Detailed information for compound 1333433

Basic information

Technical information
  • TDR Targets ID: 1333433
  • Name: N-[(4-methylphenyl)methyl]-2-(2-phenylethyl)b enzamide
  • MW: 329.435 | Formula: C23H23NO
  • H donors: 1 H acceptors: 1 LogP: 5.27 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)CNC(=O)c1ccccc1CCc1ccccc1
  • InChi: 1S/C23H23NO/c1-18-11-13-20(14-12-18)17-24-23(25)22-10-6-5-9-21(22)16-15-19-7-3-2-4-8-19/h2-14H,15-17H2,1H3,(H,24,25)
  • InChiKey: VHYFIEGOFATPSA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-methylbenzyl)-2-(2-phenylethyl)benzamide
  • MLS000582667
  • SMR000201368
  • ZINC01065003

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pepsin A precursor 0.008 0.078 0.3767
Brugia malayi N-myristoyltransferase 2 0.0188 0.207 1
Brugia malayi Cathepsin L-like precursor 0.0022 0.009 0.0436
Echinococcus multilocularis serine:threonine protein phosphatase 2B 0.0084 0.0832 0.3717
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.009 0.0436
Echinococcus granulosus serine:threonine protein phosphatase 2B 0.0084 0.0832 0.3939
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.0188 0.207 0.4357
Loa Loa (eye worm) aspartic protease BmAsp-1 0.008 0.078 0.3697
Trichomonas vaginalis N-myristoyl transferase, putative 0.0188 0.207 0.9813
Plasmodium falciparum plasmepsin IX 0.0402 0.4634 1
Brugia malayi hypothetical protein 0.008 0.078 0.3767
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0084 0.0832 0.402
Loa Loa (eye worm) hypothetical protein 0.018 0.1983 0.9398
Toxoplasma gondii aspartyl protease ASP3 0.0402 0.4634 1
Leishmania major serine/threonine protein phosphatase 2B catalytic subunit A2, putative 0.0084 0.0832 0.402
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0059 0.0526 0.221
Loa Loa (eye worm) calpain 0.0021 0.0076 0.0362
Brugia malayi Cathepsin L-like precursor 0.0022 0.009 0.0436
Echinococcus granulosus calpain A 0.0059 0.0526 0.2485
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0191 0.211 0.4444
Onchocerca volvulus 0.0022 0.009 0.1138
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.009 0.042
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0191 0.211 0.2108
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0076 0.0369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.009 0.0436
Entamoeba histolytica Ser/Thr protein phosphatase, putative 0.0084 0.0832 0.402
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0076 0.0369
Plasmodium vivax aspartyl protease, putative 0.0402 0.4634 1
Brugia malayi Cathepsin L-like precursor 0.0022 0.009 0.0436
Plasmodium falciparum plasmepsin X 0.0402 0.4634 1
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0191 0.211 1
Loa Loa (eye worm) cysteine protease 0.0022 0.009 0.0428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.009 0.042
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0076 0.0369
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.009 0.0436
Echinococcus granulosus calpain 7 C02 family 0.0021 0.0076 0.0353
Trypanosoma brucei antigen, putative 0.0021 0.0076 0.0369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.009 0.0436
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.009 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.009 0.042
Leishmania major cathepsin L-like protease 0.0022 0.009 0.0436
Trypanosoma cruzi cruzipain precursor, putative 0.0022 0.009 0.0436
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.0188 0.207 0.9806
Leishmania major cathepsin L-like protease 0.0022 0.009 0.0436
Leishmania major cathepsin L-like protease 0.0022 0.009 0.0436
Plasmodium falciparum serine/threonine protein phosphatase 2B catalytic subunit A 0.0084 0.0832 0.1633
Echinococcus granulosus calpain 5 0.0021 0.0076 0.0353
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0076 0.0369
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.009 0.0436
Echinococcus granulosus cathepsin l1 0.0022 0.009 0.042
Loa Loa (eye worm) hypothetical protein 0.008 0.078 0.3697
Trypanosoma brucei N-myristoyltransferase 0.0188 0.207 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0191 0.211 1
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.009 0.0089
Onchocerca volvulus Cathepsin L homolog 0.0022 0.009 0.1138
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.009 0.0436
Plasmodium vivax plasmepsin IV, putative 0.0191 0.211 0.4461
Brugia malayi Cathepsin L-like precursor 0.0015 0.0002 0.0009
Plasmodium falciparum plasmepsin IV 0.0191 0.211 0.4444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.009 0.042
Loa Loa (eye worm) aspartyl protease 6 0.008 0.078 0.3697
Onchocerca volvulus 0.0022 0.009 0.1138
Plasmodium falciparum plasmepsin VII 0.008 0.078 0.1518
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0084 0.0832 0.402
Schistosoma mansoni cathepsin D (A01 family) 0.085 1 1
Loa Loa (eye worm) ctsf protein 0.0022 0.009 0.0428
Schistosoma mansoni protein phosphatase-2b 0.0084 0.0832 0.083
Brugia malayi calpain 7 0.0021 0.0076 0.0369
Trichomonas vaginalis N-myristoyl transferase, putative 0.0123 0.1299 0.6156
Loa Loa (eye worm) N-myristoyltransferase 2 0.0188 0.207 0.9813
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.009 0.0069
Trypanosoma cruzi N-myristoyl transferase, putative 0.0188 0.207 1
Onchocerca volvulus 0.008 0.078 1
Echinococcus multilocularis muscleblind protein 0.018 0.1983 0.9375
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0076 0.0369
Trypanosoma cruzi serine/threonine protein phosphatase 2B catalytic subunit A2, putative 0.0084 0.0832 0.402
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0076 0.0369
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0021 0.0076 0.0369
Plasmodium falciparum plasmepsin I 0.0191 0.211 0.4444
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.009 0.0428
Brugia malayi Cathepsin L-like precursor 0.0022 0.009 0.0436
Loa Loa (eye worm) hypothetical protein 0.0084 0.0832 0.3945
Plasmodium vivax serine/threonine protein phosphatase 2B catalytic subunit A, putative 0.0084 0.0832 0.1658
Onchocerca volvulus 0.008 0.078 1
Leishmania major N-myristoyl transferase, putative 0.0188 0.207 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0818 0.3877
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.009 0.042
Leishmania major serine/threonine protein phosphatase, putative 0.0084 0.0832 0.402
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0076 0.0369
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0084 0.0832 0.402
Schistosoma mansoni protein phosphatase-2b 0.0084 0.0832 0.083
Plasmodium vivax aspartyl protease, putative 0.0402 0.4634 1
Entamoeba histolytica cysteine proteinase, putative 0.0015 0.0002 0.0009
Echinococcus multilocularis cysteine protease 0.0022 0.009 0.0069
Onchocerca volvulus 0.0022 0.009 0.1138
Onchocerca volvulus Cathepsin F homolog 0.0022 0.009 0.1138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.009 0.0436
Loa Loa (eye worm) fibroinase 0.0022 0.009 0.0428
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.009 0.042
Loa Loa (eye worm) calpain family protein 1 0.0056 0.0495 0.2348
Trypanosoma brucei N-myristoyl transferase, putative 0.0188 0.207 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.009 0.042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.009 0.042
Brugia malayi cathepsin L-like precursor 0.0015 0.0002 0.0009
Schistosoma mansoni Mername-AA248 (C02 family) 0.0021 0.0076 0.0074
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.008 0.078 0.0778
Brugia malayi Cathepsin L-like cysteine proteinase 0.0015 0.0002 0.0009
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.008 0.078 0.1518
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.009 0.0069
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0076 0.0369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.009 0.042
Trypanosoma cruzi serine/threonine protein phosphatase, putative 0.0084 0.0832 0.402
Brugia malayi Cathepsin L-like precursor 0.0022 0.009 0.0436
Leishmania major cathepsin L-like protease 0.0022 0.009 0.0436
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.008 0.078 0.0778
Echinococcus multilocularis calpain A 0.0059 0.0526 0.221
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0076 0.0369
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0076 0.0369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.009 0.042
Plasmodium falciparum plasmepsin III 0.008 0.078 0.1518
Giardia lamblia CDC72 0.0188 0.207 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.009 0.0436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.009 0.042
Echinococcus multilocularis cysteine protease 0.0022 0.009 0.0069
Onchocerca volvulus Cathepsin L homolog 0.0022 0.009 0.1138
Brugia malayi Eukaryotic aspartyl protease family protein 0.008 0.078 0.3767
Onchocerca volvulus 0.0022 0.009 0.1138
Leishmania major cathepsin L-like protease 0.0022 0.009 0.0436
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0056 0.0495 0.0494
Schistosoma mansoni memapsin-2 (A01 family) 0.008 0.078 0.0778
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0076 0.0369
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.008 0.078 0.0778
Loa Loa (eye worm) hypothetical protein 0.018 0.1983 0.9398
Leishmania major cysteine peptidase A (CPA) 0.0022 0.009 0.0436
Leishmania major cathepsin L-like protease 0.0022 0.009 0.0436
Onchocerca volvulus 0.0022 0.009 0.1138
Plasmodium falciparum plasmepsin II 0.0191 0.211 0.4444
Trypanosoma cruzi serine/threonine protein phosphatase, putative 0.0084 0.0832 0.402
Loa Loa (eye worm) hypothetical protein 0.0035 0.0241 0.1145
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.009 0.0436
Trypanosoma cruzi N-myristoyl transferase, putative 0.0188 0.207 1
Echinococcus granulosus calpain A 0.0021 0.0076 0.0353
Loa Loa (eye worm) hypothetical protein 0.005 0.0419 0.1986
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.009 0.0089
Echinococcus granulosus serine:threonine protein phosphatase 2B 0.0084 0.0832 0.3939
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.009 0.042
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.008 0.078 0.0778
Leishmania major cathepsin L-like protease 0.0022 0.009 0.0436
Brugia malayi calpain family protein 1 0.0056 0.0495 0.2392
Onchocerca volvulus 0.0022 0.009 0.1138
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0021 0.0076 0.0369
Schistosoma mansoni calpain (C02 family) 0.0021 0.0076 0.0074
Plasmodium vivax plasmepsin V, putative 0.008 0.078 0.1544
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.0188 0.207 0.4375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.009 0.042
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0015 0.0002 0.0009
Schistosoma mansoni calpain C (C02 family) 0.0021 0.0076 0.0074
Brugia malayi Cathepsin L-like precursor 0.0015 0.0002 0.0009
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0084 0.0832 0.402
Entamoeba histolytica cysteine protease, putative 0.0022 0.009 0.0436
Echinococcus multilocularis serine:threonine protein phosphatase 2B 0.0084 0.0832 0.3717
Toxoplasma gondii aspartyl protease 0.008 0.078 0.1518
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0191 0.211 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0059 0.0526 0.0524
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0076 0.0369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.009 0.042
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0059 0.0526 0.0524
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0076 0.0369
Plasmodium falciparum plasmepsin VI 0.0191 0.211 0.4444
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0076 0.0369
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.009 0.042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.009 0.0436
Brugia malayi Serine/threonine protein phosphatase 2B catalytic subunit 2 0.0084 0.0832 0.402
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0076 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.009 0.042
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.009 0.0436
Loa Loa (eye worm) hypothetical protein 0.008 0.078 0.3697
Brugia malayi calpain family protein 1 0.0056 0.0495 0.2392
Plasmodium vivax aspartyl protease, putative 0.008 0.078 0.1544
Brugia malayi Muscleblind-like protein 0.018 0.1983 0.9577
Plasmodium vivax vivapain-2 0.0022 0.009 0.0031
Plasmodium vivax aspartyl proteinase, putative 0.008 0.078 0.1544
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.009 0.0069
Echinococcus granulosus muscleblind protein 0.018 0.1983 0.9398
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.009 0.042
Loa Loa (eye worm) calpain family protein 1 0.0041 0.0318 0.1506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.009 0.042
Loa Loa (eye worm) hypothetical protein 0.0022 0.009 0.0428
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.009 0.0436
Schistosoma mansoni N-myristoyltransferase 0.0188 0.207 0.2069
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.008 0.078 0.0778
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.009 0.042
Trypanosoma brucei protein phosphatase 2B, putative 0.0084 0.0832 0.402
Trypanosoma brucei calpain-like protein, putative 0.0021 0.0076 0.0369
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.008 0.078 0.0778
Echinococcus granulosus cathepsin L cysteine proteinase 0.0022 0.009 0.042
Leishmania major cathepsin L-like protease 0.0022 0.009 0.0436
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.009 0.042
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0022 0.009 0.0428
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.009 0.042
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0056 0.0495 0.2348
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0191 0.211 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.009 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.009 0.0436
Onchocerca volvulus 0.0022 0.009 0.1138
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0191 0.211 1
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.009 0.0436
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0021 0.0076 0.0369
Echinococcus multilocularis muscleblind protein 1 0.018 0.1983 0.9375
Brugia malayi aspartic protease BmAsp-1, identical 0.008 0.078 0.3767
Brugia malayi Cathepsin L-like precursor 0.0022 0.009 0.0436
Plasmodium falciparum plasmepsin VIII, putative 0.008 0.078 0.1518
Onchocerca volvulus 0.0035 0.0241 0.308
Toxoplasma gondii aspartyl protease ASP1 0.0191 0.211 0.4444
Plasmodium falciparum plasmepsin V 0.008 0.078 0.1518
Brugia malayi hypothetical protein 0.008 0.078 0.3767
Echinococcus granulosus cathepsin l cysteine peptidase 0.0022 0.009 0.042
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.008 0.078 0.0778
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.009 0.0436
Toxoplasma gondii protein phosphatase 2B catalytic subunit, calcineurin family phosphatse superfamily protein 0.0084 0.0832 0.1633
Echinococcus granulosus calpain 0.0021 0.0076 0.0353
Loa Loa (eye worm) hypothetical protein 0.0041 0.0318 0.1506
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.0188 0.207 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0059 0.0526 0.2485
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.009 0.042
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.0188 0.207 0.9813
Brugia malayi aspartic protease BmAsp-2, identical 0.008 0.078 0.3767
Plasmodium vivax aspartyl proteinase, putative 0.0191 0.211 0.4461
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.008 0.078 0.0778
Entamoeba histolytica Ser/Thr protein phosphatase, putative 0.0084 0.0832 0.402
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.009 0.042
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0021 0.0076 0.0369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.009 0.0436
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.009 0.0436
Plasmodium vivax vivapain-2 0.0022 0.009 0.0031
Schistosoma mansoni calpain-7 (C02 family) 0.0021 0.0076 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.009 0.042
Echinococcus multilocularis calpain family protein 1, d 0.0041 0.0318 0.1188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.009 0.0436
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0009

Activities

Activity type Activity value Assay description Source Reference
Potency (binding) 0.7079 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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