Detailed information for compound 113750

Basic information

Technical information
  • TDR Targets ID: 113750
  • Name: 1-cyano-3-(4-cyanophenyl)-2-[2-(2,6-dichlorop henyl)-1-(dimethylamino)ethyl]guanidine
  • MW: 401.292 | Formula: C19H18Cl2N6
  • H donors: 2 H acceptors: 2 LogP: 4.74 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CN/C(=N\C(N(C)C)Cc1c(Cl)cccc1Cl)/Nc1ccc(cc1)C#N
  • InChi: 1S/C19H18Cl2N6/c1-27(2)18(10-15-16(20)4-3-5-17(15)21)26-19(24-12-23)25-14-8-6-13(11-22)7-9-14/h3-9,18H,10H2,1-2H3,(H2,24,25,26)
  • InChiKey: CTXKRDCBIXHBQO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-cyano-1-(4-cyanophenyl)-2-[2-(2,6-dichlorophenyl)-1-dimethylaminoethyl]guanidine
  • 3-cyano-1-(4-cyanophenyl)-2-[2-(2,6-dichlorophenyl)-1-dimethylamino-ethyl]guanidine
  • AIDS-108616
  • AIDS108616
  • Guanidine, N''-cyano-N-(4-cyanophenyl)-N'-[2-(2,6-dichlorophenyl)-1-(N,N-dimethylamino)ethyl]-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0331 0.0377 0.0377
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0331 0.0377 0.0377
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0001
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0331 0.0377 0.0377
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0002 0.0002
Brugia malayi Protein-tyrosine phosphatase 1 0.0331 0.0377 0.0377
Brugia malayi CXXC zinc finger family protein 0.0028 0.0023 0.0023
Brugia malayi Cathepsin L-like precursor 0.0016 0.0009 0.0009
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.4943 0.577 1
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0009 0.0013
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0081 0.0085 0.0084
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Echinococcus granulosus GPCR family 2 0.0015 0.0008 0.0008
Trichomonas vaginalis cysteine synthase, putative 0.001 0.0002 0.0003
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0009 0.0009
Onchocerca volvulus 0.0331 0.0377 0.0651
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0331 0.0377 0.0377
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0331 0.0377 0.0377
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0009 0.0016
Onchocerca volvulus 0.0331 0.0377 0.0651
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0331 0.0377 0.0377
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0331 0.0377 0.0377
Trichomonas vaginalis threonine synthase, putative 0.001 0.0002 0.0003
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0331 0.0377 0.0377
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0002 0.0002
Brugia malayi Cathepsin L-like precursor 0.0016 0.0009 0.0009
Toxoplasma gondii aldehyde dehydrogenase 0.0118 0.0128 1
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0009 0.0013
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0008 0.0036
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0331 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Schistosoma mansoni thyroid hormone receptor 0.001 0.0002 0.0002
Brugia malayi EGF-like domain containing protein 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0001
Toxoplasma gondii pyridoxal-phosphate dependent superfamily protein 0.001 0.0002 0.0019
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0032 1
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Echinococcus multilocularis geminin 0.033 0.0376 0.0376
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.8561 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0032 0.0032
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0331 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0033 0.0029 0.0029
Schistosoma mansoni pcd6 interacting protein-related 0.0331 0.0377 0.0377
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0085 0.0085
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0009 0.0009
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0331 0.0377 0.0377
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.4943 0.577 0.577
Loa Loa (eye worm) ctsf protein 0.0016 0.0009 0.0009
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0003 0.0003
Onchocerca volvulus 0.0331 0.0377 0.0651
Trichomonas vaginalis cysteine synthase, putative 0.001 0.0002 0.0003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0002 0.0002
Echinococcus multilocularis adam 0.001 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0009 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0002 0.0002
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0002 0.0002
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0008 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0002 0.0002
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0008 0.0008
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0331 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0118 0.0128 0.0128
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0008 0.0046
Schistosoma mansoni hypothetical protein 0.0015 0.0008 0.0008
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Schistosoma mansoni protein tyrosine phosphatase 0.0331 0.0377 0.0377
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0118 0.0128 0.0317
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0063 0.0355
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0002 0.0001
Onchocerca volvulus 0.0331 0.0377 0.0651
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0002 0.0002
Brugia malayi hypothetical protein 0.0046 0.0044 0.0044
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0331 0.0377 0.0377
Schistosoma mansoni cpg binding protein 0.003 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Brugia malayi Protein-tyrosine phosphatase 0.0331 0.0377 0.0377
Loa Loa (eye worm) cysteine protease 0.0016 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0009 0.0016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0002 0.0002
Loa Loa (eye worm) cbs-prov protein 0.001 0.0002 0.0002
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0331 0.0377 0.2128
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0017 0.0094
Trypanosoma cruzi cystathionine beta-synthase 0.001 0.0002 0.001
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0032 0.0052
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0331 0.0377 0.0377
Leishmania major cathepsin L-like protease 0.0016 0.0009 0.0042
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0331 0.0377 0.0377
Schistosoma mansoni cysteine synthase 0.001 0.0002 0.0002
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0008 0.0046
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0063 0.0355
Entamoeba histolytica cysteine synthase A, putative 0.001 0.0002 0.0003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0002 0.0002
Brugia malayi EGF-like domain containing protein 0.001 0.0002 0.0002
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0002 0.0002
Onchocerca volvulus 0.0331 0.0377 0.0651
Echinococcus multilocularis protein jagged 2 0.001 0.0002 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.1524 0.1772 1
Trichomonas vaginalis cysteine synthase, putative 0.001 0.0002 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0009 0.0016
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Echinococcus multilocularis fibrillin 2 0.001 0.0002 0.0002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Echinococcus multilocularis integrin beta 2 0.0224 0.0252 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0063 0.0355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0063 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0009 0.0016
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0063 0.0355
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0331 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0001
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0008 0.0008
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0008 0.4899
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0001
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0331 0.0377 0.0377
Trypanosoma cruzi cystathionine beta-synthase 0.001 0.0002 0.001
Onchocerca volvulus 0.0331 0.0377 0.0651
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Schistosoma mansoni thyroid hormone receptor 0.001 0.0002 0.0002
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0008 0.0008
Trichomonas vaginalis cysteine synthase, putative 0.001 0.0002 0.0003
Leishmania major hypothetical protein, conserved 0.1524 0.1772 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0009 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0009 0.0016
Onchocerca volvulus 0.0016 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0331 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0331 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0085 0.0085
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0331 0.0377 0.0377
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0002 0.0001
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0032 0.0181
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0331 0.0377 0.0377
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0331 0.0377 0.0377
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0008 0.0008
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0331 0.0377 0.0377
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0331 0.0377 0.0377
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0009
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0331 0.0377 0.0377
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0063 0.0355
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0331 0.0377 0.0377
Entamoeba histolytica cysteine synthase A, putative 0.001 0.0002 0.0003
Entamoeba histolytica hypothetical protein 0.0023 0.0017 0.0029
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0063 0.0355
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0017 0.0026
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0017 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0008 0.0008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0008 0.0008
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0017 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0009 0.0016
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0002 0.0001
Trypanosoma cruzi cystathionine beta-synthase 0.001 0.0002 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0009 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0063 0.0355
Brugia malayi steroid hormone receptor 0.001 0.0002 0.0002
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0008 0.0522
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0002 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0063 0.0355
Onchocerca volvulus 0.0016 0.0009 0.0013
Leishmania major tyrosine specific protein phosphatase, putative 0.0331 0.0377 0.212
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Brugia malayi EGF-like domain containing protein 0.001 0.0002 0.0002
Onchocerca volvulus 0.0331 0.0377 0.0651
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0002 0.0002
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0032 0.0181
Brugia malayi Cathepsin L-like precursor 0.0011 0.0003 0.0003
Brugia malayi Cathepsin L-like precursor 0.0016 0.0009 0.0009
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0008 0.0008
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0331 0.0377 0.0377
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0032 0.0171
Leishmania major cathepsin L-like protease 0.0016 0.0009 0.0042
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0331 0.0377 0.0377
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Trichomonas vaginalis threonine synthase, putative 0.001 0.0002 0.0003
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0331 0.0377 0.0377
Onchocerca volvulus 0.0331 0.0377 0.0651
Echinococcus granulosus dnaJ subfamily B 0.0399 0.0457 0.0457
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0003 0.0003
Echinococcus multilocularis cysteine protease 0.0016 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0063 0.0355
Loa Loa (eye worm) fibroinase 0.0016 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.033 0.0376 0.0376
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0331 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0015 0.0008 0.0008
Onchocerca volvulus 0.0016 0.0009 0.0013
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0008 0.0008
Plasmodium vivax vivapain-2 0.0016 0.0009 0.5544
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0008
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0787 0.091 0.091
Trypanosoma cruzi cysteine synthase, putative 0.001 0.0002 0.001
Brugia malayi hypothetical protein 0.0331 0.0377 0.0377
Onchocerca volvulus 0.0028 0.0023 0.0037
Onchocerca volvulus 0.0331 0.0377 0.0651
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0331 0.0377 0.0377
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0008 0.0008
Brugia malayi Cathepsin L-like precursor 0.0016 0.0009 0.0009
Brugia malayi cathepsin L-like precursor 0.0011 0.0003 0.0003
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0331 0.0377 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0002 0.0002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0002 0.0002
Leishmania major cathepsin L-like protease 0.0016 0.0009 0.0042
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0085 0.0085
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0009 0.0009
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0017 0.5756
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0002 0.0002
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.4943 0.577 1
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0009 0.0009
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0331 0.0377 0.0377
Toxoplasma gondii cathepsin CPL 0.0016 0.0009 0.0607
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0002 0.0002
Echinococcus multilocularis GPCR, family 2 0.0015 0.0008 0.0008
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0331 0.0377 0.0377
Schistosoma mansoni hypothetical protein 0.0033 0.0029 0.0029
Trypanosoma cruzi serine sulfhydrylase 0.001 0.0002 0.001
Brugia malayi nuclear hormone receptor 0.001 0.0002 0.0002
Echinococcus granulosus geminin 0.033 0.0376 0.0376
Onchocerca volvulus 0.0331 0.0377 0.0651
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0002 0.0002
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0331 0.0377 0.0377
Schistosoma mansoni hypothetical protein 0.033 0.0376 0.0376
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1524 0.1772 0.3071
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0057 0.0319
Echinococcus multilocularis cysteine protease 0.0016 0.0009 0.0009
Plasmodium vivax vivapain-2 0.0016 0.0009 0.5544
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0331 0.0377 0.0377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0009 0.0016
Schistosoma mansoni hypothetical protein 0.0015 0.0008 0.0008
Onchocerca volvulus 0.0331 0.0377 0.0651
Onchocerca volvulus 0.0331 0.0377 0.0651
Loa Loa (eye worm) hypothetical protein 0.0046 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0009 0.0016
Onchocerca volvulus 4.1 G protein, putative homolog 0.0331 0.0377 0.0651
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0002 0.0001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0052 0.3996
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0331 0.0377 0.0377
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Trypanosoma cruzi cystathionine beta-synthase, putative 0.001 0.0002 0.001
Trypanosoma cruzi cystathionine beta-synthase, putative 0.001 0.0002 0.001
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0331 0.0377 0.0377
Echinococcus granulosus neuropeptide receptor A26 0.09 0.1042 0.1042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0063 0.0355
Schistosoma mansoni inositol monophosphatase 0.0036 0.0032 0.0032
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0002 0.0002
Brugia malayi isocitrate dehydrogenase 0.0015 0.0008 0.0008
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0032 0.0181
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0331 0.0377 0.0377
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0331 0.0377 0.0377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0009 0.0016
Brugia malayi Pyridoxal-phosphate dependent enzyme family protein 0.001 0.0002 0.0002
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0331 0.0377 0.0377
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0002 0.0001
Onchocerca volvulus 0.0331 0.0377 0.0651
Trypanosoma cruzi serine sulfhydrylase 0.001 0.0002 0.001
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Brugia malayi Inositol-1 0.0036 0.0032 0.0032
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0118 0.0128 0.0715
Entamoeba histolytica cysteine protease, putative 0.0016 0.0009 0.0016
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0331 0.0377 0.0377
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0032 0.0056
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0331 0.0377 0.0377
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Echinococcus granulosus cathepsin l1 0.0011 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0009 0.0016
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Loa Loa (eye worm) protein-tyrosine phosphatase 0.8561 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0047 0.0047
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0032 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0003 0.0005
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0017 0.1194
Echinococcus granulosus FTZ F1 alpha 0.001 0.0002 0.0002
Trypanosoma brucei protein tyrosine phosphatase 1 0.0331 0.0377 0.2128
Schistosoma mansoni aldehyde dehydrogenase 0.0118 0.0128 0.0128
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0009 0.0009
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.4943 0.577 1
Leishmania major cathepsin L-like protease 0.0062 0.0063 0.0345
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0008 0.0008
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0002 0.0002
Trypanosoma brucei cystathionine beta-synthase, putative 0.001 0.0002 0.001
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.4943 0.577 0.577
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0331 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0048 0.0047 0.0046
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.3419 0.3988 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0032 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0002 0.0001
Onchocerca volvulus 0.0016 0.0009 0.0013
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0017 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0009 0.0016
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0009 0.0009
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0331 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Brugia malayi hypothetical protein 0.0331 0.0377 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0002 0.0002
Schistosoma mansoni aldehyde dehydrogenase 0.0118 0.0128 0.0128
Toxoplasma gondii CBS family protein 0.001 0.0002 0.0019
Schistosoma mansoni cpg binding protein 0.003 0.0025 0.0025
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0002 0.0002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0002 0.0002
Brugia malayi Cathepsin L-like precursor 0.0016 0.0009 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0009 0.0016
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0032 0.0032
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0028 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0009 0.0016
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0008 0.0008
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0118 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0002 0.0002
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.0457 0.0457
Onchocerca volvulus 0.0011 0.0003 0.0002
Onchocerca volvulus 0.0016 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0331 0.0377 0.0654
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Echinococcus granulosus protein tyrosine phosphatase n9 0.0331 0.0377 0.0377
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0331 0.0377 0.0377
Brugia malayi cbs-prov protein 0.001 0.0002 0.0002
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0331 0.0377 0.0377
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0008 0.0008
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0008 0.0522
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0009 0.5544
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0009 0.5544
Schistosoma mansoni protein tyrosine phosphatase 0.0331 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0001
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0008 0.4899
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0008 0.0008
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.8561 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0009 0.0016
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0009 0.0009
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0009 0.0016
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0085 0.0085
Echinococcus granulosus fibrillin 2 0.001 0.0002 0.0002
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.1524 0.1772 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0331 0.0377 0.0377
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0029 0.0029
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0047 0.0267
Trichomonas vaginalis cysteine synthase, putative 0.001 0.0002 0.0003
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0331 0.0377 0.212
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0032 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0063 0.0355
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.0128 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0002 0.0002
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0331 0.0377 0.0377
Echinococcus granulosus fibrillin 1 0.001 0.0002 0.0002
Echinococcus multilocularis neuropeptide s receptor 0.09 0.1042 0.1042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0009 0.0016
Loa Loa (eye worm) inositol-1 0.0036 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0002 0.0002
Onchocerca volvulus 0.4943 0.577 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.0128 0.0219
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0331 0.0377 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0002 0.0002
Onchocerca volvulus 0.0331 0.0377 0.0651
Leishmania major cathepsin L-like protease 0.0016 0.0009 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0002 0.0002
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0331 0.0377 0.2128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0063 0.0355
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0331 0.0377 0.0377
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.006 0.006
Echinococcus granulosus integrin beta 2 0.0224 0.0252 0.0252
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0009 0.5544
Onchocerca volvulus 0.0331 0.0377 0.0651
Echinococcus multilocularis hypothetical protein 0.0331 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0331 0.0377 0.0377
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0331 0.0377 0.0377
Entamoeba histolytica protein tyrosine phosphatase, putative 0.4943 0.577 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.4943 0.577 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0331 0.0377 0.0654
Brugia malayi ecdysteroid receptor 0.001 0.0002 0.0002
Brugia malayi Cathepsin L-like precursor 0.0016 0.0009 0.0009
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0331 0.0377 0.0377
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0331 0.0377 0.0377
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0331 0.0377 0.0377
Schistosoma mansoni hypothetical protein 0.0015 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Schistosoma mansoni integrin beta subunit 0.0178 0.0198 0.0198
Leishmania major cathepsin L-like protease 0.0062 0.0063 0.0345
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0017 0.1194
Schistosoma mansoni cpg binding protein 0.0028 0.0023 0.0023
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.001 0.0002 0.0003
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0331 0.0377 0.0377
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0331 0.0377 0.0377
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0017 0.0084
Loa Loa (eye worm) protein tyrosine phosphatase 0.0331 0.0377 0.0377
Trypanosoma cruzi hypothetical protein, conserved 0.1524 0.1772 1
Leishmania major cathepsin L-like protease 0.0016 0.0009 0.0042
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.4943 0.577 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0032 0.0032
Echinococcus granulosus cathepsin l1 0.0016 0.0009 0.0009
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0331 0.0377 0.0377
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0331 0.0377 0.0377
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0047 0.0047
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0017 0.5
Giardia lamblia Protein tyrosine phosphatase 0.0331 0.0377 0.0651
Echinococcus multilocularis 0.0331 0.0377 0.0377
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0002 0.0002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0331 0.0377 0.0377
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0331 0.0377 0.0377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0009 0.0016
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Onchocerca volvulus 0.0016 0.0009 0.0013
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0063 0.0355
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0063 0.0355
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Onchocerca volvulus 0.0331 0.0377 0.0651
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0017 0.5
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0331 0.0377 0.0377
Brugia malayi hypothetical protein 0.0331 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0032 0.2407
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0002 0.0002
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0009 0.0009
Onchocerca volvulus 0.0331 0.0377 0.0651
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0331 0.0377 0.0377
Onchocerca volvulus 0.0016 0.0009 0.0013
Trichomonas vaginalis pten, drome, putative 0.0331 0.0377 0.0654
Brugia malayi EGF-like domain containing protein 0.001 0.0002 0.0002
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.4943 0.577 1
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0046 0.0044 0.0044
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0002 0.0002
Echinococcus multilocularis fibrillin 1 0.001 0.0002 0.0002
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0008 0.0008
Leishmania major cathepsin L-like protease 0.0062 0.0063 0.0345
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0009 0.0016
Trypanosoma cruzi serine sulfhydrylase 0.001 0.0002 0.001
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0002 0.0002
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0331 0.0377 0.0377
Entamoeba histolytica protein tyrosine phosphatase, putative 0.4943 0.577 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0331 0.0377 0.0377
Onchocerca volvulus 0.0331 0.0377 0.0651
Brugia malayi hypothetical protein 0.0331 0.0377 0.0377
Trypanosoma cruzi cysteine synthase, putative 0.001 0.0002 0.001
Onchocerca volvulus 0.0331 0.0377 0.0651
Schistosoma mansoni coup transcription factor 0.001 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0009 0.0016
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0008 0.0008
Schistosoma mansoni nuclear hormone receptor 0.001 0.0002 0.0002
Brugia malayi hypothetical protein 0.0331 0.0377 0.0377
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0331 0.0377 0.0377
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0009 0.0009
Schistosoma mansoni cysteine synthase 0.001 0.0002 0.0002
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.8561 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.0128 0.0219
Trypanosoma cruzi cystathionine beta-synthase, putative 0.001 0.0002 0.001
Entamoeba histolytica cysteine synthase A, putative 0.001 0.0002 0.0003
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.4943 0.577 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0331 0.0377 0.0377
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0003 0.0005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0331 0.0377 0.0377
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0331 0.0377 0.0377
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0009 0.0013
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0009 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0002 0.0002
Trichomonas vaginalis hypothetical protein 0.001 0.0002 0.0003
Onchocerca volvulus 0.0331 0.0377 0.0651
Echinococcus granulosus neuropeptide s receptor 0.09 0.1042 0.1042
Trypanosoma cruzi serine sulfhydrylase 0.001 0.0002 0.001
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0331 0.0377 0.0377
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0331 0.0377 0.0377
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.1524 0.1772 0.3071
Echinococcus multilocularis cpg binding protein 0.003 0.0025 0.0025
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0331 0.0377 0.0377
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0009 0.0016
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0009 0.0016
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0001
Brugia malayi Protein-tyrosine phosphatase 0.0331 0.0377 0.0377
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0002 0.0002
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0009 0.0009
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0009 0.0042
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0009 0.0052
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.4943 0.577 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0002 0.0001
Loa Loa (eye worm) integrin beta-2 0.0303 0.0344 0.0344
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0001
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0331 0.0377 0.2128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0001
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0008 0.0046
Echinococcus granulosus cpg binding protein 0.003 0.0025 0.0025
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0028 0.0065
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0331 0.0377 0.0377
Echinococcus multilocularis neuropeptide receptor A26 0.09 0.1042 0.1042
Trichomonas vaginalis cysteine synthase, putative 0.001 0.0002 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0002 0.0002
Schistosoma mansoni protein tyrosine phosphatase 0.0331 0.0377 0.0377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0009 0.0016
Brugia malayi Kelch motif family protein 0.0046 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.0399 0.0457 0.0457
Brugia malayi Integrin beta pat-3 precursor 0.0303 0.0344 0.0344
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0009 0.0016
Onchocerca volvulus 0.0331 0.0377 0.0651
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0002 0.0002
Brugia malayi Cathepsin L-like precursor 0.0011 0.0003 0.0003
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0331 0.0377 0.0654
Onchocerca volvulus 0.0331 0.0377 0.0651
Onchocerca volvulus 0.0081 0.0085 0.0144
Onchocerca volvulus 0.0331 0.0377 0.0651
Echinococcus granulosus adam 0.001 0.0002 0.0002
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0009 0.0009

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 12.9 uM Compound potency to achieve protection of MT-4 cells from HIV-1 cytopathicity ChEMBL. 11527703

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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