TDR Targets

Basic information

Technical information

TDR Targets ID: 1284172
Name: 2-(butanoylamino)-4,5-dimethyl-N-(3-methylphe nyl)thiophene-3-carboxamide
MW: 330.444 | Formula: C18H22N2O2S
H donors: 2 H acceptors: 2 LogP: 4.46 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCC(=O)Nc1sc(c(c1C(=O)Nc1cccc(c1)C)C)C
InChi: 1S/C18H22N2O2S/c1-5-7-15(21)20-18-16(12(3)13(4)23-18)17(22)19-14-9-6-8-11(2)10-14/h6,8-10H,5,7H2,1-4H3,(H,19,22)(H,20,21)
InChiKey: LYIQEFTYYFEBDF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4,5-dimethyl-N-(3-methylphenyl)-2-(1-oxobutylamino)-3-thiophenecarboxamide
2-butyramido-4,5-dimethyl-N-(3-methylphenyl)thiophene-3-carboxamide
BAS 06104868
ZINC00546330
AE-848/34956017
SMR000178357
2-Butyrylamino-4,5-dimethyl-thiophene-3-carboxylic acid m-tolylamide
MLS000568270
Oprea1_300364
STOCK3S-00012

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	chromobox homolog 1	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	Heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Onchocerca volvulus	Heterochromatin protein 1 homolog	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Onchocerca volvulus		Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Theileria parva	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma japonicum	Chromobox protein homolog 5, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1317	0.1288
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0155	0.0122
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.1317	0.9156
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0014	0.0287	0.2215
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0097	0.0064
Onchocerca volvulus		0.0014	0.0308	0.1448
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1672	0.2795
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0077	0.0143
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0008	0.0118	0.0137
Schistosoma mansoni	hypothetical protein	0.0014	0.0287	0.0255
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0008	0.0118	0.0137
Leishmania major	4-coumarate:coa ligase-like protein	0.0008	0.0118	0.0142
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0097	0.0064
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0008	0.0118	0.0137
Brugia malayi	Heterochromatin protein 1	0.0084	0.2458	0.4295
Loa Loa (eye worm)	oxidoreductase	0.0008	0.0118	0.0085
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0014	0.0287	0.1418
Schistosoma mansoni	acetyl-CoA synthetase	0.0008	0.0118	0.0085
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0014	0.0287	0.0255
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0287	0.1015
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0077	0.0143
Echinococcus granulosus	long chain fatty acid transport protein 4	0.0183	0.5495	0.548
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.1672	0.1644
Echinococcus granulosus	chromobox protein 2	0.0014	0.0287	0.0255
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0118	0.0151
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0077	0.0143
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0008	0.0118	0.0441
Schistosoma mansoni	chromobox protein	0.0014	0.0287	0.0255
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0014	0.0287	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0287	0.0255
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0287	0.2215
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0045	0.1266	0.1237
Entamoeba histolytica	hypothetical protein	0.0014	0.0287	0.2215
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0155	0.0122
Trypanosoma cruzi	fatty acid transporter protein-like, putative	0.0183	0.5495	1
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0287	0.2215
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0329	1	1
Loa Loa (eye worm)	heterochromatin protein 1	0.0084	0.2458	0.2432
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0287	0.1015
Leishmania major	acetyl-CoA synthetase, putative	0.0008	0.0118	0.0142
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0017	0.0386	0.1426
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0155	0.4634	0.4616
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1566	0.1538
Brugia malayi	M-phase phosphoprotein, mpp8	0.0014	0.0287	0.045
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1672	0.1644
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0118	0.0137
Schistosoma mansoni	FFA transport protein	0.0183	0.5495	0.548
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0287	0.0255
Plasmodium falciparum	heterochromatin protein 1	0.0014	0.0287	0.2215
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.1317	0.5279
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0118	0.0085
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0051	0.1428	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0287	0.1015
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0287	0.0255
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0008	0.0118	0.0137
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0287	0.2215
Echinococcus granulosus	Chromobox protein 3	0.0014	0.0287	0.0255
Trichomonas vaginalis	chromobox protein, putative	0.0014	0.0287	0.1015
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0632	0.0956
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0189	0.5677	0.5663
Schistosoma mansoni	importin beta-1	0.0031	0.0812	0.0781
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0632	0.2444
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0501	0.1902
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0021	0.0501	0.1902
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0008	0.0118	0.0137
Schistosoma mansoni	hypothetical protein	0.0329	1	1
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0016	0.0341	0.0309
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.1672	0.303
Entamoeba histolytica	acetyltransferase, GNAT family	0.0042	0.1149	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1566	0.1538
Echinococcus granulosus	transportin 1	0.0006	0.0042	0.0009
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0812	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0287	0.1015
Toxoplasma gondii	propionate-CoA ligase	0.0008	0.0118	0.0441
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0008	0.0118	0.0689
Echinococcus multilocularis	Chromobox protein 3	0.0014	0.0287	0.0255
Leishmania major	acetyl-CoA synthetase, putative	0.0008	0.0118	0.0142
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0014	0.0287	0.045
Loa Loa (eye worm)	helicase	0.0014	0.0287	0.0255
Leishmania major	4-coumarate:coa ligase-like protein	0.0008	0.0118	0.0142
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0045	0.1266	1
Brugia malayi	SET domain containing protein	0.0014	0.0308	0.0487
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.1672	0.3026
Loa Loa (eye worm)	CHromoDomain protein family member	0.0016	0.0341	0.0309
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0008	0.0118	0.0689
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1566	0.1538
Trichomonas vaginalis	chromobox protein, putative	0.0014	0.0287	0.1015
Plasmodium vivax	heterochromatin protein 1, putative	0.0014	0.0287	0.2269
Echinococcus multilocularis	importin 5	0.0006	0.0042	0.0009
Plasmodium vivax	hypothetical protein, conserved	0.0014	0.0287	0.2269
Entamoeba histolytica	hypothetical protein	0.0014	0.0287	0.2215
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0155	0.0122
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0808	0.0777
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0812	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0287	0.1015
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.1672	0.9428
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1566	0.1538
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.2458	1
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0008	0.0118	0.0085
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0501	0.1902
Brugia malayi	RNA, U transporter 1	0.0088	0.2563	0.4482
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0008	0.0118	0.0085
Schistosoma mansoni	cpg binding protein	0.0031	0.0808	0.0777
Echinococcus granulosus	chromobox protein 1	0.0084	0.2458	0.2432
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0016	0.0341	0.0309
Brugia malayi	hypothetical protein	0.0014	0.0287	0.045
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0118	0.0085
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.018	0.5421	1
Echinococcus granulosus	chromobox protein 1	0.0084	0.2458	0.2432
Loa Loa (eye worm)	hypothetical protein	0.0037	0.1003	0.0973
Schistosoma mansoni	chromobox protein	0.0084	0.2458	0.2432
Echinococcus granulosus	importin 5	0.0006	0.0042	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0287	0.0255
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0501	0.1902
Plasmodium vivax	transportin, putative	0.0006	0.0042	0.0332
Mycobacterium leprae	possible long-chain acyl-CoA synthase	0.018	0.5421	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0287	0.0255
Brugia malayi	chromobox protein homolog 3	0.0047	0.1317	0.2275
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0118	0.0151
Echinococcus granulosus	cpg binding protein	0.0032	0.0862	0.0831
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0014	0.0287	0.0255
Echinococcus multilocularis	cpg binding protein	0.0032	0.0862	0.0831
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0632	0.2444
Trichomonas vaginalis	Heterochromatin protein, putative	0.0014	0.0287	0.1015
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0097	0.0064
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0189	0.5677	1
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0632	0.1098
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0008	0.0118	0.0142
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0097	0.0064
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1566	0.1538
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0118	0.0151
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0021	0.0501	0.1902
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0045	0.1266	0.5066
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.1672	0.1644
Loa Loa (eye worm)	kap beta 3 protein	0.0006	0.0042	0.0009
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0008	0.0118	0.099
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0008	0.0118	0.0441
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0892	0.352
Brugia malayi	Valyl-tRNA synthetase	0.0014	0.0287	0.045
Plasmodium vivax	hypothetical protein, conserved	0.0014	0.0287	0.2269
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0014	0.0287	0.0255
Plasmodium vivax	importin-beta 2, putative	0.0031	0.0812	0.6416
Echinococcus multilocularis	chromobox protein 1	0.0084	0.2458	0.2432
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0008	0.0118	0.0137
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0402	0.1491
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0118	0.0151
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.0812	0.4454
Echinococcus multilocularis	chromobox protein 1	0.0084	0.2458	0.2432
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0287	0.1015
Brugia malayi	kap beta 3 protein	0.0006	0.0042	0.0016
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0014	0.0308	0.0276
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0501	0.1902
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.1428	0.5736
Echinococcus multilocularis	long chain fatty acid transport protein 4	0.0183	0.5495	0.548
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0155	0.4634	0.4616
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1566	0.1538
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0118	0.0316
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0632	0.2444
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0045	0.1266	0.5066
Entamoeba histolytica	hypothetical protein	0.0025	0.0632	0.5335
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0118	0.0151
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0077	0.0143
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0118	0.0316
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.2458	1
Brugia malayi	AMP-binding enzyme family protein	0.0189	0.5677	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0014	0.0287	0.1015
Onchocerca volvulus		0.0014	0.0287	0.129
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0077	0.0143
Leishmania major	4-coumarate:coa ligase-like protein	0.0008	0.0118	0.0142
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0287	0.1015
Loa Loa (eye worm)	acetyltransferase	0.0155	0.4634	0.4616
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0077	0.0143
Plasmodium falciparum	importin beta, putative	0.0031	0.0812	0.6957
Schistosoma mansoni	cpg binding protein	0.0032	0.0862	0.0831
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0892	0.352
Loa Loa (eye worm)	importin-beta domain-containing protein	0.0006	0.0042	0.0009
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0077	0.0143
Brugia malayi	CHD4 protein	0.0016	0.0341	0.0545
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.1317	0.5279
Onchocerca volvulus		0.0031	0.0808	0.5267
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0501	0.1902
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0812	0.0781
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0008	0.0118	0.0085
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0077	0.0143
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0017	0.0402	0.1491
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0016	0.0341	0.0309
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0045	0.1266	0.7079
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0118	0.0085
Trypanosoma cruzi	fatty acid transporter protein-like, putative	0.0183	0.5495	1
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0014	0.0287	0.2215
Echinococcus granulosus	translational activator gcn1	0.0006	0.0042	0.0009
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0045	0.1266	0.7079
Onchocerca volvulus		0.0014	0.0287	0.129
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0118	0.0085
Trichomonas vaginalis	hypothetical protein	0.0014	0.0287	0.1015
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0008	0.0118	0.0137
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1672	0.2795
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.1868	0.1841
Leishmania major	fatty acid transporter protein-like protein	0.018	0.5421	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0151	0.0209
Echinococcus multilocularis	chromobox protein 2	0.0014	0.0287	0.0255
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0808	0.1373
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0118	0.0137
Plasmodium falciparum	histone acetyltransferase GCN5	0.0042	0.1149	1
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0008	0.0118	0.0935
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0014	0.0287	0.1418
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0501	0.1902
Entamoeba histolytica	hypothetical protein	0.0014	0.0287	0.2215
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0008	0.0118	0.099
Brugia malayi	Importin beta-1 subunit	0.0031	0.0812	0.138
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.1428	0.5736
Echinococcus multilocularis	translational activator gcn1	0.0006	0.0042	0.0009
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0014	0.0287	0.0255
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.1672	0.2795
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0014	0.0287	0.1418
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0287	0.1015
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0008	0.0118	0.0137
Trichomonas vaginalis	helicase, putative	0.0007	0.0077	0.0143
Trichomonas vaginalis	chromobox protein, putative	0.0014	0.0287	0.1015
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0008	0.0118	0.0689
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0287	0.0255
Echinococcus granulosus	importin subunit beta 1	0.0031	0.0812	0.0781
Schistosoma mansoni	chromobox protein	0.0084	0.2458	0.2432
Echinococcus multilocularis	transportin 1	0.0006	0.0042	0.0009
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1566	0.1538
Echinococcus multilocularis	Chromo domain	0.0014	0.0287	0.0255
Entamoeba histolytica	acyl-coA synthetase, putative	0.0008	0.0118	0.0689
Echinococcus granulosus	Chromo domain	0.0014	0.0287	0.0255
Brugia malayi	Protein cec-1.	0.0014	0.0287	0.045
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.0812	0.0781
Schistosoma mansoni	importin-beta 2	0.0006	0.0042	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0118	0.0085
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.1566	0.2716
Giardia lamblia	Histone acetyltransferase GCN5	0.0042	0.1149	0.5
Schistosoma mansoni	chromobox protein	0.0014	0.0287	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0287	0.0255
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.1672	0.1644
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0287	0.1015
Schistosoma mansoni	cpg binding protein	0.0032	0.0862	0.0831
Onchocerca volvulus		0.0037	0.1003	0.6756
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0008	0.0118	0.0689
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0077	0.0143
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0118	0.0151
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0062	0.1771	1
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0008	0.0118	0.0151
Echinococcus multilocularis	snurportin 1	0.0329	1	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0118	0.0137
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0097	0.0064
Echinococcus granulosus	histone acetyltransferase KAT2B	0.015	0.45	0.4482
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0118	0.0137
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0014	0.0287	0.1015
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0118	0.0137
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0118	0.0151
Brugia malayi	Associated with TFs and helicases family protein	0.0014	0.0287	0.045
Brugia malayi	acetyltransferase, GNAT family protein	0.0155	0.4634	0.8152
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.1566	0.1538

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.1651 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	2.5119 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	5.0119 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1390638

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1284172