Detailed information for compound 1322001

Basic information

Technical information
  • TDR Targets ID: 1322001
  • Name: NCGC00159873-01
  • MW: 473.463 | Formula: C21H22F3NO6S
  • H donors: 1 H acceptors: 4 LogP: 4.76 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1C(=C(C2=CCCCC2)c2c(N1[S+](=O)(C(F)(F)F)[O-])cccc2)C(=O)OC
  • InChi: 1S/C21H22F3NO6S/c1-3-31-20(27)18-17(19(26)30-2)16(13-9-5-4-6-10-13)14-11-7-8-12-15(14)25(18)32(28,29)21(22,23)24/h7-9,11-12,18H,3-6,10H2,1-2H3
  • InChiKey: TXFTZLKWULBMRE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus small conductance calcium activated potassium 0.0917 0.9351 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Onchocerca volvulus 0.0038 0.0105 0.0086
Toxoplasma gondii ion channel protein 0.0038 0.0105 1
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2711 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0105 0.0386
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Schistosoma mansoni hypothetical protein 0.0917 0.9351 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0105 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0038 0.0105 0.0351
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0038 0.0105 0.0351
Brugia malayi Importin beta-1 subunit 0.0035 0.0069 0.0198
Loa Loa (eye worm) hypothetical protein 0.0035 0.0069 0.0049
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Loa Loa (eye worm) TWK-28 protein 0.0038 0.0105 0.0087
Onchocerca volvulus 0.0038 0.0105 0.0086
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0023 0.2215
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0023 0.2215
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0082 0.0014
Schistosoma mansoni twik family of potassium channels-related 0.0038 0.0105 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0082 0.0014
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0038 0.0105 0.0351
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0038 0.0105 0.0351
Onchocerca volvulus 0.0038 0.0105 0.0086
Onchocerca volvulus 0.0038 0.0105 0.0086
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0038 0.0105 0.0351
Schistosoma mansoni hypothetical protein 0.0372 0.3612 0.3817
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0105 0.0386
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0038 0.0105 0.0036
Schistosoma mansoni twik family of potassium channels-related 0.0038 0.0105 0.0038
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0082 0.0015
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0038 0.0105 0.0351
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0038 0.0105 0.0351
Leishmania major hypothetical protein, conserved 0.0038 0.0105 1
Leishmania major hypothetical protein, conserved 0.003 0.0023 0.2215
Schistosoma mansoni twik family of potassium channels-related 0.0038 0.0105 0.0038
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0038 0.0105 1
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0038 0.0105 0.0036
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Loa Loa (eye worm) hypothetical protein 0.0036 0.0082 0.0063
Loa Loa (eye worm) hypothetical protein 0.027 0.2545 0.2704
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Loa Loa (eye worm) hypothetical protein 0.0393 0.3832 0.4084
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Trypanosoma cruzi ion transport protein, putative 0.0038 0.0105 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0038 0.0105 0.0351
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0038 0.0105 0.0351
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0105 0.0386
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0038 0.0105 1
Mycobacterium ulcerans ion transport protein 0.0038 0.0105 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Schistosoma mansoni hypothetical protein 0.0038 0.0105 0.0038
Loa Loa (eye worm) hypothetical protein 0.0917 0.9351 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Schistosoma mansoni calcium-activated potassium channel 0.0038 0.0105 0.0038
Echinococcus multilocularis twik family of potassium channels 0.0038 0.0105 0.0036
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0105 0.0386
Onchocerca volvulus 0.0286 0.2711 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0069 0.5655
Onchocerca volvulus 0.0038 0.0105 0.0086
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0069 0.5655
Brugia malayi hypothetical protein 0.0038 0.0105 0.0351
Echinococcus granulosus twik family of potassium channels 0.0038 0.0105 0.0039
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0038 0.0105 1
Leishmania major potassium channel subunit-like protein 0.0038 0.0105 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0038 0.0105 0.0351
Schistosoma mansoni twik family of potassium channels-related 0.0038 0.0105 0.0038
Brugia malayi Pre-SET motif family protein 0.0251 0.2346 1
Plasmodium vivax potassium channel, putative 0.0038 0.0105 1
Loa Loa (eye worm) TWK-7 protein 0.0038 0.0105 0.0087
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0038 0.0105 0.0351
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0105 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0069 0.5655
Echinococcus multilocularis geminin 0.0205 0.1855 0.1798
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0038 0.0105 1
Echinococcus multilocularis potassium channel subfamily K 8 0.0038 0.0105 0.0036
Echinococcus multilocularis twik family of potassium channels 0.0038 0.0105 0.0036
Toxoplasma gondii ion channel protein 0.0038 0.0105 1
Onchocerca volvulus 0.0038 0.0105 0.0086
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0082 0.0013
Schistosoma mansoni hypothetical protein 0.0205 0.1855 0.1924
Onchocerca volvulus 0.0038 0.0105 0.0086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0082 0.0014
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0038 0.0105 0.0351
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Schistosoma mansoni twik family of potassium channels-related 0.0038 0.0105 0.0038
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0082 0.0013
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2346 0.249
Leishmania major hypothetical protein, conserved 0.0038 0.0105 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Plasmodium vivax importin-beta 2, putative 0.0035 0.0069 0.5655
Echinococcus granulosus importin subunit beta 1 0.0035 0.0069 0.0001
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0038 0.0105 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0082 0.724
Schistosoma mansoni hypothetical protein 0.0205 0.1855 0.1924
Plasmodium falciparum potassium channel 0.0038 0.0105 1
Plasmodium falciparum potassium channel 0.0038 0.0105 1
Echinococcus granulosus potassium channel subfamily K 8 0.0038 0.0105 0.0039
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Schistosoma mansoni twik family of potassium channels-related 0.0038 0.0105 0.0038
Loa Loa (eye worm) uncoordinated protein 58 0.0038 0.0105 0.0087
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0038 0.0105 0.0351
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0038 0.0105 0.0087
Mycobacterium ulcerans transmembrane cation transporter 0.0038 0.0105 0.5
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0038 0.0105 0.0351
Plasmodium vivax SET domain protein, putative 0.0036 0.0082 0.724
Onchocerca volvulus 0.0038 0.0105 0.0086
Echinococcus multilocularis potassium channel subfamily K 0.0038 0.0105 0.0036
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3612 0.3847
Loa Loa (eye worm) hypothetical protein 0.0216 0.1978 0.2096
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0038 0.0105 0.0351
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Brugia malayi hypothetical protein 0.0038 0.0105 0.0351
Brugia malayi Pre-SET motif family protein 0.0036 0.0082 0.0254
Echinococcus multilocularis calcium activated potassium channel variant 0.0038 0.0105 0.0036
Plasmodium vivax potassium channel, putative 0.0038 0.0105 1
Schistosoma mansoni twik family of potassium channels-related 0.0038 0.0105 0.0038
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0038 0.0105 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0038 0.0105 0.0351
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0038 0.0105 0.0039
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0105 0.0386
Leishmania major calcium/potassium channel (CAKC), putative 0.0038 0.0105 1
Echinococcus multilocularis small conductance calcium activated potassium 0.0917 0.9351 0.9346
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Schistosoma mansoni calcium-activated potassium channel 0.0663 0.6674 0.7116
Schistosoma mansoni calcium-activated potassium channel 0.0038 0.0105 0.0038
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0038 0.0105 0.0087
Echinococcus granulosus potassium channel subfamily K 8 0.0038 0.0105 0.0039
Echinococcus granulosus potassium channel subfamily K 0.0038 0.0105 0.0039
Echinococcus granulosus snurportin 1 0.0372 0.3612 0.3818
Echinococcus granulosus twik family of potassium channels 0.0038 0.0105 0.0039
Giardia lamblia Hypothetical protein 0.0038 0.0105 0.5
Schistosoma mansoni calcium-activated potassium channel 0.0917 0.9351 1
Plasmodium falciparum importin beta, putative 0.0035 0.0069 0.5655
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Echinococcus granulosus calcium activated potassium channel variant 0.0038 0.0105 0.0039
Echinococcus multilocularis snurportin 1 0.0372 0.3612 0.3567
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0082 0.0014
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0038 0.0105 0.0039
Echinococcus multilocularis potassium channel subfamily K 8 0.0038 0.0105 0.0036
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0038 0.0105 0.0087
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0038 0.0105 0.0351
Loa Loa (eye worm) hypothetical protein 0.0038 0.0105 0.0087
Trypanosoma brucei calcium-activated potassium channel, putative 0.0038 0.0105 1
Leishmania major ion transport protein-like protein 0.0038 0.0105 1
Brugia malayi RNA, U transporter 1 0.0099 0.0744 0.3105
Echinococcus granulosus geminin 0.0205 0.1855 0.1925
Trypanosoma cruzi ion transport protein, putative 0.0038 0.0105 1
Schistosoma mansoni twik family of potassium channels-related 0.0038 0.0105 0.0038
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0038 0.0105 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2311 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2643 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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