Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.104 | 0.1089 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0047 | 0.1823 | 1 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.02 | 0.02 |
Echinococcus granulosus | zinc finger protein | 0.0023 | 0.0316 | 0.0331 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1601 | 0.1601 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0227 | 0.0238 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0054 | 0.2236 | 0.2342 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.104 | 0.104 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0227 | 0.0227 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0054 | 0.2236 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.2969 | 0.2969 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0.1823 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.2752 | 0.2752 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0054 | 0.2236 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0077 | 0.3681 | 0.3681 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1188 | 0.1188 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0054 | 0.2236 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0023 | 0.0316 | 0.0316 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0227 | 0.0227 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.9548 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0023 | 0.0316 | 0.0316 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.3151 | 0.3151 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.064 | 0.064 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0111 | 0.0111 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.2752 | 0.2882 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0.1823 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.1453 | 0.1453 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0054 | 0.2236 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1717 | 0.1717 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0054 | 0.2236 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0111 | 0.0111 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.