TDR Targets

Basic information

Technical information

TDR Targets ID: 1206362
Name: 2-(4-methylphenoxy)-N-[2-[2-(4-methylphenoxy) ethylsulfanyl]-1,3-benzothiazol-6-yl]acetamid e
MW: 464.6 | Formula: C25H24N2O3S2
H donors: 1 H acceptors: 2 LogP: 6.49 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)OCCSc1nc2c(s1)cc(cc2)NC(=O)COc1ccc(cc1)C
InChi: 1S/C25H24N2O3S2/c1-17-3-8-20(9-4-17)29-13-14-31-25-27-22-12-7-19(15-23(22)32-25)26-24(28)16-30-21-10-5-18(2)6-11-21/h3-12,15H,13-14,16H2,1-2H3,(H,26,28)
InChiKey: GTXMMOWNGRIFOX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(4-methylphenoxy)-N-[2-[2-(4-methylphenoxy)ethylthio]-1,3-benzothiazol-6-yl]acetamide
2-(4-methylphenoxy)-N-[2-[2-(4-methylphenoxy)ethylsulfanyl]-1,3-benzothiazol-6-yl]ethanamide
D336-3650
NCGC00118836-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Treponema pallidum	5'-nucleotidase (ushA)	0.076	0.2503	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0027	0.0167
Schistosoma mansoni	alpha-glucosidase	0.0152	0.0453	0.0451
Schistosoma mansoni	23-cyclic-nucleotide 2-phosphodiesterase	0.076	0.2503	0.2502
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0027	0.029
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0038	0.0067	0.0747
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0087	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0038	0.0067	0.0065
Schistosoma mansoni	microtubule-associated protein tau	0.2981	1	1
Onchocerca volvulus		0.0102	0.0285	0.4559
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0087	0.0976
Entamoeba histolytica	hypothetical protein	0.0043	0.0087	1
Brugia malayi	Muscleblind-like protein	0.0496	0.1614	1
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0046	0.0095	0.0668
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0087	0.0877
Onchocerca volvulus		0.0043	0.0087	0.1063
Trypanosoma brucei	DNA polymerase kappa, putative	0.0045	0.0093	0.0642
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0083	0.022	0.135
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.0136	0.0832
Mycobacterium ulcerans	lipase LipD	0.0043	0.0087	0.0877
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0027	0.029
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0002	0.0015
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0027	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0265	0.164
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0087	0.0085
Trypanosoma brucei	glucosidase, putative	0.0039	0.0072	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0087	0.0539
Trypanosoma brucei	unspecified product	0.0061	0.0146	0.1161
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0005	0.5
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0176	0.0536	0.332
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0087	0.0539
Trichomonas vaginalis	glutaminase, putative	0.0296	0.0939	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0159	0.0985
Leishmania major	DNA polymerase eta, putative	0.0065	0.0159	0.1298
Mycobacterium ulcerans	glutaminase	0.0296	0.0939	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0065	0.0159	0.0898
Echinococcus granulosus	voltage dependent calcium channel	0.002	0.0008	0.0006
Schistosoma mansoni	hypothetical protein	0.004	0.0074	0.0072
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0072	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0083	0.022	0.1362
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0041	0.0078	0.0076
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0087	0.0877
Brugia malayi	hypothetical protein	0.0043	0.0087	0.0525
Echinococcus granulosus	dna polymerase eta	0.0065	0.0159	0.0157
Loa Loa (eye worm)	glutaminase 2	0.0296	0.0939	0.5821
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0039	0.0072	0.0449
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0045	0.0093	0.1043
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0096	0.0265	0.0262
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0019	0.0006	0.0022
Echinococcus multilocularis	amyloid beta A4 protein	0.0069	0.0172	0.017
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0038	0.0067	0.0415
Giardia lamblia	Hypothetical protein	0.031	0.0988	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0087	0.0539
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0193	0.0592	1
Schistosoma mansoni	thyroid hormone receptor	0.0164	0.0494	0.0492
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0038	0.0067	0.6673
Trichomonas vaginalis	DNA polymerase eta, putative	0.0069	0.0172	0.1144
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0087	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0496	0.1614	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0155	0.0463	0.428
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0087	0.0976
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0087	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0005	0.0031
Trypanosoma brucei	DNA polymerase IV, putative	0.0061	0.0146	0.1161
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0039	0.0072	0.0435
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0027	0.0152
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0087	0.0085
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0327	0.1044	1
Toxoplasma gondii	transporter, cation channel family protein	0.002	0.0008	0.0033
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0087	0.0085
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0087	0.0584
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0172	0.1416
Echinococcus granulosus	dna polymerase kappa	0.0069	0.0172	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0087	0.0539
Brugia malayi	ImpB/MucB/SamB family protein	0.0038	0.0067	0.0401
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0027	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0005	0.0031
Loa Loa (eye worm)	apoptosis regulator protein	0.0083	0.022	0.1362
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0087	0.0976
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0005	0.0031
Echinococcus granulosus	neutral alpha glucosidase AB	0.0039	0.0072	0.007
Schistosoma mansoni	glutaminase	0.0296	0.0939	0.0937
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0087	0.0539
Brugia malayi	beta-lactamase	0.0043	0.0087	0.0525
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0096	0.0265	0.0262
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0084	0.0557
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0005	0.5
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0155	0.0463	0.4284
Loa Loa (eye worm)	hypothetical protein	0.0193	0.0592	0.367
Schistosoma mansoni	apoptosis regulator bax	0.0083	0.022	0.0218
Onchocerca volvulus		0.0043	0.0087	0.1063
Schistosoma mansoni	hypothetical protein	0.0083	0.022	0.0218
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0005	0.004
Schistosoma mansoni	hypothetical protein	0.0083	0.022	0.0218
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.0878	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0172	0.1416
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0087	0.0085
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0087	0.0085
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0176	0.0536	0.0533
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0039	0.0072	0.0286
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0152	0.0453	0.0451
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0069	0.0172	0.1028
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0087	0.0168
Echinococcus granulosus	muscleblind protein	0.0496	0.1614	0.1612
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0327	0.1044	1
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0096	0.0265	0.0262
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0172	0.1416
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0087	0.0877
Trypanosoma brucei	DNA polymerase IV, putative	0.0069	0.0172	0.1416
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0096	0.0265	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0087	0.0539
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0172	0.1416
Echinococcus multilocularis	dna polymerase eta	0.0065	0.0159	0.0157
Loa Loa (eye worm)	glutaminase	0.0296	0.0939	0.5821
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0084	0.0522
Schistosoma mansoni	thyroid hormone receptor	0.0164	0.0494	0.0492
Leishmania major	alpha glucosidase II subunit, putative	0.0039	0.0072	0.0447
Brugia malayi	beta-lactamase family protein	0.0043	0.0087	0.0525
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0087	0.0168
Schistosoma mansoni	alpha glucosidase	0.0039	0.0072	0.007
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0038	0.0067	0.0065
Trichomonas vaginalis	esterase, putative	0.0043	0.0087	0.0168
Toxoplasma gondii	hypothetical protein	0.0053	0.0118	0.0473
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0083	0.022	0.0218
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0087	0.0976
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0155	0.0463	0.4021
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0038	0.0067	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0027	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0087	0.0539
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0027	0.0152
Trypanosoma brucei	DNA polymerase IV, putative	0.0069	0.0172	0.1416
Echinococcus multilocularis	microtubule associated protein 2	0.2981	1	1
Brugia malayi	glutaminase DH11.1	0.0296	0.0939	0.5815
Leishmania major	DNA polymerase kappa, putative	0.0045	0.0093	0.0649
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0096	0.0265	0.1628
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0039	0.0072	0.007
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.0136	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0027	0.0167
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0087	1
Schistosoma mansoni	hypothetical protein	0.0083	0.022	0.0218
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0164	0.0494	0.0492
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0083	0.022	0.0218
Mycobacterium ulcerans	DNA polymerase IV	0.0069	0.0172	0.1783
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0083	0.022	0.0218
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0083	0.022	0.0218
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0172	0.1416
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0096	0.0265	0.0262
Mycobacterium ulcerans	hypothetical protein	0.0172	0.0522	0.553
Loa Loa (eye worm)	hypothetical protein	0.0496	0.1614	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0046	0.0095	0.0246
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0327	0.1044	1
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0087	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0027	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0005	0.0031
Schistosoma mansoni	hypothetical protein	0.0043	0.0087	0.0085
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0087	0.0168
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0172	0.1416
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0087	0.0539
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0054	0.0255
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0096	0.0265	0.0262
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.0136	0.0846
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0002	0.0015
Loa Loa (eye worm)	hypothetical protein	0.004	0.0074	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0136	0.0846
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0027	0.0234
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0172	0.1416
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0027	0.0234
Schistosoma mansoni	23-cyclic-nucleotide 2-phosphodiesterase	0.0757	0.2496	0.2494
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0069	0.0172	0.1028
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0069	0.0172	0.1028
Schistosoma mansoni	alpha-glucosidase	0.0152	0.0453	0.0451
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0163	0.1011
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0152	0.0453	0.0451
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0027	0.0234
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0027	0.0234
Leishmania major	hypothetical protein, conserved	0.0043	0.0087	0.0591
Leishmania major	mitochondrial DNA polymerase beta	0.0327	0.1044	1
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0087	0.0976
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0096	0.0265	0.0262
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0096	0.0265	0.0262
Brugia malayi	ImpB/MucB/SamB family protein	0.0065	0.0159	0.0972
Toxoplasma gondii	ABC1 family protein	0.0043	0.0087	0.0347
Toxoplasma gondii	5'-nucleotidase, C-terminal domain-containing protein	0.0313	0.0995	0.3976
Entamoeba histolytica	hypothetical protein	0.0043	0.0087	1
Entamoeba histolytica	hypothetical protein	0.0043	0.0087	1
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0058	0.0138	0.1082
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0087	0.0976
Trypanosoma brucei	DNA polymerase eta, putative	0.0065	0.0159	0.1292
Loa Loa (eye worm)	hypothetical protein	0.002	0.0008	0.0051
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0087	0.0525
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0039	0.0072	0.0289
Schistosoma mansoni	voltage-gated cation channel	0.0096	0.0265	0.0262
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0084	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0005	0.0031
Schistosoma mansoni	amyloid beta A4 protein related	0.0069	0.0172	0.017
Brugia malayi	polk-prov protein	0.0043	0.0084	0.0508
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0045	0.0093	0.0649
Brugia malayi	hypothetical protein	0.0066	0.0163	0.0997
Brugia malayi	abnormal cell lineage protein 10 (Protein lin-10), putative	0.0061	0.0148	0.0902
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0056	0.0129	0.0595
Onchocerca volvulus		0.0043	0.0087	0.1063
Loa Loa (eye worm)	X11 protein	0.0069	0.0172	0.1067
Echinococcus multilocularis	sodium channel protein	0.0041	0.0078	0.0076
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0054	0.0255
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0039	0.0072	0.7584
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0058	0.0138	0.0679
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0087	0.0168
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0172	0.1416
Toxoplasma gondii	5'-nucleotidase, C-terminal domain-containing protein	0.076	0.2503	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0054	0.0255
Echinococcus granulosus	lysosomal alpha glucosidase	0.0176	0.0536	0.0533
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0087	0.0159
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0087	0.0159
Trypanosoma brucei	DNA polymerase kappa, putative	0.0069	0.0172	0.1416
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0027	0.0234
Echinococcus multilocularis	muscleblind protein	0.0496	0.1614	0.1612
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0087	0.0976
Echinococcus multilocularis	voltage dependent calcium channel	0.0096	0.0265	0.0262
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0176	0.0536	0.0533
Leishmania major	DNA polymerase eta, putative	0.0039	0.0072	0.0439
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.2635	0.8833	0.8833
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0072	0.0008
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0027	0.0234
Loa Loa (eye worm)	voltage-dependent calcium channel	0.002	0.0008	0.0051
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0096	0.0265	0.0262
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0172	0.0522	0.5937
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0087	0.0877
Echinococcus granulosus	voltage dependent calcium channel	0.0096	0.0265	0.0262
Schistosoma mansoni	hypothetical protein	0.0152	0.0453	0.0451
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0176	0.0536	0.331
Echinococcus multilocularis	muscleblind protein 1	0.0496	0.1614	0.1612
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0069	0.0172	0.1028
Loa Loa (eye worm)	calcium channel	0.0096	0.0265	0.164
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0038	0.0067	0.0065
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0083	0.022	0.0218
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0095	0.0246
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0087	0.0085
Echinococcus granulosus	amyloid beta A4 protein	0.0069	0.0172	0.017
Schistosoma mansoni	DNA polymerase eta	0.0065	0.0159	0.0157
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0087	0.0976
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0069	0.0172	0.1144
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0087	0.0976
Brugia malayi	beta-lactamase family protein	0.0043	0.0087	0.0525
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0087	0.0085
Echinococcus multilocularis	voltage dependent calcium channel	0.0096	0.0265	0.0262
Brugia malayi	N-terminal motif family protein	0.0193	0.0592	0.3661
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0039	0.0072	0.7584
Mycobacterium ulcerans	DNA polymerase IV	0.0069	0.0172	0.1783
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0074	0.0447
Echinococcus multilocularis	dna polymerase kappa	0.0069	0.0172	0.0169
Entamoeba histolytica	hypothetical protein	0.0043	0.0087	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0095	0.0246

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (binding)	= 1.2589 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	= 2.5119 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1354638

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1206362