Detailed information for compound 1250245

Basic information

Technical information
  • TDR Targets ID: 1250245
  • Name: 2-[[4-(4-chlorophenyl)-5-(1-dimethylaminoethy l)-1,2,4-triazol-3-yl]sulfanyl]-N-(3-cyanothi ophen-2-yl)acetamide
  • MW: 446.977 | Formula: C19H19ClN6OS2
  • H donors: 1 H acceptors: 4 LogP: 4.02 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccsc1NC(=O)CSc1nnc(n1c1ccc(cc1)Cl)C(N(C)C)C
  • InChi: 1S/C19H19ClN6OS2/c1-12(25(2)3)17-23-24-19(26(17)15-6-4-14(20)5-7-15)29-11-16(27)22-18-13(10-21)8-9-28-18/h4-9,12H,11H2,1-3H3,(H,22,27)
  • InChiKey: SLTKVVNFYAYDQU-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[[4-(4-chlorophenyl)-5-(1-dimethylaminoethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(3-cyano-2-thienyl)acetamide
  • 2-[[4-(4-chlorophenyl)-5-(1-dimethylaminoethyl)-1,2,4-triazol-3-yl]thio]-N-(3-cyano-2-thienyl)acetamide
  • 2-[[4-(4-chlorophenyl)-5-(1-dimethylaminoethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(3-cyanothiophen-2-yl)ethanamide
  • T5421899
  • MLS000057915
  • SMR000065363
  • MLS000863910

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0015 0.0201 0.0647
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0582 0.1586
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0701 0.106
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2253 0.6141
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0701 0.0701
Brugia malayi major facilitator superfamily protein 0.0015 0.0201 0.0791
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0152 0.0673
Entamoeba histolytica protein kinase, putative 0.0033 0.0597 0.6883
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0333 0.1477
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0048 0.0132
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0606 0.6992
Onchocerca volvulus 0.0015 0.0201 0.0647
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0597 0.0597
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0201 0.2323
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0201 0.0791
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0791
Entamoeba histolytica hypothetical protein 0.0013 0.0152 0.175
Echinococcus multilocularis smad 0.0008 0.0048 0.0132
Entamoeba histolytica protein kinase, putative 0.0033 0.0597 0.6883
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0791
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0201 0.2323
Brugia malayi MH2 domain containing protein 0.0008 0.0048 0.019
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0867 0.2363
Echinococcus granulosus Chromobox protein 3 0.0013 0.0152 0.0414
Schistosoma mansoni sugar transporter 0.0015 0.0201 0.0549
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0582 0.1586
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0791
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1104 0.301
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0399 0.0603
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0606 0.6992
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0894
Leishmania major hypothetical protein, conserved 0.0015 0.0201 0.2323
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0597 0.2345
Onchocerca volvulus 0.0015 0.0201 0.0647
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0152 0.0673
Loa Loa (eye worm) hypothetical protein 0.0013 0.0152 0.0596
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0152 0.0673
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0597 0.0903
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0606 0.269
Schistosoma mansoni protein kinase 0.0033 0.0597 0.1627
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0399 0.1086
Schistosoma mansoni Smad4 0.0008 0.0048 0.0132
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0606 0.269
Loa Loa (eye worm) hypothetical protein 0.0013 0.0152 0.0596
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0597 0.2648
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.6992
Schistosoma mansoni smad1 5 8 and 0.0008 0.0048 0.0132
Schistosoma mansoni chromobox protein 0.0078 0.1614 0.4397
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0152 0.0596
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2253 0.6141
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0399 0.1086
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1104 0.4338
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.6992
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis chromobox protein, putative 0.0047 0.092 0.4082
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0201 0.2323
Schistosoma mansoni chromobox protein 0.0013 0.0152 0.0414
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0559 0.2482
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0559 0.2482
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0201 0.0549
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0597 0.1627
Leishmania major protein kinase, putative 0.0033 0.0597 0.6883
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0701 0.8082
Echinococcus multilocularis solute carrier family 22 0.0015 0.0201 0.0549
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0791
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0597 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0399 0.1086
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0201 0.0791
Trichomonas vaginalis chromobox protein, putative 0.0047 0.092 0.4082
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0201 0.2323
Onchocerca volvulus 0.0015 0.0201 0.0647
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0867 0.3848
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0399 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0048 0.019
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Brugia malayi hypothetical protein 0.0015 0.0201 0.0791
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0201 0.5052
Brugia malayi Heterochromatin protein 1 0.0078 0.1614 0.6339
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0152 0.0673
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0606 0.6992
Toxoplasma gondii sugar transporter ST3 0.0015 0.0201 0.0305
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0201 0.0791
Leishmania major glucose transporter, lmgt2 0.0033 0.0606 0.6992
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0152 0.0414
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.6992
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0867 1
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0201 0.0894
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0867 0.2363
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0152 0.0414
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0791
Echinococcus multilocularis chromobox protein 1 0.0078 0.1614 0.4397
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0597 0.2345
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0318 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Onchocerca volvulus 0.0015 0.0201 0.0647
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0013 0.0152 0.0596
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0867 0.2363
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0152 0.175
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0152 0.0673
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.2253 1
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0119 0.2978
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0701 0.8082
Loa Loa (eye worm) hypothetical protein 0.0013 0.0152 0.0596
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0048 0.0132
Trypanosoma brucei glucose transporter 1E 0.0033 0.0606 0.6992
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0152 0.0414
Giardia lamblia Sugar-proton symporter 0.0015 0.0201 0.2323
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0013 0.0152 0.0414
Echinococcus granulosus General substrate transporter 0.0092 0.1918 0.5226
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0152 0.0673
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0597 0.0597
Onchocerca volvulus 0.0015 0.0201 0.0647
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0399 0.4598
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.6992
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0845 0.3752
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.6992
Loa Loa (eye worm) hypothetical protein 0.0045 0.0867 0.3406
Toxoplasma gondii facilitative glucose transporter GT1 0.0106 0.2253 0.3408
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0606 0.269
Schistosoma mansoni protein kinase 0.0033 0.0597 0.1627
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0152 0.0673
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.6992
Echinococcus multilocularis geminin 0.017 0.3669 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1104 0.301
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0152 0.0414
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0152 0.0673
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0597 0.1627
Echinococcus multilocularis solute carrier family 22 0.0015 0.0201 0.0549
Echinococcus multilocularis Smad4 0.0008 0.0048 0.0132
Loa Loa (eye worm) sugar transporter 0.0015 0.0201 0.0791
Loa Loa (eye worm) hypothetical protein 0.0024 0.0399 0.1566
Schistosoma mansoni sugar transporter 0.0015 0.0201 0.0549
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0606 0.269
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0606 0.269
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0152 0.0673
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0013 0.0152 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0152 0.0673
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0399 0.0399
Onchocerca volvulus 0.0015 0.0201 0.0647
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0048 0.0132
Echinococcus multilocularis chromobox protein 2 0.0013 0.0152 0.0414
Plasmodium falciparum hexose transporter 0.0106 0.2253 0.2253
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0201 0.0549
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0201 0.0549
Schistosoma mansoni glucose transport protein 0.0106 0.2253 0.6141
Echinococcus granulosus solute carrier family 22 0.0015 0.0201 0.0549
Schistosoma mansoni sugar transporter 0.0015 0.0201 0.0549
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1104 0.4338
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0582 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0597 0.1627
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0152 0.0673
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0867 0.3848
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0597 0.1627
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0791
Loa Loa (eye worm) hypothetical protein 0.0013 0.0152 0.0596
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0119 0.2978
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0582 0.1586
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2253 0.6141
Schistosoma mansoni smad 0.0008 0.0048 0.0132
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0597 0.0597
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0152 0.0673
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0597 0.0597
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0201 0.0201
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0867 1
Trypanosoma cruzi hexose transporter, putative 0.0018 0.027 0.3119
Loa Loa (eye worm) hypothetical protein 0.0044 0.0845 0.3321
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0201 0.0791
Loa Loa (eye worm) hypothetical protein 0.0032 0.0582 0.2286
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0894
Brugia malayi MH1 domain containing protein 0.0008 0.0048 0.019
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0582 0.1586
Onchocerca volvulus 0.0015 0.0201 0.0647
Onchocerca volvulus 0.0015 0.0201 0.0647
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0606 0.269
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0867 0.2363
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0867 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2253 0.6141
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0152 0.175
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0048 0.0132
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0791
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0152 0.0414
Toxoplasma gondii protein kinase, putative 0.0301 0.6612 1
Echinococcus granulosus geminin 0.017 0.3669 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1104 0.301
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.092 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1104 0.301
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0152 0.0229
Mycobacterium ulcerans sugar transporter 0.0015 0.0201 0.5052
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0013 0.0152 0.0229
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0152 0.0152
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0867 1
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0201 0.0894
Schistosoma mansoni chromobox protein 0.0078 0.1614 0.4397
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0106 0.2253 0.6141
Schistosoma mansoni hypothetical protein 0.017 0.3669 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Echinococcus granulosus chromobox protein 1 0.0078 0.1614 0.4397
Giardia lamblia Hexose transporter 0.0015 0.0201 0.2323
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0201 0.5052
Entamoeba histolytica hypothetical protein 0.0013 0.0152 0.175
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0399 0.1769
Brugia malayi Cam kinase protein 1 0.0033 0.0597 0.2345
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.016 0.0627
Echinococcus granulosus chromobox protein 1 0.0078 0.1614 0.4397
Onchocerca volvulus 0.0015 0.0201 0.0647
Toxoplasma gondii sugar transporter ST2 0.0015 0.0201 0.0305
Loa Loa (eye worm) hypothetical protein 0.0013 0.0152 0.0596
Echinococcus multilocularis solute carrier family 22 0.0015 0.0201 0.0549
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0867 0.2363
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0152 0.0414
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0606 0.269
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.2546 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0606 0.6992
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0597 0.1627
Plasmodium vivax heterochromatin protein 1, putative 0.0013 0.0152 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0894
Echinococcus granulosus Smad4 0.0008 0.0048 0.0132
Onchocerca volvulus Putative transporter 0.0015 0.0201 0.0647
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0201 1
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0399 1
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0597 0.0597
Brugia malayi MH1 domain containing protein 0.0008 0.0048 0.019
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0867 0.2363
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0152 0.0673
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0318 1
Leishmania major glucose transporter, lmgt3 0.0033 0.0606 0.6992
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0867 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0201 0.0791
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0399 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1104 0.301
Brugia malayi hypothetical protein 0.0015 0.0201 0.0791
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1104 0.301
Brugia malayi M-phase phosphoprotein, mpp8 0.0013 0.0152 0.0596
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0597 0.2345
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0152 0.0414
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0152 0.0596
Echinococcus multilocularis Chromo domain 0.0013 0.0152 0.0414
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.6992
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0201 0.6328
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0152 0.0152
Loa Loa (eye worm) sugar transporter 0.0106 0.2253 0.8853
Trypanosoma brucei sugar transporter, putative 0.0015 0.0201 0.2323
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0152 0.0673
Trypanosoma brucei glucose transporter 2A 0.0033 0.0606 0.6992
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0791
Loa Loa (eye worm) hypothetical protein 0.0026 0.0448 0.1759
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0399 0.4598
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0701 0.0701
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0201 0.0894
Onchocerca volvulus 0.0015 0.0201 0.0647
Schistosoma mansoni hypothetical protein 0.0106 0.2253 0.6141
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0048 0.019
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0597 0.6883
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0048 0.0132
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0597 0.1627
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0399 0.1566
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0201 0.0549
Schistosoma mansoni smad1 5 8 and 0.0008 0.0048 0.0132
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0597 0.1627
Onchocerca volvulus 0.0034 0.0634 0.6276
Loa Loa (eye worm) hypothetical protein 0.0034 0.0634 0.249
Schistosoma mansoni protein kinase 0.0033 0.0597 0.1627
Toxoplasma gondii sugar transporter ST1 0.0015 0.0201 0.0305
Plasmodium falciparum heterochromatin protein 1 0.0013 0.0152 0.0152
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0701 0.8082
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0867 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0152 0.0673
Brugia malayi Smad1 0.0008 0.0048 0.019
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0201 0.6328
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0552 0.1503
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Schistosoma mansoni glucose transporter 0.0015 0.0201 0.0549
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0845 0.3752
Onchocerca volvulus 0.0015 0.0201 0.0647
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0399 0.1086
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Brugia malayi Sugar transporter family protein 0.0106 0.2253 0.8853
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0582 0.2583
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0582 0.6713
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0201 0.2323
Echinococcus multilocularis solute carrier family 22 0.0015 0.0201 0.0549
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0791
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0152 0.0673
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0152 0.0152
Trichomonas vaginalis hypothetical protein 0.0013 0.0152 0.0673
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0606 0.6992
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0152 0.0673
Onchocerca volvulus 0.0015 0.0201 0.0647
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0172 0.3724 0.5632
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0152 0.0673
Onchocerca volvulus 0.0015 0.0201 0.0647
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0201 0.5052
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0201 0.0549
Echinococcus granulosus solute carrier family 22 0.0015 0.0201 0.0549
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0152 0.0414
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0152 0.0596
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.2546 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0597 0.0903
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0013 0.0152 0.0596
Schistosoma mansoni glucose transport protein 0.0106 0.2253 0.6141
Brugia malayi hypothetical protein 0.0013 0.0152 0.0596
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Brugia malayi major facilitator superfamily protein 0.0015 0.0201 0.0791
Entamoeba histolytica hypothetical protein 0.0024 0.0399 0.4598
Plasmodium vivax CDK-related protein kinase 6, putative 0.0452 1 1
Brugia malayi Sugar transporter family protein 0.0015 0.0201 0.0791
Brugia malayi MH2 domain containing protein 0.0008 0.0048 0.019
Onchocerca volvulus 0.0015 0.0201 0.0647
Onchocerca volvulus 0.0015 0.0201 0.0647
Brugia malayi MH2 domain containing protein 0.012 0.2546 1
Brugia malayi Protein cec-1. 0.0013 0.0152 0.0596
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0791
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0867 0.2363
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2253 0.6141
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0552 0.1503
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0152 0.0673
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0582 0.2286
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0152 0.0673
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0597 0.1627
Entamoeba histolytica hypothetical protein 0.0013 0.0152 0.175
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0791
Echinococcus multilocularis General substrate transporter 0.0092 0.1918 0.5226
Echinococcus granulosus solute carrier family 22 0.0015 0.0201 0.0549
Loa Loa (eye worm) helicase 0.0013 0.0152 0.0596
Echinococcus granulosus smad 0.0008 0.0048 0.0132
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0606 0.6992
Loa Loa (eye worm) hypothetical protein 0.0033 0.0597 0.2345
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0152 0.0596
Trichomonas vaginalis chromobox protein, putative 0.0078 0.1614 0.716
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0867 0.2363
Echinococcus granulosus solute carrier family 22 0.0015 0.0201 0.0549
Trypanosoma cruzi hexose transporter 0.0033 0.0606 0.6992
Trichomonas vaginalis chromobox protein, putative 0.0078 0.1614 0.716
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0152 0.0673
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0106 0.2253 0.6141
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0152 0.0414
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0597 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0791
Schistosoma mansoni hypothetical protein 0.0013 0.0152 0.0414
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0845 0.9031
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0597 0.0903
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0791
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0152 0.0673
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0867 0.3848
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0399 0.4598
Echinococcus granulosus chromobox protein 2 0.0013 0.0152 0.0414
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0172 0.3724 0.3724
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1104 0.301
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.1614 0.6339
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0701 0.8082
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Brugia malayi hypothetical protein 0.0015 0.0201 0.0791
Echinococcus granulosus Chromo domain 0.0013 0.0152 0.0414
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0152 0.175
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0399 0.4598
Brugia malayi chromobox protein homolog 3 0.0044 0.0845 0.3321
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0152 0.0152
Echinococcus multilocularis chromobox protein 1 0.0078 0.1614 0.4397
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0606 0.6992
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0791
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0318 0.5469
Plasmodium falciparum protein kinase 7 0.0301 0.6612 0.6612
Schistosoma mansoni chromobox protein 0.0013 0.0152 0.0414
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0701 0.8082
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0152 0.0673
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0201 0.0305
Plasmodium vivax hexose transporter 0.0106 0.2253 0.2253
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0867 0.3406
Plasmodium falciparum mitogen-activated protein kinase 2 0.0172 0.3724 0.3724
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0597 0.1627
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0399 0.6849
Loa Loa (eye worm) hypothetical protein 0.0032 0.0582 0.2286
Plasmodium vivax sugar transporter, putative 0.0015 0.0201 0.0201
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0582 0.2286
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0106 0.2253 0.6141
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0399 0.0399
Schistosoma mansoni hypothetical protein 0.017 0.3669 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0597 0.0597
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0582 0.6713
Schistosoma mansoni sugar transporter 0.0015 0.0201 0.0549
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trypanosoma brucei glucose transporter, putative 0.0033 0.0606 0.6992
Brugia malayi CHD4 protein 0.0013 0.0152 0.0596
Loa Loa (eye worm) Smad1 0.0008 0.0048 0.019
Trichomonas vaginalis Heterochromatin protein, putative 0.0013 0.0152 0.0673
Leishmania major glucose transporter, lmgt1 0.0033 0.0606 0.6992
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0152 0.0673
Brugia malayi SET domain containing protein 0.0013 0.0152 0.0596
Brugia malayi Sugar transporter family protein 0.0015 0.0201 0.0791
Schistosoma mansoni glucose transport protein 0.0106 0.2253 0.6141
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0152 0.0673
Loa Loa (eye worm) hypothetical protein 0.0015 0.0201 0.0791
Schistosoma mansoni smad1 5 8 and 0.0008 0.0048 0.0132

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Galactosidase From Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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