TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 326.353 | Formula: C16H18N6O2
H donors: 1 H acceptors: 4 LogP: 1.23 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1ncccc1c1nc2c(C)nc(nc2n(c1=O)C(C)C)N
InChi: 1S/C16H18N6O2/c1-8(2)22-13-11(9(3)19-16(17)21-13)20-12(15(22)23)10-6-5-7-18-14(10)24-4/h5-8H,1-4H3,(H2,17,19,21)
InChiKey: VSXXFSSAABKDHD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Trichomonas vaginalis	tubulin beta chain, putative	0.0031	0.4091	0.4091
Echinococcus granulosus	tubulin alpha 3 chain	0.0031	0.4091	0.3495
Schistosoma mansoni	tubulin subunit beta	0.0031	0.4091	0.3495
Loa Loa (eye worm)	tubulin gamma chain	0.0031	0.4091	0.3631
Trypanosoma brucei	beta tubulin	0.0031	0.4091	0.3631
Echinococcus multilocularis	tubulin alpha chain	0.0031	0.4091	0.3495
Echinococcus multilocularis	Tubulin beta 2C chain	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.5501	0.5501
Echinococcus granulosus	Tubulin beta 2C chain	0.0031	0.4091	0.3495
Plasmodium vivax	tubulin beta chain, putative	0.0031	0.4091	0.5
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0026	0.2796	0.2235
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0054	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.5205	0.5205
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.6498	0.6498
Echinococcus granulosus	tubulin alpha chain	0.0031	0.4091	0.3495
Echinococcus granulosus	beta tubulin	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.3702	0.3702
Echinococcus multilocularis	tubulin gamma 1 chain	0.0031	0.4091	0.3495
Plasmodium falciparum	tubulin epsilon chain, putative	0.0031	0.4091	0.5
Echinococcus multilocularis	tubulin subunit beta	0.0031	0.4091	0.3495
Brugia malayi	beta-tubulin, identical	0.0031	0.4091	0.3631
Trichomonas vaginalis	tubulin alpha chain, putative	0.0031	0.4091	0.4091
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.6498	0.6498
Loa Loa (eye worm)	BEN-1 protein	0.0031	0.4091	0.3631
Loa Loa (eye worm)	hypothetical protein	0.0031	0.4091	0.3631
Loa Loa (eye worm)	tubulin beta-1 chain	0.0031	0.4091	0.3631
Echinococcus granulosus	Tubulin beta 2C chain	0.0031	0.4091	0.3495
Schistosoma mansoni	tubulin subunit alpha	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.6498	0.6498
Leishmania major	alpha tubulin	0.0031	0.4091	0.3495
Echinococcus multilocularis	tubulin alpha chain	0.0031	0.4091	0.3495
Echinococcus multilocularis	beta tubulin	0.0031	0.4091	0.3495
Plasmodium vivax	tubulin gamma chain, putative	0.0031	0.4091	0.5
Trichomonas vaginalis	tubulin, putative	0.0017	0.0722	0.0722
Echinococcus granulosus	tubulin alpha chain	0.0031	0.4091	0.3495
Brugia malayi	Tubulin beta-1 chain	0.0031	0.4091	0.3631
Onchocerca volvulus		0.0017	0.0722	0.5
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0054	1	1
Trypanosoma cruzi	alpha tubulin, putative	0.0031	0.4091	0.3495
Echinococcus granulosus	tubulin alpha	0.0031	0.4091	0.3495
Echinococcus granulosus	Tubulin beta 2C chain	0.0031	0.4091	0.3495
Schistosoma mansoni	tubulin subunit beta	0.0031	0.4091	0.3495
Trichomonas vaginalis	tubulin gamma chain, putative	0.0031	0.4091	0.4091
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0054	1	1
Leishmania major	gamma-tubulin	0.0031	0.4091	0.3495
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0017	0.0722	0.0722
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Echinococcus granulosus	Tubulin alpha 1 chain	0.0031	0.4091	0.3495
Echinococcus multilocularis	tubulin alpha 3 chain	0.0031	0.4091	0.3495
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Plasmodium falciparum	alpha tubulin 2	0.0031	0.4091	0.5
Echinococcus multilocularis	tubulin alpha chain	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0916	0.0916
Loa Loa (eye worm)	tubulin beta chain	0.0031	0.4091	0.3631
Loa Loa (eye worm)	beta-tubulin	0.0031	0.4091	0.3631
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.4499	0.4499
Leishmania major	alpha tubulin	0.0031	0.4091	0.3495
Trichomonas vaginalis	tubulin, putative	0.0017	0.0722	0.0722
Trypanosoma cruzi	epsilon tubulin, putative	0.0031	0.4091	0.3495
Leishmania major	alpha tubulin	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.4418	0.4418
Trichomonas vaginalis	tubulin gamma chain, putative	0.0031	0.4091	0.4091
Trichomonas vaginalis	tubulin, putative	0.0031	0.4091	0.4091
Leishmania major	alpha tubulin	0.0031	0.4091	0.3495
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.6498	0.6498
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Leishmania major	alpha tubulin	0.0031	0.4091	0.3495
Echinococcus granulosus	tubulin alpha 1C chain	0.0031	0.4091	0.3495
Brugia malayi	Tubulin alpha-2 chain	0.0031	0.4091	0.3631
Echinococcus granulosus	peroxisome assembly protein 26	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.3713	0.3713
Giardia lamblia	GTOR	0.0054	1	1
Schistosoma mansoni	tubulin subunit beta	0.0031	0.4091	0.3495
Echinococcus granulosus	tubulin beta 4A class IVa	0.0031	0.4091	0.3495
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0031	0.4091	0.3495
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0054	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0916	0.0916
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0916	0.0916
Echinococcus granulosus	Tubulin alpha 1 chain	0.0031	0.4091	0.3495
Echinococcus multilocularis	peroxisome assembly protein 26	0.0031	0.4091	0.3495
Schistosoma mansoni	tubulin subunit beta	0.0031	0.4091	0.3495
Trichomonas vaginalis	tubulin alpha chain, putative	0.0017	0.0722	0.0722
Echinococcus granulosus	tubulin alpha chain	0.0031	0.4091	0.3495
Echinococcus multilocularis	tubulin epsilon chain	0.0031	0.4091	0.3495
Schistosoma mansoni	tubulin subunit epsilon	0.0031	0.4091	0.3495
Brugia malayi	Tubulin alpha chain	0.0031	0.4091	0.3631
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0054	1	1
Brugia malayi	tubulin alpha chain - mouse	0.0031	0.4091	0.3631
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.7204	0.7204
Trypanosoma brucei	beta tubulin	0.0031	0.4091	0.3631
Trichomonas vaginalis	tubulin beta chain, putative	0.0031	0.4091	0.4091
Echinococcus multilocularis	beta tubulin	0.0031	0.4091	0.3495
Trichomonas vaginalis	tubulin beta chain, putative	0.0031	0.4091	0.4091
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0023	0.201	0.1387
Echinococcus granulosus	Tubulin alpha 1 chain	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.8002	0.8002
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.3713	0.3713
Trypanosoma brucei	beta tubulin	0.0031	0.4091	0.3631
Brugia malayi	tubulin alpha-2 chain	0.0031	0.4091	0.3631
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0031	0.4091	0.4091
Echinococcus granulosus	tubulin beta 1 chain	0.0031	0.4091	0.3495
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0916	0.0209
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0031	0.4091	0.4091
Plasmodium vivax	tubulin alpha chain, putative	0.0031	0.4091	0.5
Echinococcus multilocularis	tubulin alpha 1C chain	0.0031	0.4091	0.3495
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0018	0.0916	0.0209
Schistosoma mansoni	alpha tubulin	0.0031	0.4091	0.3495
Trichomonas vaginalis	tubulin alpha chain, putative	0.0017	0.0722	0.0722
Echinococcus multilocularis	Tubulin beta 2C chain	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0916	0.0916
Trichomonas vaginalis	tubulin alpha chain, putative	0.0017	0.0722	0.0722
Echinococcus multilocularis	tubulin beta 1 chain	0.0031	0.4091	0.3495
Trypanosoma brucei	epsilon tubulin	0.0031	0.4091	0.3631
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0916	0.0916
Echinococcus granulosus	tubulin alpha 3 chain	0.0031	0.4091	0.3495
Echinococcus granulosus	tubulin alpha 1C chain	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.7204	0.7204
Echinococcus multilocularis	tubulin subunit TubB	0.0031	0.4091	0.3495
Echinococcus multilocularis	hypothetical protein	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0031	0.4091	0.4091
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.4499	0.4499
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.3702	0.3702
Echinococcus granulosus	beta tubulin	0.0031	0.4091	0.3495
Trichomonas vaginalis	tubulin beta chain, putative	0.0031	0.4091	0.4091
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.6498	0.6498
Trypanosoma brucei	tubulin gamma chain	0.0031	0.4091	0.3631
Echinococcus granulosus	tubulin subunit TubB	0.0031	0.4091	0.3495
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Brugia malayi	Tubulin alpha-2 chain	0.0031	0.4091	0.3631
Toxoplasma gondii	target of rapamycin (TOR), putative	0.004	0.6498	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0031	0.4091	0.4091
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0054	1	1
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.4418	0.4418
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Leishmania major	alpha tubulin	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.7204	0.7204
Plasmodium falciparum	tubulin beta chain	0.0031	0.4091	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.3713	0.3713
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.4499	0.4499
Echinococcus multilocularis	Tubulin beta 2C chain	0.0031	0.4091	0.3495
Echinococcus granulosus	Tubulin beta 2C chain	0.0031	0.4091	0.3495
Trypanosoma brucei	epsilon tubulin	0.0031	0.4091	0.3631
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Loa Loa (eye worm)	phosphatidylinositol 3	0.0054	1	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0031	0.4091	0.3495
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0017	0.0722	0.0722
Loa Loa (eye worm)	tubulin beta-4 chain	0.0031	0.4091	0.3631
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.7204	0.7204
Echinococcus granulosus	tubulin epsilon chain	0.0031	0.4091	0.3495
Trypanosoma brucei	beta tubulin	0.0031	0.4091	0.3631
Brugia malayi	alpha-tubulin	0.0031	0.4091	0.3631
Schistosoma mansoni	tubulin subunit gamma	0.0031	0.4091	0.3495
Leishmania major	alpha tubulin	0.0031	0.4091	0.3495
Leishmania major	alpha tubulin	0.0031	0.4091	0.3495
Echinococcus granulosus	tubulin subunit beta	0.0031	0.4091	0.3495
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Echinococcus multilocularis	tubulin alpha 3 chain	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.6498	0.6498
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0054	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0031	0.4091	0.4091
Plasmodium vivax	tubulin alpha chain, putative	0.0031	0.4091	0.5
Leishmania major	alpha tubulin	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.3702	0.3702
Echinococcus multilocularis	Tubulin beta 2C chain	0.0031	0.4091	0.3495
Plasmodium vivax	tubulin epsilon chain, putative	0.0031	0.4091	0.5
Trypanosoma brucei	alpha tubulin	0.0031	0.4091	0.3631
Plasmodium falciparum	alpha tubulin 1	0.0031	0.4091	0.5
Schistosoma mansoni	tubulin subunit alpha	0.0031	0.4091	0.3495
Plasmodium falciparum	tubulin gamma chain	0.0031	0.4091	0.5
Schistosoma mansoni	tubulin subunit beta	0.0031	0.4091	0.3495
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0043	0.7215	0.6934
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0031	0.4091	0.4091
Trypanosoma cruzi	epsilon tubulin, putative	0.0031	0.4091	0.3495
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0031	0.4091	0.4091
Loa Loa (eye worm)	tubulin alpha chain	0.0031	0.4091	0.3631
Loa Loa (eye worm)	tubulin alpha chain	0.0031	0.4091	0.3631
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0054	1	1
Trypanosoma cruzi	tubulin gamma chain	0.0031	0.4091	0.3495
Leishmania major	alpha tubulin	0.0031	0.4091	0.3495
Echinococcus multilocularis	tubulin alpha	0.0031	0.4091	0.3495
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0031	0.4091	0.3495
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.7204	0.7204
Loa Loa (eye worm)	alpha-tubulin	0.0031	0.4091	0.3631
Trypanosoma brucei	beta tubulin	0.0031	0.4091	0.3631
Loa Loa (eye worm)	tubulin beta-2A chain	0.0031	0.4091	0.3631
Trichomonas vaginalis	tubulin beta chain, putative	0.0031	0.4091	0.4091
Trypanosoma brucei	alpha tubulin	0.0031	0.4091	0.3631
Echinococcus granulosus	tubulin gamma 1 chain	0.0031	0.4091	0.3495
Trichomonas vaginalis	tubulin beta chain, putative	0.0031	0.4091	0.4091
Leishmania major	epsilon tubulin, putative	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.3713	0.3713
Leishmania major	alpha tubulin	0.0031	0.4091	0.3495
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Trypanosoma cruzi	beta tubulin, putative	0.0031	0.4091	0.3495
Echinococcus multilocularis	tubulin alpha chain	0.0031	0.4091	0.3495
Echinococcus granulosus	tubulin alpha chain	0.0031	0.4091	0.3495
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0031	0.4091	0.3495
Trichomonas vaginalis	tubulin beta chain, putative	0.0031	0.4091	0.4091
Echinococcus multilocularis	tubulin alpha chain	0.0031	0.4091	0.3495
Echinococcus granulosus	Tubulin beta 2C chain	0.0031	0.4091	0.3495
Schistosoma mansoni	tubulin subunit alpha	0.0031	0.4091	0.3495
Loa Loa (eye worm)	alpha-tubulin	0.0031	0.4091	0.3631
Schistosoma mansoni	tubulin subunit beta	0.0031	0.4091	0.3495
Schistosoma mansoni	alpha tubulin	0.0031	0.4091	0.3495
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0054	1	1
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0018	0.0916	0.0209
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0031	0.4091	0.3631
Echinococcus granulosus	tubulin alpha chain	0.0031	0.4091	0.3495
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0054	1	1
Schistosoma mansoni	alpha tubulin	0.0031	0.4091	0.3495
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	1	1
Brugia malayi	Tubulin gamma chain	0.0031	0.4091	0.3631
Trypanosoma brucei	epsilon tubulin	0.0031	0.4091	0.3631
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.6498	0.6498
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0031	0.4091	0.3495
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0043	0.7215	0.6998
Echinococcus granulosus	alpha tubulin	0.0031	0.4091	0.3495
Trypanosoma brucei	alpha tubulin	0.0031	0.4091	0.3631
Leishmania major	alpha tubulin	0.0031	0.4091	0.3495
Trypanosoma brucei	alpha tubulin	0.0031	0.4091	0.3631
Trypanosoma cruzi	target of rapamycin kinase 3	0.0043	0.7215	0.6934
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Leishmania major	beta tubulin	0.0031	0.4091	0.3495
Trichomonas vaginalis	tubulin beta chain, putative	0.0017	0.0722	0.0722
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0054	1	1
Loa Loa (eye worm)	BEN-1 protein	0.0031	0.4091	0.3631
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0916	0.0209

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 3940 nM	Inhibition of mTOR	ChEMBL.	20817449

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1258678

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1254419