Detailed information for compound 1157941

Basic information

Technical information
  • TDR Targets ID: 1157941
  • Name: (4S,5R,6S)-5-acetamido-6-[(1R,2S)-1-amino-2,3 -dihydroxypropyl]-4-(diaminomethylideneamino) -5,6-dihydro-4H-pyran-2-carboxylic acid
  • MW: 331.325 | Formula: C12H21N5O6
  • H donors: 7 H acceptors: 5 LogP: -5.52 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]([C@H]([C@@H]1OC(=C[C@@H]([C@H]1NC(=O)C)NC(=N)N)C(=O)O)N)O
  • InChi: 1S/C12H21N5O6/c1-4(19)16-9-5(17-12(14)15)2-7(11(21)22)23-10(9)8(13)6(20)3-18/h2,5-6,8-10,18,20H,3,13H2,1H3,(H,16,19)(H,21,22)(H4,14,15,17)/t5-,6+,8+,9+,10-/m0/s1
  • InChiKey: DQUPXJPWBBJBMZ-LUTUWXHWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4S,5R,6S)-5-acetamido-6-[(1R,2S)-1-amino-2,3-dihydroxy-propyl]-4-guanidino-5,6-dihydro-4H-pyran-2-carboxylic acid
  • (4S,5R,6S)-5-acetamido-6-[(1R,2S)-1-amino-2,3-dihydroxypropyl]-4-guanidino-5,6-dihydro-4H-pyran-2-carboxylic acid
  • (4S,5R,6S)-5-acetamido-6-[(1R,2S)-1-amino-2,3-dihydroxy-propyl]-4-(diaminomethylideneamino)-5,6-dihydro-4H-pyran-2-carboxylic acid
  • AIDS-164229
  • AIDS164229
  • 5-Acetylamino-6-(1-amino-2,3-dihydroxy-propyl)-4-(diaminomethyl-amino)-5,6-dihydro-4H-pyran-2-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0017 0.0004 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0366 0.0366
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0169 0.4079
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0022 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0035 0.0081 0.0081
Onchocerca volvulus 0.003 0.0057 0.026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0086 0.0086
Echinococcus granulosus jumonji domain containing 1A 0.0022 0.0026 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0078 0.0355
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.0678 0.3086
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0409 0.3545
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0008 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0078 0.0078
Echinococcus granulosus cathepsin l1 0.0017 0.0004 0.0004
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0078 0.0355
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0000023496 0.0000023496
Trichomonas vaginalis set domain proteins, putative 0.0284 0.1145 1
Echinococcus granulosus lysine specific demethylase 5A 0.0086 0.0297 0.0297
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0068 0.031
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0033 0.0033
Brugia malayi hypothetical protein 0.0036 0.0085 0.0385
Loa Loa (eye worm) hypothetical protein 0.0034 0.0078 0.0355
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.107 0.9339
Toxoplasma gondii PHD-finger domain-containing protein 0.0069 0.0227 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0078 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0212 0.4854
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0078 0.0078
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.015 0.0685
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0004 0.002
Brugia malayi PHD-finger family protein 0.0024 0.0035 0.0158
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0679 0.2835 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.0366 0.1667
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0004 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0086 0.0086
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0038 0.0038
Onchocerca volvulus Alhambra homolog 0.0069 0.0227 0.1034
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0678 0.5905
Brugia malayi nuclear receptor RXR 0.0018 0.0008 0.0038
Schistosoma mansoni lozenge 0.0066 0.0215 0.0215
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0078 0.0078
Brugia malayi nuclear receptor NHR-88 0.0034 0.0078 0.0355
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0069 0.0227 0.0227
Loa Loa (eye worm) ctsf protein 0.0017 0.0004 0.002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0078 0.0355
Echinococcus multilocularis cpg binding protein 0.0031 0.0064 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0366 0.0366
Onchocerca volvulus 0.0017 0.0004 0.002
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0119
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.0016 0.0000023496 0.0000023496
Onchocerca volvulus 0.0017 0.0004 0.002
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.0366 0.1667
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0078 0.0078
Echinococcus granulosus dnaJ subfamily B 0.0421 0.1735 0.1735
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0366 0.0366
Echinococcus granulosus GPCR family 2 0.0016 0.0000023496 0.0000023496
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0004 0.0004
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0078 0.0078
Trypanosoma cruzi polo-like protein kinase, putative 0.0112 0.0409 1
Brugia malayi hypothetical protein 0.0018 0.0008 0.0038
Loa Loa (eye worm) hypothetical protein 0.0056 0.0169 0.0771
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0068 0.031
Echinococcus multilocularis cysteine protease 0.0017 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0529 0.2197 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0022 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0069 0.0227 0.0227
Echinococcus multilocularis jumonji domain containing protein 0.0096 0.0343 0.0343
Echinococcus multilocularis lysine specific demethylase 5A 0.0084 0.029 0.029
Loa Loa (eye worm) jmjC domain-containing protein 0.0022 0.0026 0.0119
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0008 0.0038
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0409 0.3545
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0212 0.5133
Schistosoma mansoni phosphatidylserine receptor 0.0022 0.0026 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0212 0.4854
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0212 0.4854
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0034 0.0078 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0078 0.0355
Echinococcus granulosus neuropeptide receptor A26 0.0477 0.1971 0.1971
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0457 0.2081
Toxoplasma gondii PHD-finger domain-containing protein 0.0069 0.0227 1
Echinococcus granulosus phd:f box containing protein 0.0022 0.0026 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0409 0.0409
Echinococcus multilocularis peregrin 0.0069 0.0227 0.0227
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0152 0.3643
Treponema pallidum hypothetical protein 0.0679 0.2835 0.5
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0004 0.0004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0078 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0078 0.0355
Schistosoma mansoni intermediate filament proteins 0.006 0.0187 0.0187
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0008 0.0038
Leishmania major cathepsin L-like protease 0.0066 0.0212 0.5133
Echinococcus multilocularis lamin 0.006 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0069 0.0227 0.1034
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0078 0.0078
Onchocerca volvulus 0.0017 0.0004 0.002
Brugia malayi jmjC domain containing protein 0.0022 0.0026 0.0119
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0023 0.0027 0.1038
Trypanosoma cruzi polo-like protein kinase, putative 0.0112 0.0409 1
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0679 0.2835 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.107 0.9339
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0022 0.0026 0.0542
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0078 0.0078
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0078 0.0078
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0086 0.0086
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0008 0.0038
Echinococcus granulosus intermediate filament protein 0.006 0.0187 0.0187
Schistosoma mansoni jumonji domain containing protein 0.018 0.0703 0.0703
Loa Loa (eye worm) hypothetical protein 0.0034 0.0078 0.0355
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0086 0.3662
Brugia malayi Bromodomain containing protein 0.0069 0.0227 0.1034
Schistosoma mansoni cpg binding protein 0.0031 0.0064 0.0064
Giardia lamblia Kinase, PLK 0.0112 0.0409 1
Echinococcus granulosus peregrin 0.0069 0.0227 0.0227
Brugia malayi jmjC domain containing protein 0.0022 0.0026 0.0119
Brugia malayi AF-10 protein 0.0023 0.0027 0.0125
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.107 0.9339
Echinococcus granulosus cpg binding protein 0.0031 0.0064 0.0064
Schistosoma mansoni jumonji/arid domain-containing protein 0.0086 0.0297 0.0297
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0169 0.4079
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0078 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0078 0.0355
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0205 0.0205
Loa Loa (eye worm) jmjC domain-containing protein 0.0022 0.0026 0.0119
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0004 0.002
Loa Loa (eye worm) hypothetical protein 0.0051 0.015 0.0685
Loa Loa (eye worm) hypothetical protein 0.0034 0.0078 0.0355
Onchocerca volvulus 0.0017 0.0004 0.002
Schistosoma mansoni jumonji domain containing protein 0.0022 0.0026 0.0026
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0054 0.0054
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0409 0.3545
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0038
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0078 0.0078
Loa Loa (eye worm) fibroinase 0.0017 0.0004 0.002
Loa Loa (eye worm) hypothetical protein 0.0059 0.0183 0.0832
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0078 0.0078
Loa Loa (eye worm) PHD-finger family protein 0.0069 0.0227 0.1034
Onchocerca volvulus 0.006 0.0187 0.0853
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0078 0.0078
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0409 0.3545
Brugia malayi Pre-SET motif family protein 0.0249 0.0998 0.4543
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0004 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0086 0.0086
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0078 0.0355
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0227 0.0902 0.0902
Leishmania major hypothetical protein, conserved 0.0022 0.0026 0.0542
Onchocerca volvulus 0.006 0.0187 0.0853
Schistosoma mansoni cpg binding protein 0.003 0.0057 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0078 0.0355
Onchocerca volvulus 0.0529 0.2197 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0078 0.0078
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0227 0.0902 0.0902
Schistosoma mansoni protein phosphatase 2C 0.0022 0.0026 0.0026
Echinococcus multilocularis microtubule associated protein 2 0.2352 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0366 0.0366
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0366 0.0366
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0212 0.4854
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0078 0.0355
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0078 0.0078
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0078 0.0355
Schistosoma mansoni hypothetical protein 0.0016 0.0000023496 0.0000023496
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0078 0.0078
Echinococcus multilocularis neuropeptide receptor A26 0.0477 0.1971 0.1971
Loa Loa (eye worm) intermediate filament protein 0.006 0.0187 0.0853
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.0033 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0078 0.0355
Onchocerca volvulus 0.0017 0.0004 0.002
Loa Loa (eye worm) jmjC domain-containing protein 0.0143 0.0543 0.2473
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0004 0.0004
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0008 0.0008
Onchocerca volvulus 0.0034 0.0078 0.0355
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.1735 0.1735
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0078 0.0078
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0035 0.0109
Echinococcus granulosus lysine specific demethylase 6a 0.0022 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0025 0.0038 0.0038
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0034 0.0078 0.0355
Brugia malayi jmjC domain containing protein 0.0086 0.0297 0.1352
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0212 0.4854
Trypanosoma brucei polo-like protein kinase 0.0112 0.0409 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0112 0.0409 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0078 0.0078
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.0072 0.0327
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0004 0.002
Schistosoma mansoni coup transcription factor 0.0034 0.0078 0.0078
Schistosoma mansoni kinase 0.0057 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0119 0.0439 0.2
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0008 0.0008
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0022 0.0026 0.0984
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0167 0.1428
Brugia malayi jmjC domain containing protein 0.0227 0.0902 0.4108
Schistosoma mansoni hypothetical protein 0.0023 0.0027 0.0027
Toxoplasma gondii LsmAD domain-containing protein 0.0056 0.0169 0.74
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0081 0.0368
Echinococcus multilocularis jumonji domain containing 1A 0.0022 0.0026 0.0026
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0266 0.107 0.487
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0008 0.0008
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0000023496 0.0000023496
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0004 0.0004
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0086 0.0391
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0078 0.0078
Brugia malayi jmjC domain containing protein 0.0022 0.0026 0.0119
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0022 0.0026 0.0542
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0212 0.4854
Echinococcus multilocularis lamin dm0 0.006 0.0187 0.0187
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0000023496 0.0000023496
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0078 0.0078
Echinococcus granulosus JmjC domain containing protein 4 0.0022 0.0026 0.0026
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0718 0.6258
Loa Loa (eye worm) hypothetical protein 0.006 0.0187 0.0853
Schistosoma mansoni lamin 0.006 0.0187 0.0187
Onchocerca volvulus Serine\/threonine kinase homolog 0.0112 0.0409 0.1861
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.002
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0112 0.0409 0.1861
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0078 0.0355
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0023 0.0027 0.0032
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0078 0.0078
Schistosoma mansoni phd/f-box containing protein 0.0022 0.0026 0.0026
Brugia malayi ecdysteroid receptor 0.0034 0.0078 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0078 0.0355
Plasmodium vivax SET domain protein, putative 0.0036 0.0086 0.0288
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0078 0.0355
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0078 0.0355
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.0226
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.0226
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0078 0.0355
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0078 0.0355
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.002
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0169 0.0583
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0679 0.2835 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0022 0.0026 0.0026
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0678 0.5905
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0022 0.0026 0.0984
Schistosoma mansoni hypothetical protein 0.0421 0.1735 0.1735
Leishmania major cathepsin L-like protease 0.0066 0.0212 0.5133
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0678 0.5905
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0212 0.4854
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0086 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0086 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0078 0.0355
Trypanosoma brucei PAB1-binding protein , putative 0.0056 0.0169 0.374
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0212 0.5133
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0112 0.0409 0.0409
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0078 0.0355
Loa Loa (eye worm) cysteine protease 0.0017 0.0004 0.002
Brugia malayi Intermediate filament tail domain containing protein 0.006 0.0187 0.0853
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0409 0.3545
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0368
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0678 0.5905
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0078 0.0355
Loa Loa (eye worm) jmjC domain-containing protein 0.0022 0.0026 0.0119
Brugia malayi steroid hormone receptor 0.0034 0.0078 0.0355
Toxoplasma gondii PHD-finger domain-containing protein 0.0023 0.0027 0.1038
Loa Loa (eye worm) hypothetical protein 0.0529 0.2197 1
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.107 0.9339
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0038 0.0038
Onchocerca volvulus 0.0036 0.0086 0.0391
Schistosoma mansoni microtubule-associated protein tau 0.2352 1 1
Plasmodium vivax JmjC domain containing protein 0.0022 0.0026 0.0077
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0078 0.0355
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.0158
Brugia malayi hypothetical protein 0.0529 0.2197 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.0248
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0078 0.0355
Echinococcus multilocularis musashi 0.006 0.0187 0.0187
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.006 0.0187 0.0853
Brugia malayi intermediate filament protein 0.006 0.0187 0.0853
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.015 0.0685
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0078 0.0078
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.015 0.0685
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0112 0.0409 0.0409
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0176 0.7707
Leishmania major hypothetical protein, conserved 0.0056 0.0169 0.4079
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0187 0.4529
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0078 0.0078
Brugia malayi nuclear hormone receptor 0.0034 0.0078 0.0355
Echinococcus granulosus lamin 0.006 0.0187 0.0187
Leishmania major cathepsin L-like protease 0.0066 0.0212 0.5133
Brugia malayi MH2 domain containing protein 0.0123 0.0457 0.2081
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0078 0.0078
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0078 0.0355
Onchocerca volvulus 0.0017 0.0004 0.002
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0023 0.0027 0.0032
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0169 0.0583
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0718 0.6258
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0409 0.3545
Echinococcus multilocularis Protein lozenge 0.0066 0.0215 0.0215
Schistosoma mansoni jumonji/arid domain-containing protein 0.0086 0.0297 0.0297
Echinococcus multilocularis PHD finger protein rhinoceros 0.0069 0.0227 0.0227
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0679 0.2835 0.5
Loa Loa (eye worm) runx1 0.0066 0.0215 0.0977
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0038
Schistosoma mansoni lamin 0.006 0.0187 0.0187
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0054 0.0054
Plasmodium falciparum phd finger protein, putative 0.0069 0.0227 0.0787
Echinococcus granulosus jumonji domain containing protein 0.0096 0.0343 0.0343
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.0065 0.0065
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0457 0.2081
Brugia malayi CXXC zinc finger family protein 0.003 0.0057 0.026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0212 0.4854
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0078 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0078 0.0355
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0038
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0024 0.0035 0.0109
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0000023496 0.0000023496
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0409 0.3545
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0679 0.2835 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0678 0.5905
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0212 0.4854
Echinococcus multilocularis cysteine protease 0.0017 0.0004 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.107 0.9339
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0078 0.0355
Brugia malayi hypothetical protein 0.0056 0.0169 0.0771
Echinococcus multilocularis neuropeptide s receptor 0.0477 0.1971 0.1971
Echinococcus granulosus lamin dm0 0.006 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0034 0.0078 0.0355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0212 0.4854
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.002
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0266 0.107 0.487
Brugia malayi serine/threonine-protein kinase plk-2 0.0112 0.0409 0.1861
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0249 0.0998 0.4543
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0004 0.002
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0112 0.0409 1
Plasmodium vivax ataxin-2 like protein, putative 0.0056 0.0169 0.0583
Plasmodium falciparum JmjC domain-containing protein, putative 0.0022 0.0026 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0366 0.0366
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0078 0.0078
Brugia malayi PHD-finger family protein 0.0069 0.0227 0.1034
Echinococcus granulosus neuropeptide s receptor 0.0477 0.1971 0.1971
Echinococcus multilocularis GPCR, family 2 0.0016 0.0000023496 0.0000023496
Schistosoma mansoni cpg binding protein 0.0031 0.0064 0.0064
Echinococcus multilocularis phd:f box containing protein 0.0022 0.0026 0.0026
Plasmodium vivax hypothetical protein, conserved 0.0069 0.0227 0.0787
Loa Loa (eye worm) jmjC domain-containing protein 0.0086 0.0297 0.1352
Loa Loa (eye worm) hypothetical protein 0.0034 0.0078 0.0355
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0212 0.4854
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0004 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0167 0.1428
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0057 0.026
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0678 0.5905
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0678 0.5905
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0212 0.5133
Brugia malayi Pre-SET motif family protein 0.0036 0.0086 0.0391
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0212 0.5133
Schistosoma mansoni hypothetical protein 0.0016 0.0000023496 0.0000023496
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0078 0.0355
Brugia malayi hypothetical protein 0.0018 0.0008 0.0038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0038
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.002
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0078 0.0355
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0366 0.0366
Schistosoma mansoni hypothetical protein 0.0016 0.0000023496 0.0000023496
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0004 0.002
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0078 0.0355
Brugia malayi jmjC domain containing protein 0.0022 0.0026 0.0119
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.107 0.9339
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0038
Onchocerca volvulus 0.0284 0.1145 0.5213
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0004 0.0004
Echinococcus granulosus PHD finger protein rhinoceros 0.0069 0.0227 0.0227

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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