Detailed information for compound 1257911

Basic information

Technical information
  • TDR Targets ID: 1257911
  • Name: 2-(3,5-dimethyl-4-nitropyrazol-1-yl)-N-[(2-me thylquinolin-4-yl)methyl]acetamide
  • MW: 353.375 | Formula: C18H19N5O3
  • H donors: 1 H acceptors: 5 LogP: 2.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(CNC(=O)Cn2nc(c(c2C)[N+](=O)[O-])C)c2c(n1)cccc2
  • InChi: 1S/C18H19N5O3/c1-11-8-14(15-6-4-5-7-16(15)20-11)9-19-17(24)10-22-13(3)18(23(25)26)12(2)21-22/h4-8H,9-10H2,1-3H3,(H,19,24)
  • InChiKey: CNDCJFZFIJPIIM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(3,5-dimethyl-4-nitro-pyrazol-1-yl)-N-[(2-methyl-4-quinolyl)methyl]acetamide
  • 2-(3,5-dimethyl-4-nitro-1-pyrazolyl)-N-[(2-methyl-4-quinolyl)methyl]acetamide
  • 2-(3,5-dimethyl-4-nitro-pyrazol-1-yl)-N-[(2-methylquinolin-4-yl)methyl]ethanamide
  • ZINC01423681
  • A3523/0149191
  • 2-(3,5-dimethyl-4-nitro-1H-pyrazol-1-yl)-N-[(2-methylquinolin-4-yl)methyl]acetamide
  • MLS000729070
  • SMR000307348

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.9348 0.9316
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.9348 0.9316
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.9348 0.9316
Brugia malayi ecdysone receptor 0.002 0.0472 0.0472
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0472 0.0472
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.9348 0.9316
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.9348 0.9316
Loa Loa (eye worm) hypothetical protein 0.002 0.0472 0.0472
Loa Loa (eye worm) hypothetical protein 0.0043 0.9348 0.9348
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.9348 0.9348
Brugia malayi nuclear receptor RXR 0.002 0.0472 0.0472
Loa Loa (eye worm) hypothetical protein 0.0043 0.9348 0.9348
Brugia malayi nuclear hormone receptor 0.0043 0.9348 0.9348
Brugia malayi nuclear receptor NHR-88 0.002 0.0472 0.0472
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.1423 0.1423
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.9348 0.9348
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.9348 0.9316
Echinococcus multilocularis inositol monophosphatase 1 0.0045 1 1
Brugia malayi nuclear receptor NHR-67 0.002 0.0472 0.0472
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 1 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0472 0.0472
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0472 0.0472
Loa Loa (eye worm) hypothetical protein 0.0043 0.9348 0.9348
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.9348 0.9348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.9348 0.9348
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 1 1
Schistosoma mansoni thyroid hormone receptor 0.0043 0.9348 0.9316
Loa Loa (eye worm) hypothetical protein 0.0043 0.9348 0.9348
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.9348 0.9316
Loa Loa (eye worm) hypothetical protein 0.002 0.0472 0.0472
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.9348 0.9316
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.1423 0.0998
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 1 1
Brugia malayi Nuclear hormone receptor E75 0.002 0.0472 0.0472
Brugia malayi nuclear receptor RXR 0.0023 0.1423 0.1423
Loa Loa (eye worm) hypothetical protein 0.0023 0.1423 0.1423
Loa Loa (eye worm) hypothetical protein 0.0043 0.9348 0.9348
Echinococcus granulosus inositol monophosphatase 1 0.0045 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0472 0.0472
Loa Loa (eye worm) hypothetical protein 0.002 0.0472 0.0472
Brugia malayi conserved hypotetical protein 0.002 0.0472 0.0472
Brugia malayi nuclear receptor NHR-88 0.0043 0.9348 0.9348
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.9348 0.9348
Loa Loa (eye worm) hypothetical protein 0.002 0.0472 0.0472
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 1 0.5
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.9348 0.9316
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.8171 0.5
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.9348 0.9348
Loa Loa (eye worm) DR-78 0.002 0.0472 0.0472
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.9348 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0472 0.0472
Loa Loa (eye worm) hypothetical protein 0.0043 0.9348 0.9348
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.9348 0.9316
Schistosoma mansoni coup transcription factor 0.0043 0.9348 0.9316
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 1 0.5
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0472 0.0472
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.9348 0.9316
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.9348 0.9316
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.9348 0.9348
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.1423 0.1423
Brugia malayi Cytochrome P450 family protein 0.0029 0.3969 0.3969
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.9348 0.9348
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 1 0.5
Brugia malayi hypothetical protein 0.0023 0.1423 0.1423
Brugia malayi hypothetical protein 0.0023 0.1423 0.1423
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.9348 0.9348
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0472 0.0472
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 1 0.5
Schistosoma mansoni inositol monophosphatase 0.0045 1 1
Brugia malayi ecdysteroid receptor 0.0043 0.9348 0.9348
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.9348 0.9316
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.9348 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.9348 0.9348
Loa Loa (eye worm) hypothetical protein 0.002 0.0472 0.0472
Schistosoma mansoni thyroid hormone receptor 0.0043 0.9348 0.9316
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.9348 0.9316
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.9348 0.9348
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.9348 0.9348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.9348 0.9348
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.1423 0.0998
Loa Loa (eye worm) hypothetical protein 0.002 0.0472 0.0472
Schistosoma mansoni inositol monophosphatase 0.0045 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.9348 0.9316
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.9348 0.9348
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.9348 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.9348 0.9348
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.3969 0.3969
Schistosoma mansoni nuclear hormone receptor 0.0043 0.9348 0.9316
Brugia malayi steroid hormone receptor 0.0043 0.9348 0.9348
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.9348 0.9316
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.1423 0.1423
Brugia malayi tailless protein 0.002 0.0472 0.0472
Brugia malayi hypothetical protein 0.002 0.0472 0.0472
Loa Loa (eye worm) hypothetical protein 0.0043 0.9348 0.9348
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.9348 0.9316
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.9348 0.9348
Loa Loa (eye worm) hypothetical protein 0.002 0.0472 0.0472
Loa Loa (eye worm) hypothetical protein 0.0023 0.1423 0.1423
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.9348 0.9348
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.9348 0.9348
Loa Loa (eye worm) hypothetical protein 0.0023 0.1423 0.1423
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.9348 0.9316
Onchocerca volvulus 0.0043 0.9348 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0472 0.0472
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 1 1
Loa Loa (eye worm) inositol-1 0.0045 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.9348 0.9348
Loa Loa (eye worm) hypothetical protein 0.002 0.0472 0.0472
Brugia malayi Nuclear hormone receptor E75 0.002 0.0472 0.0472
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.1423 0.0998
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.9348 0.9316
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0472 0.0472
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.1423 0.0998
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.9348 0.9316
Loa Loa (eye worm) hypothetical protein 0.002 0.0472 0.0472
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.9348 0.9316
Brugia malayi hypothetical protein 0.002 0.0472 0.0472
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.9348 0.9348
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.9348 0.9316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.9348 0.9348
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.9348 0.9316
Loa Loa (eye worm) hypothetical protein 0.0023 0.1423 0.1423
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 1 0.5
Brugia malayi nuclear hormone receptor 0.002 0.0472 0.0472
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.9348 0.9348
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.8171 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.9348 0.9316
Loa Loa (eye worm) hypothetical protein 0.002 0.0472 0.0472
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 1 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.9348 0.9348
Echinococcus granulosus FTZ F1 alpha 0.0043 0.9348 0.9316
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.9348 0.9316
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0472 0.0472
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.9348 0.9348
Loa Loa (eye worm) hypothetical protein 0.0023 0.1423 0.1423
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.9348 0.9348
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.9348 0.9316

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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