
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.003	0.0153	0.033
Brugia malayi	Glycosyl hydrolases family 31 protein	0.008	0.0811	0.1313
Leishmania major	GTP-binding protein, putative	0.0023	0.0063	0.0234
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0278	0.3418	0.5535
Entamoeba histolytica	hypothetical protein	0.0035	0.0224	0.2376
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0042	0.5
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0666	0.247
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0359	0.4486	0.4486
Plasmodium falciparum	importin beta, putative	0.0031	0.0171	0.0535
Entamoeba histolytica	hypothetical protein	0.0025	0.0094	0.0676
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0224	0.0224
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0042	0.0155
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0359	0.4486	0.7264
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.0171	0.0171
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.0063	0.0102
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0666	0.247
Trypanosoma cruzi	fatty acid desaturase, putative	0.0205	0.2457	0.9119
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.0445	0.0721
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.007	0.0691	0.0691
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.0691	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0021	0.0042	0.0603
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0666	0.247
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0359	0.4486	0.4486
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.007	0.0691	1
Echinococcus multilocularis	neutral alpha glucosidase AB	0.008	0.0811	0.0811
Schistosoma mansoni	survival motor neuron protein	0.0052	0.0445	0.0445
Trypanosoma brucei	fatty acid desaturase, putative	0.0223	0.2695	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.3418	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0666	0.247
Echinococcus granulosus	snurportin 1	0.0331	0.412	0.412
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.0171	0.2107
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0666	0.247
Leishmania major	alpha glucosidase II subunit, putative	0.008	0.0811	0.3009
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.003	0.0153	0.0568
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0042	0.5
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0042	0.0155
Brugia malayi	MH2 domain containing protein	0.0115	0.1281	0.2075
Trichomonas vaginalis	maltase-glucoamylase, putative	0.003	0.0153	0.033
Schistosoma mansoni	hypothetical protein	0.0052	0.0445	0.0445
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0042	0.0067
Trichomonas vaginalis	maltase-glucoamylase, putative	0.008	0.0811	0.2278
Echinococcus granulosus	importin subunit beta 1	0.0031	0.0171	0.0171
Trypanosoma brucei	glycosyl hydrolase-like protein	0.003	0.0153	0.0568
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0666	0.247
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0042	0.0155
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.003	0.0153	0.033
Trypanosoma cruzi	hypothetical protein, conserved	0.008	0.0811	0.3009
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0666	0.247
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0042	0.0603
Schistosoma mansoni	ran	0.0023	0.0063	0.0063
Leishmania major	fatty-acid desaturase, putative	0.0223	0.2695	1
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.003	0.0153	0.0568
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0331	0.412	0.6671
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.2161	0.6277
Onchocerca volvulus		0.0052	0.0445	0.1653
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0063	0.0587	0.218
Brugia malayi	hypothetical protein	0.0254	0.311	0.5036
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0042	0.0042
Loa Loa (eye worm)	MH2 domain-containing protein	0.0115	0.1281	0.2075
Trichomonas vaginalis	alpha-glucosidase, putative	0.003	0.0153	0.033
Toxoplasma gondii	exonuclease III APE	0.0021	0.0042	0.0514
Trichomonas vaginalis	alpha-glucosidase, putative	0.008	0.0811	0.2278
Toxoplasma gondii	aldehyde dehydrogenase	0.007	0.0691	0.8521
Leishmania major	stearic acid desaturase, putative	0.0223	0.2695	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0094	0.0154
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0666	0.247
Trichomonas vaginalis	alpha-glucosidase, putative	0.003	0.0153	0.033
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.2161	0.6277
Onchocerca volvulus	Glucosylceramidase homolog	0.0182	0.2161	0.8021
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.008	0.0811	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0666	0.247
Schistosoma mansoni	hypothetical protein	0.0331	0.412	0.412
Brugia malayi	Muscleblind-like protein	0.0487	0.6175	1
Leishmania major	cathepsin L-like protease	0.0069	0.0666	0.247
Brugia malayi	Glycosyl hydrolases family 31 protein	0.003	0.0153	0.0248
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.2161	0.6277
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0042	0.0067
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0666	0.247
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.0691	1
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0094	0.0348
Leishmania major	cathepsin L-like protease	0.0069	0.0666	0.247
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.0063	0.0102
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.008	0.0811	1
Brugia malayi	acyl-CoA desaturase	0.0205	0.2457	0.3979
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.003	0.0153	0.0568
Brugia malayi	RNA, U transporter 1	0.0088	0.0923	0.1495
Echinococcus multilocularis	microtubule associated protein 2	0.0777	1	1
Entamoeba histolytica	Ran family GTPase	0.0023	0.0063	0.0278
Trichomonas vaginalis	alpha-glucosidase, putative	0.008	0.0811	0.2278
Trypanosoma cruzi	fatty acid desaturase, putative	0.0205	0.2457	0.9119
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0278	0.3418	0.5535
Loa Loa (eye worm)	acyl-CoA desaturase	0.0205	0.2457	0.3979
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.3418	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.003	0.0153	0.033
Trichomonas vaginalis	alpha-glucosidase, putative	0.008	0.0811	0.2278
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.2161	0.6277
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.3418	1
Trichomonas vaginalis	sucrase-isomaltase, putative	0.008	0.0811	0.2278
Schistosoma mansoni	alpha-glucosidase	0.0309	0.3828	0.3828
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0094	0.0348
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.0063	0.0063
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.229	0.666
Schistosoma mansoni	importin beta-1	0.0031	0.0171	0.0171
Trichomonas vaginalis	alpha-glucosidase, putative	0.008	0.0811	0.2278
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.008	0.0811	0.1313
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.008	0.0811	0.2278
Loa Loa (eye worm)	transcription factor SMAD2	0.0115	0.1281	0.2075
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0171	0.0634
Loa Loa (eye worm)	hypothetical protein	0.003	0.0153	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0487	0.6175	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0023	0.0063	0.0063
Schistosoma mansoni	ap endonuclease	0.0021	0.0042	0.0042
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.003	0.0153	0.1448
Leishmania major	cathepsin L-like protease	0.0069	0.0666	0.247
Entamoeba histolytica	hypothetical protein	0.0035	0.0224	0.2376
Onchocerca volvulus		0.0223	0.2695	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.008	0.0811	0.2278
Trypanosoma brucei	glucosidase, putative	0.008	0.0811	0.3009
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0023	0.0063	0.0089
Schistosoma mansoni	hypothetical protein	0.0035	0.0224	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0171	0.0277
Plasmodium falciparum	stearoyl-CoA desaturase	0.0205	0.2457	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0069	0.0666	0.247
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.008	0.0811	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0224	0.0224
Schistosoma mansoni	ap endonuclease	0.0021	0.0042	0.0042
Echinococcus granulosus	survival motor neuron protein 1	0.0254	0.311	0.311
Brugia malayi	hypothetical protein	0.0035	0.0224	0.0363
Mycobacterium ulcerans	aldehyde dehydrogenase	0.007	0.0691	1
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0023	0.0063	0.0234
Schistosoma mansoni	alpha glucosidase	0.008	0.0811	0.0811
Schistosoma mansoni	aldehyde dehydrogenase	0.007	0.0691	0.0691
Trichomonas vaginalis	ran, putative	0.0023	0.0063	0.0063
Echinococcus multilocularis	survival motor neuron protein 1	0.0254	0.311	0.311
Onchocerca volvulus		0.0223	0.2695	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.3418	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.007	0.0691	0.0691
Echinococcus multilocularis	muscleblind protein	0.0487	0.6175	0.6175
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	0.0205	0.2457	1
Trypanosoma cruzi	fatty acid desaturase, putative	0.0223	0.2695	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.229	0.666
Echinococcus multilocularis	muscleblind protein 1	0.0487	0.6175	0.6175
Schistosoma mansoni	aldehyde dehydrogenase	0.007	0.0691	0.0691
Echinococcus granulosus	neutral alpha glucosidase AB	0.008	0.0811	0.0811
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0666	0.247
Entamoeba histolytica	hypothetical protein	0.0035	0.0224	0.2376
Leishmania major	glycosyl hydrolase-like protein	0.003	0.0153	0.0568
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0666	0.247
Echinococcus granulosus	lysosomal alpha glucosidase	0.0359	0.4486	0.4486
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0023	0.0063	1
Echinococcus multilocularis	snurportin 1	0.0331	0.412	0.412
Schistosoma mansoni	microtubule-associated protein tau	0.0777	1	1
Loa Loa (eye worm)	hypothetical protein	0.0487	0.6175	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0063	0.0234
Echinococcus granulosus	muscleblind protein	0.0487	0.6175	0.6175
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.008	0.0811	0.2278
Entamoeba histolytica	hypothetical protein	0.0035	0.0224	0.2376
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0094	0.0154
Brugia malayi	Importin beta-1 subunit	0.0031	0.0171	0.0277
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0224	0.0224
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0042	0.0042
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0042	0.0155
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0023	0.0063	0.0778
Schistosoma mansoni	ran	0.0023	0.0063	0.0063
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.2161	0.6277
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.3418	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0666	0.247
Trichomonas vaginalis	alpha-glucosidase, putative	0.003	0.0153	0.033
Loa Loa (eye worm)	hypothetical protein	0.0254	0.311	0.5036
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0359	0.4486	0.7264
Schistosoma mansoni	alpha-glucosidase	0.0309	0.3828	0.3828
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0063	0.0234
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.3418	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0666	0.247
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0023	0.0063	0.0089
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0171	0.0634
Trypanosoma cruzi	hypothetical protein, conserved	0.008	0.0811	0.3009
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.2161	0.6277

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 10 nM	Inhibition of rat SCD1 in rat liver microsome	ChEMBL.	21871798
IC50 (binding)	= 257 nM	Inhibition of SCD1 in human HepG2 cells	ChEMBL.	21871798
Inhibition (binding)		Inhibition of delta-5 desaturase	ChEMBL.	21871798
Inhibition (binding)		Inhibition of delta-6 desaturase	ChEMBL.	21871798

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1834451

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1136607