Detailed information for compound 113686

Basic information

Technical information
  • TDR Targets ID: 113686
  • Name: 9-chloro-2-phenyl-[1,2,4]triazolo[1,5-c][1,3] benzoxazin-5-one
  • MW: 297.696 | Formula: C15H8ClN3O2
  • H donors: 0 H acceptors: 3 LogP: 3.88 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)c1nc(nn1c(=O)o2)c1ccccc1
  • InChi: 1S/C15H8ClN3O2/c16-10-6-7-12-11(8-10)14-17-13(9-4-2-1-3-5-9)18-19(14)15(20)21-12/h1-8H
  • InChiKey: VHOCQCITNBFXRP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0052 0.0156 0.2094
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0018 0.0039 0.0515
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0047 0.0139 0.0077
Brugia malayi N-terminal motif family protein 0.0167 0.0544 0.8599
Echinococcus granulosus regulator of G protein signaling 3 0.0018 0.0039 0.0129
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0017 0.0066
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0038 0.0123
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0515
Echinococcus granulosus regulator of G protein signaling 7 0.0026 0.0067 0.024
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0017 0.0155
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0017 0.0155
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0019 0.0258
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0038 0.0491
Echinococcus multilocularis regulator of G protein signaling 3 0.0018 0.0039 0.0129
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0155
Schistosoma mansoni hypothetical protein 0.0186 0.0607 0.2425
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0025 0.0063 0.1585
Schistosoma mansoni dep domain containing protein 0.0008 0.0007 0.0027
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0017 0.0039
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0017 0.0135
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 0.2965 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0019 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0019 0.0258
Mycobacterium ulcerans undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase Rfe 0.0124 0.04 0.018
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0072 0.0224 0.5595
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0024 0.0061 0.1366
Brugia malayi Pre-SET motif family protein 0.0193 0.0631 1
Entamoeba histolytica hypothetical protein 0.0018 0.0039 0.0977
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0214 0.0854
Echinococcus granulosus Regulator of G protein signaling 20 0.0018 0.0039 0.0129
Brugia malayi Muscleblind-like protein 0.0135 0.0434 0.684
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0017 0.0066
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0515
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0072 0.0224 0.0161
Echinococcus multilocularis flap endonuclease 1 0.0024 0.0061 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0017 0.0155
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0017 0.0039
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0072 0.0224 0.5518
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0533
Echinococcus granulosus GPCR family 2 0.0017 0.0038 0.0123
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0039 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0019 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0533
Brugia malayi nuclear hormone receptor 0.0011 0.0017 0.0155
Echinococcus multilocularis UDP N acetylglucosamine dolichyl phosphate 0.0124 0.04 0.1574
Schistosoma mansoni dishevelled 0.0008 0.0007 0.0027
Brugia malayi Probable ClpP-like protease 0.0072 0.0224 0.3473
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0017 0.0039
Entamoeba histolytica Flap nuclease, putative 0.0024 0.0061 0.1514
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0072 0.0224 0.0868
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0017 0.0155
Schistosoma mansoni hypothetical protein 0.0747 0.2504 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0017 0.0039
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.2965 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0017 0.0039
Schistosoma mansoni coup transcription factor 0.0011 0.0017 0.0066
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0515
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0112 0.0358 0.1432
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0167 0.0544 0.752
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0017 0.0155
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0017 0.0066
Toxoplasma gondii hypothetical protein 0.0025 0.0063 0.1437
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0018 0.0039 0.0156
Brugia malayi Regulator of G protein signaling domain containing protein 0.0018 0.0039 0.0515
Schistosoma mansoni cpg binding protein 0.0055 0.0166 0.0665
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0515
Schistosoma mansoni flap endonuclease-1 0.0022 0.0053 0.0211
Brugia malayi PXA domain containing protein 0.0018 0.0039 0.0515
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.1127 0.3788 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0072 0.0224 0.043
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0017 0.0039
Loa Loa (eye worm) hypothetical protein 0.0055 0.0164 0.2514
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0155
Leishmania major UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0124 0.04 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0018 0.0039 0.0129
Echinococcus multilocularis cpg binding protein 0.0055 0.0166 0.0639
Loa Loa (eye worm) flap endonuclease-1 0.0024 0.0061 0.086
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0019 0.0258
Echinococcus granulosus flap endonuclease 1 0.0024 0.0061 0.0215
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0017 0.0039
Echinococcus multilocularis peptidase Clp (S14 family) 0.0047 0.0139 0.0531
Giardia lamblia UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase 0.0124 0.04 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0076 0.1106
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0515
Brugia malayi CXXC zinc finger family protein 0.0052 0.0156 0.2394
Loa Loa (eye worm) hypothetical protein 0.0072 0.0224 0.3473
Plasmodium falciparum UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0124 0.04 1
Brugia malayi regulator of G-protein signaling rgs-7 0.0018 0.0039 0.0515
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0038 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0019 0.0258
Echinococcus multilocularis muscleblind protein 1 0.0135 0.0434 0.171
Echinococcus granulosus UDP N acetylglucosamine dolichyl phosphate 0.0124 0.04 0.1574
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0037 0.0488
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0017 0.0039
Loa Loa (eye worm) hypothetical protein 0.0026 0.0067 0.096
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0214 0.0829
Schistosoma mansoni hypothetical protein 0.0037 0.0105 0.0421
Echinococcus granulosus axis inhibition protein axin 0.0018 0.0039 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0017 0.0155
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0017 0.0039
Brugia malayi hypothetical protein 0.0018 0.0039 0.0515
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0017 0.0155
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0017 0.0039
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0155
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0124 0.04 0.6294
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0027 0.0106
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0017 0.0066
Brugia malayi Regulator of G protein signaling domain containing protein 0.0018 0.0039 0.0515
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.0124 0.04 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0018 0.0039 0.0515
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0533
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0037 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0017 0.0155
Loa Loa (eye worm) hypothetical protein 0.0135 0.0434 0.684
Schistosoma mansoni axis inhibition protein axin 0.0018 0.0039 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0017 0.0155
Brugia malayi regulator of G-protein signaling egl-10 0.0026 0.0067 0.096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0038 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0017 0.0155
Echinococcus multilocularis regulator of G protein signaling 7 0.0026 0.0067 0.024
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0019 0.0258
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0017 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0017 0.0155
Echinococcus granulosus tumor protein p63 0.0311 0.1031 0.4104
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0214 0.0854
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0214 0.0854
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0155
Echinococcus multilocularis GPCR, family 2 0.0017 0.0038 0.0123
Schistosoma mansoni cellular tumor antigen P53 0.0046 0.0133 0.0532
Schistosoma mansoni regulator of G protein signaling 0.0026 0.0067 0.0267
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0018 0.0039 0.0156
Brugia malayi A-kinase anchor protein 10, precursor 0.0018 0.0039 0.0515
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0214 0.3315
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0017 0.0039
Echinococcus multilocularis expressed protein 0.0345 0.1146 0.4564
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0038 0.0123
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0105 0.1578
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0027 0.0079
Trichomonas vaginalis glucosaminephosphotransferase, putative 0.0124 0.04 0.5543
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0124 0.04 0.1597
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0019 0.0258
Brugia malayi hypothetical protein 0.0018 0.0039 0.0515
Plasmodium falciparum flap endonuclease 1 0.0024 0.0061 0.1514
Echinococcus multilocularis regulator of G protein signaling 7 0.0026 0.0067 0.024
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0017 0.0039
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0017 0.0066
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0017 0.0135
Loa Loa (eye worm) hypothetical protein 0.0017 0.0038 0.0491
Loa Loa (eye worm) CXXC zinc finger family protein 0.0052 0.0156 0.2394
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0124 0.04 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0076 0.0303
Echinococcus granulosus muscleblind protein 0.0135 0.0434 0.171
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0027 0.0079
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0017 0.0039
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0193 0.0631 1
Echinococcus multilocularis Regulator of G protein signaling 20 0.0018 0.0039 0.0129
Brugia malayi PXA domain containing protein 0.0018 0.0039 0.0515
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0124 0.04 1
Brugia malayi steroid hormone receptor 0.0011 0.0017 0.0155
Trypanosoma brucei UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0124 0.04 1
Trichomonas vaginalis helicase, putative 0.0012 0.0019 0.0258
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0026 0.0069 0.0247
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0076 0.0277
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0017 0.0155
Loa Loa (eye worm) hypothetical protein 0.0037 0.0105 0.1578
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.0124 0.04 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0076 0.0454
Echinococcus granulosus regulator of G protein signaling 3 0.0018 0.0039 0.0129
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0017 0.0066
Schistosoma mansoni z-protein (S1r protein) 0.0026 0.0067 0.0267
Brugia malayi ecdysteroid receptor 0.0011 0.0017 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0017 0.0155
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0017 0.0039
Trichomonas vaginalis flap endonuclease-1, putative 0.0024 0.0061 0.0832
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0019 0.0258
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0039 0.0156
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0017 0.0039
Echinococcus granulosus tar DNA binding protein 0.0069 0.0214 0.0829
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0017 0.0155
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0072 0.0224 0.5518
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0214 0.3315
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0017 0.0039
Schistosoma mansoni cpg binding protein 0.0055 0.0166 0.0665
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 0.1127 0.3788 1
Onchocerca volvulus 0.0011 0.0017 0.0135
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0164 0.2514
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0038 0.0491
Schistosoma mansoni peptidase Clp (S14 family) 0.0072 0.0224 0.0893
Schistosoma mansoni cpg binding protein 0.0052 0.0156 0.0624
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0017 0.0155
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0018 0.0039 0.0129
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0076 0.0303
Schistosoma mansoni dishevelled 0.0008 0.0007 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0017 0.0155
Loa Loa (eye worm) RNA binding protein 0.0069 0.0214 0.3315
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0124 0.04 0.1597
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0017 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0019 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0017 0.0155
Onchocerca volvulus 0.0029 0.0076 0.0967
Brugia malayi TAR-binding protein 0.0069 0.0214 0.3315
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0076 0.1758
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0019 0.0258
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0017 0.0066
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0026 0.0067 0.096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0017 0.0155
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0164 0.2514
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0017 0.0066
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0008 0.0032
Entamoeba histolytica hypothetical protein 0.0018 0.0039 0.0977
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0018 0.0039 0.0515
Echinococcus granulosus dnaJ subfamily B 0.0747 0.2504 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0072 0.0224 0.0868
Echinococcus multilocularis regulator of G protein signaling 0.0018 0.0039 0.0129
Schistosoma mansoni hypothetical protein 0.0186 0.0607 0.2425
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0017 0.0039
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.015
Loa Loa (eye worm) RGS-3 protein 0.0018 0.0039 0.0515
Echinococcus multilocularis axis inhibition protein axin 0.0018 0.0039 0.0129
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0039 0.0156
Echinococcus granulosus regulator of G protein signaling 7 0.0026 0.0067 0.024
Schistosoma mansoni axis inhibition protein axin 0.0018 0.0039 0.0156
Brugia malayi RNA binding protein 0.0069 0.0214 0.3315
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0076 0.0277
Loa Loa (eye worm) hypothetical protein 0.0135 0.0434 0.684
Onchocerca volvulus 0.0124 0.04 0.5504
Onchocerca volvulus 0.0046 0.0133 0.1769
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0533
Loa Loa (eye worm) hypothetical protein 0.0167 0.0544 0.8599
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0027 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0017 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0019 0.0258
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0037 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0019 0.0258
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0076 0.0303
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0533
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0019 0.0258
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0038 0.0491
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0214 0.3315
Echinococcus granulosus cpg binding protein 0.0055 0.0166 0.0639
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.015
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0037 0.0477
Echinococcus multilocularis dnaJ subfamily B 0.0747 0.2504 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0155
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0039 0.0156
Brugia malayi Pre-SET motif family protein 0.0029 0.0076 0.1106
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0017 0.0155
Toxoplasma gondii histone lysine methyltransferase SET1 0.01 0.0318 0.7927
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0039 0.0156
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0214 0.0854
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0018 0.0039 0.0533
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0017 0.0155
Echinococcus multilocularis axis inhibition protein axin 0.0018 0.0039 0.0129
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0017 0.0066
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 0.2965 1 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0018 0.0039 0.0129
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0017 0.0039
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0076 0.0277
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0017 0.0066
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0214 0.0854
Brugia malayi nuclear receptor NHR-88 0.0011 0.0017 0.0155
Echinococcus multilocularis tumor protein p63 0.0311 0.1031 0.4104
Echinococcus granulosus axis inhibition protein axin 0.0018 0.0039 0.0129
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0008 0.0007 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0017 0.0155
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0039 0.0156
Loa Loa (eye worm) hypothetical protein 0.0124 0.04 0.6294
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0018 0.0039 0.0156
Entamoeba histolytica UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0124 0.04 1
Entamoeba histolytica hypothetical protein 0.0018 0.0039 0.0977
Schistosoma mansoni regulator of G protein signaling 0.0018 0.0039 0.0156
Trichomonas vaginalis set domain proteins, putative 0.0219 0.0721 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0133 0.2022
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0072 0.0224 0.4809
Loa Loa (eye worm) PXA domain-containing protein 0.0018 0.0039 0.0515
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0533
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0076 0.0303
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0164 0.2514
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0017 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0019 0.0258
Echinococcus multilocularis geminin 0.0186 0.0607 0.2404
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0019 0.0258
Echinococcus granulosus expressed protein 0.0345 0.1146 0.4564
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0017 0.0066
Echinococcus granulosus beta-adrenergic receptor kinase 0.0018 0.0039 0.0129
Brugia malayi Flap endonuclease-1 0.0024 0.0061 0.086
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0018 0.0039 0.0129
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0025 0.0063 0.0083
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0017 0.0155
Onchocerca volvulus 0.0219 0.0721 1
Echinococcus multilocularis muscleblind protein 0.0135 0.0434 0.171
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0027 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0019 0.0258
Echinococcus granulosus geminin 0.0186 0.0607 0.2404
Schistosoma mansoni hypothetical protein 0.0017 0.0038 0.015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0155
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0155
Echinococcus granulosus peptidase Clp S14 family 0.0047 0.0139 0.0531

Activities

Activity type Activity value Assay description Source Reference
GR (binding) = 0.78 GABA ratio (where GABA ratio = IC50 (compound) / IC50 (compound + 10 uM GABA)). ChEMBL. 7783151
Ki (binding) = 568 nM Binding affinity at bovine Benzodiazepine receptor by [3H]-flunitrazepam displacement. ChEMBL. 7783151

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.