Detailed information for compound 1140392

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 249.312 | Formula: C12H19N5O
  • H donors: 3 H acceptors: 1 LogP: 1.46 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccc(cc1)/C=N/NC(=N)NO)CC
  • InChi: 1S/C12H19N5O/c1-3-17(4-2)11-7-5-10(6-8-11)9-14-15-12(13)16-18/h5-9,18H,3-4H2,1-2H3,(H3,13,15,16)/b14-9+
  • InChiKey: RJMNLWQZDYYPIR-NTEUORMPSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0106 0.0763
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0042 0.0234 0.0995
Brugia malayi Pre-SET motif family protein 0.003 0.011 0.0409
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0196 0.1889 0.1889
Schistosoma mansoni ets-related 0.0235 0.231 0.8454
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.2041 0.7615
Plasmodium falciparum glutathione reductase 0.003 0.0106 0.1492
Loa Loa (eye worm) hypothetical protein 0.0095 0.0808 0.3016
Echinococcus multilocularis exocyst complex component 2 0.0042 0.0234 0.0873
Echinococcus multilocularis beta LACTamase domain containing family member 0.0149 0.1385 0.5168
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.1385 0.5888
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0106 0.0763
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.2295 0.8565
Loa Loa (eye worm) hypothetical protein 0.0095 0.0808 0.3016
Loa Loa (eye worm) hypothetical protein 0.0042 0.0234 0.0873
Loa Loa (eye worm) hypothetical protein 0.0145 0.1347 0.5029
Brugia malayi Probable exocyst complex component Sec5 0.0042 0.0234 0.0873
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0234 0.0995
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0106 0.0763
Brugia malayi Thioredoxin reductase 0.0086 0.0708 0.2643
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0826 0.3025
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0196 0.1889 0.1889
Loa Loa (eye worm) glutathione reductase 0.0086 0.0708 0.2643
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.0354 1
Plasmodium vivax thioredoxin reductase, putative 0.0086 0.0708 0.5113
Trichomonas vaginalis penicillin-binding protein, putative 0.0149 0.1385 0.5888
Loa Loa (eye worm) beta-lactamase 0.0149 0.1385 0.5168
Loa Loa (eye worm) hypothetical protein 0.0145 0.1347 0.5029
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0106 0.0763
Onchocerca volvulus Huntingtin homolog 0.0127 0.1147 0.4625
Mycobacterium tuberculosis Probable dehydrogenase 0.0196 0.1889 0.1889
Schistosoma mansoni semaphorin 5-related 0.0095 0.0808 0.2958
Brugia malayi Sema domain containing protein 0.0095 0.0808 0.3016
Trichomonas vaginalis penicillin-binding protein, putative 0.0149 0.1385 0.5888
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0106 0.0763
Loa Loa (eye worm) hypothetical protein 0.0133 0.121 0.4515
Echinococcus multilocularis plexin a4 0.0269 0.268 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0149 0.1385 0.1385
Brugia malayi beta-lactamase 0.0149 0.1385 0.5168
Loa Loa (eye worm) hypothetical protein 0.0149 0.1385 0.5168
Loa Loa (eye worm) hypothetical protein 0.0042 0.0234 0.0873
Onchocerca volvulus 0.0149 0.1385 0.5687
Loa Loa (eye worm) hypothetical protein 0.0042 0.0234 0.0873
Giardia lamblia NADH oxidase lateral transfer candidate 0.003 0.0106 1
Brugia malayi beta-lactamase family protein 0.0149 0.1385 0.5168
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0149 0.1385 0.5168
Loa Loa (eye worm) fli-1 protein 0.0235 0.231 0.8619
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0106 0.0763
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0106 0.0394
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0106 0.0763
Schistosoma mansoni hypothetical protein 0.0095 0.0808 0.2958
Loa Loa (eye worm) hypothetical protein 0.0042 0.0234 0.0873
Echinococcus multilocularis GA binding protein alpha chain 0.0077 0.0617 0.2304
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0106 0.1492
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.1385 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0467 0.3369
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0826 0.3084
Loa Loa (eye worm) hypothetical protein 0.0095 0.0808 0.3016
Loa Loa (eye worm) hypothetical protein 0.0228 0.2232 0.8329
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0106 0.1492
Trypanosoma cruzi trypanothione reductase, putative 0.0086 0.0708 0.5113
Loa Loa (eye worm) sema domain-containing protein 0.0095 0.0808 0.3016
Entamoeba histolytica hypothetical protein 0.0042 0.0234 0.6615
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0106 0.0763
Brugia malayi Fli-1 protein 0.0235 0.231 0.8619
Mycobacterium tuberculosis Probable hydrolase 0.0149 0.1385 0.1385
Brugia malayi plexin A 0.0269 0.268 1
Echinococcus granulosus plexin a4 0.0269 0.268 1
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0042 0.0234 0.0995
Plasmodium vivax hypothetical protein, conserved 0.0149 0.1385 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0467 0.0467
Plasmodium vivax SET domain protein, putative 0.003 0.011 0.0791
Echinococcus multilocularis semaphorin 5B 0.0095 0.0808 0.3016
Loa Loa (eye worm) plexin A 0.0269 0.268 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0106 0.0763
Mycobacterium ulcerans lipase LipD 0.0149 0.1385 1
Onchocerca volvulus Huntingtin homolog 0.0127 0.1147 0.4625
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0826 0.3084
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0149 0.1385 0.5168
Echinococcus multilocularis transcription factor collier 0.0042 0.0234 0.0873
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0077 0.0617 0.2304
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1347 0.5029
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0149 0.1385 0.1385
Onchocerca volvulus 0.0149 0.1385 0.5687
Echinococcus granulosus transcription factor collier 0.0042 0.0234 0.0873
Entamoeba histolytica tyrosin kinase, putative 0.0053 0.0354 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.011 0.0409
Entamoeba histolytica hypothetical protein 0.0042 0.0234 0.6615
Brugia malayi hypothetical protein 0.0095 0.0808 0.3016
Echinococcus granulosus exocyst complex component 2 0.0042 0.0234 0.0873
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0467 0.3369
Loa Loa (eye worm) hypothetical protein 0.0095 0.0808 0.3016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.011 0.0401
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0467 0.1741
Onchocerca volvulus 0.0239 0.2352 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0234 0.0995
Loa Loa (eye worm) hypothetical protein 0.0149 0.1385 0.5168
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0467 0.1741
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.011 0.0401
Schistosoma mansoni hypothetical protein 0.0042 0.0234 0.0856
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0106 0.0763
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0234 0.0995
Loa Loa (eye worm) hypothetical protein 0.0127 0.1147 0.4279
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0149 0.1385 0.1385
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.011 0.0409
Echinococcus granulosus muscleblind protein 0.0145 0.1347 0.5029
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0149 0.1385 1
Onchocerca volvulus 0.0228 0.2232 0.9464
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0098 0.0364
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0196 0.1889 0.1889
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0042 0.0234 0.0995
Toxoplasma gondii ABC1 family protein 0.0149 0.1385 1
Brugia malayi hypothetical protein 0.0095 0.0808 0.3016
Trichomonas vaginalis esterase, putative 0.0149 0.1385 0.5888
Onchocerca volvulus 0.0149 0.1385 0.5687
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0106 0.0763
Echinococcus granulosus semaphorin 1A 0.0095 0.0808 0.3016
Loa Loa (eye worm) hypothetical protein 0.0066 0.0497 0.1854
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0106 0.0763
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.1385 0.5888
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0106 0.0763
Plasmodium falciparum glutathione reductase 0.0086 0.0708 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.0808 0.3016
Loa Loa (eye worm) hypothetical protein 0.0149 0.1385 0.5168
Schistosoma mansoni hypothetical protein 0.0042 0.0234 0.0856
Loa Loa (eye worm) hypothetical protein 0.0127 0.1147 0.4279
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.011 0.0791
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.011 0.0401
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0106 0.0763
Mycobacterium ulcerans hypothetical protein 0.0149 0.1385 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0826 0.3084
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0106 0.0449
Loa Loa (eye worm) sema domain-containing protein 0.0095 0.0808 0.3016
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0826 0.3084
Brugia malayi Plexin repeat family protein 0.0228 0.2232 0.8329
Echinococcus granulosus GA binding protein alpha chain 0.0077 0.0617 0.2304
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0106 0.0106
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0467 0.3369
Entamoeba histolytica cell surface protease gp63, putative 0.0042 0.0234 0.6615
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0106 0.0387
Echinococcus multilocularis hypothetical protein 0.0095 0.0808 0.3016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0467 0.3369
Brugia malayi Sema domain containing protein 0.0095 0.0808 0.3016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0826 0.3025
Leishmania major trypanothione reductase 0.0086 0.0708 0.5113
Onchocerca volvulus 0.0095 0.0808 0.3115
Schistosoma mansoni plexin 0.0133 0.121 0.4429
Entamoeba histolytica hypothetical protein 0.0042 0.0234 0.6615
Treponema pallidum NADH oxidase 0.003 0.0106 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0106 0.0394
Mycobacterium tuberculosis Probable oxidoreductase 0.0218 0.2124 0.2124
Loa Loa (eye worm) hypothetical protein 0.003 0.011 0.0409
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0467 0.1708
Loa Loa (eye worm) hypothetical protein 0.0149 0.1385 0.5168
Echinococcus granulosus semaphorin 5B 0.0095 0.0808 0.3016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0826 0.3084
Plasmodium vivax glutathione reductase, putative 0.0086 0.0708 0.5113
Mycobacterium tuberculosis Probable reductase 0.0196 0.1889 0.1889
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0826 0.3025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0826 0.3084
Mycobacterium tuberculosis Conserved protein 0.0149 0.1385 0.1385
Toxoplasma gondii thioredoxin reductase 0.0086 0.0708 0.5113
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0467 0.3369
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0106 0.0763
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0218 0.2124 0.2124
Mycobacterium ulcerans beta-lactamase 0.0149 0.1385 1
Brugia malayi Ets-domain containing protein 0.0077 0.0617 0.2304
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.1385 0.5888
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0106 0.0763
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0022 0.0021 0.0078
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.011 0.0409
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0149 0.1385 0.5069
Brugia malayi Muscleblind-like protein 0.0145 0.1347 0.5029
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0218 0.2124 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.1385 0.5168
Leishmania major hypothetical protein, conserved 0.0149 0.1385 1
Trypanosoma brucei trypanothione reductase 0.0086 0.0708 0.5113
Echinococcus granulosus beta LACTamase domain containing family member 0.0149 0.1385 0.5168
Brugia malayi IPT/TIG domain containing protein 0.0042 0.0234 0.0873
Entamoeba histolytica hypothetical protein 0.0042 0.0234 0.6615
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0106 1
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0106 0.0763
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0022 0.0021 0.0078
Echinococcus granulosus thioredoxin glutathione reductase 0.0086 0.0714 0.2663
Plasmodium falciparum thioredoxin reductase 0.003 0.0106 0.1492
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0106 0.0763
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0196 0.1889 0.6825
Schistosoma mansoni hypothetical protein 0.0133 0.121 0.4429
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0106 0.0763
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.1385 1
Schistosoma mansoni hypothetical protein 0.0095 0.0808 0.2958
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0106 0.0763
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0234 0.0995
Mycobacterium tuberculosis Conserved protein 0.0149 0.1385 0.1385
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0234 0.0995
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0042 0.0234 0.0995
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.003 0.0106 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0149 0.1385 1
Schistosoma mansoni fibrocystin l 0.0042 0.0234 0.0856
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0196 0.1889 0.1889
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0106 0.0763
Mycobacterium tuberculosis Probable esterase LipL 0.0149 0.1385 0.1385
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0234 0.0995
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0106 0.0394
Loa Loa (eye worm) hypothetical protein 0.0149 0.1385 0.5168
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0218 0.2124 0.2124
Brugia malayi glutathione reductase 0.0086 0.0708 0.2643
Mycobacterium tuberculosis Probable lipase LipD 0.0149 0.1385 0.1385
Loa Loa (eye worm) thioredoxin reductase 0.0086 0.0708 0.2643
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.003 0.0106 1
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0106 0.0449
Trichomonas vaginalis set domain proteins, putative 0.0239 0.2352 1
Brugia malayi Ets-domain containing protein 0.0077 0.0617 0.2304
Schistosoma mansoni plexin 0.0228 0.2232 0.817
Brugia malayi beta-lactamase family protein 0.0149 0.1385 0.5168
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0467 0.1708
Brugia malayi follicle stimulating hormone receptor 0.0234 0.2295 0.8565
Mycobacterium ulcerans esterase/lipase LipP 0.0149 0.1385 1
Schistosoma mansoni gabp alpha 0.0077 0.0617 0.226
Brugia malayi hypothetical protein 0.0127 0.1147 0.4279
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0106 0.0763
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.011 0.0401
Loa Loa (eye worm) hypothetical protein 0.0095 0.0808 0.3016
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0106 0.0763
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0086 0.0708 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0234 0.0995
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0149 0.1385 0.5069
Brugia malayi Pre-SET motif family protein 0.021 0.2041 0.7615
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0106 0.0763
Mycobacterium tuberculosis Probable lipase LipE 0.0149 0.1385 0.1385
Mycobacterium tuberculosis Conserved protein 0.0149 0.1385 0.1385
Echinococcus multilocularis muscleblind protein 0.0145 0.1347 0.5029
Plasmodium falciparum thioredoxin reductase 0.0086 0.0708 1
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0042 0.0234 0.0995
Echinococcus multilocularis thioredoxin glutathione reductase 0.0086 0.0714 0.2663
Brugia malayi DNA-binding protein LAG-1 0.0042 0.0234 0.0873

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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