Detailed information for compound 1255453

Basic information

Technical information
  • TDR Targets ID: 1255453
  • Name: N-(4-chloro-3-nitrophenyl)-2-pyridin-1-ium-1- ylacetamide chloride
  • MW: 328.151 | Formula: C13H11Cl2N3O3
  • H donors: 1 H acceptors: 3 LogP: 3.24 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C[n+]1ccccc1)Nc1ccc(c(c1)[N+](=O)[O-])Cl.[Cl-]
  • InChi: 1S/C13H10ClN3O3.ClH/c14-11-5-4-10(8-12(11)17(19)20)15-13(18)9-16-6-2-1-3-7-16;/h1-8H,9H2;1H
  • InChiKey: COZTUGYBGGTYHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-chloro-3-nitro-phenyl)-2-pyridin-1-ium-1-yl-acetamide chloride
  • N-(4-chloro-3-nitrophenyl)-2-(1-pyridin-1-iumyl)acetamide chloride
  • N-(4-chloro-3-nitro-phenyl)-2-pyridin-1-ium-1-yl-ethanamide chloride
  • 1-[(4-Chloro-3-nitro-phenylcarbamoyl)-methyl]-pyridinium

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens multiple endocrine neoplasia I No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni amine GPCR 0.006 0.1088 0.1054
Echinococcus granulosus g-protein coupled receptor 0.006 0.1088 0.1054
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Trichomonas vaginalis beta-hexosaminidase, putative 0.009 0.172 0.3542
Echinococcus granulosus allatostatin A receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Onchocerca volvulus Hexosaminidase D homolog 0.009 0.172 0.9784
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0011 0.01 0.0063
Echinococcus granulosus g protein coupled receptor 0.006 0.1088 0.1054
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0758 0.1032
Schistosoma mansoni neuropeptide f receptor 76f 0.006 0.1088 0.1054
Trichomonas vaginalis beta-hexosaminidase, putative 0.0243 0.4856 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0086 0.0049
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.1088 0.1054
Onchocerca volvulus 0.006 0.1088 0.6106
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0578 0.0691
Giardia lamblia AAA family ATPase 0.0017 0.0205 0.0974
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.1088 0.1054
Schistosoma mansoni biogenic amine receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0758 0.2622
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.0389 0.7853 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0389 0.7853 1
Brugia malayi G-protein coupled receptor 0.006 0.1088 0.1344
Schistosoma mansoni cpg binding protein 0.0035 0.0578 0.0542
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1757 1
Brugia malayi ORL1-like opioid receptor 0.006 0.1088 0.1344
Echinococcus multilocularis somatostatin receptor 0.006 0.1088 0.1054
Echinococcus granulosus thyrotropin releasing hormone receptor 0.006 0.1088 0.1054
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.1088 0.1054
Echinococcus granulosus cpg binding protein 0.0037 0.0618 0.0583
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0396 0.2087
Brugia malayi CXXC zinc finger family protein 0.0035 0.0578 0.0691
Entamoeba histolytica hypothetical protein 0.0035 0.0586 0.0246
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Echinococcus granulosus neuropeptide FF receptor 2 0.006 0.1088 0.1054
Toxoplasma gondii cell division protein CDC48AP 0.0017 0.0205 0.1424
Brugia malayi Smad1 0.001 0.0068 0.0039
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.1088 0.1054
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0758 1
Schistosoma mansoni growth hormone secretagogue receptor 0.006 0.1088 0.1054
Echinococcus multilocularis alpha 1A adrenergic receptor 0.006 0.1088 0.1054
Mycobacterium ulcerans lipase LipD 0.0043 0.0758 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0758 0.0922
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.006 0.1088 0.1344
Onchocerca volvulus 0.006 0.1088 0.6106
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.1088 0.1054
Echinococcus granulosus alpha 1A adrenergic receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1757 0.3619
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0028 0.0432 0.2296
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0396 0.0459
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0758 1
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0068 0.0039
Mycobacterium tuberculosis Conserved protein 0.0043 0.0758 0.1032
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0396 0.0459
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0396 0.0459
Loa Loa (eye worm) hypothetical protein 0.0043 0.0758 0.0922
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.1757 0.1818
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.1088 0.1344
Schistosoma mansoni neuropeptide receptor 0.006 0.1088 0.1054
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0068 0.003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.1088 0.1054
Brugia malayi neuropeptide F receptor 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0396 0.0459
Schistosoma mansoni hypothetical protein 0.006 0.1088 0.1054
Brugia malayi beta-lactamase family protein 0.0043 0.0758 0.0922
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0758 0.1561
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.006 0.1088 0.1054
Onchocerca volvulus 0.006 0.1088 0.6106
Echinococcus multilocularis neuropeptide receptor 0.006 0.1088 0.1054
Schistosoma mansoni opsin-like receptor 0.006 0.1088 0.1054
Giardia lamblia Kinase, PLK 0.0092 0.1757 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.1088 0.1054
Echinococcus granulosus neuropeptide Y receptor 0.006 0.1088 0.1054
Brugia malayi Serotonin receptor 0.006 0.1088 0.1344
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Schistosoma mansoni amine GPCR 0.006 0.1088 0.1054
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.006 0.1088 0.1344
Brugia malayi beta-lactamase 0.0043 0.0758 0.0922
Brugia malayi G-protein coupled receptor 0.006 0.1088 0.1344
Echinococcus multilocularis g protein coupled receptor 0.006 0.1088 0.1054
Echinococcus granulosus neuropeptide receptor A26 0.006 0.1088 0.1054
Entamoeba histolytica beta-N-acetylhexosaminidase, beta subunit 0.0389 0.7853 1
Trichomonas vaginalis beta-hexosaminidase, putative 0.0243 0.4856 1
Loa Loa (eye worm) melatonin receptor type 1A 0.006 0.1088 0.1344
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0758 0.2622
Brugia malayi gonadotropin-releasing hormone receptor 2 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.1088 0.1054
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.1088 0.1054
Schistosoma mansoni biogenic amine receptor 0.006 0.1088 0.1054
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.006 0.1088 0.6106
Onchocerca volvulus 0.006 0.1088 0.6106
Echinococcus granulosus peptide allatostatin:somatostatin 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Schistosoma mansoni opsin-like receptor 0.006 0.1088 0.1054
Entamoeba histolytica hypothetical protein 0.0035 0.0586 0.0246
Echinococcus multilocularis orexin receptor type 2 0.006 0.1088 0.1054
Schistosoma mansoni biogenic amine receptor 0.006 0.1088 0.1054
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0758 0.1032
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Echinococcus multilocularis biogenic amine (5HT) receptor 0.006 0.1088 0.1054
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0026 0.0403 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Onchocerca volvulus 0.006 0.1088 0.6106
Schistosoma mansoni Smad4 0.001 0.0068 0.003
Echinococcus granulosus beta hexosaminidase subunit alpha 0.0243 0.4856 0.4837
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0758 0.2622
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.006 0.1088 0.1344
Echinococcus granulosus fmrfamide receptor 0.006 0.1088 0.1054
Brugia malayi Serotonin/octopamine receptor family protein 7 0.006 0.1088 0.1344
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0068 0.003
Entamoeba histolytica beta-N-acetylhexosaminidase, alpha subunit 0.0389 0.7853 1
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0028 0.0432 0.0396
Echinococcus granulosus 7TM GPCR rhodopsin 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.0043 0.0758 0.0922
Brugia malayi larval opioid receptor 0.006 0.1088 0.1344
Brugia malayi Peroxidasin 0.0026 0.0396 0.0459
Echinococcus granulosus 7tm_1 domain containing protein 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.1088 0.1054
Echinococcus multilocularis muscleblind protein 1 0.018 0.3567 0.3543
Onchocerca volvulus 0.006 0.1088 0.6106
Brugia malayi MH2 domain containing protein 0.001 0.0068 0.0039
Echinococcus multilocularis peroxidasin 0.0026 0.0396 0.036
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0086 0.0049
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.009 0.172 0.2153
Schistosoma mansoni smad1 5 8 and 0.001 0.0068 0.003
Echinococcus granulosus neuropeptide Y receptor 0.006 0.1088 0.1054
Schistosoma mansoni hypothetical protein 0.006 0.1088 0.1054
Toxoplasma gondii ABC1 family protein 0.0043 0.0758 0.6125
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1757 0.3619
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0758 0.1032
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus granulosus g protein coupled receptor 0.006 0.1088 0.1054
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.1088 0.1054
Schistosoma mansoni opsin-like receptor 0.006 0.1088 0.1054
Brugia malayi G protein-coupled receptor F59B2.13 0.006 0.1088 0.1344
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0758 0.0723
Schistosoma mansoni neuropeptide receptor 0.006 0.1088 0.1054
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0802 0.1652
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0396 0.0459
Brugia malayi hypothetical protein 0.0026 0.0396 0.0459
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0027 0.0056
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.1088 0.1054
Brugia malayi Dopamine receptor protein 2 0.006 0.1088 0.1344
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.0043 0.0758 0.0922
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0586 0.0551
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Onchocerca volvulus 0.0043 0.0758 0.4191
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1757 0.3619
Brugia malayi MH2 domain containing protein 0.0144 0.2824 0.3565
Schistosoma mansoni peroxidasin 0.0026 0.0396 0.036
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.006 0.1088 0.1054
Trypanosoma brucei polo-like protein kinase 0.0092 0.1757 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0758 0.1032
Onchocerca volvulus 0.0026 0.0396 0.2087
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Onchocerca volvulus 0.0043 0.0758 0.4191
Echinococcus granulosus Smad4 0.001 0.0068 0.003
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.006 0.1088 0.1054
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0758 0.1032
Echinococcus granulosus neuropeptide s receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1214 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.1088 0.1054
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.006 0.1088 0.1344
Echinococcus multilocularis tachykinin peptides receptor 99D 0.006 0.1088 0.1054
Echinococcus multilocularis neuropeptide receptor 0.006 0.1088 0.1054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Echinococcus granulosus orexin receptor type 2 0.006 0.1088 0.1054
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0028 0.0432 0.089
Brugia malayi putative neuropeptide receptor 0.006 0.1088 0.1344
Loa Loa (eye worm) VCP protein 0.0011 0.01 0.008
Schistosoma mansoni smad1 5 8 and 0.001 0.0068 0.003
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) beta-lactamase 0.0043 0.0758 0.0922
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0396 0.0459
Schistosoma mansoni hypothetical protein 0.0494 1 1
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0011 0.01 0.008
Schistosoma mansoni peroxidasin 0.0026 0.0396 0.036
Loa Loa (eye worm) hypothetical protein 0.018 0.3567 0.4516
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Brugia malayi RE15519p 0.006 0.1088 0.1344
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0396 0.2087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Onchocerca volvulus 0.0026 0.0396 0.2087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Schistosoma mansoni neuropeptide receptor 0.006 0.1088 0.1054
Schistosoma mansoni amine GPCR 0.006 0.1088 0.1054
Echinococcus multilocularis sex peptide receptor 0.006 0.1088 0.1054
Entamoeba histolytica beta-N-acetylhexosaminidase, putative 0.0389 0.7853 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.006 0.1088 0.1054
Schistosoma mansoni beta-hexosaminidase B 0.0389 0.7853 0.7845
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus multilocularis g protein coupled receptor 0.006 0.1088 0.1054
Onchocerca volvulus 0.006 0.1088 0.6106
Echinococcus multilocularis g-protein coupled receptor 0.006 0.1088 0.1054
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0083 0.0059
Echinococcus multilocularis Smad4 0.001 0.0068 0.003
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.1757 1
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Onchocerca volvulus Peroxidase homolog 0.0026 0.0396 0.2087
Echinococcus granulosus neuropeptide receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.0043 0.0758 0.0922
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.1088 0.1054
Brugia malayi G protein-coupled receptor 0.006 0.1088 0.1344
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.1757 0.22
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.1088 0.1054
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0758 0.1032
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0758 0.1032
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Echinococcus multilocularis dro:myosuppressin receptor 0.006 0.1088 0.1054
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.1088 0.1054
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0026 0.0403 0.0367
Loa Loa (eye worm) hypothetical protein 0.0016 0.0198 0.0206
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0026 0.0403 0.4833
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Onchocerca volvulus 0.006 0.1088 0.6106
Echinococcus multilocularis G protein coupled receptor 139 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus multilocularis neuropeptide receptor A26 0.006 0.1088 0.1054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0027 0.0056
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Loa Loa (eye worm) TYRA-2 protein 0.006 0.1088 0.1344
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0758 0.0723
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.1088 0.1054
Brugia malayi Serotonin receptor 0.006 0.1088 0.1344
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0243 0.4856 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1757 0.3619
Trichomonas vaginalis esterase, putative 0.0043 0.0758 0.1561
Onchocerca volvulus 0.006 0.1088 0.6106
Echinococcus multilocularis beta hexosaminidase subunit beta 0.0389 0.7853 0.7845
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0011 0.01 0.0063
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0027 0.0056
Echinococcus granulosus neuropeptides capa receptor 0.006 0.1088 0.1054
Schistosoma mansoni myosin xvIII 0.006 0.1088 0.1054
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2824 0.3565
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.1757 0.1726
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0396 0.2087
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.1088 0.1344
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) follicle stimulating hormone receptor 0.006 0.1088 0.1344
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.009 0.172 0.2153
Onchocerca volvulus Peroxidase homolog 0.0026 0.0396 0.2087
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1375 0.1343
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0017 0.0205 0.1424
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Onchocerca volvulus 0.0026 0.0396 0.2087
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.1088 0.1054
Echinococcus granulosus G protein coupled receptor 139 0.006 0.1088 0.1054
Brugia malayi valosin containing protein 0.0016 0.0198 0.0206
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0396 0.0459
Loa Loa (eye worm) glycosyl hydrolase family 20 0.0389 0.7853 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.006 0.1088 0.1054
Leishmania major hypothetical protein, conserved 0.0043 0.0758 0.2622
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0043 0.0005
Brugia malayi GnHR receptor homolog 0.006 0.1088 0.1344
Brugia malayi putative neuropeptide receptor NPR1 0.006 0.1088 0.1344
Onchocerca volvulus 0.006 0.1088 0.6106
Schistosoma mansoni hypothetical protein 0.0035 0.0586 0.0551
Entamoeba histolytica hypothetical protein 0.0035 0.0586 0.0246
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0586 0.0551
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.1088 0.1054
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.006 0.1088 0.1344
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0068 0.003
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.1757 1
Echinococcus multilocularis serotonin receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Schistosoma mansoni adenoreceptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.1088 0.1054
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0758 0.1561
Echinococcus granulosus serotonin receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Brugia malayi Muscleblind-like protein 0.018 0.3567 0.4516
Echinococcus multilocularis allatostatin A receptor 0.006 0.1088 0.1054
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Echinococcus multilocularis muscleblind protein 0.018 0.3567 0.3543
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.006 0.1088 0.1054
Echinococcus multilocularis fmrfamide receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.1757 0.22
Onchocerca volvulus 0.006 0.1088 0.6106
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2824 0.3565
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.1088 0.1054
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Brugia malayi hypothetical protein 0.0035 0.0586 0.0702
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Schistosoma mansoni alpha-1 adrenergic receptor 0.006 0.1088 0.1054
Schistosoma mansoni smad1 5 8 and 0.001 0.0068 0.003
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Brugia malayi follicle stimulating hormone receptor 0.006 0.1088 0.1344
Loa Loa (eye worm) Smad1 0.001 0.0068 0.0039
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.0043 0.0758 0.0922
Echinococcus multilocularis smad 0.001 0.0068 0.003
Brugia malayi Tachykinin-like peptides receptor 99D 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Onchocerca volvulus 0.006 0.1088 0.6106
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.1088 0.1054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0586 0.0551
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1757 0.3619
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Brugia malayi vesicle-fusing ATPase 0.0016 0.0198 0.0206
Schistosoma mansoni amine GPCR 0.006 0.1088 0.1054
Brugia malayi Blistered cuticle protein 3 0.0026 0.0396 0.0459
Onchocerca volvulus Neuropeptide F receptor homolog 0.006 0.1088 0.6106
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Onchocerca volvulus 0.006 0.1088 0.6106
Brugia malayi Dopamine receptor protein 1 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.1088 0.1054
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0758 0.0922
Mycobacterium tuberculosis Conserved protein 0.0043 0.0758 0.1032
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Echinococcus granulosus neuropeptides capa receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0027 0.0056
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0027 0.0056
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.1088 0.1054
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0086 0.0062
Loa Loa (eye worm) vesicle-fusing ATPase 0.0016 0.0198 0.0206
Onchocerca volvulus 0.006 0.1088 0.6106
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0027 0.0056
Echinococcus granulosus smad 0.001 0.0068 0.003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0758 0.0723
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0068 0.003
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.1088 0.1054
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0028 0.0432 0.0396
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.006 0.1088 0.1054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.1757 0.1726
Onchocerca volvulus 0.0035 0.0578 0.3141
Mycobacterium ulcerans beta-lactamase 0.0043 0.0758 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.1088 0.1054
Brugia malayi MH1 domain containing protein 0.001 0.0068 0.0039
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0027 0.0056
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.006 0.1088 0.1344
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0758 0.0723
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0758 0.1561
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0758 0.5
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.006 0.1088 0.1344
Echinococcus multilocularis fmrfamide receptor 0.006 0.1088 0.1054
Echinococcus granulosus sex peptide receptor 0.006 0.1088 0.1054
Schistosoma mansoni hypothetical protein 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.1088 0.1344
Brugia malayi MH2 domain containing protein 0.001 0.0068 0.0039
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0043 0.0005
Brugia malayi MH1 domain containing protein 0.001 0.0068 0.0039
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Schistosoma mansoni histamine h1 receptor 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.0043 0.0758 0.0922
Schistosoma mansoni hypothetical protein 0.006 0.1088 0.1054
Trichomonas vaginalis helicase, putative 0.0008 0.0027 0.0056
Echinococcus multilocularis neuropeptide FF receptor 2 0.006 0.1088 0.1054
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0802 0.1652
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0028 0.0432 0.0396
Brugia malayi AKH receptor 0.006 0.1088 0.1344
Echinococcus granulosus somatostatin receptor 0.006 0.1088 0.1054
Onchocerca volvulus 0.006 0.1088 0.6106
Echinococcus granulosus hypothetical protein 0.006 0.1088 0.1054
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.018 0.3567 0.4516
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.1088 0.1054
Echinococcus multilocularis beta hexosaminidase subunit alpha 0.0243 0.4856 0.4837
Schistosoma mansoni kinase 0.0047 0.0827 0.0793
Brugia malayi Melatonin receptor type 1A 0.006 0.1088 0.1344
Onchocerca volvulus 0.006 0.1088 0.6106
Onchocerca volvulus 0.0043 0.0758 0.4191
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.1088 0.1054
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.006 0.1088 0.1054
Echinococcus multilocularis neuropeptide s receptor 0.006 0.1088 0.1054
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.1088 0.1054
Mycobacterium ulcerans hypothetical protein 0.0043 0.0758 1
Mycobacterium leprae Probable lipase LipE 0.0043 0.0758 0.5
Echinococcus granulosus neuropeptide receptor 0.006 0.1088 0.1054
Schistosoma mansoni peptide (allatostatin)-like receptor 0.006 0.1088 0.1054
Brugia malayi beta-lactamase family protein 0.0043 0.0758 0.0922
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0396 0.0459
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.1757 0.1726
Echinococcus granulosus dro:myosuppressin receptor 0.006 0.1088 0.1054
Mycobacterium tuberculosis Conserved protein 0.0043 0.0758 0.1032
Schistosoma mansoni neuropeptide receptor 0.006 0.1088 0.1054
Echinococcus multilocularis cpg binding protein 0.0037 0.0618 0.0583
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1757 0.3619
Toxoplasma gondii cell division protein CDC48CY 0.0028 0.0432 0.3356
Schistosoma mansoni amine GPCR 0.006 0.1088 0.1054
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0043 0.0005
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0043 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Brugia malayi Dopamine receptor 0.006 0.1088 0.1344
Echinococcus granulosus peroxidasin 0.0026 0.0396 0.036
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.1088 0.1054
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0396 0.0459
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Schistosoma mansoni cpg binding protein 0.0037 0.0618 0.0583
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.1757 0.3619
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.006 0.1088 0.1054
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.1088 0.1054
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0758 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0027 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0027 0.0056
Brugia malayi sulfakinin receptor protein 0.006 0.1088 0.1344
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0068 0.0039
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0068 0.003
Schistosoma mansoni smad 0.001 0.0068 0.003
Echinococcus granulosus tachykinin peptides receptor 99D 0.006 0.1088 0.1054
Onchocerca volvulus 0.006 0.1088 0.6106
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.5565 1
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.1088 0.1054
Loa Loa (eye worm) hypothetical protein 0.009 0.172 0.2153
Echinococcus granulosus beta hexosaminidase subunit beta 0.0389 0.7853 0.7845
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0043 0.0005
Echinococcus multilocularis serotonin receptor 0.006 0.1088 0.1054
Brugia malayi hypothetical protein 0.006 0.1088 0.1344
Schistosoma mansoni beta-hexosaminidase B 0.0389 0.7853 0.7845
Loa Loa (eye worm) hypothetical protein 0.0026 0.0396 0.0459
Brugia malayi neuropeptide F receptor 0.006 0.1088 0.1344
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0396 0.0459
Echinococcus multilocularis G-protein coupled receptor, putative 0.006 0.1088 0.1054
Trichomonas vaginalis beta-hexosaminidase, putative 0.0243 0.4856 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0758 0.1561
Echinococcus granulosus g protein coupled receptor 0.006 0.1088 0.1054
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0396 0.2087
Loa Loa (eye worm) hypothetical protein 0.006 0.1088 0.1344
Entamoeba histolytica hypothetical protein 0.0035 0.0586 0.0246
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.1757 1
Brugia malayi Glycosyl hydrolase family 20, catalytic domain containing protein 0.009 0.172 0.2153
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.1088 0.1054
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.1088 0.1054
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.006 0.1088 0.1054
Echinococcus multilocularis g protein coupled receptor 0.006 0.1088 0.1054
Schistosoma mansoni cpg binding protein 0.0037 0.0618 0.0583
Echinococcus granulosus muscleblind protein 0.018 0.3567 0.3543
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0758 0.1561
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.1088 0.1054

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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