Detailed information for compound 1281443

Basic information

Technical information
  • TDR Targets ID: 1281443
  • Name: [2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl] 2-( adamantane-1-carbonylamino)acetate
  • MW: 449.521 | Formula: C21H27N3O6S
  • H donors: 3 H acceptors: 5 LogP: 1.51 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CNC(=O)C12CC3CC(C2)CC(C1)C3)OCC(=O)Nc1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C21H27N3O6S/c22-31(28,29)17-3-1-16(2-4-17)24-18(25)12-30-19(26)11-23-20(27)21-8-13-5-14(9-21)7-15(6-13)10-21/h1-4,13-15H,5-12H2,(H,23,27)(H,24,25)(H2,22,28,29)
  • InChiKey: ISYNLOSXLHEJMJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(1-adamantyl-oxomethyl)amino]acetic acid [2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl] ester
  • 2-(adamantane-1-carbonylamino)acetic acid [2-keto-2-[(4-sulfamoylphenyl)amino]ethyl] ester
  • [2-oxo-2-[(4-sulfamoylphenyl)amino]ethyl] 2-(1-adamantylcarbonylamino)ethanoate
  • T5222948
  • MLS000776606
  • SMR000371854

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ferritin 0.001 0.0157 0.014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.006 0.0633
Schistosoma mansoni coup transcription factor 0.001 0.0149 0.0148
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0119 0.0102
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.006 0.0633
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.1331 0.132
Brugia malayi hypothetical protein 0.0005 0.0031 0.0015
Brugia malayi hypothetical protein 0.0005 0.0031 0.0015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0149 0.0144
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0149 0.0132
Brugia malayi nuclear receptor NHR-88 0.001 0.0149 0.0144
Schistosoma mansoni DNA topoisomerase type I 0.0276 0.6824 0.6823
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0149 0.0148
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0864 1
Trichomonas vaginalis helicase, putative 0.0006 0.006 0.0633
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.006 0.0633
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0149 0.0132
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0149 0.0132
Onchocerca volvulus 0.001 0.0149 0.2229
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0031 0.0015
Schistosoma mansoni apoferritin-2 0.001 0.0157 0.0155
Schistosoma mansoni nuclear hormone receptor 0.001 0.0149 0.0148
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0149 0.0132
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0149 0.0132
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0149 0.0148
Echinococcus multilocularis cpg binding protein 0.003 0.0649 0.0633
Loa Loa (eye worm) hypothetical protein 0.001 0.0149 0.0144
Schistosoma mansoni zinc finger protein 0.0005 0.0028 0.0026
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.006 0.0633
Echinococcus multilocularis expressed protein 0.001 0.0157 0.014
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0116 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0149 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0149 0.0144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0149 0.0132
Schistosoma mansoni nuclear receptor 0.0005 0.0017 0.0016
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0149 0.0132
Loa Loa (eye worm) hypothetical protein 0.0005 0.0031 0.0015
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.001 0.0157 0.5
Schistosoma mansoni DNA topoisomerase type I 0.0368 0.9148 0.9147
Echinococcus granulosus geminin 0.0205 0.5039 0.503
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0149 0.0144
Loa Loa (eye worm) hypothetical protein 0.0005 0.0031 0.0015
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0005 0.0028 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.0149 0.0144
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0149 0.0144
Loa Loa (eye worm) hypothetical protein 0.0005 0.0031 0.0015
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0149 0.0132
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.001 0.0143 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0149 0.0144
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0952 0.0936
Loa Loa (eye worm) ABC transporter 0.0008 0.0106 0.0097
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0149 0.0132
Echinococcus granulosus expressed protein 0.001 0.0157 0.014
Brugia malayi nuclear hormone receptor 0.001 0.0149 0.0144
Echinococcus granulosus cpg binding protein 0.003 0.0649 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0149 0.0144
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.006 0.0633
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0276 0.6824 1
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0143 0.0126
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0017 0.0016
Brugia malayi nuclear receptor RXR 0.0005 0.0031 0.0015
Schistosoma mansoni ferritin 0.001 0.0157 0.0155
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0076 0.0059
Schistosoma mansoni DNA topoisomerase type I 0.0276 0.6824 0.6823
Schistosoma mansoni ferritin 0.001 0.0157 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0149 0.0144
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0031 0.003
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0031 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0149 0.0144
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0119 0.0111
Treponema pallidum bacterioferrin (TpF1) 0.001 0.0157 0.5
Leishmania major DNA topoisomerase type IB small subunit 0.0093 0.2223 0.3114
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.006 0.0633
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0149 0.0132
Echinococcus granulosus FTZ F1 alpha 0.001 0.0149 0.0132
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0149 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0149 0.0144
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0864 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0149 0.0148
Brugia malayi ABC transporter family protein 0.0008 0.0106 0.0097
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0017 0.0016
Echinococcus multilocularis zinc finger protein 0.0005 0.0028 0.001
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0031 0.0014
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0149 0.2229
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0149 0.0148
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0149 0.0132
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0017 0.0016
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0005 0.0028 0.001
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0017 0.0016
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0119 0.0102
Mycobacterium ulcerans bacterioferritin BfrB 0.001 0.0157 1
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0143 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0149 0.0144
Leishmania major DNA topoisomerase IB, large subunit 0.0276 0.6824 1
Brugia malayi steroid hormone receptor 0.001 0.0149 0.0144
Trypanosoma brucei DNA topoisomerase type IB small subunit 0.0093 0.2223 0.3114
Schistosoma mansoni bromodomain containing protein 0.0005 0.0028 0.0026
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0952 0.1038
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0149 0.2229
Loa Loa (eye worm) hypothetical protein 0.001 0.0149 0.0144
Loa Loa (eye worm) hypothetical protein 0.001 0.0149 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0149 0.0144
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0276 0.6824 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.006 0.0633
Loa Loa (eye worm) hypothetical protein 0.001 0.0149 0.0144
Loa Loa (eye worm) hypothetical protein 0.0005 0.0028 0.0011
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0149 0.0144
Schistosoma mansoni hypothetical protein 0.0008 0.0103 0.0102
Schistosoma mansoni zinc finger protein 0.0005 0.0017 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.006 0.0633
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0149 0.0132
Toxoplasma gondii DNA topoisomerase I, putative 0.0368 0.9148 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0031 0.0014
Loa Loa (eye worm) DNA topoisomerase I 0.0368 0.9148 1
Schistosoma mansoni hypothetical protein 0.0402 1 1
Echinococcus multilocularis geminin 0.0205 0.5039 0.503
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.006 0.0633
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.001 0.0157 0.5
Echinococcus multilocularis DNA topoisomerase 1 0.0368 0.9148 0.9146
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0149 0.0148
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0149 0.0132
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0149 0.0144
Loa Loa (eye worm) hypothetical protein 0.001 0.0149 0.0144
Brugia malayi PHD-finger family protein 0.0005 0.0028 0.0011
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0143 0.0126
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0864 0.0802
Echinococcus granulosus DNA topoisomerase 1 0.0368 0.9148 0.9146
Schistosoma mansoni cpg binding protein 0.0028 0.0609 0.0608
Onchocerca volvulus 0.0028 0.0609 1
Brugia malayi DNA topoisomerase I 0.0368 0.9148 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0952 0.0899
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.3378 0.3367
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0143 0.0126
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.006 0.0633
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0952 1
Trichomonas vaginalis ferritin, putative 0.001 0.0157 0.1646
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.006 0.0633
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0149 0.0144
Loa Loa (eye worm) hypothetical protein 0.001 0.0149 0.0144
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0149 0.0144
Schistosoma mansoni apoferritin-2 0.001 0.0157 0.0155
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0076 0.0059
Echinococcus multilocularis ferritin 0.001 0.0157 0.014
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.3479 0.3478
Schistosoma mansoni hypothetical protein 0.0205 0.5039 0.5038
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.006 0.0633
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1404 0.1403
Plasmodium falciparum topoisomerase I 0.0368 0.9148 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0149 0.0144
Echinococcus granulosus zinc finger protein 0.0005 0.0028 0.001
Loa Loa (eye worm) hypothetical protein 0.0005 0.0031 0.0015
Schistosoma mansoni bromodomain containing protein 0.0005 0.0028 0.0026
Brugia malayi ecdysteroid receptor 0.001 0.0149 0.0144
Trypanosoma cruzi DNA topoisomerase type IB small subunit, putative 0.0093 0.2223 0.3114
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0031 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0149 0.0144
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.006 0.0633
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.006 0.0633
Schistosoma mansoni nuclear receptor 0.0005 0.0017 0.0016
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0149 0.2229
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.006 0.0633
Schistosoma mansoni thyroid hormone receptor 0.001 0.0149 0.0148
Loa Loa (eye worm) hypothetical protein 0.0005 0.0031 0.0015
Schistosoma mansoni ferritin 0.001 0.0157 0.0155
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0031 0.003
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0076 0.0059
Plasmodium vivax topoisomerase I, putative 0.0368 0.9148 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0149 0.0132
Schistosoma mansoni ferritin 0.001 0.0157 0.0155
Loa Loa (eye worm) hypothetical protein 0.001 0.0149 0.0144
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0149 0.0148
Schistosoma mansoni thyroid hormone receptor 0.001 0.0149 0.0148
Schistosoma mansoni ferritin light chain 0.001 0.0157 0.0155
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.001 0.0157 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.006 0.0633
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0609 0.0648
Schistosoma mansoni hypothetical protein 0.0205 0.5039 0.5038
Schistosoma mansoni ABC transporter 0.0008 0.0106 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0149 0.0144
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.3479 0.3467
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0143 0.0126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0149 0.0144
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0149 0.0132
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.3479 0.3791
Loa Loa (eye worm) acetyltransferase 0.0143 0.3479 0.3791
Schistosoma mansoni cpg binding protein 0.003 0.0649 0.0648
Schistosoma mansoni cpg binding protein 0.003 0.0649 0.0648
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0149 0.0148
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0076 0.0074
Echinococcus multilocularis dnaJ subfamily B 0.0402 1 1
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0143 0.0126
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0149 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0149 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.006 0.0633
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0952 0.0899
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0149 0.0144
Mycobacterium ulcerans bacterioferritin BfrA 0.001 0.0157 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0017 0.0016
Brugia malayi Bromodomain containing protein 0.0005 0.0028 0.0011
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0149 0.0144
Brugia malayi CXXC zinc finger family protein 0.0028 0.0609 0.0648
Loa Loa (eye worm) hypothetical protein 0.0005 0.0028 0.0011
Schistosoma mansoni ferritin light chain 0.001 0.0157 0.0155
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0149 0.0148
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0076 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0149 0.0144
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0149 0.0132
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0952 1
Mycobacterium tuberculosis Bacterioferritin BfrB 0.001 0.0157 1
Plasmodium vivax ABC transporter G family member 2, putative 0.001 0.0143 0.0153

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0052 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2643 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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