Detailed information for compound 1233774

Basic information

Technical information
  • TDR Targets ID: 1233774
  • Name: 3-[4-(2,5-dimethylphenyl)-5-ethyl-1,3-thiazol -2-yl]-8-methoxychromen-2-one
  • MW: 391.483 | Formula: C23H21NO3S
  • H donors: 0 H acceptors: 2 LogP: 5.81 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1sc(nc1c1cc(C)ccc1C)c1cc2cccc(c2oc1=O)OC
  • InChi: 1S/C23H21NO3S/c1-5-19-20(16-11-13(2)9-10-14(16)3)24-22(28-19)17-12-15-7-6-8-18(26-4)21(15)27-23(17)25/h6-12H,5H2,1-4H3
  • InChiKey: MBMOEDQPZFISFH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[4-(2,5-dimethylphenyl)-5-ethyl-thiazol-2-yl]-8-methoxy-chromen-2-one
  • 3-[4-(2,5-dimethylphenyl)-5-ethyl-2-thiazolyl]-8-methoxy-2-chromenone
  • 3-[4-(2,5-dimethylphenyl)-5-ethyl-thiazol-2-yl]-8-methoxy-coumarin
  • 3-[4-(2,5-dimethylphenyl)-5-ethyl-1,3-thiazol-2-yl]-8-methoxy-chromen-2-one
  • ZINC02964221
  • Oprea1_356232
  • Oprea1_079743
  • 3-[4-(2,5-Dimethyl-phenyl)-5-ethyl-thiazol-2-yl]-8-methoxy-chromen-2-one
  • BAS 01922905

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Papain family cysteine protease containing protein 0.0073 0.2361 0.2361
Echinococcus multilocularis chromobox protein 1 0.0084 0.3029 0.3029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.2361 0.7565
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.2361 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.2361 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.3029 0.3029
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0523 0.0861
Schistosoma mansoni chromobox protein 0.0084 0.3029 0.3647
Leishmania major cathepsin L-like protease 0.0073 0.2361 1
Onchocerca volvulus 0.0073 0.2361 0.4854
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.2361 0.7565
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.2361 0.7565
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.004 0.0287 0.0346
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.2321 0.2321
Echinococcus granulosus cathepsin L 0.004 0.0287 0.0287
Plasmodium vivax vivapain-2 0.0073 0.2361 1
Onchocerca volvulus 0.0037 0.0109 0.0225
Onchocerca volvulus 0.0073 0.2361 0.4854
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.2361 0.7565
Brugia malayi Cathepsin L-like precursor 0.0073 0.2361 0.2361
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.006 0.1504 0.4439
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.074 0.1652
Leishmania major cathepsin L-like protease 0.0073 0.2361 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.2361 0.7565
Entamoeba histolytica cysteine proteinase, putative 0.0073 0.2361 1
Leishmania major cathepsin L-like protease 0.0073 0.2361 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.074 0.1521
Leishmania major cathepsin L-like protease 0.0073 0.2361 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.074 0.1652
Plasmodium falciparum cysteine proteinase falcipain 1 0.004 0.0287 0.1216
Schistosoma mansoni alpha glucosidase 0.0044 0.0523 0.063
Plasmodium vivax vivapain-3 0.004 0.0287 0.1216
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0073 0.2361 1
Brugia malayi jmjC domain containing protein 0.0115 0.4959 0.4959
Plasmodium vivax unspecified product 0.004 0.0287 0.1216
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0073 0.2361 0.7565
Echinococcus granulosus cathepsin L cysteine protease 0.004 0.0287 0.0287
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0523 0.0861
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.2361 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.2361 0.7565
Echinococcus multilocularis cathepsin L cysteine protease 0.0073 0.2361 0.2361
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0523 0.2216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.2361 1
Giardia lamblia Cathepsin B precursor 0.006 0.1504 1
Loa Loa (eye worm) fibroinase 0.0073 0.2361 0.2361
Leishmania major cathepsin L-like protease 0.0073 0.2361 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0154 0.7381 0.8888
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.2361 0.7565
Brugia malayi Cathepsin L-like precursor 0.0073 0.2361 0.2361
Onchocerca volvulus Cathepsin L homolog 0.0073 0.2361 0.4854
Schistosoma mansoni chromobox protein 0.0084 0.3029 0.3647
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0073 0.2361 0.2361
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 1 1
Brugia malayi Papain family cysteine protease containing protein 0.004 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0051 0.0947 0.0947
Echinococcus multilocularis cysteine protease 0.0073 0.2361 0.2361
Onchocerca volvulus 0.0073 0.2361 0.4854
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.3029 0.3029
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 1 1
Echinococcus granulosus cathepsin b 0.0154 0.7381 0.7381
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0523 0.0523
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0073 0.2361 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0523 0.0861
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0073 0.2361 0.7565
Loa Loa (eye worm) hypothetical protein 0.006 0.1557 0.1557
Echinococcus granulosus cathepsin L cysteine proteinase 0.0073 0.2361 0.2361
Leishmania major cathepsin L-like protease 0.0073 0.2361 1
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0962 0.246
Trichomonas vaginalis chromobox protein, putative 0.0084 0.3029 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.2361 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0459 0.0552
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.2361 0.2924
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.4959 0.4959
Brugia malayi Cathepsin L-like cysteine proteinase 0.0051 0.0947 0.0947
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0523 0.0523
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 1 1
Toxoplasma gondii cathepsin B 0.006 0.1504 0.6371
Loa Loa (eye worm) hypothetical protein 0.0051 0.0947 0.0947
Schistosoma mansoni alpha-glucosidase 0.0169 0.8304 1
Entamoeba histolytica cysteine proteinase, putative 0.0051 0.0947 0.3182
Onchocerca volvulus Cathepsin F homolog 0.0073 0.2361 0.4854
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0051 0.0947 0.093
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0947 0.2407
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.004 0.0287 0.0346
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.4959 0.4959
Plasmodium falciparum cysteine proteinase falcipain 3 0.0073 0.2361 1
Leishmania major cathepsin L-like protease 0.0073 0.2361 1
Entamoeba histolytica cysteine proteinase, putative 0.0073 0.2361 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0459 0.0459
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0459 0.0459
Echinococcus multilocularis cathepsin L cysteine protease 0.0073 0.2361 0.2361
Loa Loa (eye worm) cathepsin B 0.006 0.1504 0.1504
Echinococcus granulosus chromobox protein 1 0.0084 0.3029 0.3029
Loa Loa (eye worm) hypothetical protein 0.0047 0.074 0.074
Trypanosoma brucei glucosidase, putative 0.0044 0.0523 0.1138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.2361 0.7565
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0523 0.0861
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.2361 0.7565
Leishmania major cathepsin L-like protease 0.0073 0.2361 1
Onchocerca volvulus 0.0073 0.2361 0.4854
Loa Loa (eye worm) cysteine protease 0.0073 0.2361 0.2361
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0523 0.1138
Toxoplasma gondii cathepsin CPL 0.0073 0.2361 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0154 0.7381 0.8888
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0459 0.0552
Onchocerca volvulus 0.0114 0.4865 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.2361 0.7565
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0459 0.0459
Brugia malayi Papain family cysteine protease containing protein 0.004 0.0287 0.0287
Schistosoma mansoni cathepsin F (C01 family) 0.0051 0.0947 0.1141
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0523 0.0333
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0523 0.0861
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.2361 0.7565
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0523 0.0861
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.2361 1
Brugia malayi Cathepsin L-like precursor 0.0073 0.2361 0.2361
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0962 0.246
Giardia lamblia Cathepsin B precursor 0.006 0.1504 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.7381 0.7381
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.2361 0.7565
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.2361 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.006 0.1504 0.1812
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.2361 0.7565
Loa Loa (eye worm) hypothetical protein 0.0073 0.2361 0.2361
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0523 0.0861
Brugia malayi Cathepsin L-like precursor 0.0073 0.2361 0.2361
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0523 0.0523
Echinococcus granulosus cathepsin b 0.0154 0.7381 0.7381
Trichomonas vaginalis chromobox protein, putative 0.0084 0.3029 1
Echinococcus granulosus cathepsin l1 0.0051 0.0947 0.0947
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.006 0.1504 0.1716
Onchocerca volvulus 0.0073 0.2361 0.4854
Brugia malayi Cathepsin L-like precursor 0.0051 0.0947 0.0947
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0154 0.7381 1
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.2361 0.2924
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.2361 1
Echinococcus granulosus chromobox protein 1 0.0084 0.3029 0.3029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.2361 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.2361 0.7565
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.2361 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0073 0.2361 0.2361
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0854 0.0854
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0073 0.2361 0.2361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.2361 0.7565
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0523 0.0861
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0073 0.2361 0.2361
Leishmania major cysteine peptidase A (CPA) 0.0073 0.2361 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.2361 0.7565
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.2361 0.2924
Onchocerca volvulus 0.0073 0.2361 0.4854
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.2361 0.7565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.2361 0.7565
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0962 0.1977
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0154 0.7381 0.8888
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0947 0.2407
Echinococcus multilocularis cysteine protease 0.0073 0.2361 0.2361
Giardia lamblia Cathepsin B precursor 0.006 0.1504 1
Brugia malayi cathepsin L-like precursor 0.0051 0.0947 0.0947
Echinococcus multilocularis cathepsin b 0.0154 0.7381 0.7381
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0523 0.0861
Schistosoma mansoni cathepsin F (C01 family) 0.0073 0.2361 0.2844
Loa Loa (eye worm) hypothetical protein 0.0051 0.0947 0.0947
Onchocerca volvulus 0.0073 0.2361 0.4854
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.2361 0.7565
Schistosoma mansoni jumonji domain containing protein 0.0092 0.3492 0.4205
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0854 0.0854
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0073 0.2361 0.2361
Echinococcus multilocularis cathepsin b 0.0154 0.7381 0.7381
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0523 0.0333
Brugia malayi Cathepsin L-like precursor 0.0073 0.2361 0.2361
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0523 0.0523
Echinococcus granulosus cysteine protease 0.004 0.0287 0.0287
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 1 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0154 0.7381 0.8888
Trypanosoma brucei cysteine peptidase C (CPC) 0.006 0.1504 0.5868
Brugia malayi Cathepsin L-like precursor 0.0073 0.2361 0.2361
Brugia malayi chromobox protein homolog 3 0.0047 0.074 0.074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.2361 0.7565
Schistosoma mansoni cathepsin F (C01 family) 0.0073 0.2361 0.2844
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.2361 0.7565
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0523 0.1138
Echinococcus multilocularis cathepsin L 0.004 0.0287 0.0287
Echinococcus granulosus cathepsin l1 0.0073 0.2361 0.2361
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.2361 0.7565
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.2361 1
Onchocerca volvulus 0.0051 0.0947 0.1947
Plasmodium vivax vivapain-1 0.004 0.0287 0.1216
Onchocerca volvulus Cathepsin L homolog 0.0073 0.2361 0.4854
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.2361 0.2924
Brugia malayi cathepsin B-like cysteine proteinase 0.0154 0.7381 0.7381
Brugia malayi jmjC domain containing protein 0.0043 0.0459 0.0459
Entamoeba histolytica cysteine protease, putative 0.0073 0.2361 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.006 0.1504 0.5338
Loa Loa (eye worm) ctsf protein 0.0073 0.2361 0.2361
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0109
Schistosoma mansoni alpha-glucosidase 0.0169 0.8304 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0073 0.2361 0.7565
Trypanosoma cruzi cruzipain precursor, putative 0.0073 0.2361 0.2924
Brugia malayi Cathepsin L-like precursor 0.0051 0.0947 0.0947
Brugia malayi Heterochromatin protein 1 0.0084 0.3029 0.3029
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.004 0.0287 0.0346
Plasmodium vivax vivapain-2 0.0073 0.2361 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: Confirmation of Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1466, AID1473, AID2293] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: Confirmation of Inhibitors of Human alpha-Galactosidase Using Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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