Detailed information for compound 1271014

Basic information

Technical information
  • TDR Targets ID: 1271014
  • Name: 1-(3,4-dihydro-1H-isoquinolin-2-yl)-2-[(5-met hyl-4-phenyl-1,2,4-triazol-3-yl)sulfanyl]etha none
  • MW: 364.464 | Formula: C20H20N4OS
  • H donors: 0 H acceptors: 3 LogP: 3.39 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCc2c(C1)cccc2)CSc1nnc(n1c1ccccc1)C
  • InChi: 1S/C20H20N4OS/c1-15-21-22-20(24(15)18-9-3-2-4-10-18)26-14-19(25)23-12-11-16-7-5-6-8-17(16)13-23/h2-10H,11-14H2,1H3
  • InChiKey: PUZQNEVRECOLEZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3,4-dihydro-1H-isoquinolin-2-yl)-2-[(5-methyl-4-phenyl-1,2,4-triazol-3-yl)thio]ethanone
  • AH-487/42353530
  • ZINC00983609
  • MLS000394391
  • SMR000261796
  • STK140939

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0136 0.0402
Schistosoma mansoni cyclin B 0.0105 0.2031 0.2031
Onchocerca volvulus 0.002 0.0149 0.0149
Leishmania major cathepsin L-like protease 0.0077 0.1415 0.6879
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0435
Trichomonas vaginalis cyclin A, putative 0.0105 0.2031 0.2031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0149 0.0149
Brugia malayi Protein kinase domain containing protein 0.0045 0.069 0.069
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0149 0.0435
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0457
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.069 0.321
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0157 0.0157
Plasmodium falciparum protein kinase 5 0.0045 0.069 0.2678
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0776 0.0776
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0149 0.0149
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0149 0.039
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.1266 0.6125
Loa Loa (eye worm) hypothetical protein 0.0035 0.0471 0.1374
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0057 0.0057
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0136 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0157 0.0457
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.069 0.0638
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0136 0.0669
Trypanosoma brucei cdc2-related kinase 3 0.0045 0.069 0.3399
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0105 0.2031 1
Trichomonas vaginalis cyclins, putative 0.0105 0.2031 0.2031
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0157 0.0157
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0828 0.2417
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0157 0.0157
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1857 0.1857
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0057 0.0057
Schistosoma mansoni cyclins 0.0054 0.0905 0.0905
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0157 0.0457
Trichomonas vaginalis cyclins, putative 0.0105 0.2031 0.2031
Schistosoma mansoni hypothetical protein 0.0016 0.0056 0.0056
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.069 0.321
Trichomonas vaginalis peptide N-glycanase, putative 0.0462 1 1
Mycobacterium leprae Conserved hypothetical protein 0.0462 1 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0149 0.0149
Onchocerca volvulus Cathepsin F homolog 0.002 0.0149 0.0149
Schistosoma mansoni hypothetical protein 0.0016 0.0056 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0149 0.0149
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0157 0.0157
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.1857 0.1857
Echinococcus granulosus cyclin dependent kinase 1 0.0045 0.069 0.069
Schistosoma mansoni DNA polymerase eta 0.002 0.0136 0.0136
Echinococcus multilocularis cyclin dependent kinase 0.0045 0.069 0.0638
Leishmania major cathepsin L-like protease 0.0077 0.1415 0.6879
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0157 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0157 0.0157
Trichomonas vaginalis cyclin B, putative 0.0105 0.2031 0.2031
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0136 0.0669
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0157 0.0101
Leishmania major DNA polymerase eta, putative 0.002 0.0136 0.0402
Trichomonas vaginalis cyclin B, putative 0.0105 0.2031 0.2031
Onchocerca volvulus 0.002 0.0149 0.0149
Trypanosoma brucei polo-like protein kinase 0.0097 0.1857 0.9144
Mycobacterium tuberculosis Hypothetical protein 0.0462 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0149 0.0149
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 7 0.0091 0.172 0.1674
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0669
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0057 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0136 0.0402
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0149 0.039
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0056 0.0056
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0091 0.172 0.1674
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0045 0.069 0.069
Echinococcus multilocularis cyclins 0.0054 0.0905 0.0854
Echinococcus multilocularis cyclins 0.0054 0.0905 0.0854
Trichomonas vaginalis cyclin D, putative 0.0054 0.0905 0.0905
Giardia lamblia Kinase, CMGC CDK 0.0045 0.069 0.0562
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0136 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0149 0.0149
Echinococcus granulosus cyclin b3 0.0054 0.0905 0.0905
Echinococcus multilocularis cysteine protease 0.002 0.0149 0.0093
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0136 0.0402
Onchocerca volvulus 0.0462 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0157 0.0157
Schistosoma mansoni coup transcription factor 0.0021 0.0157 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0149 0.0149
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0157 0.0157
Onchocerca volvulus 0.002 0.0149 0.0149
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0157 0.0101
Trypanosoma cruzi cdc2-related kinase 3 0.0045 0.069 0.321
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0136 0.0669
Loa Loa (eye worm) hypothetical protein 0.0043 0.0666 0.1943
Entamoeba histolytica cell division protein kinase 2, putative 0.0045 0.069 0.3399
Echinococcus multilocularis kinase protein 0.0091 0.172 0.1674
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0157 0.0101
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0157 0.0157
Onchocerca volvulus Cathepsin L homolog 0.002 0.0149 0.0149
Trichomonas vaginalis cyclin B, putative 0.0105 0.2031 0.2031
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0157 0.0157
Trichomonas vaginalis cyclins, putative 0.0064 0.1115 0.1115
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0457
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0057 0.0001
Echinococcus granulosus cyclin dependent kinase 0.0045 0.069 0.069
Echinococcus multilocularis cyclins 0.0054 0.0905 0.0854
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0149 0.0149
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0056 0.0056
Loa Loa (eye worm) fibroinase 0.002 0.0149 0.0435
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0669
Echinococcus multilocularis cyclins 0.0054 0.0905 0.0854
Echinococcus multilocularis cyclins 0.0054 0.0905 0.0854
Mycobacterium leprae Conserved hypothetical protein 0.0462 1 0.5
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.1857 0.1857
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0149 0.0149
Brugia malayi steroid hormone receptor 0.0021 0.0157 0.0157
Trypanosoma brucei unspecified product 0.002 0.0136 0.0669
Toxoplasma gondii cell-cycle-associated protein kinase, putative 0.0114 0.2244 1
Echinococcus multilocularis cysteine protease 0.002 0.0149 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0157 0.0157
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1857 0.1857
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.069 0.2015
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0157 0.0101
Schistosoma mansoni hypothetical protein 0.0016 0.0056 0.0056
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.1857 0.1857
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0057 0.0165
Echinococcus granulosus cyclins 0.0054 0.0905 0.0905
Loa Loa (eye worm) cysteine protease 0.002 0.0149 0.0435
Brugia malayi nuclear hormone receptor 0.0021 0.0157 0.0157
Leishmania major cathepsin L-like protease 0.002 0.0149 0.0468
Echinococcus multilocularis cyclins 0.0054 0.0905 0.0854
Schistosoma mansoni hypothetical protein 0.0016 0.0056 0.0056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0149 0.0149
Leishmania major cysteine peptidase A (CPA) 0.002 0.0149 0.0468
Trypanosoma cruzi cdc2-related kinase 1 0.0045 0.069 0.321
Entamoeba histolytica cyclin, putative 0.0105 0.2031 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0045 0.069 0.0638
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0149 0.0149
Trichomonas vaginalis cyclin B3, putative 0.0054 0.0905 0.0905
Echinococcus granulosus dna polymerase eta 0.002 0.0136 0.0136
Onchocerca volvulus 0.002 0.0149 0.0149
Trypanosoma cruzi CYC2-like cyclin, putative 0.0105 0.2031 1
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0157 0.0157
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0149 0.0149
Mycobacterium tuberculosis Long conserved protein 0.0462 1 1
Echinococcus granulosus 5'partial|3'partial|mitogen activated protein kinase kinase kinase 0.0091 0.172 0.172
Giardia lamblia G2/mitotic-specific cyclin B 0.0105 0.2031 0.1921
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0157 0.0157
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0157 0.0157
Trichomonas vaginalis cyclin B, putative 0.0105 0.2031 0.2031
Echinococcus multilocularis dna polymerase eta 0.002 0.0136 0.008
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.1857 0.9119
Toxoplasma gondii cathepsin CPL 0.002 0.0149 0.0422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0149 0.0149
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0136 0.0402
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0149 0.0093
Trichomonas vaginalis cyclins, putative 0.0054 0.0905 0.0905
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1415 0.6966
Plasmodium vivax vivapain-2 0.002 0.0149 0.039
Echinococcus multilocularis cyclin B3 1 0.0054 0.0905 0.0854
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1415 0.6966
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.1415 0.6879
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.069 0.069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0457
Trypanosoma brucei cdc2-related kinase 1 0.0045 0.069 0.3399
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0091 0.172 0.1674
Leishmania major cathepsin L-like protease 0.002 0.0149 0.0468
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0669
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0149 0.039
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0157 0.0157
Echinococcus multilocularis cyclin dependent kinase 1 0.0045 0.069 0.0638
Loa Loa (eye worm) hypothetical protein 0.0051 0.0824 0.2404
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0057 0.0278
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1415 0.6879
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0157 0.0157
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0157 0.0157
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0149 0.0093
Onchocerca volvulus 0.002 0.0149 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1857 0.1857
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0157 0.0157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1415 0.6966
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0045 0.069 0.2015
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0149 0.0149
Trypanosoma brucei mitotic cyclin 6 0.0105 0.2031 1
Echinococcus multilocularis cyclin b3 0.0054 0.0905 0.0854
Trichomonas vaginalis cyclins, putative 0.0105 0.2031 0.2031
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0828 0.0828
Leishmania major cathepsin L-like protease 0.0077 0.1415 0.6879
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0457
Onchocerca volvulus 0.002 0.0149 0.0149
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0149 0.0733
Trypanosoma cruzi cyclin, putative 0.0105 0.2031 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0149 0.0149
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0149 0.0149
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0157 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0149 0.0149
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0136 0.0402
Echinococcus granulosus dna polymerase kappa 0.002 0.0136 0.0136
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0157 0.0157
Brugia malayi Cyclin, N-terminal domain containing protein 0.0167 0.3427 0.3427
Mycobacterium ulcerans putative transglutaminase-like protein 0.0462 1 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.1857 0.9144
Echinococcus multilocularis kinase protein 0.0091 0.172 0.1674
Echinococcus granulosus cyclin B 0.0105 0.2031 0.2031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0149 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1415 0.6966
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.069 0.069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0457
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.069 0.069
Leishmania major cyclin 0.0105 0.2031 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0136 0.0397
Giardia lamblia Hypothetical protein 0.0462 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0149 0.0435
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0457
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0157 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0669
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.069 0.069
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0045 0.069 0.321
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0136 0.008
Giardia lamblia Hypothetical protein 0.0054 0.0905 0.078
Onchocerca volvulus 0.002 0.0149 0.0149
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0056 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0149 0.0149
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0092 0.1744 0.1697
Brugia malayi Protein kinase domain containing protein 0.0092 0.1744 0.1744
Echinococcus granulosus GPCR family 2 0.0016 0.0056 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0149 0.0149
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1415 0.6966
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1415 0.6966
Brugia malayi Cathepsin L-like precursor 0.002 0.0149 0.0149
Giardia lamblia Transglutaminase/protease, putative 0.0462 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0149 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0776 0.0776
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0149 0.0149
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.1857 0.1811
Mycobacterium ulcerans hypothetical protein 0.0462 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0136 0.0402
Leishmania major DNA polymerase kappa, putative 0.002 0.0136 0.0402
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0045 0.069 0.321
Echinococcus granulosus cyclins 0.0054 0.0905 0.0905
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0157 0.0101
Plasmodium falciparum cyclin 0.0054 0.0905 0.3587
Brugia malayi Cathepsin L-like precursor 0.002 0.0149 0.0149
Mycobacterium tuberculosis Conserved hypothetical protein 0.0462 1 1
Entamoeba histolytica cyclin family protein 0.0054 0.0905 0.4458
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1415 0.6966
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0157 0.0157
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0828 0.0828
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0157 0.0457
Onchocerca volvulus Cathepsin L homolog 0.002 0.0149 0.0149
Onchocerca volvulus 0.0021 0.0157 0.0157
Echinococcus multilocularis Transglutaminase 0.0462 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2035 0.2035
Trichomonas vaginalis CMGC family protein kinase 0.0045 0.069 0.069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0457
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0136 0.0669
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1857 0.1857
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0092 0.1744 0.5088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0149 0.0149
Brugia malayi nuclear receptor NHR-88 0.0021 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0105 0.2031 0.5926
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0905 0.0905
Entamoeba histolytica cyclin family protein 0.0054 0.0905 0.4458
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0105 0.2031 0.5926
Leishmania major cathepsin L-like protease 0.002 0.0149 0.0468
Loa Loa (eye worm) ctsf protein 0.002 0.0149 0.0435
Entamoeba histolytica cysteine protease, putative 0.002 0.0149 0.0733
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0157 0.0157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1415 0.6966
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0057 0.0278
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0056 0.0056
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0136 0.008
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0157 0.0101
Echinococcus multilocularis cyclin B 0.0105 0.2031 0.1986
Trichomonas vaginalis cyclins, putative 0.0105 0.2031 0.2031
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0669
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0122 0.2423 1
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1415 0.6879
Leishmania major cathepsin L-like protease 0.002 0.0149 0.0468
Echinococcus granulosus 3'partial|mitogen activated protein kinase kinase kinase 0.0091 0.172 0.172
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0157 0.0157
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0157 0.0157
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0045 0.069 0.2015
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0149 0.0149
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0136 0.0669
Brugia malayi Cyclin, N-terminal domain containing protein 0.0105 0.2031 0.2031
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1857 0.1857
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0136 0.0136
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0045 0.069 0.2897
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.1047 0.5019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0157 0.0457
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0057 0.0001
Loa Loa (eye worm) cyclin domain-containing protein 0.0167 0.3427 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0105 0.2031 0.2031
Mycobacterium tuberculosis Conserved protein 0.0462 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0149 0.0149
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0157 0.0157
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0149 0.0733
Echinococcus granulosus cyclins 0.0054 0.0905 0.0905
Trichomonas vaginalis cyclin D, putative 0.0054 0.0905 0.0905
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0057 0.0001
Onchocerca volvulus 0.0105 0.2031 0.2031
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.1857 0.9119
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0167 0.3427 0.339
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0669
Schistosoma mansoni hypothetical protein 0.0035 0.0471 0.0471
Trichomonas vaginalis cyclin B, putative 0.0054 0.0905 0.0905
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0157 0.0157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1415 0.6966
Loa Loa (eye worm) hypothetical protein 0.0051 0.0828 0.2417
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0149 0.0093
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0092 0.1744 0.1744
Mycobacterium tuberculosis Conserved hypothetical protein 0.0462 1 1
Giardia lamblia Kinase, PLK 0.0097 0.1857 0.1745
Schistosoma mansoni hypothetical protein 0.0462 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0056 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0669
Loa Loa (eye worm) hypothetical protein 0.0021 0.0157 0.0457
Echinococcus granulosus Transglutaminase 0.0462 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0157 0.0157
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0149 0.0149
Trypanosoma cruzi cyclin, putative 0.0105 0.2031 1
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.1857 0.1857
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0471 0.0471
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0157 0.0157
Giardia lamblia Kinase, CMGC CDK 0.0045 0.069 0.0562
Brugia malayi cell division control protein 2 homolog 0.0045 0.069 0.069
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0669
Toxoplasma gondii hypothetical protein 0.0041 0.0614 0.2548
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0157 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0149 0.0149
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0149 0.0468
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0157 0.0157
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.1857 0.9119
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0669
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0091 0.172 0.1674
Plasmodium falciparum MO15-related protein kinase 0.0122 0.2423 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0149 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0157 0.0457
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0057 0.0057
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0157 0.0157
Brugia malayi Cathepsin L-like precursor 0.002 0.0149 0.0149
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0157 0.0157
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0157 0.0157
Brugia malayi Cathepsin L-like precursor 0.002 0.0149 0.0149
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1857 0.1857
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0136 0.0136
Plasmodium vivax vivapain-2 0.002 0.0149 0.039
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0157 0.0157
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0057 0.0001
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0869 0.4278
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0397
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0136 0.0136
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0167 0.3427 0.3427
Brugia malayi ecdysteroid receptor 0.0021 0.0157 0.0157
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0136 0.0136
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0157 0.0157
Schistosoma mansoni kinase 0.005 0.0804 0.0804
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.1857 0.5419
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.1415 0.6879
Schistosoma mansoni cyclin B3 0.0167 0.3427 0.3427
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 0.0669
Trypanosoma cruzi cyclin 6, putative 0.0105 0.2031 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0136 0.008
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0136 0.0136
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0157 0.0457
Mycobacterium ulcerans hypothetical protein 0.0462 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0157 0.0457
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0149 0.0093
Echinococcus granulosus cyclins 0.0054 0.0905 0.0905
Echinococcus multilocularis cyclins 0.0054 0.0905 0.0854
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1415 0.6966
Leishmania major cathepsin L-like protease 0.002 0.0149 0.0468
Entamoeba histolytica cyclin, putative 0.0054 0.0905 0.4458
Echinococcus granulosus cyclin dependent kinase 5 0.0045 0.069 0.069
Giardia lamblia Cyclin A 0.0054 0.0905 0.078
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0157 0.0157
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0149 0.0149
Plasmodium vivax protein kinase Crk2 0.0045 0.069 0.2678
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0157 0.0101
Brugia malayi isocitrate dehydrogenase 0.0016 0.0057 0.0057
Mycobacterium ulcerans transglutaminase family protein 0.0462 1 1
Echinococcus granulosus cyclin B3 1 0.0054 0.0905 0.0905
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0157 0.0457
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.1415 0.6966
Brugia malayi Cathepsin L-like precursor 0.002 0.0149 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0157 0.0157
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0136 0.008
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0016 0.0056 0.0163
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0149 0.0149
Echinococcus granulosus cathepsin l1 0.002 0.0149 0.0149
Echinococcus granulosus cyclins 0.0054 0.0905 0.0905
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0157 0.0157

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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