TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 298.297 | Formula: C15H14N4O3
H donors: 0 H acceptors: 2 LogP: 1.98 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=C1N2CCCC2Oc2c1cc1nnn(c(=O)c1c2)C1CC1
InChi: 1S/C15H14N4O3/c20-14-10-6-11-9(15(21)19(17-16-11)8-3-4-8)7-12(10)22-13-2-1-5-18(13)14/h6-8,13H,1-5H2
InChiKey: CLWWYPUVWOFURB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.011	0.239	1
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0073	0.0306
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0584	0.1833
Loa Loa (eye worm)	hypothetical protein	0.001	0.0073	0.0162
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0007	0.0007	0.0015
Loa Loa (eye worm)	sugar transporter	0.0014	0.0179	0.0396
Entamoeba histolytica	phosphofructokinase, putative	0.011	0.239	1
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0376	0.2263
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0531	0.2199
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0041	0.0783	0.3277
Trichomonas vaginalis	glucose transporter, putative	0.0014	0.0179	0.0722
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0007	0.0007	0.0029
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.056	0.2343
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0927	0.3879
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0586	0.0586
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0247	0.1006
Trypanosoma brucei	Metacaspase-4	0.0017	0.0247	0.0307
Trypanosoma cruzi	hexose transporter, putative	0.0014	0.0179	0.0722
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.056	0.2343
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.001	0.0073	0.0146
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0679	0.2819
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0927	0.3879
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0927	0.205
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0376	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0783	0.1732
Brugia malayi	regulator of G-protein signaling egl-10	0.001	0.0073	0.0162
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0531	0.2199
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0586	0.0586
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0376	0.1575
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0073	0.0306
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0584	0.2422
Brugia malayi	RasGEF domain containing protein	0.0007	0.0007	0.0015
Brugia malayi	MAP kinase sur-1	0.0052	0.1052	0.2325
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0585	0.2449
Brugia malayi	hypothetical protein	0.0041	0.0783	0.1732
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0179	0.0396
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0137	0.0303
Echinococcus multilocularis	rap guanine nucleotide exchange factor 6	0.0007	0.0007	0.0029
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0584	0.1833
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Echinococcus granulosus	ras GTP exchange factor	0.0007	0.0007	0.0029
Onchocerca volvulus		0.0014	0.0179	0.0381
Leishmania major	metacaspase, putative	0.0017	0.0247	0.1032
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0585	0.2449
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0531	0.2199
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.053	0.2215
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1187	0.2625
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0585	0.2427
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0531	0.2199
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0179	0.0396
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0179	0.0396
Brugia malayi	Sugar transporter family protein	0.0103	0.2233	0.4939
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0586	0.0586
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2233	0.9344
Echinococcus granulosus	rap guanine nucleotide exchange factor 6	0.0007	0.0007	0.0029
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0584	0.2422
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0686	0.287
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0007	0.0015
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0017	0.0247	0.0373
Plasmodium falciparum	metacaspase 1	0.0017	0.0247	0.0247
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Echinococcus multilocularis	caspase	0.0017	0.0247	0.1032
Schistosoma mansoni	caspase-3 (C14 family)	0.0017	0.0247	0.1032
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0376	0.0893
Trichomonas vaginalis	sugar transport protein, putative	0.0014	0.0179	0.0722
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.011	0.239	1
Brugia malayi	6-phosphofructokinase	0.011	0.239	0.5285
Brugia malayi	Cell death protein 3 precursor	0.0058	0.1187	0.2625
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.003	0.0531	0.0531
Echinococcus granulosus	solute carrier family 22	0.0014	0.0179	0.0748
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0376	0.1575
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.011	0.239	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0425	0.0941
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0179	0.0722
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0438	1	1
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0586	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0179	0.0396
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0017	0.0247	0.1006
Echinococcus multilocularis	6 phosphofructokinase	0.011	0.239	1
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.001	0.0073	0.0162
Trypanosoma cruzi	metacaspase 5, putative	0.0017	0.0247	0.1006
Trypanosoma cruzi	metacaspase, putative	0.0017	0.0247	0.1006
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.056	0.1261
Onchocerca volvulus		0.0014	0.0179	0.0381
Onchocerca volvulus		0.0014	0.0179	0.0381
Trichomonas vaginalis	phosphofructokinase, putative	0.011	0.239	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0927	0.3879
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0014	0.0179	0.0361
Onchocerca volvulus		0.0041	0.0783	0.1719
Onchocerca volvulus		0.001	0.0073	0.0146
Echinococcus granulosus	caspase 2	0.0058	0.1187	0.4967
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0179	0.0722
Plasmodium falciparum	metacaspase-like protein	0.0017	0.0247	0.0247
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0586	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0179	0.0396
Echinococcus multilocularis	mitogen activated protein kinase	0.0052	0.1052	0.44
Onchocerca volvulus		0.0014	0.0179	0.0381
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0585	0.2449
Brugia malayi	RasGEF domain containing protein	0.0007	0.0007	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0179	0.0722
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0007	0.0007	0.0029
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0376	0.057
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0202	0.4522	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0584	0.1833
Leishmania major	glucose transporter, lmgt3	0.0032	0.0584	0.2444
Onchocerca volvulus		0.0014	0.0179	0.0381
Echinococcus granulosus	son of sevenless 1	0.0007	0.0007	0.0029
Toxoplasma gondii	6-phosphofructokinase	0.003	0.0531	0.0804
Schistosoma mansoni	dishevelled	0.001	0.0073	0.0306
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0311	0.1274
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Schistosoma mansoni	sugar transporter	0.0014	0.0179	0.0748
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0376	0.6445
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0014	0.0179	0.0179
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0017	0.0247	0.0373
Brugia malayi	N-terminal motif family protein	0.0007	0.0007	0.0015
Mycobacterium ulcerans	integral membrane transport protein	0.0014	0.0179	0.0361
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0376	0.1575
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0052	0.1052	0.4383
Loa Loa (eye worm)	phosphofructokinase	0.011	0.239	0.5285
Toxoplasma gondii	transporter, major facilitator family protein	0.0014	0.0179	0.0271
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0586	0.0414
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0179	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0202	0.4522	1
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0376	0.0376
Toxoplasma gondii	facilitative glucose transporter GT1	0.0103	0.2233	0.338
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0927	0.3879
Plasmodium falciparum	hexose transporter	0.0103	0.2233	0.2233
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0584	0.1833
Trypanosoma cruzi	metacaspase, putative	0.0017	0.0247	0.1006
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.1052	0.4383
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0584	0.2422
Echinococcus granulosus	apoptotic protease activating factor 1	0.0041	0.0783	0.3277
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Brugia malayi	hypothetical protein	0.0014	0.0179	0.0396
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0017	0.0247	0.0545
Echinococcus granulosus	solute carrier family 22	0.0014	0.0179	0.0748
Schistosoma mansoni	6-phosphofructokinase	0.011	0.239	1
Echinococcus granulosus	rap guanine nucleotide exchange factor 1	0.0007	0.0007	0.0029
Trypanosoma cruzi	hexose transporter	0.0032	0.0584	0.2422
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Entamoeba histolytica	hypothetical protein	0.0023	0.0376	0.155
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0586	0.0886
Giardia lamblia	Kinase, CMGC MAPK	0.0052	0.1052	1
Trichomonas vaginalis	conserved hypothetical protein	0.0103	0.2233	0.9342
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0179	0.0396
Loa Loa (eye worm)	sugar transporter	0.0103	0.2233	0.4939
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0584	0.2422
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0073	0.0306
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0584	0.1833
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0584	0.2422
Schistosoma mansoni	sugar transporter	0.0014	0.0179	0.0748
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0584	0.2422
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0584	0.2444
Onchocerca volvulus		0.0014	0.0179	0.0381
Entamoeba histolytica	phosphofructokinase, putative	0.011	0.239	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.056	0.1238
Trichomonas vaginalis	phosphofructokinase, putative	0.011	0.239	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0179	0.0396
Brugia malayi	N-terminal motif family protein	0.0202	0.4522	1
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.011	0.239	1
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0052	0.1052	0.44
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0686	0.287
Trichomonas vaginalis	6-phosphofructokinase, putative	0.003	0.0531	0.2199
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0017	0.0247	0.1032
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0179	0.0722
Trypanosoma cruzi	glucose transporter, putative	0.0014	0.0179	0.0722
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0585	0.1294
Plasmodium vivax	6-phosphofructokinase, putative	0.003	0.0531	0.0359
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Brugia malayi	6-phosphofructokinase	0.011	0.239	0.5285
Brugia malayi	hypothetical protein	0.0014	0.0179	0.0396
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0179	0.0396
Echinococcus multilocularis	segment polarity protein dishevelled	0.001	0.0073	0.0306
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0376	0.1222
Entamoeba histolytica	protein kinase, putative	0.0032	0.0585	0.2427
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0585	0.1294
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0179	0.0748
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0179	0.0722
Echinococcus granulosus	Pleckstrin G protein interacting region	0.001	0.0073	0.0306
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0585	0.2449
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.003	0.0531	0.0804
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Plasmodium vivax	hypothetical protein, conserved	0.0017	0.0247	0.0069
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0584	0.1833
Onchocerca volvulus		0.0014	0.0179	0.0381
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0052	0.1052	0.4383
Onchocerca volvulus		0.0014	0.0179	0.0381
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Toxoplasma gondii	protein kinase, putative	0.0292	0.6608	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0927	0.3879
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0179	0.0396
Echinococcus multilocularis	Protein son of sevenless	0.0007	0.0007	0.0029
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2233	0.9344
Echinococcus multilocularis	rap guanine nucleotide exchange factor 1	0.0007	0.0007	0.0029
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0585	0.1294
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0007	0.0007	0.0015
Trypanosoma brucei	metacaspase MCA2	0.0017	0.0247	0.0307
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0531	0.2199
Brugia malayi	major facilitator superfamily protein	0.0014	0.0179	0.0396
Schistosoma mansoni	dep domain containing protein	0.001	0.0073	0.0306
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0179	0.0748
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Schistosoma mansoni	regulator of G protein signaling	0.001	0.0073	0.0306
Schistosoma mansoni	protein kinase	0.0032	0.0585	0.2449
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0584	0.1833
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0585	0.2449
Onchocerca volvulus		0.0014	0.0179	0.0381
Brugia malayi	DIX domain containing protein	0.001	0.0073	0.0162
Mycobacterium ulcerans	sugar transporter	0.0014	0.0179	0.0361
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0017	0.0247	0.1006
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0376	0.0384
Entamoeba histolytica	hypothetical protein	0.0036	0.0686	0.2849
Entamoeba histolytica	hypothetical protein	0.0036	0.0686	0.2849
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0584	0.1833
Schistosoma mansoni	dishevelled	0.001	0.0073	0.0306
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0679	0.284
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.056	0.4366
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.001	0.0073	0.0306
Echinococcus multilocularis	son of sevenless 1	0.0007	0.0007	0.0029
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0679	0.2261
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0179	0.0396
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Entamoeba histolytica	hypothetical protein	0.0036	0.0686	0.2849
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0179	0.0396
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0531	0.2199
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0007	0.0007	0.0029
Loa Loa (eye worm)	DIX domain-containing protein	0.001	0.0073	0.0162
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.053	0.2215
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0376	0.1222
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0584	0.1833
Leishmania major	protein kinase, putative	0.0032	0.0585	0.2449
Leishmania major	glucose transporter, lmgt2	0.0032	0.0584	0.2444
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.0248	0.1012
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0927	0.205
Loa Loa (eye worm)	6-phosphofructokinase	0.011	0.239	0.5285
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.1052	0.4383
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Echinococcus granulosus	solute carrier family 22	0.0014	0.0179	0.0748
Echinococcus granulosus	mitogen activated protein kinase 3	0.0052	0.1052	0.44
Brugia malayi	hypothetical protein	0.001	0.0073	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0247	0.0545
Brugia malayi	Cam kinase protein 1	0.0032	0.0585	0.1294
Onchocerca volvulus		0.0014	0.0179	0.0381
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0179	0.0748
Trypanosoma brucei	metacaspase	0.0017	0.0247	0.0307
Schistosoma mansoni	glucose transport protein	0.0103	0.2233	0.9344
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0585	0.1838
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0376	0.155
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0179	0.0748
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.003	0.0531	1
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0073	0.0162
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0679	0.2819
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0017	0.0247	0.0373
Echinococcus granulosus	Protein son of sevenless	0.0007	0.0007	0.0029
Onchocerca volvulus		0.0014	0.0179	0.0381
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Entamoeba histolytica	protein kinase, putative	0.0032	0.0585	0.2427
Schistosoma mansoni	caspase-7 (C14 family)	0.0017	0.0247	0.1032
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0584	0.2422
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0179	0.0396
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0179	0.0748
Echinococcus granulosus	caspase 8	0.0017	0.0247	0.1032
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2233	0.9344
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0376	0.1575
Trypanosoma brucei	metacaspase MCA3	0.0017	0.0247	0.0307
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0179	0.0748
Plasmodium vivax	6-phosphofructokinase, putative	0.003	0.0531	0.0359
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.003	0.0531	0.1896
Schistosoma mansoni	protein kinase	0.0032	0.0585	0.2449
Schistosoma mansoni	glucose transport protein	0.0103	0.2233	0.9344
Trypanosoma cruzi	metacaspase 5, putative	0.0017	0.0247	0.1006
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0014	0.0179	0.0361
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0179	0.0396
Brugia malayi	RasGEF domain containing protein	0.0007	0.0007	0.0015
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0585	0.2449
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.1052	0.44
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.003	0.0531	0.2199
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0052	0.1052	0.3947
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0376	0.0201
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0017	0.0247	0.1006
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0586	0.0586
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0586	0.0414
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0014	0.0179	0.0748
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0927	0.3879
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0296	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0585	0.1294
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0586	0.0886
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2233	0.9344
Brugia malayi	phosphofructokinase	0.011	0.239	0.5285
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0179	0.0396
Echinococcus granulosus	General substrate transporter	0.0089	0.1897	0.7938
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.056	0.2343
Schistosoma mansoni	caspase-7 (C14 family)	0.0058	0.1187	0.4967
Schistosoma mansoni	protein kinase	0.0032	0.0585	0.2449
Toxoplasma gondii	sugar transporter ST3	0.0014	0.0179	0.0271
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0247	0.1006
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.056	0.232
Brugia malayi	N-terminal motif family protein	0.0007	0.0007	0.0015
Onchocerca volvulus	Cell death protein 3 homolog	0.0058	0.1187	0.2614
Schistosoma mansoni	z-protein (S1r protein)	0.001	0.0073	0.0306
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0247	0.1006
Leishmania major	myo-inositol/proton symporter (MIT)	0.0014	0.0179	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0179	0.0396
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0376	0.155
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0584	0.2422
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0017	0.0247	0.1006
Echinococcus granulosus	caspase	0.0017	0.0247	0.1032
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.056	0.1238
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0017	0.0247	0.1006
Echinococcus multilocularis	General substrate transporter	0.0089	0.1897	0.7938
Echinococcus multilocularis	caspase 8	0.0017	0.0247	0.1032
Toxoplasma gondii	hypothetical protein	0.001	0.0073	0.0111
Trypanosoma cruzi	metacaspase, putative	0.0017	0.0247	0.1006
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.056	0.232
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0179	0.0396
Plasmodium vivax	hexose transporter	0.0103	0.2233	0.2092
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0167	0.3716	0.5624
Entamoeba histolytica	hypothetical protein	0.0036	0.0686	0.2849
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Echinococcus granulosus	solute carrier family 22	0.0014	0.0179	0.0748
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0017	0.0247	0.1006
Echinococcus granulosus	6 phosphofructokinase	0.011	0.239	1
Onchocerca volvulus		0.0014	0.0179	0.0381
Leishmania major	hypothetical protein, conserved	0.0014	0.0179	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0179	0.0396
Trichomonas vaginalis	phosphofructokinase, putative	0.011	0.239	1
Onchocerca volvulus		0.0014	0.0179	0.0381
Onchocerca volvulus		0.0014	0.0179	0.0381
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0585	0.2449
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2233	0.9344
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0586	0.0886
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0686	0.287
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0584	0.1833
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0179	0.0748
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0031	0.056	0.1238
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0017	0.0247	0.1032
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0247	0.1006
Echinococcus granulosus	regulator of G protein signaling 7	0.001	0.0073	0.0306
Brugia malayi	major facilitator superfamily protein	0.0014	0.0179	0.0396
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0376	0.1575
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.011	0.239	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0179	0.0396
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0585	0.2449
Brugia malayi	Sugar transporter family protein	0.0014	0.0179	0.0396
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0007	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0031	0.056	0.1238
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0017	0.0247	0.1006
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Schistosoma mansoni	6-phosphofructokinase	0.011	0.239	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.1052	0.4383
Toxoplasma gondii	sugar transporter ST2	0.0014	0.0179	0.0271
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.001	0.0073	0.0306
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0927	0.3879
Brugia malayi	Sugar transporter family protein	0.0014	0.0179	0.0396
Echinococcus granulosus	segment polarity protein dishevelled	0.001	0.0073	0.0306
Schistosoma mansoni	hypothetical protein	0.0041	0.0783	0.3277
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0679	0.0509
Trypanosoma cruzi	sugar transporter, putative	0.0014	0.0179	0.0722
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0679	0.1027
Schistosoma mansoni	hypothetical protein	0.0036	0.0686	0.287
Trypanosoma brucei	protein kinase, putative	0.0052	0.1052	0.3947
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0679	0.0679
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0585	0.2449
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0007	0.0007	0.0015
Trichomonas vaginalis	phosphofructokinase, putative	0.011	0.239	1
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.1052	0.4383
Schistosoma mansoni	sugar transporter	0.0014	0.0179	0.0748
Schistosoma mansoni	ras GTP exchange factor	0.0007	0.0007	0.0029
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0017	0.0247	0.1006
Brugia malayi	hypothetical protein	0.0014	0.0179	0.0396
Leishmania major	ATP-dependent phosphofructokinase	0.011	0.239	1
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0167	0.3716	0.3716
Schistosoma mansoni	glucose transport protein	0.0103	0.2233	0.9344
Onchocerca volvulus	Putative transporter	0.0014	0.0179	0.0381
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0052	0.1052	0.44
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0247	0.1006
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0103	0.2233	0.9344
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.003	0.0531	0.4034
Onchocerca volvulus		0.0014	0.0179	0.0381
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.003	0.0531	0.0531
Toxoplasma gondii	phosphofructokinase PFKII	0.003	0.0531	0.0804
Schistosoma mansoni	glucose transporter	0.0014	0.0179	0.0748
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0103	0.2233	0.9344
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0167	0.3716	0.3602
Plasmodium falciparum	protein kinase 7	0.0292	0.6608	0.6608
Schistosoma mansoni	hypothetical protein	0.0103	0.2233	0.9344
Schistosoma mansoni	sugar transporter	0.0014	0.0179	0.0748
Echinococcus multilocularis	caspase 2	0.0058	0.1187	0.4967
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0073	0.0306
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Trypanosoma cruzi	metacaspase, putative	0.0017	0.0247	0.1006
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0052	0.1052	0.1592
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Loa Loa (eye worm)	6-phosphofructokinase	0.011	0.239	0.5285
Brugia malayi	hypothetical protein	0.0036	0.0686	0.1517
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.056	0.2343
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0007	0.0007	0.0029
Plasmodium vivax	metacaspase 1, putative	0.0017	0.0247	0.0069
Onchocerca volvulus		0.0014	0.0179	0.0381
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0103	0.2233	0.9344
Trichomonas vaginalis	myo-inositol transporter, putative	0.0014	0.0179	0.0722
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0584	0.1833
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0179	0.0396
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0296	0.0529
Mycobacterium ulcerans	6-phosphofructokinase	0.011	0.239	1
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0584	0.1833
Loa Loa (eye worm)	hypothetical protein	0.001	0.0073	0.0162
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.003	0.0531	1
Trypanosoma brucei	metacaspase 5, putative	0.0017	0.0247	0.0307
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.1052	0.4383
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0586	0.0586
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0179	0.5
Echinococcus granulosus	mitogen activated protein kinase	0.0052	0.1052	0.44
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.001	0.0073	0.0162
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0679	0.284
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0017	0.0247	0.1032
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0179	0.0722
Leishmania major	glucose transporter, lmgt1	0.0032	0.0584	0.2444
Echinococcus multilocularis	regulator of G protein signaling 7	0.001	0.0073	0.0306
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.1052	0.4383
Entamoeba histolytica	phosphofructokinase, putative	0.011	0.239	1
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0052	0.1052	0.44
Echinococcus multilocularis	ras GTP exchange factor	0.0007	0.0007	0.0029
Loa Loa (eye worm)	hypothetical protein	0.001	0.0073	0.0162
Toxoplasma gondii	sugar transporter ST1	0.0014	0.0179	0.0271
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0052	0.1052	0.2325
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0179	0.0396
Brugia malayi	hypothetical protein	0.001	0.0073	0.0162
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0376	0.0832
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0584	0.1833
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0017	0.0247	0.1006
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0247	0.1006
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0584	0.2422
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0584	0.2422

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1835469

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1165639