Detailed information for compound 1319625

Basic information

Technical information
  • TDR Targets ID: 1319625
  • Name: N4-(3-chlorophenyl)-5-nitro-N2-prop-2-enylpyr imidine-2,4,6-triamine
  • MW: 320.734 | Formula: C13H13ClN6O2
  • H donors: 3 H acceptors: 4 LogP: 4.25 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCNc1nc(Nc2cccc(c2)Cl)c(c(n1)N)[N+](=O)[O-]
  • InChi: 1S/C13H13ClN6O2/c1-2-6-16-13-18-11(15)10(20(21)22)12(19-13)17-9-5-3-4-8(14)7-9/h2-5,7H,1,6H2,(H4,15,16,17,18,19)
  • InChiKey: STFVWBFLPBXHDD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N2-allyl-N4-(3-chlorophenyl)-5-nitro-pyrimidine-2,4,6-triamine
  • N2-allyl-N4-(3-chlorophenyl)-5-nitropyrimidine-2,4,6-triamine
  • [2-(allylamino)-6-amino-5-nitro-pyrimidin-4-yl]-(3-chlorophenyl)amine
  • N4-(3-chlorophenyl)-5-nitro-N2-prop-2-enyl-pyrimidine-2,4,6-triamine
  • STOCK4S-09529

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATM serine/threonine kinase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma brucei phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_128955 All targets in OG5_128955
Neospora caninum phosphatidylinositol 3- and 4-kinase domain- containing protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum ko:K04728 ataxia telangectasia mutated family protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis serine protein kinase ATM Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania mexicana phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Leishmania donovani phosphatidylinositol 3-kinase-like protein Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128955 All targets in OG5_128955
Toxoplasma gondii FATC domain-containing protein Get druggable targets OG5_128955 All targets in OG5_128955
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to putative phosphatidylinositol kinase involved in telomere length regulation Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni ataxia telangiectasia mutated (atm) Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei gambiense phosphatidylinositol kinase domain protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative Get druggable targets OG5_128955 All targets in OG5_128955
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.03 0.192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Schistosoma mansoni cpg binding protein 0.0037 0.2035 0.2006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.03 0.192
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0022 0.0978 0.0946
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0237 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0022 0.0978 0.4987
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.4875 0.4823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0022 0.0978 0.4987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Schistosoma mansoni hypothetical protein 0.001 0.01 0.0065
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0022 0.0978 0.5386
Loa Loa (eye worm) hypothetical protein 0.0012 0.03 0.0201
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.1949 0.1868
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4875 0.4856
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.7411 0.7385
Loa Loa (eye worm) hypothetical protein 0.0035 0.1949 0.1868
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0022 0.0978 0.0946
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Brugia malayi Latrophilin receptor protein 2 0.0035 0.1949 0.1868
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0022 0.0978 0.0946
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.124 0.5
Loa Loa (eye worm) hypothetical protein 0.0077 0.4883 0.4831
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0022 0.0978 0.4987
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.003 0.156 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0022 0.0978 0.4987
Leishmania major hypothetical protein, conserved 0.0026 0.124 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.04 0.2563
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Echinococcus multilocularis serine protein kinase ATM 0.003 0.156 0.153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0978 0.5386
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0981 0.541
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.001 0.01 0.0065
Brugia malayi hypothetical protein 0.0016 0.0595 0.05
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0022 0.0978 0.0946
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.1949 0.1921
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.4666 0.4647
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.124 0.5
Echinococcus multilocularis GPCR, family 2 0.0035 0.1949 0.1921
Loa Loa (eye worm) hypothetical protein 0.0014 0.04 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.001 0.01 0.0643
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.7411 0.7385
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.124 0.2266
Schistosoma mansoni hypothetical protein 0.0035 0.1949 0.1921
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0186 0.0151
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0237 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.1949 0.1921
Leishmania major phosphatidylinositol kinase related protein, putative 0.0022 0.0981 0.0115
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0022 0.0978 0.5386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.156 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0012 0.03 0.0265
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.156 0.1474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.03 0.192
Loa Loa (eye worm) TAR-binding protein 0.0076 0.4875 0.4823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.03 0.192
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Echinococcus multilocularis cpg binding protein 0.0037 0.2035 0.2006
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4875 0.4856
Echinococcus granulosus serine protein kinase ATM 0.003 0.156 0.153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Loa Loa (eye worm) hypothetical protein 0.0112 0.7411 0.7385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0022 0.0978 0.0946
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.4105 1
Giardia lamblia GTOR 0.0022 0.0978 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.03 0.192
Loa Loa (eye worm) hypothetical protein 0.0026 0.126 0.1172
Trypanosoma cruzi target of rapamycin kinase 3 0.0022 0.0978 0.5386
Brugia malayi hypothetical protein 0.0026 0.124 0.1151
Echinococcus granulosus GPCR family 2 0.0035 0.1949 0.1921
Toxoplasma gondii FATC domain-containing protein 0.003 0.156 0.3131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0022 0.0978 0.5386
Schistosoma mansoni hypothetical protein 0.0035 0.1949 0.1921
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.04 0.2563
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0186 0.0087
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0177 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.003 0.156 1
Schistosoma mansoni cpg binding protein 0.0037 0.2035 0.2006
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.124 0.7238
Loa Loa (eye worm) RNA binding protein 0.0076 0.4875 0.4823
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0148 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.1949 0.1868
Schistosoma mansoni hypothetical protein 0.0035 0.1949 0.1921
Brugia malayi RNA binding protein 0.0076 0.4875 0.4823
Entamoeba histolytica hypothetical protein 0.003 0.156 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0978 0.0887
Schistosoma mansoni hypothetical protein 0.0035 0.1949 0.1921
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0012 0.03 0.0265
Schistosoma mansoni hypothetical protein 0.0011 0.0237 0.0202
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.126 0.7623
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0186 0.0151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.003 0.156 0.153
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0978 0.0887
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.1894 0.1812
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.03 0.192
Echinococcus multilocularis tar DNA binding protein 0.0076 0.4875 0.4856
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0012 0.03 0.0201
Loa Loa (eye worm) hypothetical protein 0.0026 0.124 0.1151
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0022 0.0978 0.5386
Onchocerca volvulus 0.0035 0.1894 0.5
Echinococcus granulosus cpg binding protein 0.0037 0.2035 0.2006
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.4883 0.4831
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0978 0.0887
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.1949 0.1921
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4875 0.4856
Brugia malayi CXXC zinc finger family protein 0.0035 0.1894 0.1812
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0022 0.0978 0.4987
Schistosoma mansoni cpg binding protein 0.0035 0.1894 0.1865
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0022 0.0978 0.5386
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0978 0.0887
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4875 0.4856
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 1 1
Echinococcus granulosus tar DNA binding protein 0.0076 0.4875 0.4856
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.4875 0.4823
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.7411 0.7385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.1949 0.1921
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.124 0.7458
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Toxoplasma gondii target of rapamycin (TOR), putative 0.0022 0.0978 0.1561
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.001 0.01 0.0065
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.124 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.124 0.7458
Schistosoma mansoni hypothetical protein 0.0077 0.4883 0.4865
Schistosoma mansoni tar DNA-binding protein 0.0076 0.4875 0.4856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.03 0.192
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0022 0.0978 0.0946
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0012 0.03 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Brugia malayi TAR-binding protein 0.0076 0.4875 0.4823
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0978 0.6272

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 1.4125 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 158.4893 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Saccharomyces cerevisiae ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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