Detailed information for compound 1174555

Basic information

Technical information
  • TDR Targets ID: 1174555
  • Name: phenylmethylsulfanylsulfinylmethylbenzene
  • MW: 262.39 | Formula: C14H14OS2
  • H donors: 1 H acceptors: 1 LogP: 3.83 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][S+](Cc1ccccc1)SCc1ccccc1
  • InChi: 1S/C14H14OS2/c15-17(12-14-9-5-2-6-10-14)16-11-13-7-3-1-4-8-13/h1-10H,11-12H2
  • InChiKey: VUJONJHZKSZFSA-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • (phenylmethylthio)sulfinylmethylbenzene
  • (benzylthio)sulfinylmethylbenzene
  • AIDS-228947
  • AIDS228947
  • Benzenemethanesulfinothioic acid, S-(phenylmethyl) ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin B Starlite/ChEMBL References
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Starlite/ChEMBL References
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia Cathepsin L precursor cysteine peptidase, Clan CA, family C1, Cathepsin L-like 450 aa 428 aa 21.5 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0032 0.0216 0.0394
Echinococcus multilocularis cathepsin L cysteine protease 0.0045 0.0731 0.0959
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.4226 0.4226
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0062 0.1356 0.2467
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0216 0.0284
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0698 0.0916
Brugia malayi Cathepsin L-like precursor 0.0045 0.0731 0.0959
Giardia lamblia Cathepsin B precursor 0.0062 0.1356 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0731 0.5389
Loa Loa (eye worm) hypothetical protein 0.0173 0.5497 0.7132
Leishmania major cathepsin L-like protease 0.0159 0.4966 0.4569
Loa Loa (eye worm) cysteine protease 0.0045 0.0731 0.0695
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.4966 0.4966
Toxoplasma gondii hypothetical protein 0.0047 0.0806 0.1206
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0731 0.5389
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0216 0.0284
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0045 0.0731 0.0959
Loa Loa (eye worm) hypothetical protein 0.0032 0.0233 0.0022
Echinococcus granulosus GPCR family 2 0.0032 0.0216 0.0284
Trypanosoma cruzi cysteine peptidase, putative 0.0045 0.0731 0.0731
Echinococcus multilocularis cathepsin b 0.0173 0.5497 0.7213
Loa Loa (eye worm) hypothetical protein 0.0068 0.1584 0.1846
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.4226 0.4226
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0146 0.4468 0.4468
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.1584 0.2078
Onchocerca volvulus 0.0045 0.0731 0.8957
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0917 0.0917
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0698 0.0916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0731 0.5389
Plasmodium vivax vivapain-2 0.0045 0.0731 1
Schistosoma mansoni hypothetical protein 0.0035 0.0344 0.0626
Onchocerca volvulus 0.0045 0.0731 0.8957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0731 0.5389
Brugia malayi MH2 domain containing protein 0.012 0.3497 0.4588
Onchocerca volvulus Cathepsin L homolog 0.0045 0.0731 0.8957
Onchocerca volvulus Cathepsin L homolog 0.0045 0.0731 0.8957
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.4966 0.4966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0731 0.5389
Schistosoma mansoni cathepsin F (C01 family) 0.0045 0.0731 0.1329
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0698 0.0916
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0216 0.0284
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.4966 0.4966
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.4966 0.4966
Schistosoma mansoni survival motor neuron protein 0.0047 0.0789 0.1435
Schistosoma mansoni cathepsin F (C01 family) 0.0045 0.0731 0.1329
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.4966 0.4966
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0344 0.0451
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0233 0.3182
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.4812 0.5
Brugia malayi Cathepsin L-like precursor 0.0032 0.0233 0.0305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0731 0.5389
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0062 0.1356 0.0674
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0698 0.0651
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0731 0.5389
Echinococcus granulosus cathepsin L cysteine proteinase 0.0045 0.0731 0.0959
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0731 0.5389
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0731 0.5389
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0344 0.0451
Brugia malayi Cathepsin L-like precursor 0.0045 0.0731 0.0959
Trypanosoma cruzi cruzipain precursor, putative 0.0159 0.4966 0.4966
Echinococcus multilocularis cysteine protease 0.0045 0.0731 0.0959
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.3497 0.443
Giardia lamblia Cathepsin B precursor 0.0062 0.1356 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0698 0.1271
Mycobacterium ulcerans hypothetical protein 0.0155 0.4812 0.5
Plasmodium vivax vivapain-2 0.0045 0.0731 1
Onchocerca volvulus 0.0045 0.0731 0.8957
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0045 0.0731 1
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.3497 0.443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.4966 0.4966
Brugia malayi Cathepsin L-like precursor 0.0045 0.0731 0.0959
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0233 0.0423
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0045 0.0731 0.0695
Trypanosoma cruzi cysteine peptidase, putative 0.0159 0.4966 0.4966
Brugia malayi cathepsin L-like precursor 0.0032 0.0233 0.0305
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.058 0.058
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0731 0.5389
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0731 0.5389
Brugia malayi hypothetical protein 0.023 0.7621 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.0731 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0731 0.5389
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0731 0.5389
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.4966 0.4966
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0173 0.5497 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0216 0.0284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0698 0.1271
Loa Loa (eye worm) hypothetical protein 0.0032 0.0233 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0731 0.5389
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0731 0.5389
Echinococcus multilocularis cathepsin L cysteine protease 0.0045 0.0731 0.0959
Echinococcus granulosus cathepsin l1 0.0032 0.0233 0.0305
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0062 0.1356 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.2762 0.3624
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0698 0.0916
Onchocerca volvulus 0.0047 0.0789 1
Leishmania major cathepsin L-like protease 0.0159 0.4966 0.4569
Leishmania major cathepsin L-like protease 0.0159 0.4966 0.4569
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0173 0.5497 1
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.0731 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.058 0.058
Echinococcus granulosus cathepsin b 0.0173 0.5497 0.7213
Entamoeba histolytica hypothetical protein 0.0035 0.0344 0.4707
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.4966 0.4966
Brugia malayi Cathepsin L-like precursor 0.0045 0.0731 0.0959
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0062 0.1356 0.1356
Brugia malayi hypothetical protein 0.0035 0.0344 0.0451
Echinococcus granulosus cathepsin b 0.0173 0.5497 0.7213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0731 0.5389
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.4966 0.4966
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0045 0.0731 0.0959
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0698 0.1271
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.4226 0.3771
Schistosoma mansoni hypothetical protein 0.0068 0.1584 0.2881
Loa Loa (eye worm) ctsf protein 0.0045 0.0731 0.0695
Entamoeba histolytica hypothetical protein 0.0035 0.0344 0.4707
Loa Loa (eye worm) hypothetical protein 0.0045 0.0731 0.0695
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0045 0.0731 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0173 0.5497 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0698 0.0916
Onchocerca volvulus Cathepsin F homolog 0.0045 0.0731 0.8957
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0045 0.0731 0.5389
Brugia malayi Cathepsin L-like precursor 0.0045 0.0731 0.0959
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0731 0.5389
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0789 0.1035
Schistosoma mansoni hypothetical protein 0.0032 0.0216 0.0394
Onchocerca volvulus 0.0045 0.0731 0.8957
Schistosoma mansoni hypothetical protein 0.0032 0.0216 0.0394
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0233 0.1715
Brugia malayi cathepsin B-like cysteine proteinase 0.0173 0.5497 0.7213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0731 0.5389
Brugia malayi Cathepsin L-like cysteine proteinase 0.0032 0.0233 0.0305
Trypanosoma cruzi cysteine peptidase, putative 0.0159 0.4966 0.4966
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0731 0.5389
Entamoeba histolytica hypothetical protein 0.0035 0.0344 0.4707
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0216 0.0284
Schistosoma mansoni hypothetical protein 0.0032 0.0216 0.0394
Loa Loa (eye worm) hypothetical protein 0.01 0.2762 0.3437
Echinococcus multilocularis GPCR, family 2 0.0032 0.0216 0.0284
Echinococcus granulosus cathepsin l1 0.0045 0.0731 0.0959
Trypanosoma brucei cysteine peptidase C (CPC) 0.0062 0.1356 0.1356
Loa Loa (eye worm) hypothetical protein 0.023 0.7621 1
Echinococcus multilocularis cysteine protease 0.0045 0.0731 0.0959
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0731 0.5389
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.058 0.058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.4966 0.4966
Onchocerca volvulus 0.0045 0.0731 0.8957
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0045 0.0731 0.5389
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.2762 0.3624
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0731 0.5389
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0216 0.0284
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.2762 0.3437
Entamoeba histolytica cysteine protease, putative 0.0045 0.0731 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0731 0.5389
Loa Loa (eye worm) fibroinase 0.0045 0.0731 0.0695
Schistosoma mansoni hypothetical protein 0.0047 0.0789 0.1435
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0045 0.0731 0.0695
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0173 0.5497 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0045 0.0731 0.0959
Trypanosoma cruzi major cysteine proteinase, putative 0.0126 0.3737 0.3737
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0344 0.0626
Loa Loa (eye worm) cathepsin B 0.0062 0.1356 0.1539
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0173 0.5497 0.5497
Brugia malayi Cathepsin L-like precursor 0.0032 0.0233 0.0305
Onchocerca volvulus 0.0045 0.0731 0.8957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0233 0.1715
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.7621 1
Brugia malayi Cathepsin L-like precursor 0.0045 0.0731 0.0959
Echinococcus multilocularis cathepsin b 0.0173 0.5497 0.7213
Onchocerca volvulus 0.0045 0.0731 0.8957
Entamoeba histolytica hypothetical protein 0.0035 0.0344 0.4707
Toxoplasma gondii cathepsin B 0.0062 0.1356 1
Brugia malayi Papain family cysteine protease containing protein 0.0045 0.0731 0.0959
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.058 0.058
Loa Loa (eye worm) hypothetical protein 0.0032 0.0233 0.0022
Echinococcus granulosus survival motor neuron protein 1 0.023 0.7621 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0731 0.5389
Plasmodium falciparum cysteine proteinase falcipain 3 0.0045 0.0731 1
Giardia lamblia Cathepsin B precursor 0.0062 0.1356 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0159 0.4966 0.4966
Trypanosoma cruzi cysteine peptidase, putative 0.0159 0.4966 0.4966

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) Antiparasitic activity against Trypanosoma brucei brucei ChEMBL. 20692829
IC50 (functional) = 30.3 uM Antiparasitic activity against Plasmodium falciparum ChEMBL. 20692829
Ki (binding) = 2.31 uM Inhibition of Trypanosoma brucei rhodesiense rhodesain ChEMBL. 20692829
Ki (binding) = 7.8 uM Inhibition of cathepsin B ChEMBL. 20692829
Ki (binding) = 31.7 uM Inhibition of cathepsin L ChEMBL. 20692829
TDI (binding) = 7800 /min/M Time dependent inhibition of Trypanosoma brucei rhodesiense rhodesain by Dixon plot analysis ChEMBL. 20692829

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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