TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 358.539 | Formula: C18H34N2O3S
H donors: 2 H acceptors: 2 LogP: 3.84 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: SCCCCCC[C@@H](C(=O)NC1CCCC1)NC(=O)OC(C)(C)C
InChi: 1S/C18H34N2O3S/c1-18(2,3)23-17(22)20-15(12-6-4-5-9-13-24)16(21)19-14-10-7-8-11-14/h14-15,24H,4-13H2,1-3H3,(H,19,21)(H,20,22)/t15-/m0/s1
InChiKey: NZIPOHHYINGNGY-HNNXBMFYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0067	0.1317	0.1343
Schistosoma mansoni	hypothetical protein	0.0053	0.0907	0.0925
Entamoeba histolytica	hypothetical protein	0.004	0.0505	0.139
Brugia malayi	Ets-domain containing protein	0.0081	0.1752	0.1752
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0343	0.9753	0.9753
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0505	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1393	0.1393
Brugia malayi	histone deacetylase 3 (HD3)	0.0143	0.3634	0.3634
Loa Loa (eye worm)	tumor suppressor	0.0351	1	1
Plasmodium vivax	importin-beta 2, putative	0.0032	0.0261	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0516	0.0516
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0227	0.6224	0.6345
Schistosoma mansoni	importin beta-1	0.0032	0.0261	0.0266
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0345	0.9809	0.9809
Schistosoma mansoni	hypothetical protein	0.003	0.0181	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0343	0.9751	0.9751
Brugia malayi	hypothetical protein	0.003	0.0181	0.0181
Plasmodium falciparum	histone deacetylase 2	0.0241	0.6632	1
Echinococcus granulosus	histone deacetylase	0.0241	0.6632	0.6762
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0053	0.0907	0.0925
Brugia malayi	RNA, U transporter 1	0.0092	0.208	0.208
Loa Loa (eye worm)	histone deacetylase 11	0.0088	0.1955	0.1955
Schistosoma mansoni	histone deacetylase 4 5	0.0241	0.6632	0.6762
Echinococcus multilocularis	expressed protein	0.0037	0.0417	0.0425
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0516	0.0516
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0026	0.0074	0.0111
Trypanosoma cruzi	histone deacetylase, putative	0.0088	0.1955	0.2947
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0053	0.0907	0.0907
Brugia malayi	Bromodomain containing protein	0.0043	0.0584	0.0584
Trypanosoma cruzi	histone deacetylase 1, putative	0.0143	0.3634	0.5479
Schistosoma mansoni	ets-related	0.0246	0.6798	0.6931
Plasmodium falciparum	importin beta, putative	0.0032	0.0261	0.0393
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0106	0.2498	0.2547
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0067	0.1317	0.1343
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0143	0.3634	1
Echinococcus granulosus	histone deacetylase 8	0.0088	0.1955	0.1993
Echinococcus multilocularis	histone deacetylase 6	0.0241	0.6632	0.6762
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0053	0.0907	0.0907
Entamoeba histolytica	hypothetical protein	0.004	0.0505	0.139
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0516	0.142
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0037	0.039	0.0588
Echinococcus granulosus	expressed protein	0.0037	0.0417	0.0425
Plasmodium vivax	histone deacetylase, putative	0.0088	0.1955	0.2947
Toxoplasma gondii	peptidylprolyl isomerase	0.0037	0.039	0.0588
Echinococcus multilocularis	histone deacetylase 6	0.0241	0.6632	0.6762
Schistosoma mansoni	histone deacetylase 1 2 3	0.0088	0.1955	0.1993
Trichomonas vaginalis	histone deacetylase, putative	0.0143	0.3634	1
Entamoeba histolytica	histone deacetylase, putative	0.0143	0.3634	1
Echinococcus multilocularis	protein quaking	0.003	0.0181	0.0185
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0516	0.0778
Loa Loa (eye worm)	hypothetical protein	0.0343	0.9753	0.9753
Mycobacterium ulcerans	beta-lactamase	0.0041	0.0516	0.5
Trypanosoma cruzi	histone deacetylase, putative	0.0241	0.6632	1
Echinococcus granulosus	histone deacetylase 6	0.0241	0.6632	0.6762
Echinococcus multilocularis	GPCR, family 2	0.0053	0.0907	0.0925
Leishmania major	histone deacetylase, putative	0.0241	0.6632	1
Trichomonas vaginalis	esterase, putative	0.0041	0.0516	0.142
Loa Loa (eye worm)	histone deacetylase 3	0.0143	0.3634	0.3634
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0516	0.0516
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.0045	0.0046
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0516	0.0516
Echinococcus granulosus	histone deacetylase 6	0.0256	0.7088	0.7226
Leishmania major	hypothetical protein, conserved	0.0041	0.0516	0.0778
Brugia malayi	histone deacetylase 11	0.0088	0.1955	0.1955
Trypanosoma brucei	importin beta-1 subunit, putative	0.0032	0.0261	0.0393
Echinococcus granulosus	histone deacetylase 1	0.0143	0.3634	0.3705
Schistosoma mansoni	histone deacetylase 4 5	0.0241	0.6632	0.6762
Schistosoma mansoni	hypothetical protein	0.0053	0.0907	0.0925
Trypanosoma brucei	histone deacetylase 1	0.0143	0.3634	0.5479
Leishmania major	histone deacetylase, putative	0.0241	0.6632	1
Trypanosoma brucei	histone deacetylase 4	0.0241	0.6632	1
Trichomonas vaginalis	histone deacetylase, putative	0.0143	0.3634	1
Echinococcus granulosus	importin subunit beta 1	0.0032	0.0261	0.0266
Schistosoma mansoni	hypothetical protein	0.004	0.0505	0.0515
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0053	0.0907	0.0925
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0516	0.0516
Brugia malayi	Histone deacetylase family protein	0.0241	0.6632	0.6632
Plasmodium falciparum	histone deacetylase 1	0.0143	0.3634	0.5479
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.0516	0.5
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0516	0.0516
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0106	0.2498	0.2547
Trichomonas vaginalis	histone deacetylase, putative	0.0143	0.3634	1
Echinococcus multilocularis	importin subunit beta 1	0.0032	0.0261	0.0266
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0169	0.4436	0.4436
Plasmodium vivax	histone deacetylase 1, putative	0.0143	0.3634	0.5479
Onchocerca volvulus		0.0343	0.9751	1
Schistosoma mansoni	histone deacetylase hda2	0.0256	0.7088	0.7226
Echinococcus multilocularis	geminin	0.019	0.5073	0.5172
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0106	0.2498	0.2547
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0516	0.0526
Toxoplasma gondii	histone deacetylase HDAC1	0.0241	0.6632	1
Echinococcus granulosus	GPCR family 2	0.0053	0.0907	0.0925
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0106	0.2498	0.2547
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0516	0.0778
Trichomonas vaginalis	rotamase, putative	0.0037	0.039	0.1073
Trypanosoma cruzi	histone deacetylase, putative	0.0241	0.6632	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0516	0.0526
Brugia malayi	histone deacetylase 1 (HD1)	0.0143	0.3634	0.3634
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.004	0.0503	0.0513
Trypanosoma brucei	histone deacetylase 3	0.0241	0.6632	1
Echinococcus granulosus	protein quaking	0.003	0.0181	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0261	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0668	0.0668
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.0045	0.0046
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0505	0.0515
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0143	0.3634	1
Echinococcus granulosus	GA binding protein alpha chain	0.0081	0.1752	0.1786
Toxoplasma gondii	HEAT repeat-containing protein	0.0032	0.0261	0.0393
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0037	0.039	0.0588
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0516	0.142
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0516	0.0516
Brugia malayi	Importin beta-1 subunit	0.0032	0.0261	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0143	0.3634	0.3634
Schistosoma mansoni	hypothetical protein	0.0053	0.0907	0.0925
Trypanosoma cruzi	histone deacetylase, putative	0.0241	0.6632	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0587	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0088	0.1955	0.1955
Loa Loa (eye worm)	fli-1 protein	0.0246	0.6798	0.6798
Brugia malayi	Ets-domain containing protein	0.0081	0.1752	0.1752
Loa Loa (eye worm)	transcription factor SMAD2	0.0269	0.7498	0.7498
Loa Loa (eye worm)	histone deacetylase 7A	0.0241	0.6632	0.6632
Schistosoma mansoni	hypothetical protein	0.019	0.5073	0.5172
Echinococcus granulosus	histone deacetylase 3	0.0143	0.3634	0.3705
Trypanosoma cruzi	histone deacetylase 1, putative	0.0143	0.3634	0.5479
Schistosoma mansoni	histone deacetylase	0.0143	0.3634	0.3705
Echinococcus granulosus	hypothetical protein	0.003	0.0181	0.0185
Entamoeba histolytica	hypothetical protein	0.004	0.0505	0.139
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0088	0.1955	0.1558
Trichomonas vaginalis	rotamase, putative	0.0037	0.0417	0.1147
Trichomonas vaginalis	histone deacetylase, putative	0.0143	0.3634	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0106	0.2498	0.2498
Echinococcus multilocularis	histone deacetylase 7	0.0241	0.6632	0.6762
Leishmania major	histone deacetylase, putative	0.0143	0.3634	0.5479
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1694	0.1694
Plasmodium falciparum	histone deacetylase, putative	0.0241	0.6632	1
Echinococcus granulosus	snurportin 1	0.0345	0.9809	1
Giardia lamblia	Histone deacetylase	0.0143	0.3634	1
Schistosoma mansoni	hypothetical protein	0.019	0.5073	0.5172
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.0045	0.0046
Trypanosoma brucei	histone deacetylase, putative	0.0241	0.6632	1
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0143	0.3634	1
Brugia malayi	hypothetical protein	0.0343	0.9751	0.9751
Trichomonas vaginalis	histone deacetylase, putative	0.0143	0.3634	1
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0037	0.039	0.1073
Schistosoma mansoni	hypothetical protein	0.0115	0.2803	0.2858
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0026	0.0074	0.0203
Brugia malayi	Bromodomain containing protein	0.0084	0.184	0.184
Echinococcus granulosus	geminin	0.019	0.5073	0.5172
Trypanosoma brucei	histone deacetylase 2	0.0088	0.1955	0.2947
Entamoeba histolytica	hypothetical protein	0.0026	0.0074	0.0203
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.026	0.7212	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0516	0.0526
Echinococcus multilocularis	histone deacetylase 1	0.0143	0.3634	0.3705
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0516	0.142
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.0516	0.5
Schistosoma mansoni	hypothetical protein	0.003	0.0181	0.0185
Brugia malayi	beta-lactamase	0.0041	0.0516	0.0516
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0516	0.0778
Brugia malayi	Fli-1 protein	0.0246	0.6798	0.6798
Echinococcus multilocularis	histone deacetylase 8	0.0088	0.1955	0.1993
Toxoplasma gondii	histone deacetylase HDAC4	0.0088	0.1955	0.2947
Mycobacterium ulcerans	hypothetical protein	0.0041	0.0516	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0505	0.0515
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0169	0.4436	0.4436
Loa Loa (eye worm)	hypothetical protein	0.0153	0.3951	0.3951
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.004	0.0503	0.0513
Schistosoma mansoni	hypothetical protein	0.0053	0.0907	0.0925
Echinococcus multilocularis	histone deacetylase 6	0.0256	0.7088	0.7226
Brugia malayi	Histone deacetylase family protein	0.0241	0.6632	0.6632
Loa Loa (eye worm)	hypothetical protein	0.0092	0.21	0.21
Trichomonas vaginalis	importin beta-1, putative	0.0026	0.0074	0.0203
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0026	0.0074	0.0203
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0081	0.1752	0.1752
Brugia malayi	Latrophilin receptor protein 2	0.0053	0.0907	0.0907
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0092	0.21	0.578
Schistosoma mansoni	bromodomain containing protein	0.0071	0.1439	0.1468
Schistosoma mansoni	histone deacetylase hda2	0.0088	0.1955	0.1993
Leishmania major	histone deacetylase, putative	0.0143	0.3634	0.5479
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0516	0.0526
Trichomonas vaginalis	histone deacetylase, putative	0.0143	0.3634	1
Brugia malayi	beta-lactamase family protein	0.0041	0.0516	0.0516
Brugia malayi	hypothetical protein	0.004	0.0505	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0516	0.0516
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0037	0.0417	0.0417
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0092	0.21	0.578
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.0516	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0516	0.142
Leishmania major	importin beta-1 subunit, putative	0.0026	0.0074	0.0111
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0106	0.2498	0.2547
Plasmodium vivax	histone deacetylase 2, putative	0.0241	0.6632	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0516	0.142
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0037	0.039	0.0588
Trypanosoma cruzi	histone deacetylase, putative	0.0088	0.1955	0.2947
Schistosoma mansoni	hypothetical protein	0.0345	0.9809	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0181	0.0181
Brugia malayi	Histone deacetylase 1	0.0143	0.3634	0.3634
Loa Loa (eye worm)	hypothetical protein	0.0115	0.2803	0.2803
Brugia malayi	Temporarily assigned gene name protein 44	0.003	0.0181	0.0181
Entamoeba histolytica	hypothetical protein	0.004	0.0505	0.139
Plasmodium vivax	histone deacetylase, putative	0.0241	0.6632	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0227	0.6224	0.6345
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0417	0.1147
Brugia malayi	PHD-finger family protein	0.0028	0.0126	0.0126
Echinococcus multilocularis	snurportin 1	0.0345	0.9809	1
Schistosoma mansoni	rotamase	0.0037	0.0417	0.0425
Echinococcus granulosus	histone deacetylase 6	0.0241	0.6632	0.6762
Loa Loa (eye worm)	MH2 domain-containing protein	0.0269	0.7498	0.7498
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0907	0.0907
Toxoplasma gondii	histone deacetylase HDAC3	0.0143	0.3634	0.5479
Toxoplasma gondii	histone deacetylase HDAC5	0.0088	0.1955	0.2947
Brugia malayi	latrophilin 2 splice variant baaae	0.0115	0.2803	0.2803
Toxoplasma gondii	histone deacetylase HDAC2	0.0143	0.3634	0.5479
Brugia malayi	beta-lactamase family protein	0.0041	0.0516	0.0516
Echinococcus multilocularis	GA binding protein alpha chain	0.0081	0.1752	0.1786
Mycobacterium leprae	Probable lipase LipE	0.0041	0.0516	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0106	0.2498	0.2547
Echinococcus multilocularis	histone deacetylase 3	0.0143	0.3634	0.3705
Schistosoma mansoni	histone deacetylase	0.0143	0.3634	0.3705
Trypanosoma brucei	importin beta-1 subunit, putative	0.0032	0.0261	0.0393
Echinococcus multilocularis	histone deacetylase	0.0241	0.6632	0.6762
Loa Loa (eye worm)	hypothetical protein	0.0168	0.4407	0.4407
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0733	0.0733
Brugia malayi	MH2 domain containing protein	0.0269	0.7498	0.7498
Loa Loa (eye worm)	histone deacetylase	0.0241	0.6632	0.6632
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0516	0.0516
Schistosoma mansoni	gabp alpha	0.0081	0.1752	0.1786
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0037	0.0417	0.0417
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0106	0.2498	0.2498
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0106	0.2498	0.2547
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0037	0.039	0.0588
Echinococcus granulosus	histone deacetylase 7	0.0241	0.6632	0.6762
Toxoplasma gondii	ABC1 family protein	0.0041	0.0516	0.0778
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0516	0.0778
Mycobacterium ulcerans	lipase LipD	0.0041	0.0516	0.5
Loa Loa (eye worm)	histone deacetylase 1	0.0143	0.3634	0.3634

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 60 %	Inhibition of recombinant human HDAC6 at 1 uM using Boc-Lys(Ac)-AMC as substrate by fluorometric analysis	ChEMBL.	20947351

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1289816

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1261446