Detailed information for compound 1303618

Basic information

Technical information
  • TDR Targets ID: 1303618
  • Name: N-[2-cyclopropyl-3-[(4-fluorophenyl)methyl]-4 -oxoquinazolin-6-yl]furan-2-carboxamide
  • MW: 403.406 | Formula: C23H18FN3O3
  • H donors: 1 H acceptors: 2 LogP: 3.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)Cn1c(nc2c(c1=O)cc(cc2)NC(=O)c1ccco1)C1CC1
  • InChi: 1S/C23H18FN3O3/c24-16-7-3-14(4-8-16)13-27-21(15-5-6-15)26-19-10-9-17(12-18(19)23(27)29)25-22(28)20-2-1-11-30-20/h1-4,7-12,15H,5-6,13H2,(H,25,28)
  • InChiKey: NGJSBDNGVRYJRC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-cyclopropyl-3-[(4-fluorophenyl)methyl]-4-oxo-quinazolin-6-yl]furan-2-carboxamide
  • N-[2-cyclopropyl-3-[(4-fluorophenyl)methyl]-4-oxo-6-quinazolinyl]-2-furancarboxamide
  • N-[2-cyclopropyl-3-(4-fluorobenzyl)-4-keto-quinazolin-6-yl]-2-furamide
  • ZINC01363108
  • Furan-2-carboxylic acid [2-cyclopropyl-3-(4-fluoro-benzyl)-4-oxo-3,4-dihydro-quinazolin-6-yl]-amide
  • MLS000029979
  • ASN 05969462
  • SMR000005896

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0631 0.7144 1
Brugia malayi hypothetical protein 0.0043 0.0065 0.0123
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0283 0.0295
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0631 0.7144 1
Mycobacterium ulcerans 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase 0.0084 0.0557 0.0378
Plasmodium falciparum acyl-CoA synthetase 0.0271 0.281 0.5
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0069 0.0372 0.013
Giardia lamblia Pyruvate-flavodoxin oxidoreductase 0.0069 0.0372 0.013
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0069 0.0372 0.013
Echinococcus multilocularis geminin 0.0205 0.2007 0.2007
Mycobacterium ulcerans putative oxalyl-CoA decarboxylase 0.0474 0.5253 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0631 0.7144 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0283 0.0283
Mycobacterium ulcerans hypothetical protein 0.0474 0.5253 1
Mycobacterium tuberculosis Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) 0.0203 0.1985 0.3304
Mycobacterium ulcerans acetolactate synthase large subunit IlvB 0.0271 0.281 0.4994
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.9584 1
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0069 0.0372 0.013
Schistosoma mansoni acetolactate synthase 0.0405 0.4422 0.4614
Mycobacterium ulcerans pyruvate or indole-3-pyruvate decarboxylase Pdc 0.0271 0.281 0.4994
Brugia malayi Thiamine pyrophosphate enzyme, central domain containing protein 0.0474 0.5253 1
Schistosoma mansoni hypothetical protein 0.0058 0.0243 0.0254
Mycobacterium tuberculosis Probable oxalyl-CoA decarboxylase OxcA 0.0474 0.5253 1
Mycobacterium ulcerans acetolactate synthase 0.0271 0.281 0.4994
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0283 0.5
Schistosoma mansoni hypothetical protein 0.0043 0.0065 0.0068
Trypanosoma cruzi phosphonopyruvate decarboxylase, putative 0.0153 0.1387 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0065 0.0068
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0308 0.3255 0.5907
Schistosoma mansoni hypothetical protein 0.0205 0.2007 0.2094
Loa Loa (eye worm) hypothetical protein 0.006 0.0261 0.087
Onchocerca volvulus 0.006 0.0261 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1279 0.4262
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0283 0.0283
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2983 0.3112
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0243 0.0463
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0631 0.7144 1
Schistosoma mansoni acetolactate synthase 0.0405 0.4422 0.4614
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0631 0.7144 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0065 0.0068
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2983 0.2983
Entamoeba histolytica pyruvate:ferredoxin oxidoreductase 0.0069 0.0372 0.0434
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0069 0.0372 0.013
Treponema pallidum fructose-bisphosphate aldolase 0.0631 0.7144 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0631 0.7144 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1279 0.4262
Echinococcus granulosus microtubule associated protein 2 0.0833 0.9584 1
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0283 0.0295
Leishmania major phosphonopyruvate decarboxylase-like protein 0.0153 0.1387 0.4371
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0631 0.7144 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0631 0.7144 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0308 0.3255 0.5746
Mycobacterium leprae PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) 0.0474 0.5253 1
Schistosoma mansoni hypothetical protein 0.0205 0.2007 0.2094
Loa Loa (eye worm) thiamine pyrophosphate enzyme 0.0272 0.2815 0.9385
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0631 0.7144 1
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0069 0.0372 0.013
Leishmania major putative pyruvate/indole-pyruvate carboxylase, putative 0.0271 0.281 1
Loa Loa (eye worm) ILVBL protein 0.0287 0.3 1
Brugia malayi MAP kinase sur-1 0.0062 0.0283 0.0538
Trichomonas vaginalis pyruvate-flavodoxin oxidoreductase, putative 0.0069 0.0372 0.013
Echinococcus granulosus geminin 0.0205 0.2007 0.2094
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0261 0.0272
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.9584 0.9584
Echinococcus granulosus tumor protein p63 0.0408 0.4459 0.4652
Loa Loa (eye worm) hypothetical protein 0.0286 0.2983 0.9943
Plasmodium vivax acyl-CoA synthetase, putative 0.0271 0.281 0.5
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0283 0.0943
Mycobacterium tuberculosis Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) 0.0474 0.5253 1
Trypanosoma brucei phosphonopyruvate decarboxylase-like protein, putative 0.0153 0.1387 1
Onchocerca volvulus 0.0058 0.0243 0.9317
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0308 0.3255 0.5907
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0631 0.7144 1
Schistosoma mansoni survival motor neuron protein 0.0058 0.0243 0.0254
Mycobacterium leprae Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) 0.0474 0.5253 1
Echinococcus multilocularis tumor protein p63 0.0408 0.4459 0.4459
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0631 0.7144 1
Trypanosoma brucei phosphonopyruvate decarboxylase-like protein, putative 0.0153 0.1387 1
Mycobacterium ulcerans acetolactate synthase 1 catalytic subunit 0.0474 0.5253 1
Mycobacterium ulcerans hypothetical protein 0.0153 0.1387 0.208
Brugia malayi hypothetical protein 0.0286 0.2983 0.5678
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0065 0.0065
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0283 0.0295
Brugia malayi MH2 domain containing protein 0.0144 0.1279 0.2434
Trypanosoma cruzi phosphonopyruvate decarboxylase, putative 0.0153 0.1387 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.2512 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 2.5119 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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