Detailed information for compound 1325131

Basic information

Technical information
  • TDR Targets ID: 1325131
  • Name: [4-(phenylamino)phenyl] acetate
  • MW: 227.259 | Formula: C14H13NO2
  • H donors: 1 H acceptors: 1 LogP: 3.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Oc1ccc(cc1)Nc1ccccc1
  • InChi: 1S/C14H13NO2/c1-11(16)17-14-9-7-13(8-10-14)15-12-5-3-2-4-6-12/h2-10,15H,1H3
  • InChiKey: NKTAIXUWRAJQFA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • acetic acid [4-(phenylamino)phenyl] ester
  • [4-(phenylamino)phenyl] ethanoate
  • ZINC03219175
  • T0505-9866
  • MLS001002014
  • SMR000353326
  • Enamine_001852
  • Oprea1_249877

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis slit 2 protein 0.0059 0.1725 0.1725
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Schistosoma mansoni heat shock protein 0.0039 0.062 0.062
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.062 0.5
Schistosoma mansoni hypothetical protein 0.0041 0.0728 0.0728
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0031 0.0167 0.5
Onchocerca volvulus Slit protein homolog 0.0059 0.1725 0.2421
Loa Loa (eye worm) hypothetical protein 0.0154 0.7124 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Loa Loa (eye worm) Notch2 0.0059 0.1725 0.2421
Schistosoma mansoni septate junction protein 0.0059 0.1725 0.1725
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Echinococcus granulosus neurogenic locus notch protein 0.0059 0.1725 0.1725
Trypanosoma brucei heat shock protein, putative 0.0039 0.062 0.5
Trypanosoma brucei heat shock protein, putative 0.0039 0.062 0.5
Trypanosoma brucei heat shock protein, putative 0.0039 0.062 0.5
Onchocerca volvulus Neurogenic locus notch homolog 0.0059 0.1725 0.2421
Loa Loa (eye worm) hypothetical protein 0.0154 0.7124 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Brugia malayi EGF-like domain containing protein 0.0059 0.1725 0.2421
Schistosoma mansoni hypothetical protein 0.0059 0.1725 0.1725
Echinococcus multilocularis endoplasmin 0.0031 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Schistosoma mansoni hypothetical protein 0.0059 0.1725 0.1725
Onchocerca volvulus 0.0059 0.1725 0.2421
Echinococcus multilocularis protein jagged 1 0.0059 0.1725 0.1725
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Echinococcus multilocularis heat shock protein 0.0039 0.062 0.062
Echinococcus granulosus neurogenic locus notch protein 0.0059 0.1725 0.1725
Echinococcus multilocularis neurogenic locus protein delta 0.0059 0.1725 0.1725
Schistosoma mansoni notch 0.0059 0.1725 0.1725
Echinococcus granulosus slit 2 protein 0.0059 0.1725 0.1725
Echinococcus multilocularis neurogenic locus notch protein 0.0059 0.1725 0.1725
Trypanosoma brucei heat shock protein, putative 0.0039 0.062 0.5
Echinococcus multilocularis protein jagged 2 0.0059 0.1725 0.1725
Brugia malayi notch-like transmembrane receptor 0.0059 0.1725 0.2421
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Brugia malayi Calcium binding EGF domain containing protein 0.0059 0.1725 0.2421
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0059 0.1725 0.2421
Echinococcus granulosus heat shock protein 90 0.0031 0.0167 0.0167
Schistosoma mansoni laminin gamma-3 chain 0.0059 0.1725 0.1725
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1808 0.2539
Echinococcus multilocularis protein jagged 1 0.0059 0.1725 0.1725
Echinococcus granulosus delta-like protein 1 0.0059 0.1725 0.1725
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.062 0.5
Loa Loa (eye worm) hypothetical protein 0.006 0.1808 0.2539
Plasmodium falciparum heat shock protein 90 0.0039 0.062 0.5
Schistosoma mansoni endoplasmin 0.0039 0.062 0.062
Schistosoma mansoni notch 0.0059 0.1725 0.1725
Schistosoma mansoni notch 0.0059 0.1725 0.1725
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Brugia malayi EGF-like domain containing protein 0.0059 0.1725 0.2421
Echinococcus multilocularis fibropellin Ia 0.0059 0.1725 0.1725
Leishmania major heat shock protein 83-1 0.0039 0.062 1
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.062 0.5
Leishmania major heat shock protein 83-1 0.0039 0.062 1
Echinococcus multilocularis fat cadherin tumor suppressor 0.0059 0.1725 0.1725
Loa Loa (eye worm) hypothetical protein 0.0154 0.7124 1
Brugia malayi EGF-like domain containing protein 0.0059 0.1725 0.2421
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Onchocerca volvulus 0.0059 0.1725 0.2421
Loa Loa (eye worm) hypothetical protein 0.0041 0.0728 0.1022
Echinococcus granulosus endoplasmin 0.0031 0.0167 0.0167
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0031 0.0167 0.0167
Echinococcus granulosus protein jagged 2 0.0059 0.1725 0.1725
Brugia malayi EGF-like domain containing protein 0.0059 0.1725 0.2421
Treponema pallidum heat shock protein 90 0.0031 0.0167 0.5
Schistosoma mansoni slit 0.0059 0.1725 0.1725
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.062 1
Echinococcus multilocularis neurogenic locus notch protein 0.0059 0.1725 0.1725
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1808 0.2539
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Leishmania major heat shock protein 83-1 0.0039 0.062 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.062 0.291
Leishmania major heat shock protein 83-1 0.0039 0.062 1
Schistosoma mansoni notch 0.0059 0.1725 0.1725
Onchocerca volvulus Arrow homolog 0.0154 0.7124 1
Schistosoma mansoni hypothetical protein 0.0205 1 1
Leishmania major heat shock protein 83-1 0.0039 0.062 1
Echinococcus multilocularis fibrillin 1 0.0154 0.7124 0.7124
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.062 1
Echinococcus multilocularis geminin 0.0205 1 1
Brugia malayi heat shock protein 90 0.0039 0.062 0.087
Brugia malayi Delta serrate ligand family protein 0.0059 0.1725 0.2421
Echinococcus multilocularis notch 0.0059 0.1725 0.1725
Schistosoma mansoni hypothetical protein 0.0205 1 1
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0154 0.7124 1
Brugia malayi Fibulin-1 precursor 0.0154 0.7124 1
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.062 0.5
Plasmodium vivax heat shock protein 86, putative 0.0039 0.062 0.5
Brugia malayi Cadherin domain containing protein 0.0059 0.1725 0.2421
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0059 0.1725 0.2421
Trypanosoma brucei heat shock protein, putative 0.0039 0.062 0.5
Echinococcus granulosus fibropellin Ia 0.0059 0.1725 0.1725
Echinococcus granulosus neural cadherin 0.0059 0.1725 0.1725
Brugia malayi Calcium binding EGF domain containing protein 0.0059 0.1725 0.2421
Echinococcus multilocularis neural cadherin 0.0059 0.1725 0.1725
Schistosoma mansoni hypothetical protein 0.0059 0.1725 0.1725
Echinococcus granulosus notch 0.0059 0.1725 0.1725
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Leishmania major heat shock protein 83-1 0.0039 0.062 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.0154 0.7124 1
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.062 1
Echinococcus granulosus protein jagged 1 0.0059 0.1725 0.1725
Echinococcus multilocularis heat shock protein 90 0.0039 0.062 0.062
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0154 0.7124 1
Leishmania major heat shock protein 83-1 0.0039 0.062 1
Echinococcus multilocularis laminin 0.0154 0.7124 0.7124
Leishmania major heat shock protein 83-1 0.0039 0.062 1
Giardia lamblia High cysteine protein 0.0059 0.1725 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1808 0.2539
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0728 0.1022
Toxoplasma gondii calcium binding egf domain-containing protein 0.0154 0.7124 1
Onchocerca volvulus 0.0059 0.1725 0.2421
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Schistosoma mansoni cell polarity protein 0.0059 0.1725 0.1725
Leishmania major heat shock protein 83-1 0.0039 0.062 1
Schistosoma mansoni hypothetical protein 0.0059 0.1725 0.1725
Echinococcus granulosus Tolloid protein 1 0.0154 0.7124 0.7124
Leishmania major heat shock protein 83-1 0.0039 0.062 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.062 1
Loa Loa (eye worm) endoplasmin 0.0039 0.062 0.087
Onchocerca volvulus Putative cubilin 0.0059 0.1725 0.2421
Brugia malayi Cadherin domain containing protein 0.0059 0.1725 0.2421
Brugia malayi Muscle positioning protein 4 0.0059 0.1725 0.2421
Schistosoma mansoni heat shock protein 0.0039 0.062 0.062
Schistosoma mansoni notch 0.0059 0.1725 0.1725
Echinococcus granulosus neurogenic locus protein delta 0.0059 0.1725 0.1725
Trypanosoma brucei heat shock protein, putative 0.0039 0.062 0.5
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0154 0.7124 1
Onchocerca volvulus 0.0059 0.1725 0.2421
Echinococcus multilocularis heat shock protein 90 0.0031 0.0167 0.0167
Echinococcus granulosus heat shock protein 0.0039 0.062 0.062
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.0167 0.5
Loa Loa (eye worm) hypothetical protein 0.0154 0.7124 1
Brugia malayi GCC2 and GCC3 family protein 0.0059 0.1725 0.2421
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Leishmania major heat shock protein 83-1 0.0039 0.062 1
Plasmodium vivax endoplasmin, putative 0.0039 0.062 0.5
Schistosoma mansoni endoplasmin 0.0039 0.062 0.062
Trichomonas vaginalis heat shock protein, putative 0.0039 0.062 1
Brugia malayi EGF-like domain containing protein 0.0059 0.1725 0.2421
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Echinococcus multilocularis neurogenic locus protein delta 0.0059 0.1725 0.1725
Schistosoma mansoni notch 0.0059 0.1725 0.1725
Loa Loa (eye worm) hypothetical protein 0.0154 0.7124 1
Leishmania major heat shock protein 83-1 0.0039 0.062 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Echinococcus multilocularis neurogenic locus notch protein 4 0.0059 0.1725 0.1725
Loa Loa (eye worm) notch protein 0.0059 0.1725 0.2421
Onchocerca volvulus 0.0059 0.1725 0.2421
Brugia malayi EGF-like domain containing protein 0.0059 0.1725 0.2421
Echinococcus granulosus heat shock protein 90 0.0039 0.062 0.062
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0059 0.1725 0.1725
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.062 1
Echinococcus granulosus neurogenic locus notch protein 4 0.0059 0.1725 0.1725
Schistosoma mansoni hypothetical protein 0.0059 0.1725 0.1725
Leishmania major heat shock protein 83-1 0.0039 0.062 1
Mycobacterium ulcerans heat shock protein 90 0.0031 0.0167 1
Schistosoma mansoni hypothetical protein 0.0059 0.1725 0.1725
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0154 0.7124 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.1725 0.2421
Leishmania major heat shock protein 83-1 0.0039 0.062 1
Toxoplasma gondii EGF family domain-containing protein 0.0059 0.1725 0.1698
Trypanosoma brucei heat shock protein, putative 0.0039 0.062 0.5
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0031 0.0167 0.5
Brugia malayi Calcium binding EGF domain containing protein 0.0154 0.7124 1
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.062 0.5
Echinococcus granulosus laminin 0.0154 0.7124 0.7124
Leishmania major heat shock protein 83-1 0.0039 0.062 1
Brugia malayi EGF-like domain containing protein 0.0059 0.1725 0.2421
Echinococcus multilocularis Tolloid protein 1 0.0154 0.7124 0.7124
Trypanosoma brucei heat shock protein, putative 0.0039 0.062 0.5
Leishmania major heat shock protein 83-1 0.0039 0.062 1
Echinococcus granulosus protein jagged 2 0.0059 0.1725 0.1725
Leishmania major heat shock protein 83-1 0.0039 0.062 1
Schistosoma mansoni egf-like domain protein 0.0154 0.7124 0.7124
Loa Loa (eye worm) heat shock protein 90 0.0039 0.062 0.087
Brugia malayi Calcium binding EGF domain containing protein 0.0059 0.1725 0.2421
Schistosoma mansoni hypothetical protein 0.0059 0.1725 0.1725
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0154 0.7124 0.7124
Brugia malayi Endoplasmin precursor 0.0039 0.062 0.087
Echinococcus granulosus protein jagged 1 0.0059 0.1725 0.1725

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.625 um PUBCHEM_BIOASSAY: Luminescence-based dose response biochemical high throughput screening assay for inhibitors of the Heat Shock Protein 90 (HSP90). (Class of assay: confirmatory) [Related pubchem assays: 1831 (Summary AID.), 1846 (Confirmation screen.), 1789 (Primary screen.)] ChEMBL. No reference
Potency (functional) 0.5012 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (binding) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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