Detailed information for compound 1219514

Basic information

Technical information
  • TDR Targets ID: 1219514
  • Name: N-[2-[(3-methoxyphenyl)amino]-2-oxoethyl]-N-m ethyl-2-(2-oxo-1,3-benzoxazol-3-yl)acetamide
  • MW: 369.371 | Formula: C19H19N3O5
  • H donors: 1 H acceptors: 3 LogP: 1.72 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)NC(=O)CN(C(=O)Cn1c(=O)oc2c1cccc2)C
  • InChi: 1S/C19H19N3O5/c1-21(11-17(23)20-13-6-5-7-14(10-13)26-2)18(24)12-22-15-8-3-4-9-16(15)27-19(22)25/h3-10H,11-12H2,1-2H3,(H,20,23)
  • InChiKey: JOKBRTPCWQMLQK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-[(3-methoxyphenyl)amino]-2-oxo-ethyl]-N-methyl-2-(2-oxo-1,3-benzoxazol-3-yl)acetamide
  • 2-(2-keto-1,3-benzoxazol-3-yl)-N-[2-keto-2-[(3-methoxyphenyl)amino]ethyl]-N-methyl-acetamide
  • N-[2-[(3-methoxyphenyl)amino]-2-oxo-ethyl]-N-methyl-2-(2-oxo-1,3-benzoxazol-3-yl)ethanamide
  • ZINC07291235

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase C (CPC) 0.0331 0.1949 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0362 0.04
Echinococcus multilocularis cathepsin L 0.0084 0.0247 0.0247
Plasmodium falciparum LCCL domain-containing protein 0.0058 0.0064 0.1045
Onchocerca volvulus 0.0137 0.061 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0247 0.1268
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0137 0.061 0.3128
Onchocerca volvulus 0.0137 0.061 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0137 0.061 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0137 0.061 0.061
Brugia malayi Doublecortin family protein 0.0058 0.0064 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0362 0.186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.061 0.3097
Brugia malayi Cathepsin L-like precursor 0.0101 0.0362 0.04
Brugia malayi Cathepsin L-like cysteine proteinase 0.0101 0.0362 0.04
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0084 0.0247 0.0247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.061 0.3097
Giardia lamblia Cathepsin B precursor 0.0331 0.1949 1
Leishmania major cathepsin L-like protease 0.0137 0.061 0.3097
Onchocerca volvulus 0.0137 0.061 1
Echinococcus granulosus cysteine protease 0.0084 0.0247 0.0247
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0137 0.061 0.0673
Entamoeba histolytica cysteine protease, putative 0.0084 0.0247 0.4054
Schistosoma mansoni jumonji domain containing protein 0.0115 0.0456 0.0456
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0137 0.061 0.3128
Schistosoma mansoni jumonji/arid domain-containing protein 0.0115 0.0456 0.0456
Onchocerca volvulus 0.0101 0.0362 0.5946
Schistosoma mansoni cathepsin F (C01 family) 0.0137 0.061 0.061
Leishmania major cathepsin L-like protease 0.0137 0.061 0.3097
Giardia lamblia Cathepsin B precursor 0.0331 0.1949 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.061 0.3097
Entamoeba histolytica cysteine protease, putative 0.0084 0.0247 0.4054
Brugia malayi Cathepsin L-like precursor 0.0137 0.061 0.0673
Loa Loa (eye worm) cathepsin B 0.0331 0.1949 0.215
Brugia malayi Cathepsin L-like precursor 0.0101 0.0362 0.04
Trypanosoma cruzi cysteine peptidase, putative 0.0084 0.0247 0.0963
Leishmania major cytochrome p450-like protein 0.0113 0.0443 0.2237
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1364 0.9061 1
Loa Loa (eye worm) CYP4Cod1 0.0113 0.0443 0.0489
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0421 0.2566 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.0064 0.0064
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0009 0.0045
Brugia malayi Papain family cysteine protease containing protein 0.0084 0.0247 0.0273
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0137 0.061 0.3128
Echinococcus multilocularis microtubule associated protein 2 0.1501 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0113 0.0443 0.0489
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.061 0.3128
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0331 0.1949 0.7595
Schistosoma mansoni microtubule-associated protein tau 0.1501 1 1
Echinococcus granulosus Polycystic kidney disease protein 0.0058 0.0064 0.0064
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0009 0.0009
Echinococcus multilocularis cathepsin b 0.0421 0.2566 0.2566
Brugia malayi Cathepsin L-like precursor 0.0137 0.061 0.0673
Loa Loa (eye worm) hypothetical protein 0.0058 0.0064 0.007
Entamoeba histolytica cysteine proteinase 1, putative 0.0084 0.0247 0.4054
Entamoeba histolytica cysteine protease, putative 0.0084 0.0247 0.4054
Brugia malayi Papain family cysteine protease containing protein 0.0084 0.0247 0.0273
Loa Loa (eye worm) hypothetical protein 0.008 0.022 0.0242
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0009 0.0045
Trypanosoma cruzi cruzipain precursor, putative 0.0137 0.061 0.2376
Entamoeba histolytica cysteine protease, putative 0.0137 0.061 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.061 0.3128
Brugia malayi hypothetical protein 0.0058 0.0064 0.007
Entamoeba histolytica cysteine proteinase, putative 0.0084 0.0247 0.4054
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0456 0.0456
Brugia malayi jmjC domain containing protein 0.0115 0.0456 0.0503
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0137 0.061 0.3128
Plasmodium vivax vivapain-2 0.0137 0.061 1
Echinococcus multilocularis cathepsin b 0.0421 0.2566 0.2566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.061 0.3128
Brugia malayi Papain family cysteine protease containing protein 0.0137 0.061 0.0673
Echinococcus multilocularis cathepsin L cysteine protease 0.0137 0.061 0.061
Entamoeba histolytica cysteine proteinase, putative 0.0137 0.061 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.061 0.3128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0247 0.1268
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.061 0.3097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.0247 0.1229
Trypanosoma cruzi cysteine proteinase, putative 0.0084 0.0247 0.0963
Entamoeba histolytica cysteine proteinase, putative 0.0084 0.0247 0.4054
Plasmodium vivax vivapain-3 0.0084 0.0247 0.4054
Brugia malayi hypothetical protein 0.0058 0.0064 0.007
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0009 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.061 0.3097
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.0064 0.0064
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0344 0.2039 0.2039
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0084 0.0247 0.0247
Echinococcus granulosus cathepsin L cysteine proteinase 0.0137 0.061 0.061
Entamoeba histolytica cysteine proteinase, putative 0.0137 0.061 1
Entamoeba histolytica cysteine proteinase, putative 0.0084 0.0247 0.4054
Onchocerca volvulus 0.0137 0.061 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.061 0.3128
Schistosoma mansoni rab6-interacting 0.0058 0.0064 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.061 0.3097
Echinococcus granulosus RUN 0.0058 0.0064 0.0064
Schistosoma mansoni loxhd1 0.0058 0.0064 0.0064
Loa Loa (eye worm) fibroinase 0.0137 0.061 0.0673
Leishmania major cathepsin L-like protease 0.0137 0.061 0.3097
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0137 0.061 0.3128
Echinococcus multilocularis lysine specific demethylase 5A 0.0115 0.0456 0.0456
Plasmodium falciparum cysteine proteinase falcipain 1 0.0084 0.0247 0.4054
Leishmania major cathepsin L-like protease 0.0137 0.061 0.3097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.061 0.3097
Schistosoma mansoni cathepsin F (C01 family) 0.0137 0.061 0.061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.061 0.3128
Leishmania major cathepsin L-like protease 0.0137 0.061 0.3097
Onchocerca volvulus 0.0137 0.061 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0137 0.061 0.3128
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0009 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.061 0.3097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.061 0.3097
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0009 0.0009
Schistosoma mansoni rab6-interacting 0.0058 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0058 0.0064 0.007
Entamoeba histolytica cysteine protease, putative 0.0084 0.0247 0.4054
Schistosoma mansoni lipoxygenase 0.0241 0.1325 0.1325
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.0064 0.0064
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0331 0.1949 0.1949
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0137 0.061 0.061
Loa Loa (eye worm) jmjC domain-containing protein 0.0115 0.0456 0.0503
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.061 0.3128
Schistosoma mansoni polycystin 1-related 0.0058 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0421 0.2566 0.2832
Brugia malayi Cathepsin L-like precursor 0.0137 0.061 0.0673
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.061 0.3128
Brugia malayi cathepsin L-like precursor 0.0101 0.0362 0.04
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.158 0.5
Echinococcus granulosus cathepsin L cysteine protease 0.0084 0.0247 0.0247
Echinococcus multilocularis Polycystic kidney disease protein 0.0058 0.0064 0.0064
Leishmania major cathepsin L-like protease 0.0137 0.061 0.3097
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0137 0.061 0.3128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.061 0.3128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.061 0.3128
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0084 0.0247 0.0963
Entamoeba histolytica cysteine protease, putative 0.0084 0.0247 0.4054
Echinococcus granulosus cathepsin l cysteine peptidase 0.0137 0.061 0.061
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0137 0.061 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.061 0.3128
Brugia malayi Cytochrome P450 family protein 0.0113 0.0443 0.0489
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0009 0.0009
Plasmodium vivax vivapain-1 0.0084 0.0247 0.4054
Loa Loa (eye worm) ctsf protein 0.0137 0.061 0.0673
Trypanosoma cruzi cysteine peptidase, putative 0.0137 0.061 0.2376
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0344 0.2039 0.2039
Onchocerca volvulus 0.0058 0.0064 0.1045
Brugia malayi MAP kinase sur-1 0.005 0.0009 0.001
Entamoeba histolytica cysteine protease, putative 0.0084 0.0247 0.4054
Trypanosoma cruzi cytochrome P450, putative 0.0113 0.0443 0.1726
Onchocerca volvulus Cathepsin L homolog 0.0137 0.061 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0362 0.04
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0009 0.0009
Echinococcus multilocularis cysteine protease 0.0137 0.061 0.061
Entamoeba histolytica cysteine protease, putative 0.0084 0.0247 0.4054
Echinococcus granulosus cathepsin b 0.0421 0.2566 0.2566
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0009 0.0045
Leishmania major cysteine peptidase A (CPA) 0.0137 0.061 0.3097
Trypanosoma cruzi cysteine proteinase, putative 0.0084 0.0247 0.0963
Entamoeba histolytica cysteine protease, putative 0.0084 0.0247 0.4054
Brugia malayi follicle stimulating hormone receptor 0.1364 0.9061 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0421 0.2566 0.2566
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0113 0.0443 0.5
Brugia malayi Cathepsin L-like precursor 0.0137 0.061 0.0673
Trypanosoma cruzi cysteine protease, putative 0.0084 0.0247 0.0963
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0137 0.061 0.0673
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0456 0.0456
Echinococcus granulosus cathepsin l1 0.0101 0.0362 0.0362
Entamoeba histolytica cysteine protease, putative 0.0084 0.0247 0.4054
Echinococcus granulosus cathepsin b 0.0421 0.2566 0.2566
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0009 0.0034
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0009 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.061 0.3097
Trypanosoma brucei cytochrome P450, putative 0.0113 0.0443 0.2237
Echinococcus multilocularis cathepsin L cysteine protease 0.0137 0.061 0.061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.061 0.3128
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0331 0.1949 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0137 0.061 0.3128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.061 0.3128
Leishmania major cathepsin L-like protease 0.0137 0.061 0.3097
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0009 0.001
Echinococcus granulosus cathepsin L 0.0084 0.0247 0.0247
Loa Loa (eye worm) cysteine protease 0.0137 0.061 0.0673
Echinococcus granulosus cathepsin l1 0.0137 0.061 0.061
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.0064 0.0064
Leishmania major cathepsin L-like protease 0.0137 0.061 0.3097
Echinococcus multilocularis RUN 0.0058 0.0064 0.0064
Onchocerca volvulus Cathepsin F homolog 0.0137 0.061 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0137 0.061 0.3128
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0137 0.061 0.3128
Trypanosoma cruzi cytochrome P450, putative 0.0113 0.0443 0.1726
Brugia malayi cathepsin B-like cysteine proteinase 0.0421 0.2566 0.2832
Schistosoma mansoni cathepsin F (C01 family) 0.0101 0.0362 0.0362
Schistosoma mansoni lipoxygenase 0.0344 0.2039 0.2039
Entamoeba histolytica cysteine proteinase, putative 0.0101 0.0362 0.5946
Giardia lamblia Cathepsin B precursor 0.0331 0.1949 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0115 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0137 0.061 0.0673
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0101 0.0362 0.1413
Loa Loa (eye worm) doublecortin family protein 0.0058 0.0064 0.007
Onchocerca volvulus 0.0058 0.0064 0.1045
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0421 0.2566 0.2566
Brugia malayi Cathepsin L-like precursor 0.0137 0.061 0.0673
Trypanosoma cruzi cysteine peptidase, putative 0.0137 0.061 0.2376
Toxoplasma gondii cathepsin B 0.0331 0.1949 1
Brugia malayi jmjC domain containing protein 0.0115 0.0456 0.0503
Onchocerca volvulus 0.0137 0.061 1
Brugia malayi Cathepsin L-like precursor 0.0137 0.061 0.0673
Trypanosoma cruzi cysteine peptidase, putative 0.0137 0.061 0.2376
Loa Loa (eye worm) hypothetical protein 0.0101 0.0362 0.04
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0137 0.061 1
Brugia malayi Cytochrome P450 family protein 0.0113 0.0443 0.0489
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0421 0.2566 0.2566
Loa Loa (eye worm) cytochrome P450 family protein 0.0113 0.0443 0.0489
Onchocerca volvulus 0.0137 0.061 1
Plasmodium vivax vivapain-2 0.0137 0.061 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0137 0.061 0.3128
Echinococcus granulosus lysine specific demethylase 5A 0.0115 0.0456 0.0456
Schistosoma mansoni hypothetical protein 0.0058 0.0064 0.0064
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0009 0.0045
Echinococcus multilocularis cysteine protease 0.0137 0.061 0.061
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0009 0.0034
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0009 0.0034
Entamoeba histolytica cysteine proteinase, putative 0.0084 0.0247 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0137 0.061 0.2376
Entamoeba histolytica cysteine protease, putative 0.0084 0.0247 0.4054
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0009 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.0247 0.1229
Toxoplasma gondii cathepsin CPL 0.0137 0.061 0.3128
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0421 0.2566 0.2566
Entamoeba histolytica cysteine protease, putative 0.0084 0.0247 0.4054
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0331 0.1949 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0137 0.061 0.3128
Plasmodium vivax multidomain scavenger receptor, putative 0.0058 0.0064 0.1045
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0084 0.0247 0.0247
Plasmodium vivax unspecified product 0.0084 0.0247 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0362 0.186
Entamoeba histolytica cysteine protease, putative 0.0084 0.0247 0.4054
Entamoeba histolytica cysteine protease, putative 0.0084 0.0247 0.4054
Onchocerca volvulus Cathepsin L homolog 0.0137 0.061 1
Entamoeba histolytica cysteine proteinase 2 0.0084 0.0247 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.061 0.3097

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.