Detailed information for compound 1236427

Basic information

Technical information
  • TDR Targets ID: 1236427
  • Name: SMR000336584
  • MW: 276.293 | Formula: C16H12N4O
  • H donors: 0 H acceptors: 3 LogP: 1.97 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)CCc1c2nc2c(C#N)cnn2c1
  • InChi: 1S/C16H12N4O/c1-21-13-4-5-14-10(6-13)2-3-11-9-20-16(19-15(11)14)12(7-17)8-18-20/h4-6,8-9H,2-3H2,1H3
  • InChiKey: IXEQQNFCNYLXPU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Bionet2_001096
  • 9W-0326
  • 3-methoxy-5,6-dihydrobenzo[h]pyrazolo[5,1-b]quinazoline-11-carbonitrile
  • MLS000696481

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 3 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens galactosidase, alpha Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Alpha-N-acetylgalactosaminidase precursor, putative Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum ko:K01204 alpha-N-acetylgalactosaminidase [EC3.2.1.49], putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Echinococcus multilocularis Glycoside hydrolase, family 27 Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Neospora caninum hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii melibiase subfamily protein Get druggable targets OG5_127620 All targets in OG5_127620
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum expressed protein Get druggable targets OG5_127620 All targets in OG5_127620
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Melibiase family protein Get druggable targets OG5_127620 All targets in OG5_127620
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus geminin 0.0205 0.3982 0.3982
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.053 0.053
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.2387 0.2373
Leishmania major aldo-keto reductase-like protein 0.0485 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.053 0.0513
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0018 0.0018
Schistosoma mansoni alpha-glucosidase 0.0169 0.3225 0.3225
Brugia malayi jmjC domain containing protein 0.0071 0.1117 0.1117
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.2387 0.2373
Trypanosoma brucei aldo/keto reductase, putative 0.0141 0.2608 0.2608
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0485 1 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.1363 0.1363
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.1117 0.1117
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1166 0.1166
Trypanosoma brucei prostaglandin f synthase 0.0485 1 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.053 0.0513
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1166 0.1166
Echinococcus granulosus hypothetical protein 0.0485 1 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0018 0.0018
Toxoplasma gondii thioredoxin reductase 0.0057 0.0818 0.0818
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0141 0.2608 0.2608
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.053 0.0513
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0018 0.0018
Echinococcus multilocularis aldehyde reductase 0.0345 0.6986 0.6986
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0485 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0485 1 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.2246 0.2246
Trichomonas vaginalis aldo-keto reductase, putative 0.0141 0.2608 0.2595
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0018 0.0018
Toxoplasma gondii melibiase subfamily protein 0.0124 0.2246 0.2246
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.3813 0.3813
Echinococcus multilocularis aldo keto reductase 0.0485 1 1
Plasmodium vivax aldehyde reductase, putative 0.0141 0.2608 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0141 0.2608 0.2595
Onchocerca volvulus 0.0141 0.2608 0.0721
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0485 1 1
Mycobacterium leprae Conserved hypothetical protein 0.0345 0.6986 0.6041
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.3813 0.3813
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0485 1 1
Loa Loa (eye worm) glutathione reductase 0.0057 0.0818 0.0818
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.2387 0.2373
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0141 0.2608 0.2608
Trichomonas vaginalis aldo-keto reductase, putative 0.0485 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0485 1 1
Giardia lamblia Aldose reductase 0.0485 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0485 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0247 0.0946
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.053 0.053
Schistosoma mansoni aldo-keto reductase 0.0485 1 1
Plasmodium falciparum glutathione reductase 0.0057 0.0818 0.3138
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0018 0.0018
Plasmodium falciparum aldo-keto reductase, putative 0.0141 0.2608 1
Plasmodium falciparum thioredoxin reductase 0.002 0.0018 0.007
Mycobacterium leprae Possible oxidoreductase 0.0141 0.2608 0.029
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0485 1 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.4269 0.2805
Onchocerca volvulus 0.0485 1 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0018 0.007
Loa Loa (eye worm) oxidoreductase 0.0485 1 1
Leishmania major prostaglandin f synthase, putative 0.0485 1 1
Treponema pallidum NADH oxidase 0.002 0.0018 0.5
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0018 0.0018
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0018 0.5
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0485 1 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0141 0.2608 0.2194
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0485 1 1
Loa Loa (eye worm) oxidoreductase 0.0485 1 1
Trypanosoma cruzi aldo-keto reductase 0.0485 1 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0485 1 1
Echinococcus multilocularis voltage gated potassium channel subunit 0.0141 0.2608 0.2608
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.2387 0.2373
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.053 0.053
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1166 0.1166
Loa Loa (eye worm) oxidoreductase 0.0485 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0485 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0018 0.0018
Trichomonas vaginalis aldo-keto reductase, putative 0.0485 1 1
Plasmodium falciparum thioredoxin reductase 0.0057 0.0818 0.3138
Loa Loa (eye worm) oxidoreductase 0.0485 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.053 0.0513
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.053 0.0513
Trypanosoma brucei aldo-keto reductase, putative 0.0485 1 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0247 0.0247
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.2699 0.0409
Echinococcus granulosus aldo keto reductase 0.0485 1 1
Loa Loa (eye worm) oxidoreductase 0.0485 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0247 0.0946
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0082 0.1363 0.1347
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0485 1 1
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0141 0.2608 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0018 0.007
Trichomonas vaginalis aldo-keto reductase, putative 0.0485 1 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.053 0.0513
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0018 0.0018
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1166 0.1166
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.1117 0.1117
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0018 0.0018
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.2246 0.2246
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0485 1 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0141 0.2608 0.2194
Leishmania major hypothetical protein, conserved 0.003 0.0247 0.0247
Onchocerca volvulus 0.0485 1 1
Echinococcus granulosus aldo keto reductase 0.0485 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0485 1 1
Giardia lamblia Aldose reductase 0.0485 1 1
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0141 0.2608 0.2608
Leishmania major trypanothione reductase 0.0057 0.0818 0.0818
Echinococcus multilocularis aldo keto reductase 0.0485 1 1
Schistosoma mansoni hypothetical protein 0.0205 0.3982 0.3982
Echinococcus granulosus aldehyde reductase 0.0345 0.6986 0.6986
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0141 0.2608 0.2608
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0141 0.2608 0.2608
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1166 0.115
Trichomonas vaginalis aldo/keto reductase, putative 0.0485 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0485 1 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.1363 0.1363
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.2699 0.2685
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0818 0.0818
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0247 0.0247
Schistosoma mansoni aldo-keto reductase 0.0485 1 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0485 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0247 0.0247
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.053 0.0513
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0018 0.007
Trichomonas vaginalis aldo-keto reductase, putative 0.0485 1 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0018 0.0018
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0485 1 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0818 0.0802
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0818 0.3138
Onchocerca volvulus 0.0485 1 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.1363 0.1363
Trichomonas vaginalis aldo/keto reductase, putative 0.0485 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.2608 0.2595
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0018 0.5
Brugia malayi hypothetical protein 0.003 0.0247 0.0247
Plasmodium falciparum aldehyde reductase, putative 0.0141 0.2608 1
Schistosoma mansoni hypothetical protein 0.0205 0.3982 0.3982
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0485 1 1
Schistosoma mansoni potassium channel beta 0.0141 0.2608 0.2608
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.1117 0.1117
Trichomonas vaginalis aldo-keto reductase, putative 0.0485 1 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0018 0.0018
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0818 0.0818
Brugia malayi N-terminal motif family protein 0.0218 0.4269 0.4269
Echinococcus multilocularis geminin 0.0205 0.3982 0.3982
Plasmodium falciparum glutathione reductase 0.002 0.0018 0.007
Mycobacterium tuberculosis Probable oxidoreductase 0.0485 1 1
Loa Loa (eye worm) hypothetical protein 0.0485 1 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.2246 0.2246
Brugia malayi Thioredoxin reductase 0.0057 0.0818 0.0818
Echinococcus multilocularis aldo keto reductase 0.0485 1 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.1117 0.1117
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0124 0.2246 0.2246
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0485 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0485 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.053 0.053
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.1117 0.1117
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0247
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.053 0.053
Trypanosoma brucei trypanothione reductase 0.0057 0.0818 0.0818
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0018 0.0018
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.3813 0.3813
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.2699 0.2685
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0018 0.0018
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.053 0.053
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.053 0.0513
Entamoeba histolytica aldose reductase, putative 0.0485 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.1117 0.1117
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0247 0.0946
Schistosoma mansoni alpha glucosidase 0.0044 0.053 0.053
Trypanosoma cruzi aldo/keto reductase, putative 0.0485 1 1
Toxoplasma gondii aldose reductase, putative 0.0485 1 1
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0141 0.2608 0.2608
Entamoeba histolytica aldose reductase, putative 0.0485 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0485 1 1
Echinococcus granulosus voltage gated potassium channel subunit 0.0141 0.2608 0.2608
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0485 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0018 0.0018
Mycobacterium ulcerans oxidoreductase 0.0485 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0485 1 1
Brugia malayi hypothetical protein 0.002 0.0015 0.0015
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1166 0.1166
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.053 0.053
Onchocerca volvulus 0.0485 1 1
Brugia malayi glutathione reductase 0.0057 0.0818 0.0818
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0485 1 1
Mycobacterium ulcerans hypothetical protein 0.0141 0.2608 0.2595
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0018 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0141 0.2608 0.2595
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.053 0.053
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0485 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0485 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0141 0.2608 0.2595
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0124 0.2246 0.2246
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0485 1 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.4269 0.4269
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.2699 0.2685
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1166 0.1166
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0485 1 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.053 0.0513
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.1117 0.1117
Brugia malayi Melibiase family protein 0.0082 0.1363 0.1363
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0485 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0018 0.0018
Brugia malayi jmjC domain containing protein 0.0071 0.1117 0.1117
Brugia malayi NADH-dependent xylose reductase 0.0141 0.2608 0.2608
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0485 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0485 1 1
Schistosoma mansoni alpha-glucosidase 0.0169 0.3225 0.3225
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0485 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1166 0.115
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0018 0.0018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0018 0.0018
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.3813 0.3813
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0247 0.0247
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0018 0.0018
Entamoeba histolytica aldose reductase, putative 0.0485 1 1
Echinococcus granulosus aldo keto reductase 0.0485 1 1
Onchocerca volvulus 0.0485 1 1
Plasmodium vivax glutathione reductase, putative 0.0057 0.0818 0.3138
Trichomonas vaginalis aldo-keto reductase, putative 0.0485 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0485 1 1
Echinococcus multilocularis aldo keto reductase 0.0485 1 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.2246 0.2246
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0018 0.0018
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0018 0.007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1166 0.115
Mycobacterium tuberculosis Probable reductase 0.013 0.2387 0.2373
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.2387 0.2373
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.3813 0.3813
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0018 0.0018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0018 0.0018
Onchocerca volvulus 0.0485 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1166 0.115
Toxoplasma gondii aldo-keto reductase 0.0141 0.2608 0.2608
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0818 0.0818
Mycobacterium tuberculosis Conserved protein 0.0141 0.2608 0.2595
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0124 0.2246 0.2246
Schistosoma mansoni jumonji domain containing protein 0.0071 0.1117 0.1117
Trichomonas vaginalis aldo-keto reductase, putative 0.0485 1 1
Trypanosoma brucei glucosidase, putative 0.0044 0.053 0.053
Schistosoma mansoni pol-related 0.0485 1 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0018 0.0018
Trichomonas vaginalis aldo-keto reductase, putative 0.0485 1 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0141 0.2608 0.2608
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0818 0.0818

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5221 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: Confirmation of Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1466, AID1473, AID2293] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: Confirmation of Inhibitors of Human alpha-Galactosidase Using Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 7.3078 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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