TDR Targets

Basic information

Technical information

TDR Targets ID: 1264482
Name: 3-(furan-2-carbonylamino)-1-(2-methylpropyl)t hiourea
MW: 241.31 | Formula: C10H15N3O2S
H donors: 2 H acceptors: 1 LogP: 2.13 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CC(CN=C(NNC(=O)c1ccco1)S)C
InChi: 1S/C10H15N3O2S/c1-7(2)6-11-10(16)13-12-9(14)8-4-3-5-15-8/h3-5,7H,6H2,1-2H3,(H,12,14)(H2,11,13,16)
InChiKey: DVOOSCJHMZUGSQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(furan-2-carbonylamino)-1-isobutyl-thiourea
3-[(2-furyl-oxomethyl)amino]-1-isobutylthiourea
3-(furan-2-ylcarbonylamino)-1-(2-methylpropyl)thiourea
2-(2-furoyl)-N-isobutylhydrazinecarbothioamide
MLS000547841
SMR000115036
IVK/1025087
AK-968/41924062
ZINC02112538

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references
Homo sapiens	bromodomain adjacent to zinc finger domain, 2B	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma mansoni	bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Cleft lip and palate transmembrane protein 1-like protein, putative	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	ko:K01549 ATP synthase [EC3.6.3.14], putative	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Conserved hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.027	0.0468	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.027	0.0468	0.6012
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0376	0.0692	0.5491
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0376	0.0692	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.011	0.0129	0.0126
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0376	0.0692	0.1724
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.1152	0.2339	0.6773
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.1649	0.3392	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0594	0.1154	0.1788
Loa Loa (eye worm)	phosphatidylinositol 3	0.011	0.0129	0.0228
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Loa Loa (eye worm)	hypothetical protein	0.0559	0.108	0.1906
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0594	0.1154	0.3228
Onchocerca volvulus		0.011	0.0129	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0232	0.0388	0.0794
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Mycobacterium leprae	conserved hypothetical protein	0.011	0.0129	0.5
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0766	0.1521	0.4265
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0232	0.0388	0.0794
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.011	0.0129	0.0081
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.1649	0.3392	0.999
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0143	0.02	0.0152
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0232	0.0388	0.0341
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0594	0.1154	0.3142
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0594	0.1154	0.3139
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0594	0.1154	0.3142
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.1325	0.2705	0.7895
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0376	0.0692	0.0647
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0376	0.0692	0.0647
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.011	0.0129	0.0126
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.011	0.0129	0.0081
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.027	0.0468	0.0704
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0376	0.0692	0.1058
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.1649	0.3392	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1649	0.3392	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.1649	0.3392	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.027	0.0468	0.1036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0254	0.0433	0.0932
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0143	0.02	0.0152
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.011	0.0129	0.0169
Giardia lamblia	GTOR	0.0376	0.0692	0.3696
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0376	0.0692	0.1609
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0376	0.0692	0.1724
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0077	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0005	0.0009
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.109	0.2207	0.2169
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Loa Loa (eye worm)	hypothetical protein	0.006	0.0022	0.0039
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.027	0.0468	0.1037
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.011	0.0129	0.0081
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Loa Loa (eye worm)	hypothetical protein	0.011	0.0129	0.0228
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.1649	0.3392	0.999
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.027	0.0468	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0254	0.0433	0.0765
Leishmania major	phosphatidylinositol 3-kinase, putative	0.027	0.0468	0.0967
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0376	0.0692	0.5491
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0232	0.0388	0.2527
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.027	0.0468	0.0826
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0594	0.1154	0.3142
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Echinococcus granulosus	serine protein kinase ATM	0.0232	0.0388	0.0341
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0232	0.0388	0.0793
Echinococcus multilocularis		0.011	0.0129	0.0081
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.1649	0.3392	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0376	0.0692	0.1724
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Loa Loa (eye worm)	phosphatidylinositol 3	0.011	0.0129	0.0228
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0232	0.0388	0.0794
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0376	0.0692	0.183
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.011	0.0129	0.0169
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.027	0.0468	0.1036
Brugia malayi	FAT domain containing protein	0.0143	0.02	0.0339
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.3046	0.6353	0.6335
Entamoeba histolytica	protein kinase rad3, putative	0.0232	0.0388	0.0794
Trichomonas vaginalis	conserved hypothetical protein	0.0122	0.0155	0.0078
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0376	0.0692	0.5491
Trypanosoma cruzi	hypothetical protein, conserved	0.165	0.3395	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0254	0.0433	0.2965
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0232	0.0388	0.0794
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.3046	0.6353	0.6335
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0434	0.0816	0.4509
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0232	0.0388	0.0794
Trypanosoma cruzi	target of rapamycin kinase 3	0.0376	0.0692	0.1724
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.027	0.0468	0.0421
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Echinococcus multilocularis	Zinc finger, PHD finger	0.027	0.0468	0.0421
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0594	0.1154	1
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0376	0.0692	0.0647
Onchocerca volvulus		0.011	0.0129	1
Trichomonas vaginalis	conserved hypothetical protein	0.0143	0.02	0.0215
Loa Loa (eye worm)	phosphatidylinositol 3	0.2722	0.5666	1
Entamoeba histolytica	hypothetical protein	0.0232	0.0388	0.0794
Loa Loa (eye worm)	phosphatidylinositol kinase	0.011	0.0129	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0232	0.0388	0.0685
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.027	0.0468	0.0421
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0594	0.1154	0.3142
Echinococcus granulosus	tumor protein p63	0.0408	0.0761	0.0716
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0376	0.0692	0.5491
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0122	0.0155	0.0078
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0376	0.0692	0.1609
Schistosoma mansoni	hypothetical protein	0.011	0.0129	0.0169
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Loa Loa (eye worm)	hypothetical protein	0.109	0.2207	0.3895
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0232	0.0388	0.091
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0232	0.0388	0.0794
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0376	0.0692	0.1609
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0232	0.0388	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0143	0.02	0.0352
Entamoeba histolytica	hypothetical protein	0.1325	0.2705	0.7895
Echinococcus multilocularis	serine protein kinase ATM	0.0232	0.0388	0.0341
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Leishmania major	hypothetical protein, conserved	0.1761	0.3629	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0232	0.0388	0.0794
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.027	0.0468	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.011	0.0129	0.0081
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.027	0.0468	0.1037
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0155	0.0273
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.109	0.2207	0.2169
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0232	0.0388	0.0341
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.027	0.0468	0.1037
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.027	0.0468	0.0967
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Echinococcus multilocularis	tumor protein p63	0.0408	0.0761	0.0716
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.011	0.0129	0.0169
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0232	0.0388	0.091
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.1152	0.2339	0.6773
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.027	0.0468	0.3301
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Schistosoma mansoni	hypothetical protein	0.0143	0.02	0.028
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Loa Loa (eye worm)	phosphatidylinositol 3	0.0484	0.0921	0.1625
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0232	0.0388	0.0578
Loa Loa (eye worm)	phosphatidylinositol 3	0.011	0.0129	0.0228
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.109	0.2207	0.6415
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.027	0.0468	0.0704
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Trichomonas vaginalis	conserved hypothetical protein	0.0254	0.0433	0.0932
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.011	0.0129	0.0126
Loa Loa (eye worm)	phosphatidylinositol 3	0.011	0.0129	0.0228
Loa Loa (eye worm)	phosphatidylinositol 3	0.0376	0.0692	0.1222
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.1539	0.3158	0.9284
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.027	0.0468	0.6012
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0594	0.1154	0.3142
Toxoplasma gondii	FATC domain-containing protein	0.0232	0.0388	0.4601
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.027	0.0468	0.1037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0376	0.0692	0.1058
Loa Loa (eye worm)	phosphatidylinositol 3	0.0376	0.0692	0.1222
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0376	0.0692	0.1725
Schistosoma mansoni	bromodomain containing protein	0.0076	0.0058	0.0056
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0829	0.1652	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0376	0.0692	0.5491
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0122	0.0155	0.0078
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0376	0.0692	0.1609
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.3046	0.6353	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0376	0.0692	0.183
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.011	0.0129	0.0081
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.027	0.0468	0.1037
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0232	0.0388	0.0578
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.4766	1	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0376	0.0692	0.1724
Mycobacterium tuberculosis	Conserved hypothetical protein	0.011	0.0129	0.5
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0254	0.0433	0.5399
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.027	0.0468	0.115
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0232	0.0388	0.0794
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.1397	0.2857	0.8381
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0376	0.0692	0.1609
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0232	0.0388	0.0793
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0376	0.0692	0.1725
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0484	0.0921	0.2424
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0376	0.0692	0.0647
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0692	0.1725

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 73.926 um	PUBCHEM_BIOASSAY: uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay. (Class of assay: confirmatory) [Related pubchem assays: 813, 518, 1548, 1450 ]	ChEMBL.	No reference
Potency (functional)	0.631 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	= 44.6684 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1339984

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1264482