TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 165.207 | Formula: C10H12FN
H donors: 1 H acceptors: 0 LogP: 1.52 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: NC[C@H]1C[C@@H]1c1cccc(c1)F
InChi: 1S/C10H12FN/c11-9-3-1-2-7(4-9)10-5-8(10)6-12/h1-4,8,10H,5-6,12H2/t8-,10-/m1/s1
InChiKey: ASHHTAGUESNAIP-PSASIEDQSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0361	0.6279	1
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0525	0.3222
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0019	0.0159	0.0159
Brugia malayi	steroid hormone receptor	0.0019	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0479	0.8382	0.8382
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0019	0.0159	0.0254
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0019	0.0159	0.0159
Schistosoma mansoni	hypothetical protein	0.0017	0.0126	0.0201
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0096	0.1531	0.5216
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0071	0.1097	0.1686
Schistosoma mansoni	nuclear hormone receptor	0.0019	0.0159	0.0254
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0361	0.6279	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0019	0.0159	0.0159
Echinococcus granulosus	hormone sensitive lipase	0.0226	0.3873	0.6168
Echinococcus granulosus	ecdysone induced protein 78C	0.0019	0.0159	0.0254
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0013	0.0046	0.0074
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0019	0.0159	0.0159
Echinococcus multilocularis	ecdysone induced protein 78C	0.0019	0.0159	0.0254
Schistosoma mansoni	coup transcription factor	0.0019	0.0159	0.0254
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0164	0.5
Loa Loa (eye worm)	sirtuin 4	0.0013	0.0046	0.0046
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0019	0.0159	0.0159
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0164	0.0189
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0142	0.2357	0.3754
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.028	0.0375
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0071	0.1097	0.1748
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0226	0.3873	0.6168
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0361	0.6279	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0019	0.0159	0.0254
Echinococcus granulosus	GPCR family 2	0.0017	0.0126	0.0201
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0019	0.0159	0.0254
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0019	0.0159	0.0052
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.1097	0.1686
Schistosoma mansoni	thyroid hormone receptor	0.0019	0.0159	0.0254
Echinococcus granulosus	FTZ F1 alpha	0.0019	0.0159	0.0254
Brugia malayi	thymidylate synthase	0.0361	0.6279	0.6279
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0096	0.1531	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0019	0.0159	0.0254
Schistosoma mansoni	thyroid hormone receptor	0.0019	0.0159	0.0254
Loa Loa (eye worm)	acetyltransferase	0.0146	0.243	0.243
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0361	0.6279	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0019	0.0159	0.0254
Loa Loa (eye worm)	transcriptional regulator	0.0013	0.0046	0.0046
Onchocerca volvulus		0.0019	0.0159	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0159	0.0159
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.0013	0.0046	0.0074
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0525	0.3959
Schistosoma mansoni	hypothetical protein	0.0146	0.2424	0.3861
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.028	0.0375
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.008	0.1255	0.1999
Echinococcus granulosus	transcription factor Dp 1	0.0041	0.056	0.0892
Schistosoma mansoni	hypothetical protein	0.0017	0.0126	0.0201
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.0013	0.0046	0.0074
Onchocerca volvulus	Protein ultraspiracle homolog	0.0019	0.0159	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0164	0.0164
Brugia malayi	MH2 domain containing protein	0.0122	0.1999	0.1999
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0126	0.0126
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0013	0.0046	0.0046
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0145	0.0159
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.028	0.1931
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.028	0.1931
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0019	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0159	0.0159
Mycobacterium tuberculosis	Hypothetical protein	0.0172	0.2893	0.4568
Schistosoma mansoni	hypothetical protein	0.0017	0.0126	0.0201
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0019	0.0159	0.0159
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0159	0.0159
Echinococcus multilocularis	jun protein	0.0179	0.3025	0.4817
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0019	0.0159	0.0254
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0145	0.0159
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0126	0.0201
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0096	0.1531	0.5216
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0146	0.243	0.3871
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0019	0.0159	0.0159
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0043	0.0589	0.087
Schistosoma mansoni	jun-related protein	0.0146	0.2424	0.3861
Brugia malayi	ecdysteroid receptor	0.0019	0.0159	0.0159
Loa Loa (eye worm)	transcriptional regulator	0.0013	0.0046	0.0046
Brugia malayi	Death domain containing protein	0.0016	0.0116	0.0116
Echinococcus multilocularis	thymidylate synthase	0.0361	0.6279	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0019	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0159	0.0159
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.028	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1307	0.1307
Echinococcus granulosus	thymidylate synthase	0.0361	0.6279	1
Echinococcus multilocularis	FTZ F1 alpha	0.0019	0.0159	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0479	0.8382	0.8382
Echinococcus granulosus	death domain containing protein	0.0016	0.0116	0.0185
Schistosoma mansoni	transcription factor LCR-F1	0.008	0.1255	0.1999
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0019	0.0159	0.0254
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0179	0.3025	0.4817
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0096	0.1531	0.5216
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.028	0.0375
Echinococcus multilocularis	Ankyrin	0.0017	0.0119	0.0189
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.0013	0.0046	0.0074
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0071	0.1097	0.1748
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.028	0.1931
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0019	0.0159	0.0254
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0019	0.0159	0.0159
Mycobacterium ulcerans	thymidylate synthase	0.0361	0.6279	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0019	0.0159	0.0254
Brugia malayi	hypothetical protein	0.0141	0.2337	0.2337
Loa Loa (eye worm)	hypothetical protein	0.0037	0.048	0.048
Brugia malayi	Steroid receptor seven-up type 2	0.0019	0.0159	0.0159
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0013	0.0046	0.0074
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.1097	0.1686
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.028	0.0375
Brugia malayi	Uncoordinated protein 44	0.0016	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0026	0.028	0.028
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0019	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0164	0.0164
Onchocerca volvulus		0.0026	0.028	0.0197
Mycobacterium ulcerans	hypothetical protein	0.0026	0.028	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0569	1	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0164	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0026	0.028	0.028
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0043	0.0589	0.087
Schistosoma mansoni	chromatin regulatory protein sir2	0.0013	0.0046	0.0074
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0013	0.0046	0.0074
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0146	0.243	0.3871
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.028	0.0375
Schistosoma mansoni	RAR-like nuclear receptor	0.0019	0.0159	0.0254
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0019	0.0159	0.0159
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0016	0.0116	0.0185
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0071	0.1097	0.1097
Schistosoma mansoni	hypothetical protein	0.0016	0.0116	0.0185
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0126	0.0126
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0361	0.6279	1
Onchocerca volvulus		0.0141	0.2337	0.2686
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0172	0.2893	0.4568
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0071	0.1097	0.8695
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0159	0.0159
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0019	0.0159	0.0254
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0019	0.0159	0.0254
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.028	0.0375
Echinococcus granulosus	jun protein	0.0179	0.3025	0.4817
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.028	0.028
Schistosoma mansoni	hypothetical protein	0.008	0.1255	0.1999
Onchocerca volvulus	Bile acid receptor homolog	0.0019	0.0159	0.0052
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.028	0.0375
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0043	0.0589	0.1905
Brugia malayi	acetyltransferase, GNAT family protein	0.0146	0.243	0.243
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.028	0.0375
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0126	0.0201
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0071	0.1097	0.1097
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0019	0.0159	0.0254
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0043	0.0589	0.087
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0043	0.0589	0.1905
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.028	0.0375
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0019	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0159	0.0159
Onchocerca volvulus		0.0361	0.6279	0.7455
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0019	0.0159	0.0254
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0361	0.6279	1
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0071	0.1097	0.1748
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0096	0.1531	0.2439
Echinococcus granulosus	chromatin regulatory protein sir2	0.0013	0.0046	0.0074
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0071	0.1097	0.1686
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0164	0.0164
Schistosoma mansoni	chromatin regulatory protein sir2	0.0013	0.0046	0.0074
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0016	0.0116	0.0185
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0019	0.0159	0.0159
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0019	0.0159	0.0159
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0016	0.0116	0.0116
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0019	0.0159	0.0254
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0226	0.3873	0.6168
Schistosoma mansoni	retinoic acid receptor RXR	0.0019	0.0159	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0164	0.0164
Schistosoma mansoni	chromatin regulatory protein sir2	0.0013	0.0046	0.0074
Schistosoma mansoni	hypothetical protein	0.0037	0.048	0.0765
Echinococcus multilocularis	hormone sensitive lipase	0.0226	0.3873	0.6168
Entamoeba histolytica	hypothetical protein	0.008	0.1255	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0164	0.0164
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.0013	0.0046	0.0074
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0126	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0226	0.3873	0.3873
Brugia malayi	nuclear hormone receptor	0.0019	0.0159	0.0159
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.028	0.0375
Loa Loa (eye worm)	steroid hormone receptor	0.0019	0.0159	0.0159
Schistosoma mansoni	hypothetical protein	0.0017	0.0126	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0174	0.2937	0.2937
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.1999	0.1999
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0785	0.0785
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0096	0.1531	0.1531
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0019	0.0159	0.0254
Entamoeba histolytica	hypothetical protein	0.008	0.1255	1
Schistosoma mansoni	chromatin regulatory protein sir2	0.0013	0.0046	0.0074
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.048	0.048
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0116	0.0116
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0019	0.0159	0.0254
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0019	0.0159	0.0254
Loa Loa (eye worm)	runx1	0.006	0.0895	0.0895
Brugia malayi	hypothetical protein	0.008	0.1255	0.1255
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0785	0.0785
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1531	0.1531
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0043	0.0589	0.0938
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0084	0.1333	0.2122
Schistosoma mansoni	chromatin regulatory protein sir2	0.0013	0.0046	0.0074
Schistosoma mansoni	hormone-sensitive lipase (S09 family)	0.0226	0.3873	0.6168
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0017	0.0119	0.0189
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0019	0.0159	0.0254
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0096	0.1531	0.2439
Echinococcus granulosus	Ankyrin	0.0017	0.0119	0.0189
Schistosoma mansoni	chromatin regulatory protein sir2	0.0096	0.1531	0.2439
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0016	0.0116	0.0116
Loa Loa (eye worm)	thymidylate synthase	0.0361	0.6279	0.6279
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0361	0.6279	1
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.028	0.028
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0013	0.0046	0.0046
Loa Loa (eye worm)	transcriptional regulator	0.0013	0.0046	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0026	0.028	0.028
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0179	0.3025	0.4817
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0019	0.0159	0.0159
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.008	0.1255	0.1999
Schistosoma mansoni	ankyrin 23/unc44	0.0016	0.0116	0.0185
Entamoeba histolytica	hypothetical protein	0.008	0.1255	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0096	0.1531	0.5216
Echinococcus granulosus	netrin receptor unc 5	0.0016	0.0116	0.0185
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.1999	0.1999
Onchocerca volvulus		0.0479	0.8382	1
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0361	0.6279	1
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0084	0.1333	0.2122
Schistosoma mansoni	netrin receptor unc5	0.0016	0.0116	0.0185
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0019	0.0159	0.0159
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0126	0.0201
Echinococcus multilocularis	netrin receptor unc 5	0.0016	0.0116	0.0185
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0164	0.0189
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.028	0.028
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0019	0.0159	0.0254
Echinococcus multilocularis	Protein lozenge	0.006	0.0895	0.1426
Schistosoma mansoni	chromatin regulatory protein sir2	0.0013	0.0046	0.0074
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0019	0.0159	0.0159
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0126	0.0201
Brugia malayi	hypothetical protein	0.0479	0.8382	0.8382
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0159	0.0159
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0126	0.0201
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.028	0.0375
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0164	0.0189
Brugia malayi	hypothetical protein	0.0172	0.2893	0.2893
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0019	0.0159	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0159	0.0159
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0361	0.6279	1
Brugia malayi	nuclear receptor NHR-88	0.0019	0.0159	0.0159
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0785	0.0785
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0785	0.0785
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0019	0.0159	0.0159
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0013	0.0046	0.0046
Schistosoma mansoni	lozenge	0.006	0.0895	0.1426
Entamoeba histolytica	hypothetical protein	0.008	0.1255	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0145	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0119	0.0119
Brugia malayi	photoreceptor-specific nuclear receptor	0.0019	0.0159	0.0159
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0019	0.0159	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0159	0.0159
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0019	0.0159	0.0254
Brugia malayi	bZIP transcription factor family protein	0.0179	0.3025	0.3025
Echinococcus multilocularis	transcription factor Dp 1	0.0041	0.056	0.0892
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0145	0.0159
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0126	0.0126
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0525	0.0768
Trichomonas vaginalis	conserved hypothetical protein	0.0172	0.2893	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1187187

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1144602