Detailed information for compound 1283360

Basic information

Technical information
  • TDR Targets ID: 1283360
  • Name: N-[(4-tert-butylcyclohexylidene)amino]-2,3-di hydro-1,4-benzodioxine-2-carboxamide
  • MW: 330.421 | Formula: C19H26N2O3
  • H donors: 1 H acceptors: 1 LogP: 3.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1COc2c(O1)cccc2)N/N=C/1\CCC(CC1)C(C)(C)C
  • InChi: 1S/C19H26N2O3/c1-19(2,3)13-8-10-14(11-9-13)20-21-18(22)17-12-23-15-6-4-5-7-16(15)24-17/h4-7,13,17H,8-12H2,1-3H3,(H,21,22)/b20-14-
  • InChiKey: MIPLFEBEXIEHKK-ZHZULCJRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • T5536589

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) histone deacetylase 11 0.0216 0.0173 0.4564
Schistosoma mansoni histone deacetylase 4 5 0.04 0.0326 0.9068
Loa Loa (eye worm) histone deacetylase 7A 0.04 0.0326 0.8601
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0045 0.0044
Brugia malayi nuclear hormone receptor 0.0015 0.0006 0.0156
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0007 0.0092
Trypanosoma brucei importin beta-1 subunit, putative 0.0021 0.0011 0.0107
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0008
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0007 0.0082
Loa Loa (eye worm) glutamate receptor 0.0016 0.0006 0.0171
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0006 0.0164
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0039 0.1093
Trypanosoma cruzi histone deacetylase 1, putative 0.0414 0.0338 0.7668
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0007 0.0184
Leishmania major importin beta-1 subunit, putative 0.0017 0.0008 0.003
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0007 0.0174
Brugia malayi jmjC domain containing protein 0.006 0.0043 0.1133
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0015 0.0006 0.0164
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0028 0.0017 0.0209
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0039 0.0487
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0039 0.1093
Brugia malayi secreted modular calcium-binding protein 1 0.0019 0.0009 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0006 0.0156
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0043 0.0532
Onchocerca volvulus Huntingtin homolog 0.0119 0.0093 0.2852
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0007 0.0184
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0286
Schistosoma mansoni histone deacetylase hda2 0.0216 0.0173 0.4812
Giardia lamblia Hypothetical protein 0.004 0.0027 0.0624
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.002 0.0543
Echinococcus granulosus GPCR family 2 0.0031 0.002 0.0543
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0007 0.0082
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0155 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0249
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0049 0.0034 0.0425
Echinococcus granulosus agrin 0.0019 0.0009 0.0262
Onchocerca volvulus 0.0381 0.031 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0015 0.0006 0.0073
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.0808 1
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.004 0.0027 0.0749
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0015 0.0006 0.0156
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0042 0.0517
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0042 0.116
Plasmodium vivax hypothetical protein, conserved 0.004 0.0027 0.0478
Brugia malayi Steroid receptor seven-up type 2 0.0015 0.0006 0.0156
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0007 0.0008
Trichomonas vaginalis histone deacetylase, putative 0.0414 0.0338 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0015 0.0006 0.0156
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0015 0.0006 0.0164
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0008 0.0208
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0.0001 0.5
Brugia malayi hypothetical protein 0.0028 0.0017 0.0445
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0464 0.0379 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0045 0.0886
Brugia malayi hypothetical protein 0.0036 0.0024 0.0625
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0015 0.0006 0.0156
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.004 0.0027 0.0333
Brugia malayi hypothetical protein 0.002 0.001 0.0257
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0028 0.0017 0.0469
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0007 0.0092
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.004 0.0027 0.0478
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.004 0.0027 0.071
Echinococcus granulosus Solute carrier organic anion transporter family 0.0028 0.0017 0.0469
Trichomonas vaginalis BRCA1-associated protein, putative 0.004 0.0027 0.0782
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.004 0.0027 0.0749
Schistosoma mansoni ferritin 0.0009 0.0001 0.0015
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0042 0.0041
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0007 0.0184
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0156
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0009 0.0074
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0024 0.0659
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0015 0.0006 0.0164
Echinococcus multilocularis thyroid hormone receptor alpha 0.0015 0.0006 0.0073
Echinococcus granulosus thymidylate synthase 0.0381 0.031 0.8611
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0039 0.1093
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.004 0.0027 0.0749
Echinococcus granulosus FTZ F1 alpha 0.0015 0.0006 0.0164
Trypanosoma brucei histone deacetylase 2 0.0216 0.0173 0.3858
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.002 0.0242
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.004 0.0027 0.0624
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.001 0.0267
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0042 0.116
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0015 0.0006 0.0156
Entamoeba histolytica hypothetical protein 0.0036 0.0024 0.0526
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.009 0.2374
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0015 0.0006 0.0073
Plasmodium falciparum importin beta, putative 0.0021 0.0011 0.0107
Loa Loa (eye worm) hypothetical protein 0.0031 0.002 0.0515
Onchocerca volvulus 0.0021 0.0011 0.0161
Chlamydia trachomatis dihydrofolate reductase 0.0155 0.0122 0.5
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0017 0.0445
Schistosoma mansoni dihydrofolate reductase 0.0155 0.0122 0.3402
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.004 0.0027 0.0478
Brugia malayi histone deacetylase 1 (HD1) 0.0414 0.0338 0.891
Echinococcus multilocularis histone deacetylase 0.04 0.0326 0.4039
Toxoplasma gondii histone deacetylase HDAC5 0.0216 0.0173 0.3858
Mycobacterium ulcerans thymidylate synthase 0.0381 0.031 0.0309
Brugia malayi MH2 domain containing protein 0.0116 0.009 0.2374
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0414 0.0338 1
Trypanosoma cruzi histone deacetylase, putative 0.04 0.0326 0.7397
Brugia malayi follicle stimulating hormone receptor 0.0464 0.0379 1
Loa Loa (eye worm) histone deacetylase 3 0.0414 0.0338 0.891
Schistosoma mansoni agrin 0.0019 0.0009 0.0262
Brugia malayi hypothetical protein 0.0119 0.0093 0.2441
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0007 0.0008
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0019 0.0288
Brugia malayi hypothetical protein 0.003 0.0019 0.0493
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0015 0.0006 0.0156
Plasmodium falciparum histone deacetylase 2 0.04 0.0326 0.7397
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0009 0.0249
Loa Loa (eye worm) thymidylate synthase 0.0381 0.031 0.8167
Onchocerca volvulus 0.0028 0.0017 0.0362
Trypanosoma brucei histone deacetylase 3 0.04 0.0326 0.7397
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0015 0.0006 0.0164
Echinococcus granulosus dihydrofolate reductase 0.0155 0.0122 0.3402
Brugia malayi CXXC zinc finger family protein 0.0021 0.0011 0.0284
Brugia malayi Latrophilin receptor protein 2 0.0031 0.002 0.0515
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0039 0.1037
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0015 0.0006 0.0156
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0024 0.0659
Schistosoma mansoni hypothetical protein 0.0298 0.0241 0.6704
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0044 0.1159
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.004 0.0027 0.071
Trypanosoma cruzi MFS transporter, putative 0.0028 0.0017 0.0246
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0445
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0006 0.0164
Brugia malayi thymidylate synthase 0.0381 0.031 0.8167
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0017 0.0445
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0381 0.031 0.0309
Plasmodium vivax histone deacetylase 1, putative 0.0414 0.0338 0.7668
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0007 0.0028
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0027 0.0782
Brugia malayi jmjC domain containing protein 0.0016 0.0007 0.0174
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0007 0.0174
Brugia malayi Importin beta-1 subunit 0.0021 0.0011 0.0286
Loa Loa (eye worm) dihydrofolate reductase 0.0155 0.0122 0.3227
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0006 0.0073
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0156
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0007 0.0184
Echinococcus granulosus ecdysone induced protein 78C 0.0015 0.0006 0.0164
Trichomonas vaginalis importin beta-1, putative 0.0017 0.0008 0.0208
Brugia malayi Histone deacetylase family protein 0.04 0.0326 0.8601
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0044 0.1222
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0019 0.0288
Brugia malayi Histone deacetylase family protein 0.04 0.0326 0.8601
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0045 0.0044
Leishmania major histone deacetylase, putative 0.0414 0.0338 0.7668
Leishmania major histone deacetylase, putative 0.0414 0.0338 0.7668
Schistosoma mansoni hypothetical protein 0.0031 0.002 0.0543
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0006 0.0164
Schistosoma mansoni cpg binding protein 0.0021 0.0011 0.03
Schistosoma mansoni ran 0.0015 0.0006 0.0174
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.004 0.0027 0.0478
Entamoeba histolytica hypothetical protein 0.0017 0.0008 0.0039
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0042 0.11
Schistosoma mansoni hypothetical protein 0.0224 0.018 0.5
Brugia malayi jmjC domain containing protein 0.0061 0.0044 0.1159
Schistosoma mansoni coup transcription factor 0.0015 0.0006 0.0164
Brugia malayi photoreceptor-specific nuclear receptor 0.0015 0.0006 0.0156
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.004 0.0027 0.0478
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0045 0.0044
Schistosoma mansoni hypothetical protein 0.0031 0.002 0.0543
Leishmania major hypothetical protein, conserved 0.003 0.0019 0.0288
Brugia malayi steroid hormone receptor 0.0015 0.0006 0.0156
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.004 0.0027 0.0749
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0027 0.0478
Onchocerca volvulus 0.0019 0.0009 0.0116
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0007 0.0028
Leishmania major histone deacetylase, putative 0.04 0.0326 0.7397
Echinococcus multilocularis histone deacetylase 6 0.0441 0.036 0.4455
Brugia malayi RNA, U transporter 1 0.006 0.0043 0.1135
Brugia malayi Receptor family ligand binding region containing protein 0.001 0.0002 0.0051
Schistosoma mansoni ferritin 0.0009 0.0001 0.0015
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0027 0.071
Schistosoma mansoni metabotropic glutamate receptor 0.0034 0.0021 0.0591
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0381 0.031 0.8611
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0015 0.0006 0.0156
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0174
Schistosoma mansoni ferritin 0.0009 0.0001 0.0015
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0044 0.1222
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0045 0.1239
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0156
Leishmania major histone deacetylase, putative 0.04 0.0326 0.7397
Onchocerca volvulus 0.0028 0.0017 0.0362
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0028 0.0017 0.0209
Toxoplasma gondii histone deacetylase HDAC3 0.0414 0.0338 0.7668
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0036 0.0024 0.062
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0019 0.0288
Loa Loa (eye worm) histone deacetylase 1 0.0414 0.0338 0.891
Plasmodium falciparum histone deacetylase, putative 0.04 0.0326 0.7397
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0045 0.1239
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0039 0.1037
Giardia lamblia Histone deacetylase 0.0414 0.0338 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0006 0.0164
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0027 0.071
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0181 0.0144 0.3183
Trichomonas vaginalis histone deacetylase, putative 0.0414 0.0338 1
Brugia malayi hypothetical protein 0.0181 0.0144 0.3794
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0445
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0027 0.071
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0156
Trypanosoma brucei histone deacetylase 4 0.04 0.0326 0.7397
Echinococcus multilocularis histone deacetylase 8 0.0216 0.0173 0.2144
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0414 0.0338 1
Toxoplasma gondii transporter, major facilitator family protein 0.0028 0.0017 0.0246
Plasmodium vivax histone deacetylase, putative 0.04 0.0326 0.7397
Schistosoma mansoni ferritin light chain 0.0009 0.0001 0.0015
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0007 0.0028
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0007 0.0007
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0034 0.0021 0.0263
Echinococcus granulosus cpg binding protein 0.0022 0.0012 0.0327
Schistosoma mansoni cpg binding protein 0.0022 0.0012 0.0327
Loa Loa (eye worm) hypothetical protein 0.0414 0.0338 0.891
Brugia malayi SPARC precursor 0.0019 0.0009 0.0249
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0015 0.0006 0.0165
Toxoplasma gondii protease inhibitor PI2 0.0019 0.0009 0.0074
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0007 0.0082
Echinococcus multilocularis cpg binding protein 0.0022 0.0012 0.0146
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.002 0.0543
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0008 0.0094
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0009 0.0074
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0043 0.0532
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0044 0.003 0.0842
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0015 0.0006 0.0156
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0027 0.0478
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 1.2028 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0015 0.0006 0.0156
Echinococcus multilocularis ecdysone induced protein 78C 0.0015 0.0006 0.0073
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0536 0.0439 1
Leishmania major hypothetical protein, conserved 0.004 0.0027 0.0478
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0007 0.0207
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.0017 0.0445
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0009 0.0074
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0536 0.0439 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.005 0.1315
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0009 0.0249
Loa Loa (eye worm) agrin synaptic family protein 0.0019 0.0009 0.0249
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0015 0.0006 0.0073
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.009 0.2374
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0445
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0043 0.1194
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0015 0.0006 0.0077
Echinococcus multilocularis expressed protein 0.0019 0.0009 0.0117
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0155 0.0122 0.0122
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0007 0.0092
Toxoplasma gondii histone deacetylase HDAC1 0.04 0.0326 0.7397
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0006 0.0156
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0051
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0414 0.0338 1
Brugia malayi nuclear receptor NHR-88 0.0015 0.0006 0.0156
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0156
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.004 0.0027 0.0478
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0006 0.0156
Echinococcus granulosus histone deacetylase 0.04 0.0326 0.9068
Brugia malayi metabotropic glutamate receptor type 2 0.002 0.001 0.0253
Echinococcus multilocularis FTZ F1 alpha 0.0015 0.0006 0.0073
Echinococcus multilocularis histone deacetylase 1 0.0414 0.0338 0.4184
Schistosoma mansoni follistatin 0.0019 0.0009 0.0262
Schistosoma mansoni histone deacetylase 0.0414 0.0338 0.9393
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0536 0.0439 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0015 0.0006 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0144 0.4249
Echinococcus granulosus snurportin 1 0.0224 0.018 0.5
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.001 0.0002 0.0051
Loa Loa (eye worm) hypothetical protein 0.0224 0.018 0.4747
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0044 0.1222
Loa Loa (eye worm) hypothetical protein 0.0119 0.0093 0.2441
Schistosoma mansoni apoferritin-2 0.0009 0.0001 0.0015
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0009 0.0249
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0007 0.0008
Echinococcus granulosus GTP binding nuclear protein Ran 0.0015 0.0006 0.0174
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0007 0.0184
Trichomonas vaginalis ran, putative 0.0015 0.0006 0.0169
Loa Loa (eye worm) histone deacetylase 0.04 0.0326 0.8601
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0015 0.0006 0.0164
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0007 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0015 0.0006 0.0156
Plasmodium vivax JmjC domain containing protein 0.0016 0.0007 0.0008
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.004 0.0027 0.0333
Trypanosoma cruzi histone deacetylase, putative 0.0216 0.0173 0.3858
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0007 0.0028
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.004 0.0027 0.0478
Schistosoma mansoni importin beta-1 0.0021 0.0011 0.0302
Echinococcus multilocularis follistatin 0.0019 0.0009 0.0117
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.004 0.0027 0.0478
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0445
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0224 0.018 0.4742
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0007 0.0174
Leishmania major hypothetical protein, conserved 0.004 0.0027 0.0478
Onchocerca volvulus Histone deacetylase 10 homolog 0.0216 0.0173 0.5503
Brugia malayi ecdysteroid receptor 0.0015 0.0006 0.0156
Schistosoma mansoni ferritin 0.0009 0.0001 0.0015
Schistosoma mansoni RAR-like nuclear receptor 0.0015 0.0006 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0015 0.0006 0.0156
Echinococcus multilocularis agrin 0.0019 0.0009 0.0117
Brugia malayi Histone deacetylase 1 0.0414 0.0338 0.891
Mycobacterium ulcerans transcriptional regulator 1.2028 1 1
Brugia malayi BRCA1-associated protein 2 containing protein 0.004 0.0027 0.071
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0007 0.0028
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0445
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0007 0.0028
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0019 0.0288
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0445
Trypanosoma cruzi histone deacetylase, putative 0.04 0.0326 0.7397
Schistosoma mansoni histone deacetylase 4 5 0.04 0.0326 0.9068
Plasmodium falciparum histone deacetylase 1 0.0414 0.0338 0.7668
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0008 0.0211
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0028 0.0017 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.0019 0.0493
Brugia malayi jmjC domain containing protein 0.0016 0.0007 0.0174
Brugia malayi hypothetical protein 0.0028 0.0017 0.0445
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0027 0.0478
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0045 0.0044
Schistosoma mansoni histone deacetylase hda2 0.0441 0.036 1
Schistosoma mansoni retinoic acid receptor RXR 0.0015 0.0006 0.0164
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0005 0.0059
Schistosoma mansoni cpg binding protein 0.0022 0.0012 0.0327
Loa Loa (eye worm) hypothetical protein 0.0216 0.0173 0.4564
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.002 0.0515
Entamoeba histolytica histone deacetylase, putative 0.0414 0.0338 1
Mycobacterium tuberculosis Hypothetical protein 0.0181 0.0144 0.0143
Trichomonas vaginalis histone deacetylase, putative 0.0414 0.0338 1
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0155 0.0122 0.0122
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.004 0.0027 0.0624
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0015 0.0006 0.0156
Echinococcus multilocularis histone deacetylase 6 0.04 0.0326 0.4039
Echinococcus multilocularis histone deacetylase 7 0.04 0.0326 0.4039
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.002 0.0242
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0007 0.0028
Trypanosoma cruzi histone deacetylase, putative 0.04 0.0326 0.7397
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0042 0.0041
Toxoplasma gondii HEAT repeat-containing protein 0.0021 0.0011 0.0107
Onchocerca volvulus 0.0028 0.0017 0.0362
Brugia malayi isocitrate dehydrogenase 0.0017 0.0007 0.0197
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0249
Schistosoma mansoni hypothetical protein 0.0014 0.0005 0.0132
Brugia malayi dihydrofolate reductase family protein 0.0155 0.0122 0.3227
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0076 0.2005
Schistosoma mansoni histone deacetylase 1 2 3 0.0216 0.0173 0.4812
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0015 0.0006 0.0156
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0006 0.0073
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0015 0.0006 0.0164
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.004 0.0027 0.071
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0027 0.0782
Trypanosoma brucei histone deacetylase, putative 0.04 0.0326 0.7397
Mycobacterium ulcerans AcrR family transcriptional regulator 1.2028 1 1
Echinococcus multilocularis histone deacetylase 6 0.04 0.0326 0.4039
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0007 0.0028
Onchocerca volvulus 0.0028 0.0017 0.0362
Schistosoma mansoni hypothetical protein 0.0031 0.002 0.0543
Schistosoma mansoni ferritin light chain 0.0009 0.0001 0.0015
Echinococcus granulosus histone deacetylase 6 0.04 0.0326 0.9068
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0019 0.0288
Brugia malayi prostaglandin transporter 0.0028 0.0017 0.0445
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0015 0.0006 0.0073
Echinococcus granulosus histone deacetylase 6 0.0441 0.036 1
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.004 0.0027 0.0478
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0017 0.0362
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0039 0.1093
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0045 0.0031 0.0868
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.004 0.0027 0.0692
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0249
Loa Loa (eye worm) CXXC zinc finger family protein 0.0021 0.0011 0.0284
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0009 0.0074
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0536 0.0439 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0174
Echinococcus multilocularis snurportin 1 0.0224 0.018 0.2227
Loa Loa (eye worm) glutamate receptor 0.004 0.0027 0.0703
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0039 0.1093
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0007 0.0184
Echinococcus multilocularis thymidylate synthase 0.0381 0.031 0.3836
Echinococcus granulosus phd:f box containing protein 0.0016 0.0007 0.0184
Schistosoma mansoni histone deacetylase 0.0414 0.0338 0.9393
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0536 0.0439 1
Echinococcus multilocularis dnaJ subfamily B 0.0298 0.0241 0.2986
Toxoplasma gondii histone deacetylase HDAC4 0.0216 0.0173 0.3858
Schistosoma mansoni apoferritin-2 0.0009 0.0001 0.0015
Schistosoma mansoni ran 0.0015 0.0006 0.0174
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0027 0.0782
Echinococcus granulosus metabotropic glutamate receptor 5 0.0049 0.0034 0.0955
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0015 0.0006 0.0164
Brugia malayi histone deacetylase 11 0.0216 0.0173 0.4564
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0009 0.0249
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0007 0.0082
Schistosoma mansoni hypothetical protein 0.0068 0.005 0.1387
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0007 0.0092
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0007 0.0207
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0007 0.0092
Echinococcus granulosus histone deacetylase 1 0.0414 0.0338 0.9393
Echinococcus granulosus ferritin 0.0009 0.0001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0184 0.0147 0.3862
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0015 0.0006 0.0164
Trypanosoma brucei histone deacetylase 1 0.0414 0.0338 0.7668
Trichomonas vaginalis brca1-associated protein, putative 0.004 0.0027 0.0782
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.001 0.0002 0.0051
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0445
Echinococcus granulosus importin subunit beta 1 0.0021 0.0011 0.0302
Trichomonas vaginalis histone deacetylase, putative 0.0414 0.0338 1
Toxoplasma gondii UBA/TS-N domain-containing protein 0.004 0.0027 0.0478
Onchocerca volvulus 0.0028 0.0017 0.0362
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.004 0.0027 0.0749
Echinococcus granulosus BRCA1 associated protein 0.004 0.0027 0.0749
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0027 0.0478
Loa Loa (eye worm) hypothetical protein 0.0119 0.0093 0.2441
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.004 0.0027 0.071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0015 0.0006 0.0156
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0015 0.0006 0.0164
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0015 0.0006 0.0165
Brugia malayi jmjC domain containing protein 0.0016 0.0007 0.0174
Loa Loa (eye worm) hypothetical protein 0.0049 0.0034 0.0905
Echinococcus multilocularis dihydrofolate reductase 0.0155 0.0122 0.1516
Schistosoma mansoni thyroid hormone receptor 0.0015 0.0006 0.0164
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0039 0.1015
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0007 0.0028
Entamoeba histolytica hypothetical protein 0.0036 0.0024 0.0526
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0042 0.082
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0015 0.0006 0.0156
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0027 0.0782
Schistosoma mansoni hypothetical protein 0.0036 0.0024 0.0659
Brugia malayi Metabotropic glutamate receptor precursor. 0.004 0.0027 0.0703
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0015 0.0006 0.0156
Toxoplasma gondii histone deacetylase HDAC2 0.0414 0.0338 0.7668
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0007 0.0197
Plasmodium vivax histone deacetylase 2, putative 0.04 0.0326 0.7397
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0039 0.0487
Schistosoma mansoni organic anion transporter 0.0028 0.0017 0.0469
Plasmodium vivax histone deacetylase, putative 0.0216 0.0173 0.3858
Schistosoma mansoni jumonji domain containing protein 0.006 0.0043 0.1194
Toxoplasma gondii histone lysine methyltransferase SET1 0.004 0.0026 0.0465
Entamoeba histolytica hypothetical protein 0.0036 0.0024 0.0526
Echinococcus multilocularis BRCA1 associated protein 0.004 0.0027 0.0333
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0249
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0024 0.0294
Echinococcus granulosus histone deacetylase 6 0.04 0.0326 0.9068
Echinococcus granulosus histone deacetylase 3 0.0414 0.0338 0.9393
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0156
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0045 0.0886
Echinococcus granulosus histone deacetylase 7 0.04 0.0326 0.9068
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0027 0.0624
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0017 0.0362
Echinococcus granulosus histone deacetylase 8 0.0216 0.0173 0.4812
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0005 0.0132
Entamoeba histolytica hypothetical protein 0.0036 0.0024 0.0526
Schistosoma mansoni brca1-associated protein (brap2) 0.004 0.0027 0.0749
Trypanosoma brucei importin beta-1 subunit, putative 0.0021 0.0011 0.0107
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0019 0.0288
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0006 0.0164
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0009 0.0249
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.004 0.0027 0.0333
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0076 0.2005
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0001 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0015 0.0006 0.0164
Echinococcus multilocularis ferritin 0.0009 0.0001 0.0007
Echinococcus granulosus expressed protein 0.0009 0.0001 0.0015
Echinococcus multilocularis importin subunit beta 1 0.0021 0.0011 0.0134
Schistosoma mansoni organic anion transporter 0.0028 0.0017 0.0469
Echinococcus multilocularis histone deacetylase 3 0.0414 0.0338 0.4184
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.005 0.1315
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0019 0.0288
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0156
Echinococcus multilocularis GPCR, family 2 0.0031 0.002 0.0242
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0027 0.0478
Echinococcus granulosus follistatin 0.0019 0.0009 0.0262
Echinococcus granulosus dnaJ subfamily B 0.0298 0.0241 0.6704
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0536 0.0439 1
Trichomonas vaginalis histone deacetylase, putative 0.0414 0.0338 1
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.004 0.0027 0.0478
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0007 0.0184
Trichomonas vaginalis histone deacetylase, putative 0.0414 0.0338 1
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0007 0.0197
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0027 0.0782
Onchocerca volvulus Huntingtin homolog 0.0119 0.0093 0.2852
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.004 0.0027 0.0624
Brugia malayi jmjC domain containing protein 0.0016 0.0007 0.0174
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0076 0.2005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0174
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0381 0.031 0.0309
Loa Loa (eye worm) steroid hormone receptor 0.0015 0.0006 0.0156
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0042 0.0041
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.004 0.0027 0.0478
Mycobacterium ulcerans TetR family transcriptional regulator 1.2028 1 1
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0007 0.0184
Brugia malayi histone deacetylase 3 (HD3) 0.0414 0.0338 0.891
Schistosoma mansoni brca1-associated protein (brap2) 0.004 0.0027 0.0749
Plasmodium vivax importin-beta 2, putative 0.0021 0.0011 0.0107
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0045 0.1239
Trypanosoma cruzi importin beta-1 subunit, putative 0.0017 0.0008 0.003
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0006 0.0156
Schistosoma mansoni hypothetical protein 0.0031 0.002 0.0543
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.004 0.0027 0.0478
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.004 0.0027 0.071
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0008 0.0208
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0045 0.0552
Schistosoma mansoni steroid hormone receptor ad4bp 0.0015 0.0006 0.0164
Echinococcus multilocularis expressed protein 0.0009 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0099 0.0076 0.2005
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.002 0.0515
Trypanosoma cruzi histone deacetylase 1, putative 0.0414 0.0338 0.7668
Trypanosoma cruzi histone deacetylase, putative 0.0216 0.0173 0.3858
Onchocerca volvulus Putative organic anion transporter 0.0028 0.0017 0.0362
Brugia malayi Dihydrofolate reductase 0.0155 0.0122 0.3227
Echinococcus granulosus metabotropic glutamate receptor 2 0.0034 0.0021 0.0591

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.3183 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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