Detailed information for compound 1293917

Basic information

Technical information
  • TDR Targets ID: 1293917
  • Name: N-[1-[(2R,4R,5R)-5-(hydroxymethyl)-4-prop-2-y noxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamid e
  • MW: 369.371 | Formula: C19H19N3O5
  • H donors: 2 H acceptors: 3 LogP: 0.29 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C#CCO[C@@H]1C[C@@H](O[C@@H]1CO)n1ccc(nc1=O)NC(=O)c1ccccc1
  • InChi: 1S/C19H19N3O5/c1-2-10-26-14-11-17(27-15(14)12-23)22-9-8-16(21-19(22)25)20-18(24)13-6-4-3-5-7-13/h1,3-9,14-15,17,23H,10-12H2,(H,20,21,24,25)/t14-,15-,17-/m1/s1
  • InChiKey: VUDFTOHJBXWAGS-BFYDXBDKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[1-[(2R,4R,5R)-5-(hydroxymethyl)-4-prop-2-ynoxy-tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]benzamide
  • N-[1-[(2R,4R,5R)-5-(hydroxymethyl)-4-prop-2-ynoxy-2-tetrahydrofuranyl]-2-oxo-4-pyrimidinyl]benzamide
  • N-[2-keto-1-[(2R,4R,5R)-5-methylol-4-propargyloxy-tetrahydrofuran-2-yl]pyrimidin-4-yl]benzamide
  • N-[1-[(2R,4R,5R)-5-(hydroxymethyl)-4-prop-2-ynoxy-oxolan-2-yl]-2-oxo-pyrimidin-4-yl]benzamide
  • AM001
  • MLS000562506
  • SMR000453693

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0036 0.0369 0.0475
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0965 0.116
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0998 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0369 0.3639
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0369 0.0454
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.1671 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0724 1
Schistosoma mansoni tar DNA-binding protein 0.0133 0.3519 0.3519
Brugia malayi hypothetical protein 0.0038 0.0417 0.0464
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.2847 0.4184
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0369 0.3639
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0816 0.0816
Loa Loa (eye worm) hypothetical protein 0.0076 0.1671 0.1628
Loa Loa (eye worm) glutaminase 0.0268 0.7922 0.7912
Schistosoma mansoni hypothetical protein 0.0292 0.8699 0.8699
Loa Loa (eye worm) hypothetical protein 0.0036 0.0369 0.0319
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0403 0.0446
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0753 0.0705
Trichomonas vaginalis esterase, putative 0.0036 0.0369 0.0454
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.3255 0.4795
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0369 0.0475
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.1671 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0816 0.2404
Loa Loa (eye worm) hypothetical protein 0.0056 0.0998 0.0951
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0417 0.0417
Brugia malayi Importin beta-1 subunit 0.0031 0.0201 0.019
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0792 0.0792
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.4885 0.4885
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0369 0.0454
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0369 0.0369
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0753 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0369 0.0475
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0792 0.792
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0816 0.1143
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0864 0.5039
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.2847 0.4184
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.1671 0.2057
Schistosoma mansoni hypothetical protein 0.0171 0.4746 0.4746
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.1671 0.5067
Loa Loa (eye worm) hypothetical protein 0.0048 0.0753 0.0705
Plasmodium vivax ataxin-2 like protein, putative 0.0056 0.0998 0.5864
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0753 0.0753
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.1671 0.2057
Brugia malayi mbt repeat family protein 0.0048 0.0753 0.0891
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.4725 0.4725
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.4885 0.4885
Mycobacterium tuberculosis Conserved protein 0.0036 0.0369 0.0475
Schistosoma mansoni tar DNA-binding protein 0.0133 0.3519 0.3519
Loa Loa (eye worm) glutaminase 2 0.0268 0.7922 0.7912
Brugia malayi RNA binding protein 0.0133 0.3519 0.4405
Plasmodium falciparum importin beta, putative 0.0031 0.0201 0.0968
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0052 0.0589
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0369 0.0475
Echinococcus granulosus geminin 0.0171 0.4746 0.4746
Onchocerca volvulus 0.0036 0.0369 0.4529
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0052 0.0589
Trypanosoma brucei PAB1-binding protein , putative 0.0056 0.0998 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0969 0.0969
Brugia malayi beta-lactamase family protein 0.0036 0.0369 0.0403
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.6733 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0854 0.0854
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0969 0.1166
Leishmania major trypanothione reductase 0.0049 0.0792 0.792
Mycobacterium ulcerans lipase LipD 0.0036 0.0369 0.0403
Loa Loa (eye worm) RNA binding protein 0.0133 0.3519 0.3485
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0854 0.0854
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0417 0.0417
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0864 0.5039
Entamoeba histolytica hypothetical protein 0.0038 0.0417 0.5704
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 0.3519 0.3485
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0369 0.0475
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.5353 0.5353
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0792 0.1108
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.1671 0.1671
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0369 0.0454
Echinococcus multilocularis geminin 0.0171 0.4746 0.4746
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0369 0.0454
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0369 0.0369
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0369 0.0369
Brugia malayi mbt repeat family protein 0.0048 0.0753 0.0891
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0369 0.1014
Loa Loa (eye worm) TAR-binding protein 0.0133 0.3519 0.3485
Plasmodium falciparum thioredoxin reductase 0.0049 0.0792 0.46
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0969 0.0969
Brugia malayi hypothetical protein 0.0056 0.0998 0.1202
Plasmodium vivax importin-beta 2, putative 0.0031 0.0201 0.0968
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0052 0.0426
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0854 0.0854
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0998 0.5864
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0052 0.0589
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0052 0.0426
Onchocerca volvulus 0.0036 0.0369 0.4529
Entamoeba histolytica hypothetical protein 0.0038 0.0417 0.5704
Loa Loa (eye worm) hypothetical protein 0.0036 0.0369 0.0319
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0998 0.5864
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.2847 0.8729
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.1671 1
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0753 0.0753
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0052 0.0025
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0369 0.0475
Loa Loa (eye worm) glutathione reductase 0.0049 0.0792 0.0744
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0854 0.0806
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0201 0.0201
Echinococcus granulosus tar DNA binding protein 0.0133 0.3519 0.3519
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.1671 1
Brugia malayi glutaminase DH11.1 0.0268 0.7922 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0052 0.0426
Loa Loa (eye worm) hypothetical protein 0.0036 0.0369 0.0319
Brugia malayi beta-lactamase 0.0036 0.0369 0.0403
Mycobacterium ulcerans glutaminase 0.0268 0.7922 1
Mycobacterium tuberculosis Probable reductase 0.0112 0.2847 0.4184
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0369 0.0454
Schistosoma mansoni tar DNA-binding protein 0.0133 0.3519 0.3519
Leishmania major hypothetical protein, conserved 0.0056 0.0998 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0369 0.2109
Loa Loa (eye worm) hypothetical protein 0.0036 0.0369 0.0319
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0816 0.1143
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.1671 0.5
Schistosoma mansoni hypothetical protein 0.0171 0.4746 0.4746
Brugia malayi RNA, U transporter 1 0.0088 0.2068 0.2562
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.1671 0.5
Brugia malayi Thioredoxin reductase 0.0049 0.0792 0.0941
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0816 0.0816
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0965 0.116
Loa Loa (eye worm) acetyltransferase 0.0175 0.4885 0.4859
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0998 1
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0201 0.0968
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.015
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0965 0.0918
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0854 0.0854
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0854 0.0854
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0969 0.0969
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.1671 0.1671
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0753 0.0753
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0724 0.5
Toxoplasma gondii LsmAD domain-containing protein 0.0056 0.0998 0.5864
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.3255 1
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0792 0.0744
Echinococcus granulosus importin subunit beta 1 0.0031 0.0201 0.0201
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0753 0.0753
Brugia malayi beta-lactamase family protein 0.0036 0.0369 0.0403
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0724 0.4181
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.2847 0.4184
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0369 0.0475
Loa Loa (eye worm) hypothetical protein 0.0055 0.0969 0.0922
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0369 0.0475
Schistosoma mansoni tar DNA-binding protein 0.0133 0.3519 0.3519
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0753 0.0753
Mycobacterium leprae Probable lipase LipE 0.0036 0.0369 0.1014
Mycobacterium ulcerans beta-lactamase 0.0036 0.0369 0.0403
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0369 0.0403
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0969 0.0969
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0369 0.0403
Brugia malayi Probable ClpP-like protease 0.0076 0.1671 0.2057
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.5353 0.5353
Mycobacterium ulcerans hypothetical protein 0.0036 0.0369 0.0403
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.1671 1
Onchocerca volvulus 0.0048 0.0753 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0864 0.1079
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0854 0.0854
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.2847 0.4184
Trypanosoma brucei trypanothione reductase 0.0049 0.0792 0.7419
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.3255 0.4795
Loa Loa (eye worm) hypothetical protein 0.0037 0.0403 0.0353
Brugia malayi RNA recognition motif domain containing protein 0.0133 0.3519 0.4405
Plasmodium falciparum glutathione reductase 0.0049 0.0792 0.46
Entamoeba histolytica hypothetical protein 0.0038 0.0417 0.5704
Onchocerca volvulus 0.0036 0.0369 0.4529
Schistosoma mansoni importin beta-1 0.0031 0.0201 0.0201
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.1671 0.1671
Entamoeba histolytica hypothetical protein 0.0038 0.0417 0.5704
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0753 0.0753
Schistosoma mansoni hypothetical protein 0.0037 0.0403 0.0403
Brugia malayi TAR-binding protein 0.0133 0.3519 0.4405
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0864 0.1079
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0417 0.0417
Loa Loa (eye worm) MBCTL1 0.0055 0.0969 0.0922
Brugia malayi hypothetical protein 0.0036 0.0357 0.0387
Loa Loa (eye worm) beta-lactamase 0.0036 0.0369 0.0319
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0036 0.0369 0.0319
Toxoplasma gondii ABC1 family protein 0.0036 0.0369 0.2
Loa Loa (eye worm) hypothetical protein 0.0036 0.0369 0.0319
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0052 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0854 0.0854
Schistosoma mansoni glutaminase 0.0268 0.7922 0.7922
Schistosoma mansoni tar DNA-binding protein 0.0133 0.3519 0.3519
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0369 0.2
Loa Loa (eye worm) hypothetical protein 0.0055 0.0965 0.0918
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.3255 0.4795
Schistosoma mansoni hypothetical protein 0.0038 0.0417 0.0417
Brugia malayi glutathione reductase 0.0049 0.0792 0.0941
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0369 0.0403
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0792 0.46
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0864 0.5039
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0854 0.1019
Plasmodium vivax glutathione reductase, putative 0.0049 0.0792 0.46
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0864 0.0864
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.2847 0.4184
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.4885 0.6141
Trichomonas vaginalis glutaminase, putative 0.0268 0.7922 1
Echinococcus multilocularis tar DNA binding protein 0.0133 0.3519 0.3519
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0969 0.0969
Toxoplasma gondii thioredoxin reductase 0.0049 0.0792 0.46
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0792 0.0792
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0369 0.0475
Leishmania major hypothetical protein, conserved 0.0036 0.0369 0.3639
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0369 0.0319
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.1671 0.5
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0753 0.0753

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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