Detailed information for compound 1197944

Basic information

Technical information
  • TDR Targets ID: 1197944
  • Name: N-[3-(butyl-ethylamino)propyl]-1,5-dimethyl-4 -oxopyrrolo[4,5-c]quinoline-2-carboxamide
  • MW: 396.526 | Formula: C23H32N4O2
  • H donors: 1 H acceptors: 2 LogP: 3.04 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(CCCNC(=O)c1cc2c(n1C)c1ccccc1n(c2=O)C)CC
  • InChi: 1S/C23H32N4O2/c1-5-7-14-27(6-2)15-10-13-24-22(28)20-16-18-21(25(20)3)17-11-8-9-12-19(17)26(4)23(18)29/h8-9,11-12,16H,5-7,10,13-15H2,1-4H3,(H,24,28)
  • InChiKey: LZWIHINQWHMUFB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-(butyl-ethyl-amino)propyl]-1,5-dimethyl-4-oxo-pyrrolo[4,5-c]quinoline-2-carboxamide
  • N-[3-(butyl-ethylamino)propyl]-1,5-dimethyl-4-oxo-2-pyrrolo[4,5-c]quinolinecarboxamide
  • N-[3-(butyl-ethyl-amino)propyl]-4-keto-1,5-dimethyl-pyrrolo[4,5-c]quinoline-2-carboxamide
  • MLS000118128
  • SMR000095076

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.006 0.0041 0.0982
Schistosoma mansoni hypothetical protein 0.035 0.0424 0.4306
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0039 0.093
Echinococcus multilocularis UDP N acetylglucosamine dolichyl phosphate 0.0319 0.0384 0.3039
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0035 0.0826
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0038 0.0351
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 0.2892 0.3778 0.5
Loa Loa (eye worm) MBCTL1 0.0066 0.0049 0.1185
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0049 0.0497
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.7609 1 0.5
Schistosoma mansoni hypothetical protein 0.0058 0.0039 0.0399
Loa Loa (eye worm) hypothetical protein 0.0058 0.0038 0.0908
Brugia malayi mbt repeat family protein 0.0058 0.0038 0.0908
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0049 0.036
Loa Loa (eye worm) hypothetical protein 0.0319 0.0384 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0035 0.032
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 0.7609 1 1
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0041 0.0419
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0038 0.0276
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0056 0.0418
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0049 0.0459
Brugia malayi mbt repeat family protein 0.0058 0.0038 0.0908
Brugia malayi jmjC domain containing protein 0.0071 0.0056 0.1374
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0035 0.0251
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0056 0.0532
Onchocerca volvulus 0.0058 0.0039 0.0025
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0056 0.057
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0319 0.0384 1
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0319 0.0384 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0056 0.1374
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0049 0.036
Schistosoma mansoni microtubule-associated protein tau 0.0776 0.0986 1
Leishmania major UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0319 0.0384 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0035 0.0359
Echinococcus granulosus UDP N acetylglucosamine dolichyl phosphate 0.0319 0.0384 0.387
Onchocerca volvulus 0.0319 0.0384 1
Brugia malayi hypothetical protein 0.0286 0.0339 0.8823
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0056 0.057
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.2892 0.3778 0.5
Brugia malayi jmjC domain containing protein 0.0071 0.0056 0.1374
Trypanosoma brucei UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0319 0.0384 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0035 0.0359
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.0319 0.0384 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0035 0.0826
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0319 0.0384 0.3895
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0056 0.057
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.0262 0.2628
Loa Loa (eye worm) hypothetical protein 0.0286 0.0339 0.8823
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0319 0.0384 0.3895
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0038 0.0908
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0035 0.032
Trichomonas vaginalis glucosaminephosphotransferase, putative 0.0319 0.0384 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0038 0.0276
Echinococcus granulosus microtubule associated protein 2 0.0776 0.0986 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.1254 1
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0038 0.039
Giardia lamblia UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase 0.0319 0.0384 1
Echinococcus multilocularis tumor protein p63 0.0408 0.0501 0.3973
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0319 0.0384 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0049 0.1185
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0035 0.0251
Echinococcus multilocularis microtubule associated protein 2 0.0776 0.0986 0.7852
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0035 0.0359
Onchocerca volvulus 0.006 0.0041 0.0081
Schistosoma mansoni survival motor neuron protein 0.0058 0.0039 0.0399
Entamoeba histolytica UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0319 0.0384 1
Echinococcus granulosus tumor protein p63 0.0408 0.0501 0.506
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 0.7609 1 0.5
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0339 0.3415
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0056 0.0418
Loa Loa (eye worm) hypothetical protein 0.0066 0.0049 0.1185
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0339 0.2681
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0056 0.0532
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0038 0.0351
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0049 0.0459
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.0319 0.0384 1
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0038 0.039
Plasmodium falciparum UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0319 0.0384 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.0262 0.2063
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0038 0.039

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) 22.16 uM PubChem BioAssay. Identification of Inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493182] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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